Christoph Grunau
, Perpignan · IHPE Laboratory for Host-Pathogen-Environment Interactions

Ecology, Evolutionary Biology, Genetics

The goal of the project is to understand how epigenetic changes contribute to carcinogenesis. The idea is to understand cancer as an evolutionary process in which epigenetic information plays a role alongside with genetic alterations.
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The goal of the project is to understand how epigenetics contributes to adaptive evolution of Schistosoma mansoni to new environments and hosts.
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DNA methylation was studied in great detail in vertebrates, and basically it was assumed that the its role in invertebrates would be roughly the same. More and more data indicate that this is certainly not the case: DNA methylation does not lead to transcription silencing, conserved genes are more methylated than divergent ones and the types of DNA methylation are very divergent in phylogenetically closely related species.
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What means "genomewide line" and "suggestive line" in genome-wide association studies (GWAS)?
When results of GWAS are published as Manhattan plot, one often sees genomewide line at -log10(5e-08) and suggestive line at -log10(1e-05). Where do these values come from and what do they mean exactly? Many thanks.


Awards and achievements (2)

  • May 2015
    Wellcome Trust Strategic Award
  • Mar 2010
    ANR 2010 BLAN 1720 01 (EPIGEVOL)


The goal of our group is to elucidate the multiple relations between environment, organisms and their fitness in the lab and in the field, in order to understand and control host-symbiont/parasite interactions. We see inheritance in a broad sense including genetic, epigenetic, cytoplasmic, and holobiont elements. My specialty is evolutionary epigenetics.
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