Christine Ann Edwards

Christine Ann Edwards
University of Glasgow | UofG · Human Nutrition Section

PhD

About

274
Publications
37,788
Reads
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10,066
Citations
Additional affiliations
October 1990 - present
University of Glasgow
January 1986 - September 1990
September 1980 - December 1987
The University of Sheffield
Position
  • Royal Hallamshire Hospital
Education
October 1980 - March 1984
The University of Sheffield
Field of study
  • Physiology - gut microbiota
October 1977 - July 1980
The University of Sheffield
Field of study
  • Biochemistry and Physiology

Publications

Publications (274)
Article
Full-text available
Objectives Environmental enteropathy (EE) is a subclinical disorder highly prevalent in tropical and disadvantaged populations and is thought to play a role in growth faltering in children, poor responses to oral vaccines, and micronutrient deficiencies. This study aims to evaluate the potential of a non-invasive breath test based on stable isotope...
Article
Research characterising the gut microbiota in different populations and diseases has mushroomed since the advent of next generation sequencing techniques. However, there has been less emphasis on the impact of dietary fibres and other dietary components that influence gut microbial metabolic activities. Dietary fibres are the main energy source for...
Article
Full-text available
Gut function remains largely underinvestigated in undernutrition, despite its critical role in essential nutrient digestion, absorption and assimilation. In areas of high enteropathogen burden, alterations in gut barrier function and subsequent inflammatory effects are observable but remain poorly characterised. Environmental enteropathy (EE)—a con...
Article
Objectives Fibre intakes in UK adults are below recommended levels, therefore, individuals should be encouraged to increase their consumption of fibrous foods. However, this could increase digestive symptoms in some people. To establish to what extent this might be a problem, we sought to better understand the experience of digestive symptoms and t...
Article
Introduction In coeliac disease (CD) micronutrient deficiencies may occur due to malabsorption in active disease and diminished intake during treatment with a gluten-free diet (GFD). This study assessed the micronutrient status in children with CD at diagnosis and follow-up. Methods Fifteen micronutrients were analysed in 106 blood samples from ne...
Chapter
Food and supplement hydrocolloids have many potential health effects, impacting on gut health, digestion, and absorption of nutrients and postprandial plasma constituents. The impact depends on their physicochemical properties. The recent substantial increase in recommended intakes of dietary fiber and the desire to reduce sugar content may lead to...
Article
Dietary fibre intake levels in UK adults are not currently meeting the recommended 30 g per day guidance(Reference Roberts1). Individuals are encouraged to increase their fibre intake, however, this may result in an increase in digestive symptoms in some people(Reference Grabitske and Slavin2). We aimed to explore current experiences of digestive s...
Article
Dietary fibre intake is below recommendations in children and some staple foods, rich in inulin, may help to increase its consumption. Inulin a prebiotic dietary fibre(Reference Roberfroid, Gibson and Hoyles1) is mainly found in plant-based foods. Food reformulation has led to an increase on inulin content in various food products recently, yet the...
Article
Environmental enteric dysfunction (EED) is a complex disorder characterised by structural and functional aberrations within the small intestine(Reference Crane, Jones and Berkley1). It is hypothesised that EED is the result of repeated enteric infections combined with under-nutrition and is prevalent throughout low and middle income countries. EED...
Article
Short chain fatty acids (SCFA) are produced by bacterial fermentation of non-digestible carbohydrates (NDC) and have many potential tissue and SCFA specific actions, from providing fuel for colonic cells to appetite regulation. Many studies have described the fermentation of different carbohydrates, often using in vitro batch culture. As evidence-b...
Article
Full-text available
With the important role of the gut microbiome in health and disease, it is crucial to understand key factors that establish the microbial community, including gut colonization during infancy. It has been suggested that the first bacterial exposure is via a placental microbiome. However, despite many publications, the robustness of the evidence for...
Article
Full-text available
Background & Aims It is not clear whether alterations in the intestinal microbiota of children with celiac disease cause the disease or are a result of disease and/or its treatment with gluten-free diet (GFD). Methods We obtained 167 fecal samples from 141 children (20 with new-onset celiac disease, 45 treated with a GFD, 57 healthy children, and...
Article
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It has long been recognized that albumin has prognostic value in patients with cancer. However, although the Global Leadership Initiative on Malnutrition GLIM criteria (based on five diagnostic criteria, three phenotypic criteria and two etiologic criteria) recognize inflammation as an important etiologic factor in malnutrition, there are limited d...
Article
Full-text available
Introduction Interactions between polyphenols and non-digestible carbohydrates (NDC) can impact on polyphenolic metabolites bioavailability, including phenolic acids. The BLEND2 trial (NCT03840746) aims to study longer-term interactions of a flavonoid-rich food with/without NDC on microbiota metabolites and cardiometabolic markers. Trial feasibilit...
Article
Full-text available
Polyphenols are often ingested alongside dietary fibres. They are both catabolised by, and may influence, the intestinal microbiota; yet, interactions between them and the impact on their resultant microbial products are poorly understood. Dietary fibres (inulin, pectin, psyllium, pyrodextrin, wheat bran, cellulose-three doses) were fermented in vi...
Article
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Background In the literature, there is considerable variation of the proportion of patients reported as having a low skeletal muscle index (SMI) (sarcopenia) or skeletal muscle radiodensity (SMD) (myosteatosis). The aim of the present study was to compare two commonly used software packages, one manual and one semi‐automated to quantify body compos...
Article
Full-text available
Introduction: In the UK, colorectal cancer is the fourth most common cancer and the second most common cause of cancer death. Surgery is the primary modality of treatment, but it is not without complications. Post-operative complications have been linked to preoperative of weight loss and loss of lean tissue, and also to obesity. Given sex differe...
Article
Background: Nutritional status is an important factor affecting a patient's clinical outcomes. Early identification of patients who are at risk of malnutrition is important to improve clinical outcomes and reduce health cost. The Malnutrition Universal Screening Tool (MUST) has been recommended as part of the routine nursing assessment for all pat...
Article
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Background Donated human milk (DHM) is a safe alternative in the absence of mother’s own milk (MOM); however, specific clinical indications for DHM use and its impact on subsequent feeding practice remain unclear. We aimed to audit local DHM use and explore the impact of the introduction of DHM as the first enteral feed on subsequent MOM availabili...
Article
Full-text available
Background: Donated human milk (DHM) is a safe alternative in the absence of mother's own milk (MOM); however, specific clinical indications for DHM use and its impact on subsequent feeding practice remain unclear. We aimed to audit local DHM use and explore the impact of the introduction of DHM as the first enteral feed on subsequent MOM availabi...
Article
Full-text available
Orange juice is an important source of flavanones in the Western diet. However, little is known of the variation in flavanone content of shop-bought orange juice with pulp (OJP) or without pulp (OJ), nor the impact of pulp on the fate of flavanones in the gut. Total phenols, total flavonoids, antioxidant capacity, hesperidin and narirutin, and diet...
Article
Impact of inulin on phenolic acid bioavailability of tomato onion and lovage soup in healthy individuals: a randomized cross-over trial - Volume 78 Issue OCE2 - W. Cong, V. Marinello, M. Martiniuc, B. Nemeckova, W. S. Chung, W. Mullen, T. Preston, D. Morrison, E. Combet, C. Edwards
Article
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Expressed breast milk (EBM) is commonly supplemented with commercially prepared human milk fortifier to meet the additional nutritional needs of preterm infants. The optimal milk intake at which to introduce fortification is unknown. The objective of this systematic review was to compare the effect of early fortification (EF) versus that of delayed...
Article
Full-text available
Dietary mycoprotein (marketed as QuornTM) has many health benefits, including reductions in energy intake. The majority of studies evaluating mycoprotein focus on the protein content and very few consider the fibre content. Fibre consumption is also associated with decreased energy intake, which is partly attributed to short chain fatty acids (SCFA...
Article
Full-text available
Purpose: To investigate whether age influences colonic polyphenol metabolism. Methods: Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and gas were monitored, along...
Article
Background: There is increasing evidence that an increased BMI is associated with increased complications after surgery for colorectal cancer (CRC). However, the basis of this relationship is not clear. Since men and women have different fat distribution, with men more likely to have excess visceral fat in BMI defined obesity, there may be a sex d...
Article
Full-text available
Dietary fibre and polyphenols are both metabolised to short-chain fatty acids (SCFAs) and phenolic acids (PA) by the colonic microbiota. These may alter microbiota growth/diversity, but their interaction is not understood. Interactions between rutin and raftiline, ispaghula or pectin were investigated in human faecal batch cultures (healthy partici...
Article
Full-text available
Glucan and black tea are fermented by the colonic microbiota producing short chain fatty acids (SCFA) and phenolic acids (PA). We hypothesized that the addition of β-glucan, a dietary fiber, and tea polyphenols to a food matrix like bread will also affect starch digestion in the upper gut and thus further influence colonic fermentation and SCFA pro...
Technical Report
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The HUNGer consortium is comprised of a multi-disciplinary, multi-national consortium of world leading researchers, with expertise in physiology and nutrition, through to clinical research, public health and agriculture in LMIC settings. The HUNGer consortium was awarded the MRC Confidence in Global Nutrition and Health award in 2018. The HUNGer c...
Article
Background & aims: Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn's disease (CD), but its acceptability is limited. There is a need for novel dietary treatments for CD. Methods: We evaluated the effects of an individualized food-based diet (CD-TREAT), with similar composition to EEN, on the gut microbiome,...
Article
Full-text available
Metabolomic profiling using high resolution mass spectrometry with hydrophilic interaction chromatography was applied to 11 faecal extracts from eleven healthy children and to 43 faecal extracts from eleven children undergoing exclusive enteral nutrition for the treatment of active Crohn’s disease (CD) at timepoints before, during (15, 30, and 60 d...
Article
Background The gut microbiota is a putative target for dietary interventions for cardio-metabolic health (CMH), including prevention of obesity, type 2 diabetes, and cardiovascular disease. This has generated considerable interest, but the actual feasibility for diet or specific foods to induce measurable, sustained and meaningful benefits for CMH...
Article
The relationship between sex, body mass index, and postoperative outcomes in patients undergoing surgery for colorectal cancer - Volume 77 Issue OCE2 - A.S. Almasaudi, S. McSorley, D. McMillan, C. Edwards
Article
Full-text available
Changes in human colonic bacteria production of phenolic acids from rutin in the presence of different dietary fibres - Volume 77 Issue OCE2 - J Havlik, M. Hou, V. Marinello, A. Gardyne, W Mullen, D. Morrison, T. Preston, E Combet, C.A. Edwards
Article
Objectives: Detection of faecal gluten immunogenic peptides (GIP) is a biomarker of recent gluten consumption. GIP levels can be used to monitor gluten intake and compliment clinical methods to evaluate compliance to gluten free diet (GFD). In this study, recent gluten intake was measured by GIP in CD children and compared to routine clinical meas...
Chapter
Most polyphenols in the diet, both extractable and non-extractable, escape digestion in the human small intestine and enter the colon, where they are subject to catabolism by the complex microbiota. This results in the production of phenolic acids, which may then influence the function and health of colonic cells and/or be absorbed into the systemi...
Article
Full-text available
Perceptions of Saudi Arabian adults towards food and health: careless or clueless? - Volume 76 Issue OCE4 - M.M. Alkhalaf, C.A. Edwards, E. Combet
Article
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A high-fibre diet and one rich in fruit and vegetables have long been associated with lower risk of chronic disease. There are several possible mechanisms underpinning these associations, but one likely important factor is the production of bioactive molecules from plant-based foods by the bacteria in the colon. This links to our growing understand...
Article
Background: The prevalence of obesity has increased worldwide over the last few decades, and is a well-recognized risk factor for colorectal cancer. Surgical site infection is the most frequent complication following surgery for colorectal cancer, and the main cause of postoperative morbidity. The aim of the present systematic review and meta-anal...
Poster
Full-text available
The aim of the present study was to evaluate the metabolic activity of the faecal microbial community of children with Coeliac Disease and explore the effect of treatment with Gluten Free Diet.
Article
Background: An increasing number of studies show low diversity of the gut microbiome in those with chronic diseases such as obesity, inflammatory bowel disease, and allergy. Manipulation of the microbiota may promote health. However, the adult microbiota is stable and may be difficult to change. Understanding the fixed and modifiable factors, whic...
Article
Full-text available
Background/Aims Studying the gut microbiota in unaffected relatives of people with Crohn’s disease (CD) may advance our understanding of the role of bacteria in disease aetiology. Methods Faecal microbiota composition (16S rRNA gene sequencing), genetic functional capacity (shotgun metagenomics) and faecal short chain fatty acids (SCFA) were compa...
Data
Kendal rank correlations between individual SCFA and the relative abundance of discriminatory OTUs between CDR and HUC. CDR: Unaffected blood relatives of children with Crohn’s disease; HUC: Healthy controls unrelated to patients with inflammatory bowel disease. SCFA: Short Chain Fatty Acids (PDF)
Data
Metadata associated with the samples and description of sequencing data. (CSV)
Data
Log-relative abundances of OTUs which differentiated children with CD from their unaffected relatives. 1: Taxonomic classification is given at the highest level of phylogenetic resolution. CDR: Unaffected blood relatives of children with Crohn’s disease; CD: children with CD (PDF)
Data
Kendal rank correlations between individual SCFA and the relative abundance of discriminatory OTUs between CD and CDR. CDR: Unaffected blood relatives of children with Crohn’s disease; CD: children with CD; SCFA: Short Chain Fatty Acids (PDF)
Data
Log-relative abundances of KEGG pathways which differentiated children with CD from their unaffected relatives. CDR: Unaffected blood relatives of children with Crohn’s disease; CD: children with CD; KEGG: Kyoto Encyclopedia of Genes and Genomes (PDF)
Article
Full-text available
Short chain fatty acids (SCFA) are the major products of carbohydrate fermentation by gut bacteria. Different carbohydrates are associated with characteristic SCFA profiles although the mechanisms are unclear. The individual SCFA profile may determine any resultant health benefits. Understanding determinants of individual SCFA production would enab...
Article
Full-text available
Obesity is the most common cause of metabolic complications and poor quality of life in Prader-Willi syndrome (PWS). Hyperphagia and obesity develop after an initial phase of poor feeding and failure to thrive. Several mechanisms for the aetiology of obesity in PWS are proposed, which include disruption in hypothalamic pathways of satiety control r...
Data
Figure S1. Propionate production from incubation of IPE‐27 and ethyl propionate (EP; positive control) from esterases from Candida lipolytica, Mucor miehei, Pseudomonas fluorescens (recombinant from E. coli), Streptomyces diastochromogenes (recombinant from E.coli), horse liver and hog liver. Data are expressed and % of theoretical propionate recov...
Article
Full-text available
Background Short-chain fatty acids (SCFA) produced through fermentation of nondigestible carbohydrates by the gut microbiota are associated with positive metabolic effects. However, well-controlled trials are limited in humans. Aims To develop a methodology to deliver SCFA directly to the colon, and to optimise colonic propionate delivery in humans...
Article
This study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). Faecal calprotectin was measured in 232 children; 55 children (n = 11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and aft...
Article
Full-text available
Background Short-chain fatty acids (SCFA) produced through fermentation of nondigestible carbohydrates by the gut microbiota are associated with positive metabolic effects. However, well-controlled trials are limited in humans. AimsTo develop a methodology to deliver SCFA directly to the colon, and to optimise colonic propionate delivery in humans,...
Article
To the Editor: We are pleased to hear that our recent publication in AJG (1) was of interest to other groups engaged in similar research. In their letter, Kaakoush et al. (2) summarize previously published research on the effect of exclusive enteral nutrition (EEN) on the gut microbiota in Crohn’s disease (CD) and refer to their own case series on...
Article
Objective: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical co-morbidity in a randomized placebo controlled pilot study. Methods: Rando...
Article
Full-text available
Acute effects of breads prepared with β-glucan and black tea on glucose and insulin responses in healthy volunteers - Volume 75 Issue OCE2 - A.M.M. Jalil, E. Combet, C.A. Edwards, A.L. Garcia
Article
Full-text available
Propionate production from fermentation of selected β-glucans by gut microbiota in vitro - Volume 75 Issue OCE2 - H.C. Harris, C.A. Edwards, D.J. Morrison
Article
Interaction of yoghurt and orange juice flavanones in an in vitro model of the upper GI tract does not explain reduced urinary excretion of phenolic acids in humans - Volume 75 Issue OCE2 - M. Hou, E. Combet, C.A. Edwards
Article
Full-text available
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide. Gut microbiota located at the interface of host and environment in the gut are a new area of research being explored to explain the e...
Article
Full-text available
div class="title">Risk classification paradox of anthropometric measurements in Saudi Arabia: need for further consideration - Volume 75 Issue OCE3 - M.M. Alkhalaf, C.A. Edwards, M.E.J. Lean, E. Combet
Article
Full-text available
div class="title">Impact of a 3-weeks randomized double-blind cross-over study curuminoid supplementation on endotoxemia, inflammatory markers, and lipid profiles in healthy overweight and obese adults - Volume 75 Issue OCE3 - M. Nuraiza, C.A. Edwards, E. Combet