Christina Bahrs

Christina Bahrs
Medical University of Vienna | MedUni Vienna · Department of Medicine I, Division of Infectious Diseases and Tropical Medicine

Assoc.Prof. PD Dr. med. univ.

About

140
Publications
13,562
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1,644
Citations
Citations since 2017
60 Research Items
1199 Citations
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Introduction
Christina Bahrs currently works at the Institute of Infectious Diseases and Infection Control, Jena University Hospital, Germany as senior physician. Christina does clinical research in Infectious Diseases.
Additional affiliations
March 2014 - present
Universitätsklinikum Jena
Position
  • Fachärztin
Description
  • Funktionsoberärztin des infektiologischen Konsildienstes
March 2014 - present
Universitätsklinikum Jena
Position
  • Specialist for Internal Medicine
Description
  • Senior physician of infectiological consultation
April 2006 - present
Medical University of Vienna
Position
  • Medical Doctor
Description
  • Training as a specialist in internal medicine and infectious diseases and Qualification to Associate Professor (since 2014, currently on leave of absence)

Publications

Publications (140)
Preprint
Full-text available
Background: The Co-HCW study is a prospective, longitudinal single center observational study on the SARS-CoV-2 seroprevalence and infection status in staff members of Jena University Hospital (JUH) in Jena, Germany. Material and Methods: This follow-up study covers the observation period from 19th May 2020 to 22nd June 2021. At each out of three v...
Article
Pneumonia is a very frequent and potentially fatal disease. It can be classified into 3 different entities, community-acquired (CAP), hospital-acquired (HAP) and pneumonia in immunosuppressed patients. The CAP and HAP are primarily eligible for antibiotic stewardship (ABS) interventions, strategies to enhance the rational use of antibiotic agents....
Article
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Introduction Despite improvements in medical science and public health, mortality of community-acquired pneumonia (CAP) has barely changed throughout the last 15 years. The current SARS-CoV-2 pandemic has once again highlighted the central importance of acute respiratory infections to human health. The “network of excellence on Community Acquired P...
Article
Objectives The optimal treatment duration for vancomycin-resistant enterococcal (VRE) bacteraemia is still a matter of debate. The aim of the present study was to compare short-course (<=9 days) versus long-course (>=10 days) antibiotic treatment in hospitalised adult patients with uncomplicated VRE bacteraemia. Methods This retrospective study wa...
Article
Importance: Staphylococcus aureus bacteremia (SAB) is a common and potentially severe infectious disease (ID). Retrospective studies and derived meta-analyses suggest that bedside infectious disease consultation (IDC) for SAB is associated with improved survival; however, such IDCs might not always be possible because of the lack of ID specialists...
Article
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During the last few years, we have experienced a shift in how we evaluate the effectiveness of vaccines [...]
Article
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Strategies to contain the current SARS-CoV-2 pandemic rely, beside vaccinations, also on molecular and serological testing. For any kind of assay development, screening for the optimal antigen is essential. Here we describe the verification of a new protein microarray with different commercially available preparations significant antigens of SARS-C...
Article
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There are few data on mortality after discharge with community-acquired pneumonia (CAP). Therefore, we evaluated risk factors for 30-day post-discharge mortality after CAP. We included all patients of the prospective multi-national CAPNETZ study between 2002 and 2018 with (1) hospitalized CAP, (2) survival until discharge, and (3) complete follow-u...
Article
Objectives Classification of Staphylococcus aureus bacteremia (SAB) as “complicated” or “uncomplicated” and management of both is based on low-quality evidence. The aim of the study was to determine the degree of agreement among infectious diseases physician experts in the management of patients with SAB. Methods A stepwise RAND-modified Delphi pr...
Article
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The LAMP-based eazyplex® BloodScreen GN was evaluated for the detection of frequent Gram-negatives directly from positive blood culture (BC) bottles. A total of 449 BCs were analyzed. Sensitivities and specificities were 100% and 100% for Escherichia coli , 95.7% and 100% for Klebsiella pneumoniae , 100% and 100% for bla CTX-M , 100% and 100% for K...
Preprint
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Recently, a 15-valent (PCV15) and a 20-valent pneumococcal conjugate vaccine (PCV20) have been licensed by the US Food and Drug Administration and are under evaluation by the European Medicines Agency.PCV15 contains all serotypes of the 13-valent conjugate vaccine (PCV13) plus serotype 22F and 33F and PCV20 includes PCV13 serotypes plus serotype 8,...
Article
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Purpose: Thorough knowledge of the nature and frequency of co-infections is essential to optimize treatment strategies and risk assessment in cases of coronavirus disease 2019 (COVID-19). This study aimed to evaluate the multiplex polymerase chain reaction (PCR) screening approach for community-acquired bacterial pathogens (CABPs) at hospital admi...
Article
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The aim of this prospective study was to assess lymphocyte proliferative and cytokine response prior to and following tick-borne encephalitis (TBE) immunization among patients after allogeneic hematopoietic stem cell transplantation (HSCT). Seventeen adult patients 11–13 months after HSCT and eight unvaccinated healthy adults received up to three T...
Article
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Pneumococci are the most frequent bacterial agent of community-acquired pneumonia and are one of the most common vaccine-preventable causes of death worldwide. There is a polysaccharide vaccine that contains the capsular polysaccharides of 23 of the more than 90 known serotypes. PPV23 confers good protection against invasive pneumococcal infections...
Article
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The Gram-negative bacilli Serratia spp., Providencia spp., Morganella morganii, Citrobacter freundii complex, Enterobacter spp. and Klebsiella aerogenes are common Enterobacterales that may harbor inducible chromosomal AmpC beta-lactamase genes. The purpose of the present study was to evaluate treatment outcomes and identify predictors of early tre...
Article
Staphylococcus aureus bloodstream infections are associated with a high morbidity and mortality. Nevertheless, significance of a positive blood culture with this pathogen is often underestimated or findings are misinterpreted as contamination, which can result in inadequate diagnostic and therapeutic consequences. We here review and discuss current...
Article
Full-text available
The Co-HCW study is a prospective cohort study among hospital staff, including healthcare workers (HCWs) and administration staff, at the Jena University Hospital (JUH), Germany. The objectives of this study were to assess SARS-CoV-2 IgG seroprevalence, individual exposure risk factors and compliance of HCWs to wear personal protective equipment (P...
Article
Full-text available
The aim of this prospective study was to characterize the humoral immune response to TBE vaccination after hematopoietic stem cell transplantation (HSCT). Nineteen adult patients 11–13 months after HSCT and 15 age-matched immunocompetent adults received up to three TBE vaccinations. Antibodies against TBE virus were measured by neutralization test...
Article
Full-text available
Objectives Due to a substantial proportion of asymptomatic and mild courses, many SARS-CoV-2 infections remain unreported. Therefore, assessment of seroprevalence may detect the real burden of disease. We aimed at determining and characterizing the rate of SARS-CoV-2 infections and the resulting seroprevalence in a defined population. The primary o...
Article
Full-text available
Background Early diagnosis of invasive fungal diseases (IFDs) remains a major challenge in routine clinical practice. Objectives The aim of this retrospective cohort study was to evaluate the diagnostic performance of the fungal biomarker (1,3)‐ß‐d‐glucan (BDG) using the β‐Glucan test (GT) and the well‐established Fungitell assay® (FA) in real‐lif...
Preprint
Full-text available
Background: Healthcare workers (HCWs) are at particular risk to acquire SARS-CoV-2 infections. Aim: The objectives of this study were to compare SARS-CoV-2 IgG seroprevalence and compliance to wear personal protective equipment (PPE) between HCWs working within (high-risk) or outside (intermediate-risk) units treating suspected or confirmed COVID-1...
Article
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[This corrects the article DOI: 10.1371/journal.pntd.0008183.].
Preprint
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Background: Due to the substantial proportion of asymptomatic and mild courses many SARS-CoV-2 infections remain unreported. Therefore, assessment of seroprevalence may detect the real burden of disease. We aimed at determining and characterizing the rate of SARS-CoV-2 infections and the resulting immunity in a defined population. Methods: CoNAN is...
Article
Background Herpes simplex virus type 1 (HSV-1) is frequently detected in the BAL fluid of patients on mechanical ventilation. Research Question The aim of the study was to investigate whether antiviral therapy is associated with improved overall survival within 30 days. Study Design and Methods This was a retrospective cohort study in four ICUs b...
Article
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The original version of this article unfortunately contained a mistake. The presentation of Fig. 1 was incorrect. The corrected figure is given below.
Article
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Staphylococcus aureus is a facultative pathogenic bacterium that colonizes the nasopharyngeal area of healthy individuals, but can also induce severe infection, such as pneumonia. Pneumonia caused by mono- or superinfected S. aureus leads to high mortality rates. To establish an infection, S. aureus disposes of a wide variety of virulence factors,...
Article
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Purpose Dalbavancin is a novel lipoglycopeptide with potent activity against several gram-positive pathogens, an excellent safety profile and a long elimination half-life. Methods In this case series observed at the University Hospital of Vienna between 2015 and 2017, all adult patients with gram-positive infections who received at least one dosag...
Article
Introduction: Implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in infant vaccination programs has substantially reduced the burden of PCV7 serotypes also in adult community-acquired pneumonia (CAP). Currently, it is unclear, if this extensive herd protection effect can be extrapolated to the additional 6 serotypes included in t...
Article
Background: Although blood cultures (BCs) are the gold standard for detecting bacteremia, the utility of BCs in patients with community-acquired pneumonia (CAP) is controversial. This study describes the proportion of patients with CAP and afebrile bacteremia and identifies the clinical characteristics predicting the necessity for BCs in afebrile...
Article
Background The role of macrolide/beta-lactam combination therapy in community-acquired pneumonia (CAP) of moderate severity is a matter of debate. Macrolides expand the coverage to atypical pathogens and attenuate pulmonary inflammation, but have been associated with cardiovascular toxicity and drug interactions. We developed a decision tree based...
Chapter
Patients with high risk for clinically relevant mycoses are severely immunocompromised and critically ill. Fungal infections originate from exogenous source by inhalation (such as Aspergillus sp., Cryptococcus sp., Mucorales or in case of endemic mycosis) or from endogenous source mainly from the gastrointestinal tract for commensals (Candida sp.)...
Article
Im Alter wird der Mensch anfälliger für Infektionen, weshalb ein Impfschutz immer wichtiger wird. Allerdings ist die Impfantwort bei alten Menschen oft reduziert. Wie man dieser Tatsache begegnen kann und welche Impfungen sinnvoll sind, erfahren Sie hier.
Article
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This study analyzed the performance of different molecular technologies along with blood culture (BC) in the diagnosis of bloodstream infections (BSI) in patients from internal medicine wards - including intensive care units (ICUs) - and the emergency room. Patients with systemic inflammatory response syndrome were prospectively included. BCs and E...
Article
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Zusammenfassung Einleitung Staphylococcus-aureus-Bakteriämien sind schwere Infektionserkrankungen mit oftmals langwierigen klinischen Verläufen und hoher Sterblichkeit. Retrospektive Studien zeigen, dass infektiologische Konsile die Adhärenz an Therapiestandards erhöhen und das Überleben von Staphylococcus-aureus-Bakteriämie-Patienten verbessern kö...
Article
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Background: Influenza and pneumococcal vaccination can prevent disease and potentially life-threatening complications like sepsis. Elderly people have an increased risk of severe disease and therefore constitute a major target group for vaccination. To increase vaccination coverage, targeted interventions are needed that take theory-based specific...
Article
Background: Patients with inflammatory rheumatic diseases are at higher risk for influenza and current guidelines recommend vaccination for this group of patients. The aim of this study was to evaluate the vaccination coverage and predictors for influenza vaccination among patients with inflammatory rheumatic diseases. Methods: This survey was c...
Article
In this retrospective study clinical outcomes and safety of dalbavancin as primary and sequential treatment of Gram-positive bacteremia with infective endocarditis were evaluated. Clinical success under dalbavancin was high (92.6%) but in the majority of patients (24/27) dalbavancin was only used after clearance of bacteria from bloodstream.
Article
Urosepsis is defined as a severe disease due to organ failure caused by a urinary tract infection. An empirical antibiotic therapy should be instigated within the first hour after diagnosis. Urine cultures and blood cultures should be performed before antibiotic treatment. Further diagnostics should be carried out at an early stage to enable an int...
Article
Objectives: The objective was primarily to identify risk factors for bloodstream infections (BSI) caused by different pathogens. Methods: A retrospective single-center cohort study was performed on 472 burn patients with an abbreviated burn severity index (ABSI)≥3, a total burn surface area (TBSA)≥10%, and an ICU stay of at least 24h. Risk facto...
Article
Die Urosepsis ist als schweres Krankheitsbild durch Organversagen aufgrund einer Harnwegsinfektion definiert. Eine empirische Antibiotikatherapie sollte innerhalb der ersten Stunde nach Diagnose erfolgen. Des Weiteren sollten Urin- und Blutkulturen vor Antibiotikatherapie angelegt werden. Eine weiterführende Diagnostik sollte frühzeitig erfolgen, u...
Article
The spread of antimicrobial resistance challenges the empiric treatment in urinary tract infections (UTI). Among others, nitrofurantoin is recommended for first line treatment, but acceptance among clinicians is limited due to chronic nitrofurantoin-induced lung toxicity and insufficient coverage of Enterobacteriaceae other than Escherichia coli. N...
Article
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Introduction: Staphylococcus aureus bacteraemia (SAB) is a frequent infection with high mortality rates. It requires specific diagnostic and therapeutic management such as prolonged intravenous administration of antibiotics and aggressive search for and control of infectious sources. Underestimation of disease severity frequently results in delaye...
Article
Biofilms are the preferred environment of micro-organisms on various surfaces such as catheters and heart valves, are associated with numerous difficult-to-treat and recurrent infections, and confer an extreme increase in antibiotic tolerance to most compounds. The aim of this study was to evaluate how colistin affects both the extracellular biofil...
Article
Peritoneal dialysis fluids (PDFs) impair microorganisms’ growth, which may compromise effectivity of some antimicrobials. The purpose of this study was to investigate the effect of three different PDFs (lactate/bicarbonate-buffered Physioneal 40® with 2.2% glucose, lactate-buffered Nutrineal PD4® with 1.1% amino acid, and lactate-buffered Extraneal...
Article
Objectives: Influenza vaccination is recommended for HIV-infected patients, but limited data about vaccination rates are available. The aim of this study was to evaluate the coverage of and predictors for influenza vaccination among HIV-positive patients. Methods: All HIV-positive patients who visited the HIV out-patient department of the Univer...
Article
Objective: To evaluate the effect of pre-operative octenidine (OCT) decolonization on surgical site infection (SSI) rates. Design: Before-and-after cohort study. Patients: Patients undergoing an elective isolated coronary artery bypass graft (CABG) procedure: control group (1(st) January to 31(st) December 2013), N=475; intervention group (1(s...
Article
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The objective of this study was to review the management of patients with influenza during the influenza season 2014/2015 (n = 197). Our study revealed a high rate of healthcare-associated influenza infection (35.5 %) and a correlation between the total number of patients with HA influenza and the number of nurses on sick leave. The results of the...
Article
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African tick bite fever is an emerging infectious disease among travellers caused by the pathogen Rickettsia africae. Most travel-associated cases have been reported from countries in southern Africa. So far it has rarely been reported among travellers to eastern Africa and our patient is one of the first described cases imported from Tanzania. A w...
Article
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Purpose There is increasing clinical evidence from observational studies, that combination therapy of daptomycin with rifampin is a valuable treatment option for biofilm-associated difficult to treat Staphylococcus aureus infections such as osteomyelitis, prosthetic joint infection and endocarditis. However, two studies analyzing a limited number o...
Article
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Background: Q fever in Kenya is poorly reported and its surveillance is highly neglected. Standard empiric treatment for febrile patients admitted to hospitals is antimalarials or penicillin-based antibiotics, which have no activity against Coxiella burnetii. This study aimed to assess the seroprevalence and the predisposing risk factors for Q fev...
Poster
Full-text available
Background: Biofilms are the preferred appearance of microorganisms on various surfaces, such as catheters or heart valves and are associated with numerous difficult-to-treat and relapsing infections. In our previous experiments we observed that colistin has a destabilizing effect on the biofilm matrix. The aim of this study was to evaluate the imp...
Article
The aim of this study was to evaluate the vaccination coverage of Austrian health care workers (HCWs), their knowledge concerning the current guideline on vaccination for HCWs and their attitudes towards vaccination. A cross-sectional survey was performed by distributing 200 questionnaires among the nursing staff of several medical wards and intens...
Article
Infections with multi-drug resistant bacteria are increasing worldwide. Glycopeptides, linezolid, daptomycin and 5th generation cephalosporins ("MRSA-cephalsoporins") are used against severe infections with MRSA, combination partners are rifampin and fosfomycin. Treatment options against VRE-infections are limited to linezolid, daptomycin and tigec...
Article
The aim of the study was to compare the distribution of the vaccine-serotypes covered by pneumococcal conjugate vaccines (PCV7 and PCV13) in adult patients with pneumococcal community-acquired pneumonia in Germany between the periods 2002-2006 and 2007-2011 using a novel serotype-specific multiplex urinary antigen detection assay (SSUA). Vaccinatio...
Article
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Objectives: We aimed to identify clinical characteristics and to assess effectiveness of different initial antibiotic regimens in adult patients with community-acquired pneumonia (CAP) caused by Haemophilus influenzae. Methods: Characteristics were compared between patients with H. influenzae monoinfection versus CAP of other and unknown aetiolo...
Chapter
Die Dynamik der Ausbreitung bakterieller Resistenzen lässt befürchten, dass in absehbarer Zeit die Wirksamkeit und die Anzahl der zur Verfügung stehenden Antibiotika deutlich eingeschränkt sein werden. Insbesondere bei multiresistenten gramnegativen Bakterien (MRGN) und Vancomycin-resistenten Enterokokken (VRE) sind derzeit unsere therapeutischen M...
Article
Full-text available
Background Allogeneic hematopoietic stem cell transplant (HSCT) recipients experience an increased risk for invasive fungal diseases (IFDs). Methods This retrospective cohort study at the Medical University of Vienna aspired to assess the incidence, characteristics and the outcome of IFDs as well as the associated risk factors in a setting where o...
Article
Full-text available
Emergence of colonization and infection with vancomycin-resistant enterococci (VRE) has become a worldwide challenge. To investigate whether the increasing incidence of VRE isolation can be correlated with use of glycopeptides in the hospital setting, we conducted a hospital-wide two-year study in the university hospital of Vienna. Within the perio...
Article
Malaria may lead to spontaneous splenic rupture as a rare but potentially lethal complication. Most frequently, this has been reported in patients infected with Plasmodium falciparum and Plasmodium vivax, while other parasitic agents are less likely to be the cause. We report a 29-year-old British Caucasian, who after returning from a business trip...
Article
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Here, we report on a case of VL in an HIV-infected patient from the Republic of Georgia who had moved to Germany 14 years before and who had travelled several times to southern Europe in between. After presenting with typical Pneumocystis jiroveci pneumonia, which was treated appropriately, the patient was started on antiretroviral therapy. Shortly...