Christine Boesch

Christine Boesch
University of Leeds · Procter Department of Food Science

Dr oec troph

About

98
Publications
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2,944
Citations
Citations since 2017
43 Research Items
1453 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300

Publications

Publications (98)
Article
With very little research exploring intestinal effects of red beetroot consumption, the present pilot study investigated gut microbial changes following red beetroot consumption, via a 14-day intervention trial in healthy adults. Compared to baseline, the study demonstrates transient changes in abundance of some taxa e.g., Romboutsia and Christense...
Article
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The present study aimed to compare the absorption and transport patterns of three main betalains, betanin, vulgaxanthin I and indicaxanthin, into intestinal epithelial cells and to assess their distinct molecular effects on inflammatory and redox-related cell signalling in association with their radial scavenging potencies. All three betalains show...
Article
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Proteins from underutilized defatted oilseed meals have been proposed as promising sources of bioactive peptides. This study was conducted to determine the anti-inflammatory activities of five oilseed proteins (flaxseed, rapeseed, sunflower, sesame and soybean) hydrolysed via alcalase, pepsin (at pH 1.3 and pH 2.1), respectively, and to compare the...
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Purpose Findings from randomized controlled trials (RCTs) evaluating the effect of pulse intake on glycemic control are inconsistent and conclusive evidence is lacking. The aim of this study was to systematically review the impact of pulse consumption on post-prandial and long-term glycemic control in adults with and without type 2 diabetes (T2D)....
Article
The present study focused on the development of a new purification protocol suitable for betanin and other major betalains, vulgaxanthin I, indicaxanthin and neobetanin, using flash chromatography which is a convenient and fast method to isolate unstable materials. Following preliminary tests, a gradient procedure using 0-60% acetonitrile, with 0.1...
Article
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Nobiletin, a natural polymethoxylated flavonoid compound, has been shown to exert a wide range of biological activities. However, there is limited evidence on the molecular mechanisms by which nobiletin modulates endothelial cell function. Our aim was to investigate the potential of nobiletin to enhance endothelial cell functionality under nonstimu...
Article
Chickpeas are among the lowest glycaemic index carbohydrate foods eliciting protracted digestion and enhanced satiety responses. In vitro studies suggest that mechanical processing of chickpeas significantly increases starch digestion. However, there is little evidence regarding the impact of processing on postprandial glycaemic response in respons...
Chapter
Inflammation is the body’s immune response to nonlethal injury involving production of proinflammatory mediators. The inflammatory response can be acute or chronic. An acute response is temporary and is followed by healing while a chronic response is ongoing and may be permanent. However, the production of mediators in an uncontrolled way and in ex...
Chapter
With the rising prevalence of obesity, the incidence of type 2 diabetes mellitus (T2DM) has been steadily increasing globally over the last three decades. T2DM is characterized by elevated blood glucose levels associated with insulin resistance. Elevated blood glucose is associated with the formation of glycated hemoglobin (HbA1c) and other advance...
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Context: Hibiscus sabdariffa (hibiscus) has been proposed to affect cardiovascular risk factors. Objective: To review the evidence for the effectiveness of hibiscus in modulating cardiovascular disease risk markers, compared with pharmacologic, nutritional, or placebo treatments. Data sources: A systematic search of the Web of Science, Cochran...
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Common bean consumption is associated with the prevention of chronic diseases and these effects are partially attributed to their polyphenol content. In this study, the bioaccessibility and anti-inflammatory activity of polyphenols from six Mexican cultivars of beans (Phaseolus vulgaris) varying in their seed colour, was evaluated. In all cultivars...
Article
With a dramatic increase in overweight and population with obesity over the last decades, there is an imminent need to tackle this issue using novel strategies. Addressing obesity issues by generating satiety in food to reduce energy intake has been one of those prominent strategies and often textural interventions have been used to generate satiet...
Article
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There is emerging evidence on the importance of food-derived bioactive peptides to promote human health. Compared with animal derived proteins, plant proteins, in particular, oilseed proteins, are considered as affordable and sustainable sources of bioactive peptides. Based on our previous bioinformatic analysis, five oilseed proteins (flaxseed, ra...
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The glycaemic index (GI) of carbohydrate foods is a useful tool for predicting postprandial glucose and insulin responses(Reference Krog-Mikkelsen, Sloth and Dimitrov1). Results from human studies suggest an inverse relationship between GI of ingested food and postprandial appetite responses(Reference Ford and Frost2). However, evidence on the effe...
Article
Weaned pigs are prone to gut dysbiosis and microbiota disruptions that result in diarrhoea and impaired growth. Dietary modulation of the gut bacterial composition and metabolism plays a vital role in proliferation of beneficial bacteria to alleviate this condition(Reference Celi, Cowieson and Fru-Nji1). Currently, weaned pig diet is supplemented w...
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Chickpeas are low glycaemic index foods with delayed digestion and reduced postprandial glycaemic responses (PPGR)(Reference Augustin, Chiavaroli and Campbell1). However, in vitro studies suggest that mechanical processing of chickpeas, that result in cell wall disruption, significantly increase both the rate and extent of starch digestion(Referenc...
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Background: The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. Therefore, this study aimed to examine the efficacy of daily high-dose-bolus n-3PUFA supplementation on vascular health, glycaemic co...
Article
Background: Epidemiological studies have indicated an inverse association between citrus fruit consumption and cardiovascular disease (CVD) risk. There is, however, a paucity of data concerning effects of blood orange juice (BOJ) intake on endothelial function and cardiovascular risk biomarkers. Objectives: We examined short-term effects of BOJ...
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Objective This study sought to examine the effects of moderate intensity exercise on lubrication performance of saliva. We hypothesized that exercise would result in enhanced salivary lubricity by direct sympathetic stimulation of the salivary proteins. Study design In total, 11 healthy young pre-menopausal female participants (mean age: 24.4 ± 1....
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The aim of this study was to investigate the fate of curcumin (CUR)-loaded Pickering emulsions with complex interfaces during in vitro gastrointestinal transit and test the efficacy of such emulsions on improving the bioaccessibility and cellular uptake of CUR. CUR-loaded Pickering emulsions tested were whey protein nanogel particle-stabilized Pick...
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“Stay-green” crop phenotypes have been shown to impact drought tolerance and nutritional content of several crops. We aimed to genetically describe and functionally dissect the particular stay-green phenomenon found in chickpeas with a green cotyledon color of mature dry seed and investigate its potential use for improvement of chickpea environment...
Article
Currently the world is facing an incredibly costly epidemic of obesity. Almost two-thirds of UK adults are either overweight or obese with estimated financial costs to the UK economy alone of £27 billion per year. While fundamentally obesity is a disorder of energy balance, several decades of research has demonstrated that maintaining energy balanc...
Article
Iron deficiency represents a global nutrition gap that calls for innovative strategies including food fortification, while overcoming the drawbacks of taste and reactivity of iron. The aim of this work was to develop iron-rich colloidal microparticles laden with a Brazilian plant food extract from ora-pro-nobis (OPN, Pereskia aculeata Miller). We f...
Article
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In vitro and in vivo anti-diabetic properties of Hibiscus sabdariffa - Volume 78 Issue OCE2 - S. Zulfiqar, K. Benton, T. Hassan, L. Marshall, C. Boesch
Article
Oxidative stress caused by free radicals is one of the great threats to inflict intracellular damage. Here, we report a conventional approach to synthesis, characterization and evaluation of radical activity of titanium based composites. We have investigated the potential of natural antioxidants (curcumin, quercetin, catechin and vitamin E) as radi...
Article
Some food bioactives potentially exert anti-obesity effects. Anthocyanins, catechins, beta-glucan, and n-3 long chain polyunsaturated fatty acids are among the most promising candidates and have been considered as a strategy for the development of functional foods counteracting body weight gain. At present, clinical trials, reviews and meta-analyse...
Article
Angiotensin-converting enzyme (ACE) and dipeptidyl peptidase-IV (DPP-IV) play critical roles in the development of hypertension and type 2 diabetes, respectively. Inhibiting ACE and DPP-IV activity using peptides has become part of new therapeutic strategies for supporting medicinal treatment of both diseases. In this study, oilseed proteins, inclu...
Article
Pearl millet: a sustainable cereal with low glycemic potential - Volume 77 Issue OCE4 - B.D. Igbetar, C. Bosch, C. Orfila
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Beetroot juice attenuates glycaemic response in healthy volunteers - Volume 77 Issue OCE4 - P.Y. Chang, M.S. Hafiz, C. Boesch
Article
Release of Angiotensin-Converting Enzyme (ACE) and Dipeptidyl Peptidase-IV (DPP-IV) inhibitory peptides from oilseed proteins – a bioinformatic prediction approach - Volume 77 Issue OCE4 - R. Han, J. Maycock, B.S. Murray, C. Boesch
Article
Iron uptake by Caco-2 cells from a Brazilian natural plant extract loaded into chitosan/pectin nano- and micro-particles - Volume 77 Issue OCE2 - V.B.V. Maciel, C.M.P. Yoshida, C. Boesch, F.M. Goycoolea, R.A. Carvalho
Conference Paper
Full-text available
The current study evaluates the potential of Withania som�nifera, a traditional Indian herb, to contribute to prevention and progression of neurodegenerative disorders such as Alzheimers’ disease through modulation of inflammation and cell protective signalling pathways in lipopolysaccharide (LPS) stimulated BV2 microglia cells, an established neur...
Article
Background: Fe deficiency anemia (IDA) is one of the most common nutritional problems in the world and it is accepted that ROS production is altered during IDA. The aim of the current study is to assess the influence of fermented goat or cow milk on enzymatic antioxidant activities and gene expression, and their roles protecting main from the oxid...
Article
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Aggressive interactions between members of a social group represent an important source of social stress with all its negative follow-ups. We used the ponerine ant Harpegnathos saltator to study the effects of frequent aggressive interactions on the resistance to different stressors. In these ants, removal or death of reproducing animals results in...
Article
In spite of the crucial role of Duodenal cytochrome b (Dcytb), Divalent metal transporter 1 (DMT1), Ferritin light chain (Ftl1), Ferroportin 1 (FPN1), Transferrin receptor 1 (TfR1) and Hepcidin antimicrobial peptide (Hamp) in Fe metabolism, no studies have investigated the modulations of these genes during Fe repletion with fermented milks. Analysi...
Article
Polyphenol release in Borlotti beans (Phaseolus vulgaris) during cooking, soaking, simulated digestion and acid hydrolysis - Volume 75 Issue OCE2 - L. Perez-Hernandez, M. Morgan, C. Bosch, C. Orfila
Article
Effects of a 4-week intervention with ready-made bioactive enriched pancakes on biomarkers of the metabolic syndrome - Volume 75 Issue OCE2 - S. Sutulic, C. Bösch, L. Marshall, A. Bordoni, H. Hingyi, M. Muller, C. Orfila, on behalf of the PATHWAY-27 consortium Grant agreement 311876
Article
Background and aimsThe polyphenol quercetin may prevent cardiovascular diseases due to its vasorelaxant and anti-oxidative properties. We investigated the effects of quercetin on risk factors of atherosclerosis, biomarkers of inflammation and oxidative stress, depending on the apolipoprotein E (APOE) genotype.Methods and resultsIn a double-blind cr...
Chapter
Factors Affecting the Bioefficacy of Provitamin A Carotenoids. Low Responder/Converter Phenotype. Influence of Common Genetic Variations on β-Carotene Cleavage.
Article
Ochratoxin A (OTA) is a mycotoxin exhibiting nephrotoxic and potential carcinogenic activity. We investigated the cross-talk between microRNAs, nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in ochratoxin A-mediated effects. In porcine renal proximal tubular cells, OTA increased expression of profibrotic transforming growth...
Article
The aim of the study was to compare apparent Zn absorption and Zn status of weanling rats fed diets that differed in Zn level, fat level and fat source. Semi-synthetic diets, which were about isoenergetic and contained 3% soyabean oil, were supplemented with 7 or 100 mg Zn/kg to create a mild Zn deficiency (LZ) or a high Zn supply (HZ) and with 0 (...
Article
In humans, varying amounts of absorbed β-carotene are oxidatively cleaved by the enzyme β,β-carotene 15,15'-monooxygenase 1 (BCMO1) into two molecules of all-trans-retinal. The other carotenoid cleavage enzyme β,β-carotene 9',10'-dioxygenase (BCDO2) cleaves β-carotene at the 9',10' double bond forming β-apo-10'-carotenal and β-ionone. Although the...
Article
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The present investigation aimed to compare fetal calf serum (FCS) and Tween 40 with the commonly employed tetrahydrofuran (THF) with respect to cytotoxicity, stability of the solubilized carotenoids, and uptake and accumulation of the xanthophylls astaxanthin (AX) and canthaxanthin (CX) in cultured human liver cells (HepG2). Incubation of HepG2 cel...
Article
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The impact of a moderate Zn deficiency on growth and plasma and liver lipids was investigated in two 4-week experiments with male weanling rats fed fat-enriched diets. Semisynthetic, approximately isocaloric diets containing 3% soybean oil were supplemented with either 7 or 100 mg Zn/kg diet and with 22% beef tallow (BT) or sunflower oil (SF). In E...
Article
In this study, the underlying mechanisms of the potential anti-inflammatory properties of allyl-isothiocyanate (AITC) were analysed in vitro and in vivo. Murine RAW264.7 macrophages stimulated with lipopolysaccharide (LPS) were supplemented with increasing concentrations of AITC. In addition, C57BL/6 mice (n= 10 per group) were fed a pro-inflammato...
Article
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The allele ε4 of apolipoprotein E (APOE), which is a key regulator of lipid metabolism, represents a risk factor for cardiovascular diseases and Alzheimer's disease. Despite its adverse effects, the allele is common and shows a nonrandom global distribution that is thought to be the result of evolutionary adaptation. One hypothesis proposes that th...
Article
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An apoE4 genotype is an important risk factor for cardiovascular and other chronic diseases. The higher cardiovascular disease risk of apoE4 carriers as compared to the apoE3 genotype has been mainly attributed to the differences in blood lipids between the two genotype subgroups. Recently, a potential protective role of the transcription factor Nr...
Article
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Human paraoxonase 1 (PON1) is an HDL-associated enzyme with anti-oxidant/anti-inflammatory properties that has been suggested to play an important protective role against coronary heart diseases and underlying atherogenesis. The common PON1 Q192R polymorphism (rs662, A>G), a glutamine to arginine substitution at amino acid residue 192, has been ana...
Article
In the present study the effect of quercetin and its major metabolites quercetin-3-glucuronide (Q3G) and isorhamnetin on inflammatory gene expression was determined in murine RAW264.7 macrophages stimulated with lipopolysaccharide. Quercetin and isorhamnetin but not Q3G significantly decreased mRNA and protein levels of tumor necrosis factor alpha....
Article
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Background: The molecular mechanisms of variations in individual longevity are not well understood, even though longevity can be increased substantially by means of diverse experimental manipulations. One of the factors supposed to be involved in the increase of longevity is a higher stress resistance. To test this hypothesis in a natural system,...
Article
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Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ascorbic acid. The antioxidant enzymes heme oxygenase-1 and paraoxonase-1 were analysed for their mRNA and prote...
Article
Paraoxonase-1 (PON-1), associated with HDL, is regarded as anti-atherogenic, attributed to its ability to hydrolyze oxidized lipids. Here, the impact of PON and apolipoprotein E genotypes, age, alcohol and HDL-cholesterol (HDL-C) on PON activity is examined. In total, 104 healthy UK adults participated in the study, with basal (PONA) and stimulated...
Article
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Our objective was to examine the effect of a quercetin supplementation on blood pressure, lipid metabolism, markers of oxidative stress, inflammation, and body composition in an at-risk population of 93 overweight-obese volunteers aged 25-65 y with metabolic syndrome traits in relation to apolipoprotein (apo) E genotype. Participants were randomize...
Article
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There is increasing evidence that the HDL-associated enzyme paraoxonase 1 (PON1) may have a protective function in the atherosclerotic process. An enhancement of PON1 activity by dietary factors including flavonoids is therefore of interest. Quercetin, a flavonol frequently present in fruits and vegetables has been shown to induce PON1 in cultured...
Article
The aim of the present study was to determine hepatic paraoxonase 1 (PON1) status in response to apoE genotype and dietary quercetin supplementation in mice. ApoE3 and apoE4 transgenic mice were fed semi-synthetic diets without (controls) and with quercetin (2 mg/g diet) for 6 weeks. Hepatic mRNA and protein levels of PON1 were significantly lower...
Article
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Overproduction of reactive oxygen species and impaired antioxidant defence accompanied by chronic inflammatory processes may impair joint health. Pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) stimulate the expression of metalloproteinases which degrade the extracellular matrix. Little is...
Article
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Cell culture data indicate that quercetin and catechin may affect the activity of phase II and antioxidant enzymes. However, little is known about the impact of dietary flavonoids in vivo. Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes gl...
Article
The aim of the present feeding trial was to investigate the effect of the dietary flavonol quercetin on brain quercetin concentration and the expression of antioxidant and Alzheimer's disease relevant genes in mouse brain. Laboratory mice were fed control and quercetin-enriched diets (2 mg/g diet) for 6 weeks. Dietary quercetin supplementation sign...
Article
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Microglia and astrocytes are the cellular key players in many neurological disorders associated with oxidative stress and neuroinflammation. Previously, we have shown that microglia activated by lipopolysaccharides (LPS) induce the expression of antioxidative enzymes in astrocytes and render them more resistant to hydrogen peroxide (H2O2). In this...
Article
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There is increasing evidence that the intracellular antioxidant enzyme paraoxonase 2 (PON2) may have a protective function in the prevention of atherogenesis. An enhancement of PON2 activity by dietary factors including flavonoids is therefore of interest. In the present study we determined the effect of quercetin on paraoxonase 2 levels in culture...
Article
This study aimed at investigating potential effects of the flavonoids genistein, quercetin and catechin and the role of co-ingested dietary fat on vitamin E concentrations in rats. In experiment 1, genistein, quercetin and catechin were fed to rats, incorporated into semisynthetic diets at concentrations of 2 g/kg, either as individual compounds or...