Christof E Dörfer

Kiel University | CAU · Klinik für Zahnerhaltungskunde und Parodontologie

Background: As a unique joint that facilitates the articulation of the upper and lower jaws, the temporomandibular joint (TMJ) is concerned with several critical functions, such as speech and mastication. Pain that can become incapacitating is a result of temporomandibular disorders (TMDs), which are complex disorders affecting the masticatory musc...

Regelmäßig erfolgt eine Instruktion zur Interdentalraumpflege (IDRP), die in der zahnärztlichen Praxis zumeist an Zahnmedizinische Fachangestellte (ZF) delegiert wird. Zwei aktuelle S3-Leitlinien (AWMF-Reg.-Nrn. 083-022 und 083-043) beschreiben die Notwendigkeit und den Umfang der IDRP. Da jedoch bis heute kaum Erkenntnisse bezüglich der Empfehlung...

Periodontitis is associated with systemic chronic inflammatory diseases. There is limited evidence on the influence of anti-cytokine therapies on the periodontal condition and microbiome in the tooth pocket of such patients, so the aim of this study was to elucidate this issue. In this observational trial, the periodontal status and the gingival cr...

Background The aim of the randomized controlled clinical trial study was to evaluate the effectiveness in reducing pathologically increased pocket probing depths (PPD > 3 mm) using the Guided Biofilm Therapy (GBT) protocol (adapted to the clinical conditions in non-surgical periodontal therapy (NSPT): staining, air-polishing, ultrasonic scaler, air...

Aims: Oxidized low-density lipoprotein (oxLDL) is an important player in the course of metabolic inflammatory diseases. oxLDL was identified in the gingival crevicular fluid, denoting possible associations between oxLDL-induced inflammation and periodontal disease. The current investigation compared for the first-time direct effects of oxLDL to a c...

Hintergrund Ziel dieser experimentellen Studie war es, eine halbjährliche professionelle mechanische Plaquereduktion (PMPR) im Bereich der Zementierungsfuge von Keramikrestaurationen über fünf Jahre (V1-V5) zu simulieren, wobei ein Polierkelch mit Polierpaste (RCP), zwei verschiedene Pulver-Wasser-Strahlgeräte mit zwei verschiedenen niedrig-abrasiv...

Objective The objective of this long‐term clinical study was to evaluate the influence of a newly developed powered toothbrush (PT) on the size and number of pre‐existing gingival recessions (GR) in comparison to a manual toothbrush (MT). Methods This was a prospective, single‐blind, parallel‐group, randomized controlled clinical study. Participan...

Background To compare acceptance and preference of topical lidocaine gel anesthesia with articaine injection anesthesia in patients with moderate periodontitis undergoing scaling and root debridement. Methods Ninety‐one patients completed this randomized multicenter split‐mouth controlled study and underwent two separate periodontal treatment sess...

Background Up to date, interdental brushes (IDB) are the first choice for interdental cleaning because of their cleaning efficacy. Cylindrical ones must be selected individually according to the size/morphology of the interdental area (IDR), whereas conical ones cover a larger variability of IDR. However, there is a trend on the part of patients to...

Background Achieving sufficient professional mechanical biofilm removal (PMPR) can be challenging in supportive periodontal therapy (SPT), particularly in patients with prosthetic restorations. This experimental study aimed to simulate five years of SPT with periodic PMPR near the luting gap of ceramic restorations using a rubber cup with polishing...

Caries detection in dental radiographs is a challenging and time consuming task even for experts in the field. Recent studies have shown the potential of tooth instance segmentation and caries detection with neural networks. We present a tooth level pathology annotation pipeline, based on automated tooth instance segmentation and numbering with a M...

Periodontitis and type-2-diabetes are mutually dependent on each other with an increased risk of atherosclerotic cardiovascular disease (ASCVD). Underdiagnosed Prediabetes is also associated with ASCVDs, but without approved therapy. Thus, this study aimed to investigate whether there is an association between periodontitis and prediabetes. For a s...

Dental mesenchymal stem cells (MSCs) constitute a promising candidate for tissue regeneration in regenerative medicine. While cellular transplantation of MSCs has shown potential for achieving functional tissue regeneration, several clinical challenges hinder its implementation. An alternative approach, harnessing the secretome of MSCs, has gained...

Background and Aims: Pathogenic bacteria and host cells counteract or neutralize each other's effect in two fundamental ways: Direct invasion and secretion of various substances. Among these, lipases secreted by pathogenic bacteria and host cell lysozyme are key actors. Secreted lipases from pathogenic bacterial are suggested as a key player in the...

Gummierte Interdentalraumpicks (IRP) werden meist als eine einfach anzuwendende Form der häuslichen Interdentalraum-pflege (IDRP) vermarktet. Obwohl wissenschaftliche Studien eine große Patientenakzeptanz zeigen, ist die Evidenzlage zur Auswahl und Präferenz der IRPs in der zahnärztlichen Praxis unklar. Mit dieser Studie soll deshalb die Frage bean...

The present study explores for the first time the effect of hyperbaric oxygen (HBO) on gingival mesenchymal stem cells’ (G-MSCs) gene expression profile, intracellular pathway activation, pluripotency, and differentiation potential under an experimental inflammatory setup. G-MSCs were isolated from five healthy individuals (n = 5) and characterized...

Periodontitis is a complex inflammatory disorder of the tooth supporting structures, associated with microbial dysbiosis, and linked to a number if systemic conditions. Untreated it can result in an irreversible damage to the periodontal structures and eventually teeth loss. Regeneration of the lost periodontium requires an orchestration of a numbe...

Background: Stem/progenitor cells from human exfoliated deciduous teeth (SHED) show remarkable pluripotency, regeneration and immunological capacities. During in-vivo regenerative events, SHED could crosstalk with the surrounding inflammatory microenvironment, through toll-like-receptors (TLRs). Aim: The current investigation depicts a character...

Objectives Sonic/ultrasonic devices are essential tools in today’s endodontics. This prospective trial evaluated for the first time the impact of practitioners’ proficiency levels and patient-related factors on complications associated with a high frequency polyamide sonic irrigant activation device. Methods In total 334 patients (females:158, mal...

Periodontitis is the sixth most common chronic inflammatory disease, destroying the tissues supporting the teeth. There are three distinct stages in periodontitis: infection, inflammation, and tissue destruction, where each stage has its own characteristics and hence its line of treatment. Illuminating the underlying mechanisms of alveolar bone los...

Strukturierte Mundhygieneinstruktion bei der Parodontitisbehandlung-eine explorative Studie Warum Sie diesen Beitrag lesen sollten Obwohl die erste Therapiestufe sowohl in der gängigen Praxis als auch in den aktuellen europäischen Leitlinien die Mund-hygieneinstruktion inklusive der Anleitung zur Anwendung von Interdentalraumbürsten beinhaltet, ist...

Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can create a three-dimens...

Aim There is a lack of data on long-term impact of different psychological variables on periodontitis. Aim of the current study was to investigate the impact of psychological factors in patients with chronic periodontitis (CP; according to the 1999 Classification of Periodontal Diseases) to explain adherence to or discontinuation of supportive peri...

Frühkindliche Karies ist eine vermeidbare Erkrankung, die bei Kindern unter 6 Jahren weiterhin verbreitet ist. Ihre Entstehung ist multifaktoriell und zeigt in allen Altersgruppen eine starke soziale Polarisierung. Für die Prävention ist eine frühzeitige gemeinsame Betreuung der Kinder durch alle Berufsgruppen entscheidend. Dabei sollten neben Kind...

Background: The familiar aids for interdental cleaning such as dental floss or interdental brushes (IDB) are often associated with difficult handling or an increased potential for trauma. Interdental picks (IRP), which have no metal core and silicone flaps instead of nylon brushes, offer the alternative. However, in-vitro studies found a lower cle...

Early childhood caries is a challenge. Early dental screening flanked by multidisciplinary preventions by pediatricians, dentists, and midwives (MWs) may be helpful. New recommendations for dental screening in children (FUs) and fluoride have been introduced in Germany. The aim of this study was to investigate whether midwives consider FUs useful a...

Objectives: The study aimed to analyze different ways to control air quality during/after aerosol-generating procedures (AGPs) in a small skills lab with restricted natural air ventilation in preclinical dental training (worst-case scenario for aerogen infection control). Different phases were investigated (AGP1: intraoral high-volume evacuation (...

As data on the long-term impact of different psychological variables on periodontitis are scarce, the aim of this study was to investigate differences in psychological factors in patients with periodontal disease in order to determine the reasons for adherence and non-adherence with supportive periodontal therapy (SPT) in a university setting.

Objectives SOPs recommend high-volume evacuation (HVE) for aerosol-generating procedures (AGPs) in dentistry. Therefore, in the exploratory study, the area of splatter contamination (SCON in %) generated by high-speed tooth preparation (HSP) and air-polishing (APD) was measured when different suction cannulas of 6 mm diameter (saliva ejector (SAE))...

Vitamins and omega-3 fatty acids (Ω3FA) modulate periodontitis-associated inflammatory processes. The aim of the current investigation was to evaluate associations of oral nutrient intake and corresponding serum metabolites with clinical severity of human periodontitis. Within the Food Chain Plus cohort, 373 periodontitis patients—245 without (POL)...

Thymoquinone (TQ), the key active component of Nigella sativa (NS), demonstrates very promising biomedical anti-inflammatory, antioxidant, antimicrobial and anticancer properties. Several investigations have inspected the modulative activities of TQ on different stem/progenitor cell types, but its possible role in the regulation of gingival mesench...

Background and aims: Dietary habits-, food-, and nutrition-associated oral dysbiosis leads to the formation of microbial biofilm, which affects the overall health of an individual by promoting systemic diseases like cardiovascular disease, immunological disorders, and diabetes. Today's diets contain a variety of fermentable carbohydrates, includin...

Introduction: According to the actual EFP guidelines, first step of periodontal therapy should include oral hygiene instructions (OHI), comprising the use of interdental brushes (IDBs). Yet, non-conclusive evidence exists for their effect. The present multicentric clinical controlled explorative study compared the clinical outcomes of two NSPT (non...

Mesenchymal stem/progenitor cells (MSCs) are prospective cellular candidates for numerous regenerative and immunotherapeutic purposes. Their immunomodulatory potential and multilineage abilities allow them to be deployed for the treatment of various conditions. Nevertheless, depending on the local microenvironment, different biological tasks of MSC...

Frühkindliche Karies ist eine vermeidbare Erkrankung, die bei Kindern unter 6 Jahren weiterhin verbreitet ist. Ihre Entstehung ist multifaktoriell und zeigt in allen Altersgruppen eine starke soziale Polarisierung. Für die Prävention ist eine frühzeitige gemeinsame Betreuung der Kinder durch alle Berufsgruppen entscheidend. Dabei sollten neben Kind...

(1) Background: In Germany, new recommendations for dental examinations of children and the use of fluorides have been introduced. The pediatrician (PA) should refer the patient to the dentist for dental examinations and check-ups (DEs) from the sixth month of age. Therefore, our aim was to determine with a questionnaire the extent to which PAs fin...

Dentists should present to patients as good role models in their oral health behaviour. Previous studies have demonstrated how education can improve dental students’ oral health. This pilot investigation aimed to compare and evaluate the features of the oral health behaviour and attitudes of preclinical and clinical dental students at Ain Shams Uni...

Objectives To characterize human-gingival-fibroblast-(HGFs) viability, proliferation and adhesion on polymer-infiltrated-ceramic-network-(PICN), polyetheretherketone-(PEEK), hydroxyapatite-reinforced-polyetheretherketone-(HA-PEEK), polyetherketoneketone-(PEKK), as well as conventional titanium-(Ti) and zirconia ceramic-(Zr) implant materials in-vit...

Citation: Fawzy El-Sayed, K.M.; Bittner, A.; Schlicht, K.; Mekhemar, M.; Enthammer, K.; Höppner, M.; Es-Souni, M.; Schulz, J.; Laudes, M.; Graetz, C.; et al. Ascorbic Acid/Retinol and/or Inflammatory Stimuli's Effect on Proliferation/Differentiation

Seit der Neufassung der Richtlinie über die Früherkennungsuntersuchungen (FU) auf Zahn-, Mund- und Kieferkrankheiten aus dem Jahr 2019 sind drei zahnärztliche FU ab dem 6. Lebensmonat vorgesehen. Der Kinder- und Jugendarzt (KJA) trägt eine primäre Verantwortung als oftmals erster medizinischer Kontakt der Eltern, Kinder mit einem erhöhten Kariesris...

Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex r...

Background: Deciduous molar hypomineralization (DMH) and molar-incisor hypomineralization (MIH) represent dental defects in primary and secondary dentition and have been diagnosed worldwide. The aim of this retrospective study was to evaluate pseudonymized DMH and MIH results of eight private pedodontists' practices in northern Germany.Methods: The...

This study compared endodontic access cavities prepared by operators of different experience levels (students, general‐practitioners and specialists), guided by periapical radiographs, cone‐beam computed tomography (CBCT) or 3D CBCT‐based planning software, with regards to tooth substance loss and preparation errors. Operators (n = 34) prepared end...

Mesenchymal stem/progenitor cells (MSCs) have a multi-differentiation potential into specialized cell types, with remarkable regenerative and therapeutic results. Several factors could trigger the differentiation of MSCs into specific lineages, among them the biophysical and chemical characteristics of the extracellular matrix (ECM), including its...

Objective To obtain a current overview of the use of mandibular advancement splints (MAS) as a therapeutic option for obstructive sleep apnea (OSA) in the dental profession in Northern Germany. Methods A questionnaire was mailed to 2431 dental professionals, and 8.3% responded. Descriptive data analysis was performed on each question separately....

Several studies have found a rise in the rate of psychological discomfort among healthcare personnel since the COVID-19 pandemic outbreak. In this study, we analyzed the relationship between psychological variables of anxiety, depression, stress, avoidance, intrusion and hyperarousal and several factors among German dental nurses. For this poll, de...

Objectives: Ascorbic-acid and Retinol (AA/Retinol) application could drive cellular reprogramming, pluripotency and regeneration. As gingival mesenchymal stem/progenitor cells (G-MSCs)-mediated periodontal regeneration would occur under inflamed micro-environmental conditions, the present investigation explored for the first time the combined effec...

Being driver of cell renewal and differentiation, gingival mesenchymal stem cells (G-MSCs) are key players in periodontal regeneration. Thus, investigating MSC differentiative properties has become a much-noticed issue. Requiring a three-dimensional setting, no visual quantification of chondrogenic differentiation has been established yet. Here we...

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Multiple investigations have reported high psychological distress among students since the coronavirus (COVID-19) outbreak started. This survey examined the associations between psychological features, and several demographic and social factors among dental students in German universities. Dental students registered in German universities nationwid...

Objective/aim To identify small particle concentrations (eight categories: ≤0.1 µm × ≤5.0 µm) induced by aerosol-generating procedures (AGPs; high-speed tooth preparation, ultrasonic scaling; air polishing) under high-flow suction with a 16-mm intraoral cannula with and without an additional mobile extraoral scavenger (EOS) device during student tr...

Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antioxidant, antimicrobial, anti-inflammatory and antiparasitic effects. Several investigations have studied the pharmacological actions of SP in the treatment of oral conditions but its potential role in periodontal therapy and health is not yet fully describe...

Aim: Dental treatments generate spray and aerosols (AGP), which may pose an aerogenic infection risk. This pilot study investigated the particle number concentration (PN, n/m3) of aerosols between ≥0.1µm to ≤5.0µm generated during treatment on manikin head. A high-speed handpiece (HSH), an ultrasonic scaler (US) and an air polishing device with no...

Background Interdental brushes (IDB) are according to the actual evidence the first choice for cleaning interdental areas (IDR). Their size should be chosen individually according to the IDR morphology. However, interdental rubber picks (IRP) are appreciated better by the patients and are hence becoming more and more popular but the evidence regard...

Since the announcement of the coronavirus 2019 (COVID-19) outbreak as a pandemic, several studies reported increased psychological distress among healthcare workers. In this investigation, we examined the association between psychological outcomes and various factors among German dentists. Dentists from all German federal states were invited to par...

Objectives Whereas the key role of subgingival instrumentation in periodontal therapy is well known, the influence of operators’ experience/training with different devices on treatment results is yet uncertain. Therefore, we assessed untrained undergraduate students, working on manikins, as to how effectively they learn to use curettes (GRA) and so...

Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseas...

Dentin-pulp complex is a term which refers to the dental pulp (DP) surrounded by dentin along its peripheries. Dentin and dental pulp are highly specialized tissues, which can be affected by various insults, primarily by dental caries. Regeneration of the dentin-pulp complex is of paramount importance to regain tooth vitality. The regenerative endo...

Currently, there is no standard treatment protocol for apical periodontitis (AP). Thus, restorable teeth might get extracted and replaced prosthetically. This study evaluated German dentists' preferred AP treatment decisions and the influencing factors for selecting tooth retention by initial/repeated surgical/non-surgical root-canal treatment (RCT...

It is well established that dental plaque on teeth leads to gingivitis and periodontitis, and that several mechanical and chemical methods of plaque control can prevent gingivitis. The aim of the current review is to summarize and synthesize the available scientific evidence supporting practices for mechanical oral hygiene to prevent periodontal di...

Objective. Ascorbic acid (AA) and controlled inflammatory stimuli are postulated to possess the ability to independently exert positive effects on a variety of proliferative, pluripotency, and differentiation attributes of gingival mesenchymal stem/progenitor cells (G-MSCs). The current study’s objective was to explore and compare for the first tim...

Mesenchymal stem/progenitor cells (MSCs) are key players in regenerative medicine, relying principally on their differentiation/regeneration potential, immunomodulatory properties, paracrine effects, and potent homing ability with minimal if any ethical concerns. Even though multiple preclinical and clinical studies have demonstrated remarkable pro...

Objectives Stem/progenitor Cells form the Apical Papilla (SCAP) demonstrate remarkable regenerative and immunomodulatory properties. During their regenerative events, SCAP, similar to other stem/progenitor cells could interact with their local inflammatory micro-environment via their expressed toll-like-receptors (TLRs). The present study aimed to...

In December 2019 an outbreak of a new corona virus was reported in the city Wuhan, China. End of January, the WHO declared this development as a public health emergency of international concern (WHO, 2020). Germany reported a rapidly increasing number of 186,461 infected persons in the period from February to June (Robert‐Koch‐Institut, 2020). This...

Oral health care providers are expected to show good examples of oral health behaviours and attitudes to their community. Previous studies displayed the constructive effect of dental education on oral hygiene manners of undergraduate students. The aim of this survey was to assess and compare aspects of oral health attitudes and behaviours between p...

Deciduous molar hypomineralization (DMH) and molar-incisor hypomineralization (MIH) are global diseases with high variability that cause considerable clinical problems in paediatric dentistry. Several etiological risks were hypothesized, however, their relevance is still under discussion. The objective of this cohort study was to investigate the co...

Aim Toll‐like‐receptors are key players in mesenchymal stem/progenitor cells’ micro‐environmental crosstalk, endorsing various biological reactions. For the first, time this study investigates the effects of TLR3‐ligation on gingival mesenchymal stem/progenitor cells (G‐MSCs) stemness and differentiation properties. Material and Methods G‐MSCs (n=...