Christo Damyanov

Medical center Integrative medicine Sofia

Viral epidemics are constant satellite of human civilization and for millennia, the only achievement of common sence has been quarantine. Unlike in the time of dark days knowledge about the new coronavirus was gained almost lightning-fast. Its genetic code was read within days following the start of the epidemic in Wuhan. The structure of the virus...

The current presentation displays chronologically our summarized and updated results of more than 12 years of the accumulated experience of integrative oncology application in our medical practice. Based on our concept of systemic approach, we have created treatment protocol for cancer patients with leading method of administering Insulin Potentiat...

Purpose. To evaluate the results and quality of life of patients with resistant of castration-resistant tumors previously treated with Insulin-potentiation therapy (IPT) combined with hormone therapy. Materials and methods. Sixteen patients with metastasis prostate tumors after bilateral castration, androgenic blockade, and progression of the disea...

Problem Statement: Even after decades of scientific research, the application of chemotherapy in the management of neoplastic disease still presents numerous difficulties. Significant, amongst potential complications are numerous toxicity related side effects and the potential for chemoresistance. Despite the widespread tendency to include a variet...

Toxic effects and chemoresistance are serious problems concerning chemotherapy administration. Until now adequate solutions have not been found. In the past few years, while searching for possibilities to decrease toxicity, chemotherapy given in low, frequent doses - a novel strategy called "metronomic" administration - showed promising results. Th...

To assess the effectiveness of two approaches of organ-sparing treatment in patients with invasive transitional cell bladder carcinoma. During the period from June 1996 to June 2000, 33 patients with invasive transitional cell carcinoma (T2-4) of the bladder were treated. Patients were divided into two groups. Group A included 17 patients treated w...

Prognosis in urinary bladder cancer is clearly worse if cancer cells reach the muscle bladder wall (stage pT2-4) compared to minimal invasion (stage pTl) in which cancer cells do not go beyond lamina propria. Increased genomic instability is suspected to increase the malignant potential of cancer cells. The aim of our study was to compare the genom...

This report confirms experimental data on direct inhibitory effects of LH-RH agonists in growth control of human prostate cancer cells. The patient had hormone-refractory prostatic carcinoma after hormonal therapy, including orchiectomy, and responded successfully to a 6-month treatment with goserelin acetate (3.6 mg depot s.c.). The treatment has...

Purpose: The incidence of hormonal independence is considered as the main reason for the palliative character of androgen ablation in prostate cancer. The potential of current treatment modalities for hormone-refractory tumours is limited. Recent experimental research on LHRH analogues has shown that along with an antiandrogen action they also have...

This clinical study is intended to estimate the potentials of immunochemotherapy (CEP, M-VEC+Intravesical BCG) in patients with invasive bladder tumours to achieve local response and bladder preservation. Between June 1986 and December 1994, forty-six patients with advanced bladder tumours were treated with systemic chemotherapy Cyclophosphamide 60...

Diagnostic cystoscopy under local anaesthesia is a frequently used method in patients with transitional cell bladder tumors. In most cases, disease recurrences detected during cystoscopic examination require additional endoscopic manipulations (TURB, laser) under general anaesthesia. In 1987, Hata et al. reported successful treatment of 5 bladder t...

With the aid of an original jet cutting apparatus 29 partial and 3 hemiresections of the kidney were performed in dogs. Another 10 animals, as a control group, were subjected to ordinary scalpel resection and electric knife treatment. Consideration has been given to immediate and early postoperative blood losses as well as to immediate and later-st...

In 1988, Shafik et al. presented their first attempt to apply cytostatics in the treatment of pelvic malignancies. Experimentally and clinically, they studied the anal route for administration of methotrexate, and their first results showed that higher concentration of drugs can be achieved in the bladder wall compared to that in serum. Since Decem...