Christoph Centner

Roche

Applying blood flow restriction (BFR) during low load exercise induces beneficial adaptations of the myotendinous and neuromuscular system. Despite the low mechanical tension, BFR exercise facilitates a localized hypoxic environment and increase in metabolic stress, widely regarded as the primary stimulus for tissue adaptations. First evidence indi...

Background First evidence indicates that the supplementation of specific collagen peptides (SCP) is associated with a significant improvement in running performance in physically active women; however, it is unclear if the same is true in males. The purpose of the present study was to investigate the effects of a concurrent training program includi...

Web-based lifestyle interventions are a new area of health research. This randomized controlled trial evaluated the effectiveness of an interactive web-based health program on physical fitness and health. N = 189 healthy adults participated in a 12-week interactive (intervention) or non-interactive (control) web-based health program. The interventi...

Background This study aimed to evaluate the physiological and metabolic adaptations to an eight-week running intervention with whole-body electromyostimulation (wbEMS) compared to running without wbEMS. Methods In a randomized controlled trial (RCT), 59 healthy participants (32 female/ 27 male, 41 ± 7 years, rel.V̇O2max 40.2 ± 7.4 ml/min/kg) ran t...

Trial registration: German Clinical Trials Register identifier: DRKS00029244. A daily supplementation of 5g of specific collagen peptides during 14 weeks of high-load resistance training increase patellar tendon hypertrophy compared to the same training regimen and placebo.The resistance training-induced CSA increase, which was most pronounced on p...

Background: The high proportion of people with overweight and obesity has become a worldwide problem in recent decades, mainly due to health consequences, such as cardiovascular diseases, neoplasia, and type 2 diabetes mellitus. Regarding effective countermeasures, the digitization of health services offers numerous potentials, which, however, have...

Für eine optimale Steuerung von Trainingsumfängen und -intensitäten im Leistungssport oder in der Rehabilitation nach Verletzungen und Erkrankungen werden zunehmend neuartige Trainingsmethoden integriert. Das Blutflussrestriktionstraining (engl. Blood-Flow-Restriction Training, BFR) beschreibt eine dieser neuen Trainingsmethoden, bei der es zu eine...

Background: Occupational reintegration after anterior cruciate ligament (ACL) rupture is an important clinical issue including economic and health-related perspectives. This study aims to develop and validate a clinical prediction model of return to work in patients with ACL reconstruction surgery considering evidence-based clinical, anthropometri...

Functional diagnostics (FD) of the human musculoskeletal system are primarily understood as the recording and analysis of movement to identify the current functional status. The objectification of movements and functioning of the neuromuscular system is particularly decisive, in order to differentiate these from subjective impressions. Thus, defici...

Resistance exercise with blood flow restriction (BFR) is considered a safe and powerful training tool. Low-load (LL) resistance training with BFR results in comparable hypertrophy compared to conventional heavy-load (HL) resistance training (Centner et al., 2019). Additionally, LL training with BFR (LL-BFR) induces comparable (Grønfeldt et al., 202...

Purpose: Recent evidence indicates that low-load blood flow restriction (LL-BFR) training elicits an anabolic response in tendinous tissue. The purpose of the present study was to investigate the hypertrophic pattern induced in the Achilles tendon by LL-BFR, in comparison to the regional hypertrophy typically observed with conventional high-load (...

Keller, M, Faude, O, Gollhofer, A, and Centner, C. Can we make blood flow restriction training more accessible? Validity of a low-cost blood flow restriction device to estimate arterial occlusion pressure. J Strength Cond Res XX(X): 000-000, 2022-Evidence indicates that low-load resistance training with blood flow restriction (BFR) results in compa...

Background Timing for return to sport (RTS) after anterior cruciate ligament (ACL) injury is paramount for the avoidance of a secondary injury. A common criterion in RTS decision-making is the limb symmetry index (LSI) which quantifies (a)symmetries between the affected and unaffected limb. Limb dominance is one of many factors that may contribute...

Background Muscle strain injuries (MSIs) in the hamstrings are among the most prevalent injuries in elite soccer. We aimed to examine the relation between biomechanical maladaptation in eccentric strength and neuromuscular factors separated by their time and frequency domains. Methods 20 elite soccer players with a previous history of unilateral M...

BACKGROUND The high proportion of people with overweight and obesity has become a worldwide problem in recent decades, mainly due to the health consequences such as cardiovascular diseases, neoplasia, or type 2 diabetes mellitus. Regarding effective countermeasures, the digitization of health services offers numerous potentials, which, however, hav...

Background: The high proportion of people with overweight and obesity has become a worldwide problem in recent decades, mainly due to health consequences, such as cardiovascular diseases, neoplasia, and type 2 diabetes mellitus. Regarding effective countermeasures, the digitization of health services offers numerous potentials, which, however, hav...

Background: Secondary anterior cruciate ligament (ACL) ruptures are a relevant clinical concern after surgical treatment of a primary ACL rupture. However, there is a lack of scientific evidence related to the role of muscle strength prior to revision surgery in a second ACL rupture. The aim of this study was to assess differences in knee extensor...

Background The anterior cruciate ligament (ACL) plays a major role in knee proprioception and is thus responsible for maintaining knee joint stability and functionality. The available evidence suggests that ACL reconstruction diminishes somatosensory feedback and proprioceptive functioning, which are vital for adequate joint positioning and movemen...

The coronavirus disease 2019 (COVID-19) pandemic has induced unhealthy lifestyles, particularly an increase in overweight and obesity, which have been shown to be associated with an increased risk of unfavorable COVID-19 outcomes. Web-based health programs could be a helpful measure, especially in times of severe restrictions. Therefore, the presen...

The purpose of this study was to investigate the effect of specific collagen peptides (SCP) combined with resistance training (RT) on changes in tendinous and muscular properties. In a randomized, placebo‐controlled study, 40 healthy male volunteers (age: 26.3 ± 4.0 years) completed a 14‐week high‐load resistance training program. One group receive...

Previous evidence suggests that resistance training in combination with specific collagen peptides (CP) improves adaptive responses of the muscular apparatus. Although beneficial effects have been repeatedly demonstrated, the underlying mechanisms are not well understood. Therefore, the primary objective of the present randomized trial was to eluci...

Editorial on the Research Topic Neuromechanics in Movement and Disease With Physiological and Pathophysiological Implications: From Fundamental Experiments to Bio-Inspired Technologies

Bioactive peptides are physiologically active peptides mostly derived from proteins following gastrointestinal digestion, fermentation or hydrolysis by proteolytic enzymes. It has been shown that bioactive peptides can be resorbed in their intact form and have repeatedly been shown to have a positive effect on health-related parameters such as hype...

Introduction: Low-load resistance training with blood flow restriction (LL-BFR) has emerged as a viable alternative to conventional high-load (HL) resistance training regimens. Despite increasing evidence confirming comparable muscle adaptations between LL-BFR and HL resistance exercise, only very little is known about tendinous mechanical and mor...

Objectives: To compare the short- and long-term effects of low load blood flow restriction (LL-BFR) versus low- (LL-RT) or high-load (HL-RT) resistance training with free blood flow on myoelectric activity, and investigate the differences between failure and non-failure protocols. Data Source: We identified sources by searching the MEDLINE/PUBMED,...

Context Hop tests play an important role in the rehabilitation process after injuries. A comparison of the jumping distances of both extremities allows for an evaluation of the injured limb. In the conventional cross-over hop test for distance, the jump width (medial vs. lateral) that the athlete has to cross during the jump is not standardised and...

Zusammenfassung Verletzungen des oberen Sprunggelenks zählen zu den häufigsten orthopädischen Verletzungen. Bis zu 50% der Patienten erfahren Rezidive und entwickeln eine chronische Sprunggelenksinstabilität. Diagnostisch und therapeutisch wird die Sprunggelenksinstabilität anhand der Ätiologie in mechanische und funktionelle Insuffizienzen geglied...

Exhaustive exercise can induce excessive generation of reactive oxygen species (ROS), which may enhance oxidative stress levels. Although physiological levels are crucial for optimal cell signaling and exercise adaptations, higher concentrations have been demonstrated to damage macromolecules and thus facilitate detrimental effects. Besides single...

During the past two decades, metabolic dysfunction and concomitant reduction-oxidation reaction (redox) imbalances (i.e., oxidative stress) have been suggested to be associated with numerous age-related chronic diseases. One profound result of metabolic imbalances is endothelial dysfunction, a pathophysiological condition that increases risk of dow...

Background Numerous studies have demonstrated that the addition of blood flow restriction (BFR) to low-load (LL) resistance exercise leads to elevated levels of muscle hypertrophy and strength gains. In terms of main underlying mechanisms, metabolic accumulation and increased neuromuscular adaptations seem to play a primary role. However, this evid...

This chapter discusses the uses of biologically active peptides in sports nutrition and their potential mechanisms. In the beginning, it presents physiological parameters that determine athletic performance and how they may be positively influenced by nutrition and potentially the intake of bioactive peptides. It then discusses the potential effect...

High-intensity interval training (HIIT) has been demonstrated to increase the generation of reactive oxygen species (ROS). Therefore, strategies to mitigate excessive ROS productions could be useful to reduce the negative consequences of oxidative damage for health, as well as for physical, performances. The aim of this study was to investigate the...

The purpose was to examine the effects of concurrent training (CT) combined with specific collagen peptides (SCP) intake on cardiometabolic parameters and performance indices in women. In a double-blind, placebo-controlled, randomized trial recreationally active women (n = 59) completed a 12-week CT training (3 day/week) and ingested 15 g of SCP (t...

The present study investigated whether changes in diet associated with an increased intake of micronutrients with antioxidant potential could affect reactive oxygen species (ROS) generation determined by EPR-spectroscopy. Out of initial 16 participants, 6 participants (28.3 ± 6.8 years) demonstrated a nutritional behavior below current national rec...

Objective: To summarize the existing evidence on the long-term effects of low-load (LL) blood flow restricted (BFR) exercise on neural markers including both central and peripheral adaptations. Methods: A systematic review and meta-analysis was conducted according to the PRISMA guidelines. The literature search was performed independently by two r...

Zusammenfassung Die medizinische und sportwissenschaftliche Forschung der letzten Jahre konnte zeigen, dass ein niedrig-intensives (20-30% des Einwiederholungsmaximums, 1RM) Krafttraining (NI) mit gleichzeitiger Blutflussrestriktion (engl.: Blood Flow Restriction, BFR) ähnliche muskuläre Adaptionen hervorruft wie ein konventionelles hoch-intensives...

Centner, C, Ritzmann, R, Gollhofer, A, and König, D. Effects of whole-body vibration training and blood flow restriction on muscle adaptations in women: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2019-The purpose of the present randomized controlled trial was to investigate potential synergistic effects of whole-body vibrati...

Low-load blood flow restriction (LL-BFR) training has gained increasing interest in the scientific community by demonstrating that increases in muscle mass and strength are comparable to conventional high-load (HL) resistance training. Although adaptations on the muscular level are well documented, there is little evidence on how LL-BFR training af...

Blood flow restriction (BFR) training has been shown to induce favorable changes in muscle mass and strength with a considerably low training load (20 - 30% 1RM). However, it has never been evaluated if an additional post-exercise protein supplementation enhances the effects of this training regimen. Thirty healthy older men (60.1 ± 7.6 years) were...

Purpose Whole-body vibration (WBV) training is frequently applied in sports and rehabilitation with the aim of inducing beneficial functional and structural adaptations. In the past decades, blood flow restriction (BFR) training has received increasing attention by enhancing the effectiveness of several low-load exercise regimens. The objective of...

The aim was to investigate the effects of resistance exercise combined with supplementation of specific collagen peptides (SCP) on body composition and muscle strength in premenopausal women. In a double-blind, placebo-controlled, randomized trial 77 premenopausal women completed a 12-week resistance training (3 day/week) and ingested 15 g of SCP o...

PURPOSE: Setting the optimal cuff pressure is a crucial part when prescribing blood flow restriction (BFR) training. It is currently recommended to use percentages of each individual's arterial occlusion pressure (AOP), which is most accurately determined by the Doppler ultrasound (DU). However, the practicality of this gold standard method in dail...

Purpose: Oxidative stress (OS) has been implicated in the pathogenesis of metabolic syndrome (MetS). The acute change in OS biomarkers due to exercise, known as Exercise-Induced OS (EIOS), is postulated to be a more appropriate marker of OS compared to spot OS measures. This studies objectives were to investigate EIOS in participants with MetS and...

Background The combination of low-load resistance training with blood flow restriction (BFR) has recently been shown to promote muscular adaptations in various populations. To date, however, evidence is sparse on how this training regimen influences muscle mass and strength in older adults. Purpose The purpose of this systematic review and meta-an...

Figures 2 and 3 were transposed.

Introduction/Background Blood-flow-restriction (BFR) training is recently progressively applied in functional training settings. The optimal cuff pressure during BFR exercise, current literature recommends using percentages of each individual's arterial occlusion pressure (AOP). Most frequently, blood flow is determined by Doppler ultrasound (DU) t...

It is generally believed that several nutrients such as β-carotene, vitamin C, E and Zinc exert a protective effect against oxidative damage. However, there is little evidence if a healthy mixed diet affects antioxidant defense mechanisms through an increased intake of micronutrients. In an open-label study, we investigated the reactive oxygen spec...

The main purpose of this study was to investigate the acute local and systemic effects of low-load resistance exercise (30% 1RM) with partial vascular occlusion on exercise-induced free radical production and to compare these effects with other established training methods. Fifteen young and healthy males (25 ± 3 years) performed the following four...

Preservation of skeletal muscle mass and strength is of vital importance in older age for maintaining musculoskeletal and functional capacity and thus independence. Recent research has indicated that high-intensity resistance training (RT) is an effective strategy to counteract the age-related decline of muscle mass and function. According to the A...

Recent interest has focused on maintenance of healthy levels of redox signalling and the related oxidants; these parameters are crucial for providing us with concrete nutritional targets that may help us to better understand and maintain "optimal health". Following the above hypothesis, we performed a pilot double-blind, crossover, placebo-controll...

Recent interest has focused on maintenance of healthy levels of redox signaling and the related oxidants; these parameters are crucial for providing us with concrete nutritional targets that may help us to better understand and maintain “optimal health”. Following the above hypothesis we performed a pilot double blind, crossover, placebo controlled...