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Background/Objectives: XTEND is the largest global, prospective, observational study of treatment-naïve patients with neovascular age-related macular degeneration (nAMD) receiving 2 mg of intravitreal aflibercept (IVT-AFL) in routine clinical practice designed to examine the real-world effectiveness of IVT-AFL proactive treatment regimens. The outc...
Anti-vascular endothelial growth factor (anti-VEGF) therapies have become the standard of care in the treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME), resulting in a remarkable decrease in disease-related vision loss. However, the need for regular injections places a significant burden on patients,...
A remarkable proportion of neovascular age-related macular degeneration (nAMD) patients respond rather poorly to ranibizumab treatment, in spite of the minimum 4-week follow-up and treatment interval. Usually, retreatments are based on nAMD activity as evaluated by Spectral-domain Optical coherence Tomography (SD-OCT), biomicroscopic fundus examina...
Purpose:
To investigate longer-term functional and morphological outcomes and their predictors in diabetic macular edema (DME) following a treat and extend regimen (TER) without loading dose under ranibizumab.
Methods:
Patient data were reviewed and analyzed retrospectively over a period of 24 months after initiation of TER. Best-corrected visua...
Background
For treatment of neovascular age-related macular degeneration (nAMD), multiple intravitreal injections of drugs targeting vascular endothelial growth factors (VEGF) result in a high burden for patients and healthcare systems. Low-energy stereotactic radiotherapy (SRT) might reduce the anti-VEGF need. This study evaluated the long-term ef...
The aim of this observational study was to assess the use and outcome of intravitreal aflibercept in a treat and extend regimen in treatment-naïve neovascular AMD patients in routine practice. This both retrospective and prospective study was conducted in four larger Swiss retina clinics (ASTERIA study). The primary endpoint was the mean change in...
Purpose:
To evaluate early changes in retinal layers using optical coherence tomography (OCT) in patients with long-standing type 1 diabetes (DM1) receiving intensified insulin therapy.
Methods:
In a cross-sectional case-control study 150 patients with DM1 and 150 age- and sex-matched healthy control participants underwent OCT imaging. Scans of...
Purpose:
To analyze the efficacy and outcome predictors of SD-OCT (spectral-domain optical coherence tomography)-driven ranibizumab treatment in patients with choroidal neovascularization due to myopia (mCNV).
Methods:
This prospective investigator-initiated study includes 20 patients with treatment-naïve mCNV. Evaluation included best-corrected...
Aim
Prevalence of retinopathy (DR) in patients with type 1 diabetes treated with education-based intensified insulin therapy (EBIIT) and its association with parameters of glucose control.
Methods
151 patients with mean diabetes duration of 14.3 years [SD ± 5.8]) were analyzed. Eyes were examined using standardized 7 field ETDRS (Early Treatment D...
Purpose:
To analyse the efficacy and outcome predictors of ranibizumab using a spectral-domain optical coherence tomography (SD-OCT)-driven treat-and-extend regimen (TER) versus SD-OCT-driven pro re nata regimen (PRN) in patients with cystoid macular oedema (CME) due to branch or central retinal vein occlusion (BRVO, CRVO).
Methods:
Retrospectiv...
Purpose:
To investigate dexamethasone intravitreal implant 0.7 mg (DEX implant) for the treatment of diabetic macular oedema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) therapy and evaluate predictive factors.
Methods:
Two-centre retrospective interventional case series, including 40 eyes of 31 patients treated with D...
BACKGROUND AND OBJECTIVE
To evaluate the effectiveness and safety of low-energy stereotactic radiotherapy (SRT) combined with anti-vascular endothelial growth factor (VEGF) treatment following a treat-and-extend regimen (TER) in wet age-related macular degeneration (AMD).
PATIENTS AND METHODS
Before/after SRT, the authors compared retrospective co...
Purpose:
To evaluate outcome predictors of aflibercept in neovascular age-related macular degeneration pretreated with ranibizumab based on a treat-and-extend regimen (TER).
Methods:
We performed a retrospective evaluation of 18-month follow-up of 45 consecutive patients with limited response to ranibizumab.
Results:
At month 18, mean central...
Purpose
To evaluate retreatment indications/morphologic responses to ranibizumab monotherapy and combination with verteporfin photodynamic therapy (PDT).
Methods
A total of 40 patients received 3 monthly intravitreal ranibizumab 0.3 mg injections combined with either PDT or sham PDT at baseline (1:1) followed by as-needed ranibizumab based on pred...
Purpose : To evaluate early changes of retinal layers as evaluated by Optical Coherence Tomography (OCT) in patients with long standing diabetes type 1 under intensified insulin therapy.
Methods : All 152 patients of a cross-sectional study and 152 age- and gender-matched healthy controls underwent spectral-domain OCT imaging with Heidelberg Spect...
BACKGROUND AND OBJECTIVES
The aim of this study was to identify the rate of early visual acuity poor responders in patients with neovascular age-related macular degeneration (AMD) after the first intravitreal injection of ranibizumab (Lucentis; Genentech, South San Francisco, CA) and to determine potential predictors for early response.
PATIENTS A...
Purpose:
Iron can exert oxidative damage, and increased accumulation is believed to play a role in age-related macular degeneration. Hereditary hemochromatosis leads to an increase in total body iron. Patients with HH were assessed for drusen and other retinal changes.
Methods:
Descriptive uncontrolled study of spectral-domain optical coherence...
Diabetes is a growing worldwide epidemic and a leading cause of blindness in working-age people around the world. Diabetic retinopathy (DR) and diabetic macular edema (DME) are common causes of visual impairment in people with diabetes and often indicate the presence of diabetes-associated preclinical micro- and macrovascular complications. As such...
Basically 3 different approaches to anti-VEGF treatment in AMD are in clinical use, a fixed regimen using monthly or bi-monthly injections (IVI), a PRN strategy and a Treat and Extend (T&E) regimen.
T&E is a proactive and individualized anti-VEGF treatment regimen. Basically IVI are performed monthly until stability is achieved. When disease activi...
Purpose:
To evaluate aflibercept treat-and-extend regimen for treatment of neovascular age-related macular degeneration in patients with limited response to ranibizumab.
Methods:
This prospective single-arm trial included 33 patients with neovascular age-related macular degeneration pretreated with treat-and-extend regimen ranibizumab for ≥6 mon...
Purpose:
To compare outcomes in patients with treatment-naïve neovascular age-related macular degeneration (nAMD) receiving ranibizumab treat and extend (TE) with those receiving ranibizumab pro re nata (PRN) in a clinical setting.
Methods:
During this 12-month retrospective, consecutive, comparative case series, patients received ranibizumab 0....
Background:
Treat and extend (TE) treatment regimens have the potential to reduce the treatment burden placed upon patients receiving ranibizumab for neovascular age-related macular degeneration (nAMD). This study aimed to analyse changes in best corrected visual acuity (BCVA) and anatomical parameters in patients switching from a pro re nata (PRN...
Purpose:
The Geographic Atrophy Progression (GAP) study was designed to assess the rate of geographic atrophy (GA) progression and to identify prognostic factors by measuring the enlargement of the atrophic lesions using fundus autofluorescence (FAF) and color fundus photography (CFP).
Design:
Prospective, multicenter, noninterventional natural...
Aims To demonstrate non-inferiority of ranibizumab treat-and-extend (T&E) with/without laser to ranibizumab pro re nata (PRN) for best-corrected visual acuity (BCVA) in patients with diabetic macular oedema (DMO).
Methods A 24-month single-masked study with patients randomised 1:1:1 to T&E+laser (n=121), T&E (n=128) or PRN (control; n=123). All pat...
Purpose
To analyze the efficacy of Aflibercept in patients with choroidal neovascularization (CNV) due to Age related macular degeneration (AMD) who were previously treated with Ranibizumab based on a Treat and Extend protocol (T&E).
Methods
We have reviewed 30 eyes of 30 patients with CNV due to neovascular AMD. All patients were previously trea...
Purpose: The Diabetes Control and Complications Trial demonstrated that a mean of about 6 years of intensive therapy aimed at near normal glucose levels reduced the risk of retinopathy by as much as almost 80% compared to conventional therapy. Therefore the purpose of this trial was to evaluate the prevalence and stage of diabetic retinopathy (DR)...
The number of cases of patients with exudative age-related macular degeneration (wet AMD) is increasing, partly due to an ageing population and lifestyle risk factors, such as smoking. The treatment of wet AMD has been revolutionised by the advent of anti-vascular endothelial growth factor (anti-VEGF) agents, though it is an important aim to reduce...
Purpose:
To investigate the injection frequency and visual acuity (VA) outcomes with combination therapy (ranibizumab plus verteporfin photodynamic therapy, PDT) versus monotherapy (ranibizumab).
Methods:
A total of 40 patients with exudative age-related macular degeneration were randomized 1:1 to ranibizumab 0.3 mg plus single standard vertepor...
Purpose
To identify reliable criteria based on spectral-domain optical coherence tomography (SD-OCT) to monitor disease progression in geographic atrophy due to age-related macular degeneration (AMD) compared with lesion size determination based on fundus autofluorescence (FAF).
Design
Prospective longitudinal observational study
Methods
Setting:...
To determine the prevalence of polypoidal choroidal vasculopathy (PCV) in patients with presumed neovascular age-related macular degeneration (AMD) who were considered poor responders to ranibizumab.
Caucasian patients with suspected neovascular AMD, presumed to be choroidal neovascularisation, previously treated with ≥8 intravitreal injections of...
Purpose:
To evaluate microperimetry changes in patients with acute macular edema secondary to branch retinal vein occlusion during a follow-up period of 12 months with intravitreal ranibizumab treatment (Lucentis; Novartis).
Methods:
Patients with macular edema secondary to branch retinal vein occlusion received an intravitreous injection of 0.5...
BACKGROUND:
The aim of this study was to evaluate the effect of postoperative systemic steroid treatment on retinal sensitivity in patients with epiretinal membrane (ERM) after successful surgery.
PATIENTS AND METHODS:
A total of 28 patients with ERM, macular edema and visual loss were included in this study. All patients were treated with combine...
Hintergrund
Ziel dieser Studie war es, die Wirkung der postoperativen systemischen Steroidgabe auf die retinale Sensitivität bei Patienten mit epiretinaler Membran (ERM) nach erfolgreicher chirurgischer Behandlung zu evaluieren.
Patienten und Methoden
Es wurden 28 Patienten mit signifikantem Makulaödem und Visusabfall bei ERM in diese Studie inklu...
To evaluate the 3-year therapeutic benefit of intravitreal bevacizumab in neovascular related macular degeneration (nAMD) in a standard clinical setting involving 3 initial injections and a pro re nata regimen as recommended in the PRONTO study.
In this interventional clinical study, 181 eyes of 160 consecutive patients with active neovascular rela...
The current standard therapy for patients with diabetic macular oedema (DME)--focal/grid laser photocoagulation--usually does not improve impaired vision, and many patients lose vision despite laser therapy. Recent approval of ranibizumab by the European Medicines Agency to treat visual impairment due to DME fulfils the previously unmet medical nee...
This study aims to assess the impact of continued ranibizumab treatment for neovascular age-related macular degeneration on patients from the MARINA and ANCHOR randomised clinical studies who lost ≥ 3 lines of best-corrected visual acuity (BCVA) at any time during the first year of treatment.
Baseline characteristics, mean BCVA over time and ocular...
To evaluate the functional and morphological outcomes of postoperative systemic steroid therapy after successful macular surgery in eyes with macular edema due to idiopathic macular epiretinal membranes (ERMs).
Prospective, randomized, investigator-masked, controlled clinical study.
Twenty-eight patients scheduled for 23-gauge vitrectomy combined w...
Linguatula serrata, the so-called tongue worm, is a worm-like,
bloodsucking parasite belonging to the Pentastomida group. Infections with
L. serrata tongue worms are rare in Europe. We describe a
case of ocular linguatulosis in central Europe and provide molecular data on
L. serrata tongue worms.
Purpose: : Retinal vein occlusions cause severe visual function loss due to macular edema. Off label treatment with intravitreal anti-VEGF injections is nowadays a common therapeutical choice. Despite the efficacy in reducing macular edema we noticed an increase of retinal nonperfusion in the follow up course of these patients. The purpose of this...
Purpose: : To evaluate the efficacy of ranibizumab treatment in diabetic macular edema (DME) in a routine clinical setting and correlations of baseline characteristics, Spectral(SD)-OCT and visual acuity outcomes.
Methods: : Data of 30 eyes with visual impairment due to DME with a follow-up of 12 months were analyzed. All eyes were treated followi...
To characterise the extension and progression of alteration of neurosensory layers following acute and chronic branch retinal artery occlusion (BRAO) in vivo using spectral-domain optical coherence tomography.
In this observational case series, eight eyes with acute BRAO and nine eyes with chronic BRAO were analysed using a Spectralis Heidelberg Re...
To evaluate spectral-domain optical coherence tomography (SD-OCT) in providing reliable and reproducible parameters for grading geographic atrophy (GA) compared with fundus autofluorescence (FAF) images acquired by confocal scanning laser ophthalmoscopy (cSLO).
Prospective observational study.
A total of 81 eyes of 42 patients with GA.
Patients wit...
To compare retinal thickness (RT) measurement and segmentation performance of time domain (TD, Stratus) and spectral domain (SD) optical coherence tomography (OCT) devices (Cirrus, Spectralis) for imaging macular oedema (ME) secondary to branch retinal vein occlusion (BRVO).
In this study, 20 eyes of 20 consecutive patients with acute BRVO were inc...
To compare different spectral domain optical coherence tomography devices regarding retinal thickness values in patients with diabetic macular edema and to correlate the results with conventional time domain Stratus OCT data.
Thirty eyes of 30 consecutive patients with diabetic macular edema were included into a prospective study. The macula was ex...
To investigate whether intravitreal ranibizumab (0.05 mL) treatment affects retinal vessel diameters and retrobulbar blood velocities in patients with acute branch retinal vein occlusion (BRVO).
Thirty patients with clinically significant macular edema secondary to BRVO were included. The duration of the study was three months. Patients were studie...
To analyze the functional and morphologic effects of different ranibizumab treatment regimens on retinal and subretinal as well as sub-RPE compartments in neovascular age-related macular degeneration (nAMD) using spectral-domain optical coherence tomography (SD-OCT) and manual segmentation software.
Twenty-seven eyes of 27 patients with nAMD were e...
The aim of this study is to evaluate the long-term efficacy of intravitreal bevacizumab (IVB) for eyes with non-proliferative idiopathic macular telangiectasia type 2 (IMT2) and acute vision loss.
In this interventional case series, treatment-naive eyes of 13 consecutive patients with IMT2 were included. Eyes with a recent onset of visual loss were...
Purpose Objective: To describe the cytology characteristics in a case of Norrie’s disease.
Methods This is a retrospective case report of a 3‐weeks‐old boy. Diagnosis was based on findings at the initial and follow‐up examinations, cytology of the pseudotumor mass and the retina of both eyes and genetic work up.
Results The excised material was ric...
To analyze immediate in vivo intraretinal morphologic changes secondary to standardized grid photocoagulation using spectral domain optical coherence tomography (SD OCT).
Prospective clinical trial.
Thirteen consecutive patients with treatment-naïve clinically significant diabetic macular edema (DME).
Before and 1 day after standardized grid photoc...
The aim of this study was to evaluate the clinical outcomes of the combination therapy with intravitreal recombinant tissue plasminogen activator (rTPA), gas and lucentis for patients with extensive subfoveal haemorrhages secondary to neovascular age-related macular degeneration (AMD).
In this retrospective clinical study 10 eyes with extensive sub...
Hintergrund Ziel dieser Studie war es, den Einfluss antiangiogener Therapie auf die Unterschiede zwischen Netzhautdickenmessungen zweier optischer Kohärenztomographie- (OCT-)Systeme desselben Herstellers zu überprüfen. Material und Methoden Mittels Stratus®- und hochauflösendem (HD) Cirrus®-OCT-System wurden 20 Patienten mit altersbedingter Makulad...
To evaluate long-term morphologic and functional changes after intravitreal ranibizumab in avascular pigment epithelial detachment (PED) secondary to age-related macular degeneration (AMD).
Interventional, prospective case series; the first group of six patients received three and the second group of six patients received six intravitreal injection...
This study aimed to evaluate the course of macular sensitivity (MS) following treatment with reduced fluence photodynamic therapy (RPDT) versus standard photodynamic therapy (SPDT) in combination with intravitreal triamcinolone acetonide (IVTA) in patients with neovascular age-related macular degeneration, and to investigate the correlation between...
This study compared automatic- and manual segmentation modalities in the retina of healthy eyes using high-definition optical coherence tomography (HD-OCT).
Twenty retinas in 20 healthy individuals were examined using an HD-OCT system (Carl Zeiss Meditec, Inc.). Three-dimensional imaging was performed with an axial resolution of 6 μm at a maximum s...
To quantify and correlate the morphological and functional effects of the recommended loading regimen with intravitreal ranibizumab in neovascular age-related macular degeneration (AMD).
In a prospective, interventional clinical trial, 29 consecutive patients (29 eyes) with choroidal neovascularisation secondary to AMD received three initial monthl...
To correlate the morphologic characteristics of choroidal neovascular lesions (CNV) in age-related macular degeneration (AMD) using raster scanning high-definition optical coherence tomography (HD-OCT) and conventional fluorescein angiography (FA).
In this comparative clinical study, 37 consecutive patients with classic, minimally classic, or occul...
Neovascular age-related macular degeneration (AMD) has a poor prognosis if left untreated, frequently resulting in legal blindness. Ranibizumab is approved for treating neovascular AMD. However, further guidance is needed to assist ophthalmologists in clinical practice to optimise treatment outcomes.
An international retina expert panel assessed ev...
Optical coherence tomography (OCT) is restricted by its low scanning speed and limited resolution. High-definition raster-scanning OCT (HD-OCT) was used to evaluate changes in retinal microstructure in patients with acute central serous chorioretinopathy (CSCR) and to find new morphological features.
Eighteen patients with subretinal fluid accumula...
Purpose: : To evaluate retreatment frequency and indications in a randomized controlled trial comparing Ranibizumab monotherapy with combination therapy using Ranibizumab + standard fluence PDT.
Methods: : Patients were randomized to receive PDT or sham PDT, followed by 3 initial monthly 0.3mg intravitreal Lucentis injections. Over the course of t...
Purpose: : This double-blind monocenter study was designed to investigate the efficacy and safety of Lucentis (ranibizumab) monotherapy compared to standard verteporfin therapy in combination with Lucentis in all subtypes of CNV secondary to AMD during a one year follow-up.
Methods: : Patients were randomized to receive initial PDT or sham PDT in...
This study evaluated the impact of antiangiogenetic therapy on differences in central retinal thickness (CRT) as measured with two optical coherence tomography (OCT) systems from the same manufacturer.
Data were obtained from a group of 20 patients with neovascular age-related macular degeneration before and after intravitreal treatment with ranibi...
To investigate color perception and contrast sensitivity with and without additional glare in pseudophakic patients with a conventional intraocular lens (IOL) in one eye and a blue light-filtering IOL in the fellow eye.
Twenty-three bilaterally pseudophakic patients with a conventional IOL (AcrySof SA60AT) and a blue light-filtering IOL (AcrySof Na...
Purpose
To investigate color perception and contrast sensitivity with and without additional glare in pseudophakic patients with a conventional intraocular lens (IOL) in one eye and a blue light-filtering IOL in the fellow eye.
Methods
Twenty-three bilaterally pseudophakic patients with a conventional IOL (Acr ySof SA60AT) and a blue light-filteri...
To investigate the potential role of optical density ratios (ODRs) obtained from subretinal fluid analysis in exudative macular disease and to identify the predictive role of ODRs under therapy in comparison to conventional morphometric measurements (CMMs).
Fifteen patients with neovascular age-related macular degeneration (nAMD) and 15 with acute...
To compare 1-year functional and anatomic outcomes of intravitreal bevacizumab (IVB) and photodynamic therapy plus intravitreal triamcinolone (PDT+IVTA) combination in patients with neovascular age-related macular degeneration (AMD).
In this prospective, randomised, controlled clinical trial, 28 patients were included. All patients were randomised...
To report a series of severe intraocular inflammatory events following intravitreal injections of bevacizumab (Avastin). This procedure is performed on a rapidly increasing number worldwide, and rare complications such as intraocular inflammation, endophthalmitis or intraocular haemorrhage are gaining in importance in clinical routine.
This is a si...
Optical coherence tomography (OCT) is used to image branch retinal vein occlusion (BRVO) but lacks information about leakage dynamics and perfusion status. Topographical angiography (TAG) is capable of providing this information and has been described previously in age-related macular degeneration. This study evaluates TAG in BRVO.
We included 56 e...
To analyze the effect of ranibizumab therapy on retinal and subretinal compartments in age-related macular degeneration and to compare the time course of compartment specific effects to visual function.
Prospective noncomparative case series.
Fourteen patients with changes in 3 major compartments owing to neovascular age-related macular degeneratio...
To evaluate the clinical outcomes of subfoveal haemorrhages secondary to neovascular age-related macular degeneration (AMD), which were treated with intravitreal recombinant tissue plasminogen activator (rTPA)/gas and anti-vascular endothelial growth factor (anti-VEGF) drug or with an intravitreal anti-VEGF monotherapy.
This is a retrospective pilo...
The evaluation of OCT3 during anti-VEGF therapy.
A total of 29 patients with choroidal neovascularization secondary to AMD received 3 intravitreal injections of ranibizumab. OCT examination and visual acuity testing (ETDRS) were performed before therapy onset, after 1 week and after 1, 2 and 3 months.
The central retinal thickness (CRT) was assesse...
Idiopathic macular holes usually develop in the elderly. We report the case of a spontaneous macular hole in a 23-year-old man.
The patient noticed decreased central vision in his left eye since 5 days without any history of trauma or intraocular inflammation. On examination the best corrected visual acuity was 20/20 in the right eye and 20/50 in t...
To evaluate morphological and functional recovery after macular hole surgery using pars plana vitrectomy (PPV), inner limiting membrane (ILM) peeling, air-tamponade and short-time limited face-down positioning.
Retrospective, interventional, non-comparative consecutive case series.
Thirty eyes in 30 patients (30 eyes) with unilateral full-thickness...
Purpose: : The aim of this study was to evaluate re-treatment frequency and indications in a randomized controlled trial comparing Lucentis (Ranibizumab) monotherapy and combination therapy using standard fluence PDT and Lucentis.
Methods: : Patients were randomized to receive initial PDT or sham PDT, followed by 3 initial monthly 0.3mg intravitre...
Central serous chorioretinopathy (CSC) is a disease of the retina characterized by serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE). CSC occurs most frequently in mid-life and more often in men than in women. Major symptoms are blurred vision, usually in one eye only and per...
All commercially available triamcinolone acetonide (TACA) suspensions, used for intravitreal treatment, contain retinal toxic vehicles (e.g., benzyl alcohol, solubilizer). Our aim was to find a convenient and reproducible method to compound a completely preservative-free TACA suspension, adapted to the intraocular physiology, with consistent qualit...
Die Evaluierung des OCT3 während einer Anti-VEGF-Therapie.Im Rahmen einer AMD bekamen 29 Patienten mit choroidalen Neovaskularisationen insgesamt 3 intravitreale Injektionen mit Ranibizumab. Vor Therapiebeginn, nach 1 Woche sowie nach 1, 2 und 3 Monaten wurden OCT3-Untersuchungen durchgeführt sowie der Visus (ETDRS) ermittelt.Die zentrale Netzhautd...
We undertook this study to evaluate the expression of septin family members SEPT5, SEPT8, and SEPT11 in proliferative retinal membranes. Epiretinal membranes (ERM) were obtained from seven patients with proliferative vitreoretinopathy (PVR) and from four patients and four postmortem eyes with proliferative diabetic retinopathy (PDR). Subretinal mem...
Neovascular age-related macular degeneration (AMD) is becoming an increasing socio-medical problem as the proportion of the aged population is continuously increasing. However, new insights in the pathogenesis of the disease offer the opportunity to develop targeted therapies that attack the disease process more successfully than ever. This review...
Purpose:: Anti-VEGF-therapy induces characteristic effects on retinal morphology and function most intensively during the first months following treatment initiation with consecutive monthly injections. The morphologic changes in retina, retinal pigment epithelium (RPE) and choroidal neovascularization (CNV) were analyzed using high-resolution OCT...
Photodynamic therapy (PDT) performed in this rare condition showed promising results according to 3 other case reports.
A 47-year-old female patient with fundus flavimaculatus developed metamorphopsia and minimal vision deterioration (20/25) in her left eye. Fluorescein angiography revealed all signs of classic choroidal neovascularisation (CNV).
A...
Ohne Zusammenfassung
To compare the efficacy and safety of early retreatment with verteporfin therapy with that of approved standard verteporfin therapy in neovascular age-related macular degeneration.
Prospective, randomized, multicenter clinical trial.
Two hundred three patients with predominantly classic choroidal neovascularization secondary to age-related macular...
