Christian Foerster

University of Alberta | UAlberta · Department of Oncology

Unnatural mirror image L-configured oligonucleotides (L-ONs) are a convenient substance class for the application as complementary in vivo recognition system between a tumor specific antibody and a smaller radiolabeled effector molecule in pretargeting approaches. The high hybridization velocity and defined melting conditions are excellent precondi...

Radiolabeled phosphatidylserine (PS)-binding peptides represent an innovative strategy for molecular imaging of apoptosis with positron emission tomography (PET). The goal of this study was the radiopharmacological evaluation of radiolabeled peptides for their binding to PS on apoptotic cancer cells, involving metabolic stability, cellular uptake,...

A novel, promising strategy for cancer diagnosis and therapy is the use of a pretargeting approach. For this purpose, the non-natural DNA/RNA analogues Peptide Nucleic Acids (PNAs) are ideal candidates as in vivo recognition units due to their high metabolic stability and lack of unspecific accumulation. In the pretargeting approach, an unlabeled,...

Methods: Stability of [64Cu]Cu-CryptTM was assessed in vitro by challenging experiments using competitive chelators EDTA and NOTA. Radiopharmacological profile of [64Cu]Cu-CryptTM was evaluated by dynamic PET studies in EMT6-tumor bearing Balb/C mice. The current “gold standard” for kinetically inert 64Cu-cryptates [64Cu]Cu-DiAmSar was prepared and...

The radiosynthesis and radiopharmacological evaluation including small animal PET imaging of a novel 64Cu-labelled cryptand molecule ([64Cu]CryptTM) possessing a tris-pyridyl/tris-amido set of donor atoms is described.

Peptide nucleic acids (PNAs) have very attractive properties for applications in nuclear medicine. Because PNAs have high selectivity for DNA/RNA recognition, resistance to nuclease/protease degradation, and high thermal and radiolytic stabilities, PNA bioconjugates could transform the areas of diagnostic and therapeutic nuclear medicine. In this b...

For their application in the area of diagnosis and therapy, single-domain antibodies (sdAbs) offer multiple advantages over conventional antibodies and fragments thereof in terms of size, stability, solubility, immunogenicity, production costs as well as tumor uptake and blood clearance. Thus, sdAbs have been identified as valuable next-generation...

Two basic and simple synthetic routes for mono- and bis-maleimide bearing 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) chelators as new bifunctional chelators are described. The syntheses are characterized by their simplicity and short reaction times, as well as practical purification methods and acceptable to very good chemical yields. T...

The aromatic monoboranes 1, 2 and bisboranes 3, 4 of which 4 is a newly synthesised compound have been studied with reference to their supramolecular behaviour in the crystalline state. While the monoboranes crystallise purely, the bisboranes form channel-type solvent inclusions with m-xylene /(3a) and nitrobenzene (4a) in the crystals, showing the...

The invention relates to a ligand of formula (I), where (CH-R1) and (CH-R1’) are substituted or non-substituted methylene bridges; the individual R1 and R1’, and R3 and R3’, are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups; and m and n are positive w...