Christian Quirouette

Toronto Metropolitan University · Department of Medical Physics

Mechanistic mathematical models (MMs) are a powerful tool to help us understand and predict the dynamics of tumour growth under various conditions. In this work, we use 5 MMs with an increasing number of parameters to explore how certain (often overlooked) decisions in estimating parameters from data of experimental tumour growth affect the outcome...

A virus infection can be initiated with very few or even a single infectious virion, and as such can become extinct, i.e. stochastically fail to take hold or spread significantly. There are many ways that a fully competent infectious virion, having successfully entered a cell, can fail to cause a productive infection, i.e. one that yields infectiou...

[This corrects the article DOI: 10.1371/journal.pcbi.1009480.].

A virus infection can be initiated with very few or even a single infectious virion, and as such can become extinct, i.e. stochastically fail to take hold or spread significantly. There are many ways that a fully competent infectious virion, having successfully entered a cell, can fail to cause a productive infection, i.e. one that yields infectiou...

[This corrects the article DOI: 10.1371/journal.pcbi.1007705.].

The endpoint dilution assay’s output, the 50% infectious dose (ID50), is calculated using the Reed-Muench or Spearman-Kärber mathematical approximations, which are biased and often miscalculated. We introduce a replacement for the ID50 that we call Specific INfection (SIN) along with a free and open-source web-application, midSIN (https://midsin.ph...

Experiments have shown that hepatitis C virus (HCV) infections in vitro disseminate both distally via the release and diffusion of cell-free virus through the medium, and locally via direct, cell-to-cell transmission. To determine the relative contribution of each mode of infection to HCV dissemination, we developed an agent-based model (ABM) that...

The infectivity of a virus sample is measured by the infections it causes, via a plaque or focus forming assay (PFU or FFU) or an endpoint dilution (ED) assay (TCID$_{50}$, CCID$_{50}$, EID$_{50}$, etc., hereafter collectively ID$_{50}$). The counting of plaques or foci at a given dilution intuitively and directly provides the concentration of infe...

[This corrects the article DOI: 10.1371/journal.pcbi.1007705.].

Within the human respiratory tract (HRT), virus diffuses through the periciliary fluid (PCF) bathing the epithelium. But virus also undergoes advection: as the mucus layer sitting atop the PCF is pushed along by the ciliated cell’s beating cilia, the PCF and its virus content are also pushed along, upwards towards the nose and mouth. While many mat...

Undoped and boron- (B) doped VO 2 thin films were successfully deposited by pulsed laser deposition. Boron doping enables to drastically reduce the metal–insulator transition (MIT) temperature ( T MIT ) at a rate as large as 31.5 °C/at.%B. As boron doping is interstitial, B atoms can be incorporated in the VO 2 matrix without affecting its stoichio...

Within the human respiratory tract (HRT), viruses diffuse through the periciliary fluid (PCF) bathing the epithelium, and travel upwards via advection towards the nose and mouth, as the mucus escalator entrains the PCF. While many mathematical models (MMs) to date have described the course of influenza A virus (IAV) infections in vivo, none have co...

Effect of the O2 pressure on the electrical and optical properties of pulsed laser deposited VO2 thin films

Le dioxyde de vanadium (VO2) possède des propriétés optiques exceptionnelles dans la gamme des longueurs d’onde infrarouges (IR). Durant sa transition de phase isolant-métal à 68 °C, une couche mince de VO2 passe en effet de transparente à opaque aux IR pour les hautes températures. Cela fait de ce matériau une solution adaptée pour la fabrication...