Christoph van Thriel

Christoph van Thriel
Leibniz Research Center for Working Enviroment and Human Factors | IFADO · Neurotoxicology and Chemosensation

PhD

About

200
Publications
30,106
Reads
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3,974
Citations
Citations since 2016
75 Research Items
2539 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Additional affiliations
June 1999 - present
Leibniz Research Center for Working Enviroment and Human Factors
Position
  • Project Manager

Publications

Publications (200)
Article
The solvent toluene has neurotoxic properties that are especially relevant in the working environment. Short-term exposure limits (STELs) vary from 50 ppm up to 300 ppm across countries but their acute effects remain elusive in humans. Several in vitro and in vivo studies elucidated that toluene acutely acts by perturbations of different neurotrans...
Chapter
Organic solvents are a diverse set of chemicals and chemical mixtures that are among the most widely used class of chemicals in industry and commerce. Many solvents are volatile leading to a risk of inhalation exposure. Typically, solvents are also highly lipid soluble and readily partition into lipid-rich brain tissue. In the nervous system, solve...
Article
Full-text available
It has been widely recognized that nanosafety studies are limited in reproducibility, caused by missing or inadequate information and data gaps. Reliable and comprehensive studies should be performed supported by standards or guidelines, which need to be harmonized and usable for the multidisciplinary field of nanosafety research. The previously de...
Article
Full-text available
Background Assessing the safety of engineered nanomaterials (ENMs) is an interdisciplinary and complex process producing huge amounts of information and data. To make such data and metadata reusable for researchers, manufacturers, and regulatory authorities, there is an urgent need to record and provide this information in a structured, harmonized,...
Article
Full-text available
Non-invasive direct current stimulation (DCS) of the human brain induces neuronal plasticity and alters plasticity-related cognition and behavior. Numerous basic animal research studies focusing on molecular and cellular targets of DCS have been published. In vivo, ex vivo, and in vitro models enhanced knowledge about mechanistic foundations of DCS...
Preprint
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BACKGROUND Previous research revealed a number of biological and environmental factors modulating cognitive functioning over a human’s lifespan. However, the relationships and interactions between biological factors, such as genetic polymorphisms, immunological parameters, metabolic products or infectious diseases, and environmental factors, like l...
Article
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Background: Previous research revealed several biological and environmental factors modulating cognitive functioning over a human's lifespan. However, the relationships and interactions between biological factors (eg, genetic polymorphisms, immunological parameters, metabolic products, or infectious diseases) and environmental factors (eg, lifesty...
Article
Full-text available
Since the addition of fluoride to drinking water in the 1940s, there have been frequent and sometimes heated discussions regarding its benefits and risks. In a recently published review, we addressed the question if current exposure levels in Europe represent a risk to human health. This review was discussed in an editorial asking why we did not ca...
Technical Report
Full-text available
The partners of the research project NanoS-QM (Quality- and Description Standards for Nanosafety Research Data) identified and invited relevant experts from research institutions, federal agencies, and industry to evaluate the traceability of the results generated with the existing standards and quality criteria. During the discussion it emerged th...
Article
Full-text available
The neuronal cascade related to the perception of either purely olfactory or trigeminal airborne chemicals has been investigated using electroencephalography (EEG) microstate analyses and source localization. However, most airborne chemicals are bimodal in nature, encompassing both properties. Moreover, there is an ongoing debate regarding whether...
Article
Full-text available
Effect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to provide an overview of available effect biomarkers for monitoring chemical exposures in the general a...
Article
The aim of this study was to evaluate the effect of exposure to manganese (Mn) on fine motor functions. A total of 48 welders and 30 unexposed workers as controls completed questionnaires, underwent blood examinations, and a motor test battery. The shift exposure of welders to respirable Mn was measured with personal samplers. For all subjects accu...
Article
Objectives: In recent years, complaints of patients about burning pain in arms and legs after the injection of gadolinium-based contrast agents (GBCAs) have been reported. In the current study, we investigated changes of small fibers in the epidermis as a potential cause of the patient complaints in a mouse model. Methods: Six groups of 8 mice w...
Article
Full-text available
Threshold assessments for the reference odorant n-butanol are an integral part of various research, clinical, and environmental sensory testing procedures. However, the practical significance of a high or low threshold for n-butanol beyond a particular testing environment and procedure are often unclear. Therefore, this study aimed to determine bet...
Article
Full-text available
Sensory irritation is an acute adverse effect caused by chemicals that stimulate chemoreceptors of the upper respiratory tract or the mucous membranes of the outer eye. The avoidance of this end point is of uttermost importance in regulatory toxicology. In this study, repeated exposures to ethyl acrylate were analyzed to investigate possible carryo...
Article
Full-text available
Recently, epidemiological studies have suggested that fluoride is a human developmental neurotoxicant that reduces measures of intelligence in children, placing it into the same category as toxic metals (lead, methylmercury, arsenic) and polychlorinated biphenyls. If true, this assessment would be highly relevant considering the widespread fluorida...
Article
The remarkable advances coming about through nanotechnology promise to revolutionize many aspects of modern life, however, these advances come with a responsibility for due diligence to assure that they are not accompanied by adverse consequences for human health or the environment. Many novel nanomaterials (having at least one dimension < 100 nm)...
Article
Full-text available
Health conditions characterized by symptoms associated with chemical, physical and biological environmental factors unrelated to objectifiable pathophysiological mechanisms are often labelled by the general term "idiopathic environmental intolerances". More specific, exposure-related terms are also used, e.g. "multiple chemical sensitivities", "ele...
Article
Full-text available
The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology tests, e.g. developed during the ESNATS project, use human cells and measure mechanistic endpoints (such as transcriptome changes). However, the toxicological implications of mechanistic parameters are hard to judge, without functional/morphological endpo...
Chapter
In 2017, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value (BAT value) for aluminium [7429‐90‐5]. Available publications are described in detail. The BAT value of 60 µg aluminium/g creatinine evaluated in 2009 was based on the linear correlation betwe...
Poster
One important function of the peripheral nervous system is the detection of harmful chemicals in the environment. Transient receptor potential (TRP) ion channels play a major role and some volatile organic compounds (VOCs) are able to activate TRP channels located on trigeminal nerve fibers innervating the upper airways. This activation is one of t...
Article
The effects of engineered nanomaterials on human health are still intensively studied in order to facilitate their safe application. However, relatively little is known how mechanical strain as induced in alveolar epithelial cells by breathing movements modifies biological responses to nanoparticles (NPs). In this study, A549 cells as a model for a...
Article
Four undescribed lignans and two undescribed sesquiterpenic acids, together with three known compounds (hypochoeroside C, hypochoeroside D, and 5-O-caffeoylshikimic acid) were isolated from the roots of Hypochaeris radicata subsp. neapolitana (Asteraceae, Cichorieae). The lignans were identified as 4-(3,4-dihydroxybenzyl)-2-(3,4-dihydroxyphenyl)tet...
Article
Full-text available
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To overcome this limitation, an in vitro/in silico method was established that predicts the risk of human D...
Article
Full-text available
We took advantage of magnetic resonance imaging (MRI) and spectroscopy (MRS) as non-invasive methods to quantify brain iron and neurometabolites, which were analyzed along with other predictors of motor dysfunction in Parkinson’s disease (PD). Tapping hits, tremor amplitude, and the scores derived from part III of the Movement Disorder Society-Spon...
Chapter
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the biological tolerance value (BAT value) for aluminium [CAS No. 7429‐90‐5] in 2017. Available publications are described in detail. The BAT value of 60 µg aluminium/g creatinine evaluated in 2009 was based on the linear correlatio...
Article
Full-text available
Toluene is a well-known neurotoxic organic solvent and a major component of many industrial and commercial products such as adhesives, paint thinners and gasoline. Many workers are regularly exposed to toluene in their working environment and occupational exposure limits (OELs) have been set to avoid adverse health effects. These OELs or short-term...
Article
Full-text available
Functional near-infrared spectroscopy (fNIRS) is an optical imaging technique measuring relative hemodynamic changes in superficial cortical structures. It has successfully been applied to detect a hemodynamic response in the somatosensory cortex evoked by irritating mechanical, electrical, and heat stimulations of limbs or the face. The aim of the...
Article
Lead (Pb) is a recognized neurotoxin. Pb2+ can interfere with divalent metal transporters and ion channels and may thus affect other brain metals and cation signaling in neurons. Thereby, cognitive and sensory functions can be impaired. Whereas cognitive effects are well described less is known about olfaction and motor functions in the general pop...
Conference Paper
Full-text available
The acute neurotoxic effects of organic solvents are well described in human in vivo studies, as well as in experimental studies investigation the neurophysiological mechanisms. Many solvents disturb the fine-tuned balance of excitatory and inhibitory pathways in the brain shifting it into a more inhibitory state. During repeated, occupational expo...
Conference Paper
Aim of the special session The typical adverse neurological effect of long-term occupational solvent exposure is called chronic solvent encephalopathy, characterised by persistent neurocognitive symptoms, often leading to early retirement. Surprisingly, under detection of CSE occurs even in targeted health screens by occupational health services. T...
Conference Paper
Multiple chemical sensitivities (MCS) nowadays more often called idiopathic environmental intolerance (IEI) is characterised by the recurrent occurrences of multiple symptoms involving in multiple organ systems. With respect to the aetiology of IEI toxico-, immune-, and psychogenic theories have been proposed but the exact physiological mechanisms...
Article
Objectives: Exposure to manganese (Mn) may cause movement disorders, but less is known whether the effects persist after the termination of exposure. This study investigated the association between former exposure to Mn and fine motor deficits in elderly men from an industrial area with steel production. Methods: Data on the occupational history...
Article
Full-text available
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event relationships...
Article
Full-text available
Human data about the potency of ethyl acrylate to evoke sensory irritation is currently not available. Therefore, we conducted an experimental exposure study and the magnitude of chemosensory effects in healthy human volunteers was mathematically modeled by combining the factors current concentration (c) and duration/time (t). In a repeated-measure...
Article
Full-text available
Background: Aluminum is regularly taken up with the daily diet. It is also used in antiperspirants, as an adjuvant for vaccination, and in desensitization procedures. In this review, we present the scientifically documented harmful effects of aluminum on health and the threshold values associated with them. Methods: This review is based on publi...
Article
Full-text available
Manganese (Mn) is an essential trace element with well characterized neurotoxic effects in high concentrations. Neurochemically, the initial neurotoxic effect of Mn is the perturbation of striatal γ-aminobutyric acid (GABA) levels. Specific tasks for the assessment of cognitive functions subserved by fronto-striatal loops are available as the stop-...
Article
Objective: Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the striatum and thalamus of 154 me...
Article
Objective: Magnetic resonance imaging is a non-invasive method that allows the indirect quantification of manganese (Mn) and iron (Fe) accumulation in the brain due to their paramagnetic features. The WELDOX II study aimed to explore the influence of airborne and systemic exposure to Mn and Fe on the brain deposition using the relaxation rates R1...
Article
Allergic inflammation in the upper airways represents a wide-spread health issue: Little is known about whether it increases sensitivity to airborne chemicals thereby challenging established exposure limits that neglect such differences in susceptibility. To investigate the role of pre-existing allergic inflammation, 19 subjects with seasonal aller...
Chapter
Die chemosensorischen Sinne des Menschen besitzen für die Erkennung und Vermeidung von Gefährdungen aus der Umwelt evolutionär eine besondere Bedeutung. Das olfaktorische System gewährleistet durch seine enge anatomische Anbindung an das emotionale System, dass schon geringe Geruchsstoffkonzentrationen Gefühle wie Ekel (z. B. verdorbenes Essen) und...
Article
Full-text available
Stem cell-based in vitro test systems can recapitulate specific phases of human development. In the UKK test system, human pluripotent stem cells (hPSCs) randomly differentiate into cells of the three germ layers and their derivatives. In the UKN1 test system, hPSCs differentiate into early neural precursor cells. During the normal differentiation...
Article
Perceptions that arise from stimulation of olfactory and trigeminal receptors in the nasal cavity guide the evaluation of chemical environment in humans. Strong interindividual differences in these assessments may be attributed to nonsensory factors such as gender, anxiety, and chemical sensitivity. Knowledge regarding the influence of these factor...
Article
Occupational exposure to manganese (Mn) has been associated with impairments in olfaction and motor functions, but it has yet to be determined if such effects persist upon cessation of exposure. The objective of this study was to evaluate the influence of former occupational Mn exposure on olfaction within the framework of a prospective cohort stud...
Article
Background Occupational exposure to manganese (Mn) has been associated with parkinsonism. Impairment of olfaction is an early symptom of Parkinson’s disease but evidence about olfactory dysfunction in Mn-exposed subjects is missing. Objectives The objective of this study was to evaluate the influence of former occupational Mn exposure on olfaction...
Article
Objective Occupational exposure to Mn is subject to regulation due to potential neurotoxic effects. Mn-exposed animals show a selective deposition in the basal ganglia. Magnetic resonance imaging is a non-invasive method to assess the brain accumulation of Mn by a reduction of the T1 relaxation time (T1). Here, we explored the association between e...
Article
Background High exposure to manganese (Mn) can cause movement disorders, but less is known if subclinical effects can occur at low doses or persist after termination of exposure. Objectives This study aimed to investigate the effect of exposure to Mn on fine motor deficits in a prospective cohort among elderly men from an industrial area with stee...
Article
One important function of the peripheral nervous system is the detection of noxious chemicals in the environment as well as the recognition of tissue damage throughout the body. Transient receptor potential (TRP) ion channels are able to sense a multitude of signaling factors involved in these processes. Via the sensory ganglia these sentinels conv...
Article
Full-text available
Purpose: Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective...
Article
Full-text available
Peripheral nerves innervating the mucosae of the nose, mouth, and throat protect the organism against chemical hazards. Upon their stimulation, characteristic perceptions (e.g., stinging and burning) and various reflexes are triggered (e.g., sneezing and cough). The potency of a chemical to cause sensory irritation can be estimated by a mouse bioas...
Article
Environmental exposures to tri-cresyl phosphates (TCPs) and the possible formation of toxic metabolites (e.g. cresyl saligenin phosphate; CBDP) may cause a variety of neurotoxic effects in humans. As reported for other organophosphorus compounds (OPs), the inhibition of acetylcholine esterase (AChE) has also been proposed as the underlying mechanis...
Article
Full-text available
Correction for 'Micropatterning neuronal networks' by Heike Hardelauf, et al., Analyst, 2014, 139, 3256-3264.
Article
Local irritants stimulate the nervous system via chemosensory pathways that trigger cognitive distraction, subjective complaints about impaired health, and physiological defense reflexes (e.g. eye-blinks). At workplaces and in the environment chemical exposures often co-occur with psychosocial stress. This study investigated if stress modulates adv...