Christine Briton-Jones

• Reproductive Medicine Associates of New York

Purpose This study is to evaluate duration of oocyte cryostorage and association with thaw survival, fertilization, blastulation, ploidy rates, and pregnancy outcomes in patients seeking fertility preservation. Methods Retrospective cohort study to evaluate clinical outcomes in patients who underwent fertility preservation from 2011 to 2023 via oo...

Purpose What is the rate of euploidy and clinical viability of embryos resulting from micro 3 pronuclei zygotes? Methods Retrospective cohort analysis in a single, academic in vitro fertilization (IVF) center from March 2018 to June 2021. Cohorts were separated by fertilization as either a 2 pronuclear zygote (2PN) or micro 3 pronuclear zygote (mi...

Objective To analyze the correlation between TE grading and initial β-hCG serum level after single euploid embryo transfer. Secondarily, to explore the association between TE grading with subsequent IVF outcomes. Design Retrospective cohort analysis. Setting Single, academic, private infertility and assisted reproductive care institute. Patients...

PurposeTo understand the clinical factors associated with embryo survival after vitrification in a cohort of human blastocysts screened by preimplantation genetic testing for aneuploidy (PGT-A).Methods Patient demographic, embryo, and cycle characteristics associated with failed euploid blastocyst survival were compared in a cohort of women (n = 61...

Objective: To investigate the association between cleavage stage development, embryonic competence, and euploidy in patients undergoing in vitro fertilization (IVF) with subsequent next generation sequencing. Methods: The retrospective cohort study included patients at an academic fertility center who underwent IVF with at least one cleavage sta...

Purpose: To assess whether utilization of a mathematical ranking algorithm for assistance with embryo selection improves clinical outcomes compared with traditional embryo selection via morphologic grading in single vitrified warmed euploid embryo transfers (euploid SETs). Methods: A retrospective cohort study in a single, academic center from S...

Objective The coronavirus (COVID-19) pandemic has forever reshaped the United States health care system. However, assisted reproductive technology (ART) treatment remains an essential form of medicine. Reproductive practices have since incorporated vigilant practices regarding social distancing, ample use of Personal Protective Equipment (PPE), and...

Objective: To investigate whether the duration of estrogen administration before euploid embryo transfer affects clinical outcome. Design: Retrospective cohort study. Setting: Private, academic fertility center. Patient(s): Patients (n = 1,439) undergoing autologous freeze-only in vitro fertilization with preimplantation genetic testing (PGT...

Purpose: The study purpose was to evaluate the reproductive experience, specifically cycle characteristics and treatment outcomes, of lesbian women. In addition, we aimed to determine whether there are differences in pregnancy outcomes when comparing lesbian women undergoing ovulation induction (OI) versus natural cycles with donor intrauterine in...

Research question: Does the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates? Design: Retrospective cohort study including a total of 2236 embryos...

Study question: What clinical factors are associated with optimal cryopreserved oocyte survival, fertilization, embryo culture, and transfer outcomes? Summary answer: The outcome of autologous oocyte vitrification-warming cycles is optimized in younger patients who undergo transfer of blastocyst-stage embryos.

Transfer of a single euploid embryo results in high implantation and low miscarriage rates as well as decreases the risk of multiple gestations. In some cycles, not a single euploid embryo is produced. This study aimed to compare the relative importance of factors contributing to the development of at least one euploid embryo.

STUDY QUESTION Do the reproductive outcomes from the transfer of fully hatched (FH) blastocysts differ from those of not fully hatched (NFH) blastocysts? SUMMARY ANSWER Biochemical pregnancy rate (BPR), implantation rate (IR), live birth rate (LBR) and early pregnancy loss (EPL) rate are similar in FH and NFH single euploid blastocyst embryo trans...

The aim of this study as to analyze published evidence regarding the effectiveness of aromatase inhibitor therapy on improving spermatogenesis in infertile men. We carried out a systematic review of randomized controlled trials. The date of the most recent search was October 4, 2015. Two authors independently selected relevant clinical trials, asse...

To evaluate the relationship between blastomere number and aneuploidy. Historical cohort study. In vitro fertilization clinic. Two hundred fifty-nine patients undergoing in vitro fertilization (IVF) in combination with comprehensive chromosomal screening of embryos. A total of 1,915 embryos were biopsied on day 3 and underwent comprehensive chromos...

Quantitative real-time RT-PCR (qPCR) has proven to be a valuable molecular technique to quantify gene expression. There are few studies in the literature that describe suitable reference genes to normalize gene expression data. Studies of transcriptionally disruptive toxins, like tetrachlorodibenzo-p-dioxin (TCDD), require careful consideration of...

Context: Mineralocorticoid synthesis by the nonhuman primate periovulatory follicle enhances luteinization. Whether a similar event occurs in women undergoing in vitro fertilization (IVF) is unknown. Objective: The objective of the study was to determine whether human luteinized granulosa cells (LGCs) produce mineralocorticoids derived from 21-h...

To explore outcomes of donor In Vitro Fertilization (IVF) cycles with regards to cryopreservation and utilization of extra embryos after fresh transfer. A database search was performed to identify all consecutive fresh donor oocyte cycles from January 1, 2000 to December 31, 2010 at a private fertility laboratory. Parameters analyzed included: numb...

Purpose: To quantify intracellular lipid levels in cumulus cells (CCs) and mural granulosa cells (MGCs) of lean women undergoing gonadotropin therapy for in vitro fertilization (IVF), based upon different cell preparation methods. Methods: CCs and MGCs from 16 lean women undergoing ovarian stimulation for IVF were studied. Cells were pooled by c...

To evaluate the relationship between aneuploidy and timing of blastocyst formation. Historical cohort study. Private IVF clinic. Ninety-four couples undergoing IVF treatment in combination with chromosomal screening of embryos. The mean maternal age was 39.2 years and average number of embryos per patient 5.3. A total of 530 embryos were biopsied o...