Christoph Correll

Zucker School of Medicine at Hofstra Northwell + Charite Universitry · Psuchiatry and Molecular Medicine and Child and Adolescent Psychiatry

Antipsychotic treatment is associated with cardiometabolic risks that may be especially detrimental to children and adolescents. In this Danish population‐based cohort study, we included individuals with psychiatric diagnoses who initiated antipsychotics in 2000‐2021 at age 6‐31 years. We assessed the risk of cardiometabolic adverse events up to 10...

IntroductionIn RISE, TV46000 once monthly (q1m) or once every 2 months (q2m) significantly extended time to impending schizophrenia relapse. The current study (SHINE, NCT03893825) evaluated the long-term safety, tolerability, and effect of TV46000. Methods Patients completing RISE without relapse (rollover) or newly recruited (de novo) were eligibl...

IntroductionHealthcare professionals (HCPs) face unique challenges when managing patients with schizophrenia. Educational initiatives targeting common clinical dilemmas encountered by clinicians, including partial or nonadherence, may alleviate knowledge gaps and clarify the role of long-acting injectable antipsychotic agents (LAIs) in treating thi...

IntroductionHealthcare professionals (HCPs) face unique challenges when managing patients with schizophrenia. Educational initiatives targeting common clinical dilemmas encountered by clinicians, such as unfamiliarity with prescribing information for long-acting injectable antipsychotics (LAIs), may assist clinicians when treating patients with sch...

Importance Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical. Objective To examine mental health care utilization and prescription rates for children, adolescents, and young adults before and after the COVID-19 pandemic. Design, Setting, and Participan...

The United States Food and Drug Administration approved xanomeline-trospium combination for schizophrenia on September-26-2024. We conducted a PRISMA 2020-compliant systematic review with random-effects meta-analysis on the efficacy and safety of xanomeline-trospium in randomized controlled trials in patients with schizophrenia (MEDLINE, EMBASE, Co...

Background Trace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis. Aims To evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of an...

Tardive Dyskinesia (TD) can occur in people exposed to dopamine receptor antagonists (DRAs). Its clinical management remains challenging. We conducted a systematic review/random-effects network meta-analysis (NMA) searching PubMed/MEDLINE/PsycINFO/ClinicalTrials.gov/Cochrane Central Register (22/05/2023, pre-defined protocol https://osf.io/b52ae/ )...

There is growing interest in lifestyle interventions as stand-alone and add-on therapies in mental health care due to their potential benefits for both physical and mental health outcomes. We evaluated lifestyle interventions focusing on physical activity, diet, and sleep in adults with severe mental illness (SMI) and the evidence for their effecti...

Während der COVID-19-Pandemie zeigte sich eine Zunahme von Angstsymptomen bei 11-17-Jährigen in Deutschland von 14.9% (2014/2017) auf 24.1% (05-06/2020) bzw. 30.1% (12/2020-01/2021). Auch die deutsche Krankenkasse DAK berichtete einen Inzidenzanstieg um bis zu 44% bei weiblichen Jugendlichen. Differenzierte und repräsentative Untersuchungen adminis...

Background and Hypothesis: Duration of untreated psy-chosis (DUP) has been linked to worse mental health outcomes in psychotic disorders. We meta-analytically studied the relationship between "long" vs. "short" DUP and mental health outcomes. Study Design: This PRISMA/MOOSE-compliant meta-analysis searched for nonoverlapping individual studies fr...

Introduction The impact of antipsychotic use on weight gain and eating disorder-related psychopathology in adult inpatients with anorexia nervosa (AN) is unclear. Methods Consecutively hospitalized adults with AN were retrospectively analyzed. Co-primary outcomes were body mass index (BMI) and weekly weight change. Secondary outcomes were Eating Di...

La pandemia de COVID-19 y las restricciones asociadas han tenido efectos significativos sobre la salud mental a nivel mundial. Esta investigación, parte del estudio global COH-FIT, buscó describir los efectos de la pandemia sobre la salud mental de adultos en Uruguay a través de una metodología de encuesta online. Se estudió una muestra de 1936 adu...

Background A double-blind, randomized, active-controlled, parallel-group, noninferiority trial (NCT03345342) demonstrated that paliperidone palmitate once-every-6-months (PP6M) was noninferior to paliperidone palmitate once-every-3-months (PP3M) in preventing relapse in clinically stable adults with schizophrenia. This post hoc analysis assessed ef...

Background Virtual reality exposure therapy (VRET) is a promising treatment approach for anxiety disorders. However, while its efficacy has been demonstrated in adults, research on the efficacy of VRET in the treatment of adolescents with anxiety disorders is largely lacking. Objective A pilot study was carried out to test whether exposure to a vi...

Aripiprazole is approved for various severe mental disorders in adults and adolescents. However, off-label prescribing is common, especially in children and adolescents (youth) in whom aripiprazole therapeutic serum level reference ranges are lacking for any disorders. The aim of the study was to evaluate the relationship between aripiprazole dose...

Despite evidence of benefits beyond those of oral antipsychotics, long-acting injectable antipsychotics (LAIs) are underused in schizophrenia treatment. Underuse may be partially a result of misconceptions held by some healthcare professionals (HCPs) pertaining to LAIs. A panel of four experts convened between January 2022 and May 2022 to identify...

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechno...

There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on representative/weighted non-probability sample...

Repräsentative Daten zur Epidemiologie, Komorbiditäten und Versorgung der Posttraumatischen Belastungsstörung (PTBS) während der COVID-19-Pandemie fehlen, insbesondere bei Kindern und Jugendlichen. Studiengegenstand waren daher Abrechnungsdaten von 0.0-17.9-jährigen Kindern und Jugendlichen aus über 50 gesetzlichen Krankenversicherungen in Deutschl...

Ziel des vorliegenden Umbrella Reviews ist eine Aktualisierung des Umbrella Reviews von Monteleone et al. (2022)[6] zur Wirksamkeit psychotherapeutischer Behandlungsansätze speziell für AN bei Jugendlichen und Erwachsenen vorzunehmen, um damit eine Grundlage für evidenzbasierte Behandlungsentscheidungen zu schaffen.

Die in-virtuo Spiegelkonfrontation (VRET) ist ein vielversprechender Ansatz in der ergänzenden Behandlung bei erwachsenen AN-Patient:innen, Studien bei Jugendlichen fehlen bisher. In der vorliegenden Pilotstudie wird ein Körperexpositionsverfahren in VR untersucht.

Many studies have shown that COVID-19 caused many problems in mental health. This paper presents the results of the Cyprus sample, part of the global initiative named “The Collaborative Outcomes Study on Health and Functioning during Infection Times” (COH-FIT). Methods: The study took place from April 2019 to January 2022, using the Greek version o...

Introduction: People with severe mental illness have poor cardiometabolic health. Commonly used antidepressants and antipsychotics frequently lead to weight gain, which may further contribute to adverse cardiovascular outcomes. Areas covered: We searched MEDLINE up to April 2023 for umbrella reviews, (network-)meta-analyses, trials and cohort st...

Studies demonstrated increased obstetric and neonatal complications in women with schizophrenia-spectrum disorder (SSD), but most inadequately addressed confounders and rarely considered antipsychotic effects. We conducted a meta-analysis and a population-based cohort study evaluating associations of adverse obstetric/neonatal outcomes with SSD and...

Introduction Relapse is defined as the return of psychotic symptoms after a period of improvement/stability. Relapse is often associated with the disruptive re-hospitalization of patients. Importantly, relapse history is a strong predictor of subsequent relapses and poorer outcomes. Therefore, relapse prevention in the beginning of the disorder is...

Objective: To conduct a targeted literature review to examine the impact of cognitive impairment and negative symptoms among patients with schizophrenia treated in the United States across a range of outcomes pertinent to the US health care system decision-makers, such as payers and policy-makers. Data Sources: The authors searched EMBASE and PubMe...

Background The 33-item Hypomania Checklist (HCL-33) has been shown to distinguish between adolescent bipolar disorder (BD) and unipolar depression. To investigate the utility of the HCL-33 as a screening tool in routine diagnostics, the frequency and psychopathological characteristics of detected individuals in a mixed psychiatric sample necessitat...

Schizophrenia is a frequently debilitating and complex mental disorder affecting approximately 1% of the global population, characterized by symptoms such as hallucinations, delusions, disorganized thoughts and behaviors, cognitive dysfunction, and negative symptoms. Traditional treatment has centered on postsynaptic dopamine antagonists, commonly...

The COVID-19 pandemic appears to have had a considerable impact on the mental health of children and adolescents, particularly regarding eating disorders. However, it remains unclear whether the pandemic affected only the frequency or also the severity of eating disorders. We examined potential pandemic-related changes in the administrative prevale...

Sub-optimal response in schizophrenia is frequent, warranting augmentation strategies over treatment-as-usual (TAU). We assessed nutraceuticals/phytoceutical augmentation strategies via network meta-analysis. Randomized controlled trials in schizophrenia/schizoaffective disorder were identified via the following databases: PubMed, MEDLINE, EMBASE,...

Introduction: Despite a steady increase of antipsychotic prescriptions in children and adolescents, knowledge about pharmacokinetics and dosing of antipsychotics in children and adolescents remains limited. Areas covered: We discuss seven issues with major impact on the pharmacokinetics of antipsychotics in youth: estrogens, ii) obesity, iii) et...

TV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United States Food and Drug Administration for the treatment of schizophrenia in adults. In the phase 3, randomized, double-blind RIsperidone Subcutaneous Extended-release (RISE) study, TV-46000 once monthly (q1m) and once every 2 months...

Importance Long-acting injectable (LAI) antipsychotics have the potential to improve adherence and symptom control in patients with schizophrenia, promoting long-term recovery. Paliperidone palmitate (PP) once every 6 months is the first and currently only LAI antipsychotic with an extended dosing interval of 6 months. Objective To assess long-ter...

Importance Antipsychotic drugs (particularly clozapine) have been associated with pneumonia in observational studies. Despite studies of the associations between antipsychotic use and incident pneumonia, it remains unclear to what degree antipsychotic use is associated with increased risk of pneumonia, whether dose-response associations exist, and...

There is a growing literature exploring the placebo response within specific mental disorders, but no overarching quantitative synthesis of this research has analyzed evidence across mental disorders. We carried out an umbrella review of meta-analyses of randomized controlled trials (RCTs) of biological treatments (pharmacotherapy or neurostimulati...

Objectives: This survey assessed psychiatry residents'/early-career psychiatrists' attitudes towards the utility of therapeutic drug monitoring (TDM) of antipsychotics. Methods: A previously developed questionnaire on attitudes on TDM utility during antipsychotic treatment was cross-sectionally disseminated by national coordinators between 01/01...

Background Schizophrenia is most times a chronic and often debilitating illness associated with poor mental health outcomes. Early and effective treatment of schizophrenia in the most appropriate setting can make a significant difference in the long-term recovery. The aim of this narrative review was to provide suggestions and recommendations for e...

Links between premorbid physical activity (PA) and disease onset/course in patients with anorexia nervosa (AN) remain unclear. The aim was to assess self-reported PA as a predictor of change in percent median BMI (%mBMI) and length of hospital stay (LOS). Five PA domains were assessed via semi-structured interview in adolescents with AN at hospital...

Mit Pandemiebeginn im März 2020 stieg die Inzidenz von Essstörungen und die Inanspruchnahme entsprechender Versorgungsleistungen bei Kindern und Jugendlichen. Unklar ist bisher, welchen Einfluss die COVID-19-Pandemie auf das Störungsbild der Bulimia nervosa (BN) bei Kindern und Jugendlichen hatte. Studiengrundlage bildete die Forschungsdatenbank de...

Introduction: Fluvoxamine is used in children and adolescents (‘youths’) for treating obsessive compulsive disorder (OCD) but also off-label for depressive and anxiety disorders. This study aimed to investigate the relationship between fluvoxamine dose and serum concentrations, independent correlates of fluvoxamine concentrations, and a preliminary...

Background Long-acting injectable antipsychotics (LAIs) have advantages over oral antipsychotics (OAPs) in preventing relapse and hospitalization in chronically ill patients with schizophrenia-spectrum disorders (SSDs), but evidence in patients with first-episode/recent-onset, that is, early-phase-SSDs is less clear. Objectives To assess the relat...

Objectives Previous research has demonstrated gender differences in the clinical presentation of first episode psychosis (BMJ Open 2021, https://doi.org/10.1136/bmjopen-2020-042949). However, less is known about gender differences related to the tolerability of antipsychotics used to treat psychotic disorders. We sought to investigate the associati...

Zusammenfassung: Minderjährige sind als vulnerable Gruppe in Studien besonders zu schützen. Daher sind Forscher_innen bei der Studieninitiierung und Ethikkommissionen bei der Studienbewilligung oft zurückhaltend, so dass Minderjährigen von der Studienteilnahme häufig ausgeschlossen sind. Dieser Ausschluss kann dazu führen, dass Forscher_innen und K...

Background Individuals at risk for bipolar disorder (BD) have a wide range of genetic and non-genetic risk factors, like a positive family history of BD or (sub)threshold affective symptoms. Yet, it is unclear whether these individuals at risk and those diagnosed with BD share similar gray matter brain alterations. Methods In 410 male and female p...

Introduction Schizophrenia is a severe mental illness that usually begins in late adolescence or early adulthood. Current pharmacological treatments, while acceptably effective for many patients, are rarely clinically tailored or individualized. The lack of sufficient etiopathological knowledge of the disease, together with overall comparable effec...

Objective: Youth with bipolar spectrum disorders (BSD) are frequently prescribed second-generation antipsychotics (SGAs). Nonadherence to treatment often results in increased mood symptoms and diminished quality of life. We examined SGA adherence rates and adherence barriers among youth who have overweight/obesity and are diagnosed with BSD enrolle...

Purpose/Background Using data from KINECT® 4, a phase 3, 48-week study of valbenazine, post hoc analyses were conducted to assess long-term outcomes that are relevant to the real-world management of tardive dyskinesia (TD). Methods/Procedures Post hoc analyses of the participants of the KINECT 4 study who completed 48 weeks of open-label valbenazi...

We provide here the first bottom‐up review of the lived experience of mental disorders in adolescents co‐designed, co‐conducted and co‐written by experts by experience and academics. We screened first‐person accounts within and outside the medical field, and discussed them in collaborative workshops involving numerous experts by experience – repres...

Psychotic depression (PD) is a severe mental disorder leading to functional disability and high risk of suicide, but very little is known about the comparative effectiveness of medications used in its maintenance treatment. The objective of this study was to investigate the comparative effectiveness of specific antipsychotics and antidepressants, a...

Antipsychotics are core treatments for people living with psychotic disorders. Understanding individualised factors that influence both efficacy and adverse responses will improve outcomes. The objective of this study was to examine sex differences in antipsychotic-related efficacy and tolerability. This was a secondary analysis of data from phase...

Background and hypothesis Breast cancer is more prevalent in women with severe mental illness than in the general population, and use of prolactin-increasing antipsychotics may be a contributing factor. Study design A nested case–control study was conducted using the Swedish nationwide registers (inpatient/outpatient care, sickness absence, disabi...

Expositionstherapie in virtueller Realität (VR) gilt als vielversprechender Ansatz in der ergänzenden Behandlung bei erwachsenen Patient:innen mit AN, jedoch fehlen bislang Studien bei Jugendlichen. Da sich die AN jedoch mehrheitlich im Jugendalter manifestiert, wird in dieser noch laufenden Pilotstudie ein VR-basiertes Körperexpositionsverfahren f...

Congress of the Schizophrenia International Research Society (SIRS) Florence, Italy, 3-7 April 2024.

Congress of the Schizophrenia International Research Society (SIRS), Florence, Italy, 3-7 April 2024.

Patients with severe mental illness (SMI) including schizophrenia and bipolar disorder die on average 15-20 years earlier than the general population often due to sudden death that, in most cases, is caused by cardiovascular disease. This state-of-the-art review aims to address the complex association between SMI and cardiovascular risk, explore di...

Objective For adolescents, DSM‐5 differentiates anorexia nervosa (AN) and atypical AN with the 5th BMI‐centile‐for‐age. We hypothesized that the diagnostic weight cut‐off yields (i) lower weight loss in atypical AN and (ii) discrepant premorbid BMI distributions between the two disorders. Prior studies demonstrate that premorbid BMI predicts admiss...