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Publications (394)
Lyme disease is caused by an infection with the bacterium Borrelia
burgdorferi. Other Borrelia species have been discovered and cause
similar diseases. The first species described, Borrelia burgdorferi sensu
stricto, was isolated in the United States. Lyme disease is a great imitator,
resembling many conditions, including autoimmune diseases.
The d...
The pharmaceutical industry regularly uses highly biased, unreliable studies
to oversell their drugs. In recent years, a growing number of scientific
publications studying innovative pharmaceutical products have included
studies with such significant biases as to invalidate the results promoted by
the authors. Remdesivir caught our attention becaus...
Despite a peer review process prior to being published in Biomedicine & Pharmacotherapy, Pradelle et al, "Deaths induced by compassionate use of hydroxychloroquine (HCQ) during the first COVID-19 wave: an estimate" is cluttered with several scientific integrity issues, one of them being the lack of validation against real life data. Mathematical mo...
This is the case of a 40-year-old immunocompetent, female patient presenting with a "polymorphic persistent syndrome after a possible tick bite" (SPPT), a syndrome officially recognized by the French High Authority for Health (HAS). This patient presented with polymorphic symptoms and was unable to walk without a walker. Only ceftriaxone was effect...
Citation: Alexis Lacout, Christian Perronne. Effect of Flubendazole, with Jarish-Herxheimer Reactions Followed by Cure, in A Patient with A Polymorphic Persistent Syndrome Suggestive of Chronic Lyme Disease: A Sign of Parasitic Disease. Archives of Microbiology and Immunology. 8 (2024): 96-100. Abstract This paper discusses the case of a 40-year-ol...
A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify efficacy with respect to the composite endpoint of transfer to intensive care unit or death, within a couple...
A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify vaccination efficacy with respect to the composite endpoint of transfer to intensive care unit or death, with...
The COVID-19 pandemic is a unique crisis challenging healthcare institutions as it rapidly overwhelmed hospitals due to a large influx of patients. This major event forced all the components of the healthcare systems to adapt and invent new workflows. Thus, our tertiary care hospital was reorganized entirely. During the cruising phase, additional s...
.The emergence of the Omicron variant of SARS-CoV2 identified first in South Africa was announced with anxiety in media following alarm and concern by many researchers in the scientific community and the WHO has declared it a variant of concern (VOC): “The discovery of a highly mutated coronavirus variant in South Africa has triggered a global scra...
Introduction
Ticks are frequently polyinfected and can thus transmit numerous microorganisms. A large number of bacteria, parasites and viruses are transmitted by tick bites and could cause different signs and symptoms in patients. The main goal of this study was to search for these numerous microorganisms in patients presenting with persistent pol...
Objective
To compare the impact of a care bundle including medication reconciliation at discharge by a pharmacist versus standard of care, on continuity of therapeutic changes between hospital and primary care and outcome of patients, within one month after discharge.
Methods
Randomized controlled trial in 120 adult patients with at least one chro...
TO THE EDITOR
We were surprised by the hydroxychloroquine dose chosen in the Randomized Evaluation of Covid-19 Therapy (RECOVERY) trial conducted by Horby et al. (Nov. 19 issue).1 In this trial, patients received a higher dose of hydroxychloroquine (4 g cumulated over the first 3 days) than that administered in the trial conducted by Lagier et al.2...
Background
Shortening the duration of antibiotic therapy for patients admitted to hospital with community-acquired pneumonia should help reduce antibiotic consumption and thus bacterial resistance, adverse events, and related costs. We aimed to assess the need for an additional 5-day course of β-lactam therapy among patients with community-acquired...
Several points of concern arise regarding the methodology and the presented results of Discovery, the large French multicenter, randomized, controlled trial which evaluated the efficacy and safety of lopinavir + ritonavir (L/r), lopinavir/ritonavir + Interferon β-1a (L/r + IFN), and hydroxychloroquine (HCQ) in adults hospitalized for COVID-19. Resu...
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients.
Methods
We performe...
Introduction
La résistance bactérienne est un enjeu majeur de santé publique, directement liée à la prescription antibiotique. Parmi les grands consommateurs, les infections urinaires sont au second rang en France. La littérature des dix dernières années relate des difficultés dans l’application des recommandations en médecine de ville, et une pres...
Introduction
Limited data are reported regarding osteomyelitis due to Carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with Extended-Spectrum Beta-Lactamase (ESBL) microorganisms.
Methods
We conducted a retrospective study in a reference center for bone and joint infection (BJI) from 2011 to 2019 among patients infected by...
Introduction
Interest of anti-infective agents in COVD-19 showed discrepant results. However, there is no evaluation about the impact in changes of practices on the prognosis over time.
Methods
Single center, retrospective study, conducted from March 5th to April 25th 2020, in adults hospitalized in a medicine ward for a COVID-19. Patient characte...
Background: Borrelia species are divided into three groups depending on the induced disease and the tick vector. Borrelia miyamotoi is a relapsing fever Borrelia but can induce symptoms related to Lyme disease. Discovered in 1995, it is found in ticks around the world. In France, this species of Borrelia has been isolated in ticks and rodents, but...
Introduction
L’érysipèle est une infection fréquente des tissus mous, de diagnostic clinique et d’origine souvent streptococcique. Les recommandations françaises ont récemment évolué : hospitalisation si signe de gravité local ou général, comorbidités, IMC > 40, âge > 75 ans polypathologique et < 1 an, ou en cas d’évolution défavorable après 24–48...
Introduction
Cefoxitin has a good in vitro activity and stability in resistance to hydrolysis by extended-spectrum beta-lactamases and is a good candidate for the treatment of urinary tract infection. However, data are scarce regarding its use in clinical practice.
Methods
We conducted a retrospective study from September 2014 to November 2017, in...
Objective:
A rapid and worrying emergence of vancomycin-resistant enterococci (VRE) gut colonization is occurring worldwide and may be responsible for outbreaks, especially in healthcare facilities. While no efficient decolonization strategies are recommended, we assessed fecal microbiota transplantation (FMT) to eradicate VRE colonization.
Patie...
Background:
Intermittent treatment could improve the convenience, tolerability and cost of ART, as well as patients' quality of life. We conducted a 48 week multicentre study of a 4-days-a-week antiretroviral regimen in adults with controlled HIV-1-RNA plasma viral load (VL).
Methods:
Eligible patients were adults with VL < 50 copies/mL for at l...
Background
Physicians are facing a worldwide increase in multidrug-resistant (MDR) organisms. Eradication of such bacteria, including so called superbugs (XDR), may cause physicians to prescribe last-resort antibiotics. However, experience with these drugs is limited and few data are available.
Methods
A before and after retrospective study was co...
Background: The effects on ventricular repolarisation — recorded on the ECG as lengthening of the QT interval — of acute tuberculosis and those of standard and alternative anti-tuberculosis regimens are under-documented. A correction factor (QTc) is introduced to make the QT independent of the heart rate, translating into the slope of the regressio...
Introduction
Eosinopenia has been in the centre of debates for decades as a criterion of sepsis. Depending on authors, different cut-off values are proposed.
Methods
We conducted a prospective study, from February to August 2016, of hospitalized adults suffering from bacterial infection with eosinopenia defined by an eosinophil count <100/mm3. Pat...
Objective:
Non-typhi Salmonella enterica urinary tract infections (UTIs) are not frequent and rarely reported in the literature. We aimed to characterize clinical presentations and risk factors for the infection.
Patients and methods:
We performed a retrospective study of non-typhi Salmonella enterica strains isolated from urine cytobacteriologi...
Carbapenem-resistant Enterobacteriaceae (CRE) or vancomycin-resistant enterococci (VRE) carriage present a major public health challenge. Decolonization strategies are lacking. We aimed to evaluate the impact of faecal microbiota transplantation (FMT) on a cohort of patients with digestive tract colonization by CRE or VRE. Eight patients were inclu...
Background:
Controlling antibiotic use in healthcare establishments limits their consumption and the emergence of bacterial resistance.
Aim:
To evaluate the efficiency of an innovative antibiotic stewardship strategy implemented over three years in a university hospital.
Methods:
An antimicrobial multi-disciplinary team (AMT) [pharmacist, micr...
Objective . Pyogenic vertebral osteomyelitis (PVO) are frequently misdiagnosed and patients often receive anti-inflammatory drugs for their back pain. We studied the impact of these medications. Methods . We performed a prospective study enrolling patients with PVO and categorized them depending on their drugs intake. Then, we compared diagnosis de...
29-69 % of pneumonias are microbiologically documented because it can be considered as an invasive procedure with variable test sensitivity. However, it drastically impacts therapeutic strategy in particular the use of antibiotics. Serum protein electrophoresis (SPEP) is a routine and non-invasive test commonly used to identify serum protein disord...
Objectives:
The proper use of antibiotics is a public health priority to preserve their effectiveness. Little data is available on outpatient antibiotic prescriptions, especially in the emergency department. We aimed to assess the quality of outpatient antibiotic prescriptions in our hospital.
Patients and methods:
Retrospective monocentric stud...
The use of antibiotics, as any other drug, is regulated by the terms of its marketing authorisation, notified in the Summary of Product Characteristics (SPC). If a prescription is not in accordance with the SPC, the physician prescribes off-label. There is very little literature regarding off-label use of antibiotics in adult healthcare facilities....
Objectives:
Patients presenting with neurogenic bladder often require urological procedures (urodynamic testing and botulinum toxin injections) and a preventive antibiotic therapy. We aimed to assess the efficacy of this little known strategy in a cohort of patients.
Patients and methods:
All patients presenting with neurogenic bladder who under...
Objectives:
Pyogenic vertebral osteomyelitis (PVO) is a rare disease with possible severe complications (e.g. sepsis and spinal cord injury). In the 1990s, diagnostic delay (DD) was often extensive as PVO has a non-specific clinical spectrum, mostly afebrile with back pain, and access to magnetic resonance imaging (MRI) was not straightforward. Ou...
Study design:
Retrospective study.
Objectives:
We aimed to describe the epidemiology of multidrug-resistant organisms (MDROs) during bloodstream infection (BSI) and identify associated risks of MDROs among patients with spinal cord injury (SCI).
Setting:
A teaching hospital, expert center in disability, in France.
Methods:
We studied a retro...
Many more questions than answers
Lyme disease is the most common vector borne disease in North America and Europe, with 300 000 new cases in the United States1 and an estimated 100 000 new cases in Europe each year.2 These numbers are likely to be underestimates because case reporting is inconsistent3 and many infections go undiagnosed.4 Climate c...
Background:
In sub-Saharan Africa, the burden of human immunodeficiency virus (HIV)-associated tuberculosis is high. We conducted a trial with a 2-by-2 factorial design to assess the benefits of early antiretroviral therapy (ART), 6-month isoniazid preventive therapy (IPT), or both among HIV-infected adults with high CD4+ cell counts in Ivory Coas...
Short, intraweekly cycles of anti-HIV combinations have provided intermittent, effective therapy (on 48 patients) (1). The concept is now extended to 94 patients on treatment, 4 days per week or less, over a median of 2.7 discontinuous treatment years per patient. On suppressive combinations, 94 patients volunteered to treatment, 5 and 4 days per w...
Pulmonary actinomycosis is a rare disease that is often misdiag-nosed as tuberculosis or lung cancer.
Actinomyces graevenitzii
is a relatively new recognized
Actinomyces
species isolated from various clinical samples. The authors report a case of pulmonary actinomycosis caused by
A graevenitzii
. A computed tomography examination revealed an excava...
BACKGROUND : Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin-sensitive pulmonary tuberculosis.
METHODS : We conducted a noninferiority, randomized, open-labe...
Objective:
To assess the performance of QuantiFERON-TB Gold In-Tube (QFT-GIT) test for active tuberculosis (TB) in HIV adults, and its variation over time in patients on antiretroviral therapy (ART) and/or isoniazide preventive therapy (IPT).
Methods:
Transversal study and cohort nested in the Temprano ANRS 12136 randomized controlled trial asse...
Background: Progressive multifocal leukoencephalopathy (PML) is a rare
but frequently fatal demyelinating disease caused by the JC polyomavirus
BMC Infectious Diseases 2014, Volume 14 Suppl 7
http://www.biomedcentral.com/bmcinfectdis/supplements/14/S7
Page 43 of 45
(JCV). It has been traditionally associated to severe immunosuppression
and describe...
Background:
Bone and joint infection due to bacteria producing Extended Broad Spectrum Beta lactamase (ESBL) are rare but rising nowadays. Data on this disease are scarce and outcome is not well known. We present a cohort of 43 cases
Methods:
Multicentric retrospective cohort of consecutive cases of bone and joint infection due to ESBL produc...
Lyme disease, caused by Borrelia burgdorferi and transmitted by ticks, was initially considered a recent, rare and regional occurrence. We now have evidence that very similar bacteria infected humans in Europe during the ice age (Keller et al., 2012). Evidence-based data are scarce therefore many aspects of the disease remain controversial (Auwaert...
Gonococcal arthritis is typically acute and appears within 3 weeks after initial infection. Chronic gonococcal arthritis is now exceptionally rare, since the advent of the antibiotic era. Numerous host factors are involved in gonococcal dissemination, such as complement deficiency, HIV and gonococcus strain characteristics. Gonococcal arthritis sha...
