Christian Dobel

Christian Dobel
Friedrich Schiller University Jena | FSU · Department of Otolaryngology and the Institute of Phoniatry and Pedaudiology

About

183
Publications
23,528
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2,693
Citations
Citations since 2017
53 Research Items
1484 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250

Publications

Publications (183)
Article
Full-text available
Despite the fact that chronic diseases usually occur together with a spectrum of possible comorbidities that may differ strongly between patients, they are classically still viewed as distinct disease entities and, consequently, are often treated with uniform therapies. Unfortunately, such an approach does not take into account that different combi...
Article
Full-text available
Tinnitus treatment, diagnosis and management across Europe varies significantly. The lack of national clinical guidelines for tinnitus management in most European countries and the absence of a common language across all disciplines involved is reflected in the diversification of healthcare practices. Interprofessional Training for Tinnitus Researc...
Article
Full-text available
The ability to recognize someone’s voice spans a broad spectrum with phonagnosia on the low end and super-recognition at the high end. Yet there is no standardized test to measure an individual’s ability of learning and recognizing newly learned voices with samples of speech-like phonetic variability. We have developed the Jena Voice Learning and M...
Article
Background and objective Despite the availability of successful treatment approaches for chronic tinnitus, it has proven difficult to predict who profits from treatment and it is still an open question if it is possible at all. We tried to overcome methodological shortcomings and to predict treatment outcome indicated by questionnaires measuring ti...
Article
Full-text available
To determine treatment and outcome in a tertiary multidisciplinary facial nerve center, a retrospective observational study was performed of all patients referred between 2007 and 2018. Facial grading with the Stennert index, the Facial Clinimetric Evaluation (FaCE) scale, and the Facial Disability Index (FDI) were used for outcome evaluation; 1220...
Article
Full-text available
Learning from errors as the main mechanism for motor adaptation has two fundamental prerequisites: a mismatch between the intended and performed movement and the ability to adapt motor actions. Many neurological patients are limited in their ability to transfer an altered motor representation into motor action due to a compromised motor pathway. St...
Article
Full-text available
Purpose To evaluate the continued rehabilitation motivation in patients with postparalytic facial synkinesis (PFS). Methods In this single-center cross-sectional survey, the multidimensional patient questionnaire for assessment of rehabilitation motivation (PAREMO-20) was used to assess the rehabilitation motivation. Associations Sunnybrook and St...
Article
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Background: There is no current standard for facial synkinesis rehabilitation programs. The benefit and stability of effect of an intensified 10-day facial training combining electromyography and visual biofeedback training was evaluated. Methods: Fifty-four patients (77.8% female; median age: 49.5 years) with post-paralytic facial synkinesis (medi...
Preprint
The ability to recognize someone’s voice exists on a broad spectrum with phonagnosia on the low end and super recognition at the high end. Yet there is no standardized test to measure an individual’s ability of learning and recognizing newly-learnt voices with samples of speech-like phonetic variability. We have developed the Jena Voice Learning an...
Article
Objectives Chronic tinnitus negatively impacts daily functioning. To specifically assess this impairment, the Tinnitus Functional Index (TFI) was developed. The current study investigated the hierarchical, eight-factorial structure for the German TFI and examined its psychometric properties. Design In an online assessment, the TFI and other valida...
Article
Full-text available
Objectives/Hypothesis To evaluate the role of body dysmorphic disorder (BDD) in patients with postparalytic facial nerve syndrome with synkinesis (PFS). Study Design A single‐center retrospective cohort study. Methods A total of 221 adults (74% women; median age: 44 years; median duration since onset of facial palsy: 1.6 years) were included. To...
Chapter
While tinnitus is known to compromise the perception of speech, it is unclear if the same holds for extralinguistic speaker information. Furthermore, research with simple tone stimuli showed that unilateral tinnitus binds spatial attention, thereby impeding the detection of auditory changes in the non-affected ear. Using dichotic listening tasks, w...
Article
Background Botulinum toxin A (BTX) is a neurotoxin widely used for facial aesthetics. It causes dose-dependent muscle paralysis. It was hypothesized that treatment of mimic muscles with BTX might have a positive impact on emotional expression in static images (photos), but a negative impact in dynamic recordings (videos). Objective Comparison of e...
Article
Purpose In their letter, Meister et al. (2020) appropriately point to a potential influence of stimulus type, arguing cochlear implant (CI) users may have the ability to use timbre cues only for complex stimuli such as sentences but not for brief stimuli such as vowel–consonant–vowel or single words. While we cannot exclude this possibility on the...
Preprint
Full-text available
There is growing evidence that humans use olfactory chemosensory signals for social communication, but their role in affective associative learning is largely unknown. To examine this, women implicitly learned face-odor associations by pairing different neutral male faces with either a male chemosignal presumably involved in human mating behavior (...
Article
Purpose Using naturalistic synthesized speech, we determined the relative importance of acoustic cues in voice gender and age perception in cochlear implant (CI) users. Method We investigated 28 CI users' abilities to utilize fundamental frequency (F0) and timbre in perceiving voice gender (Experiment 1) and vocal age (Experiment 2). Parameter-spe...
Article
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The use of signs as a major means for communication affects other functions such as spatial processing. Intriguingly, this is true even for functions which are less obviously linked to language processing. Speakers using signs outperform non-signers in face recognition tasks, potentially as a result of a lifelong focus on the mouth region for speec...
Chapter
Tinnitus assessment is a precursor for individualized treatment and outcome measurement. In the recent years, several studies proposed two-alternative forced choice (2AFC) recursive matching as a method to determine tinnitus pitch-match frequency in a standardized reliable manner. Currently, pure tones are used as comparison stimuli to assess pitch...
Article
Full-text available
Affective pictures are widely used in studies of human emotions. The objects or scenes shown in affective pictures play a pivotal role in eliciting particular emotions. However, affective processing can also be mediated by low-level perceptual features, such as local brightness contrast, color or the spatial frequency profile. In the present study,...
Article
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PurposeTo evaluate optimal stimulation parameters with regard to discomfort and tolerability for transcutaneous electrostimulation of facial muscles in healthy participants and patients with postparetic facial synkinesis.Methods Two prospective studies were performed. First, single pulse monophasic stimulation with rectangular pulses was compared t...
Article
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Background: To evaluate the face-specific quality of life after hypoglossal-facial jump nerve suture for patients with long-term facial paralysis. Methods: A single-center retrospective cohort study was performed. Forty-one adults (46% women; median age: 55 years) received a hypoglossal-facial jump nerve suture. Sunnybrook and eFACE grading was per...
Article
Introduction: The determination of the tinnitus pitch-match (PM) frequency is not straightforward but an important audiological assessment recommended for clinical and research purposes. We evaluated repetitive recursive matching using an iPod-based matching procedure as a method to estimate a patient's PM frequency without audiometric equipment....
Chapter
This historical review covers the scientific background of the discipline as reflected in documents from antiquity, the Renaissance, the seventeenth to the nineteenth centuries and the twentieth century up to present times.
Preprint
Purpose: Using naturalistic synthesized speech, we determined the relative importance of acoustic cues in voice gender and, for the first time, vocal age perception in Cochlear Implant (CI) users. Method: We investigated 28 CI users’ abilities to utilize fundamental frequency (F0) and timbre in perceiving voice gender (Experiment 1) and additiona...
Article
Full-text available
The present study used resting state MEG whole-head recordings to identify how chronic tonal tinnitus relates to altered functional connectivity of brain’s intrinsic cortical networks. Resting state MEG activity of 40 chronic tinnitus patients and 40 matched human controls was compared identifying significant alterations in intrinsic networks of th...
Article
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Previous neuroimaging studies have shown that sounds can be discriminated due to living-related or man-made-related characteristics and involve different brain regions. However, these studies have mainly provided source space analyses, which offer simple maps of activated brain regions but do not explain how regions of a distributed system are func...
Article
Tinnitus describes the perception of a sound without external source and is characterized by high comorbidity, e.g. depression. In many studies, tinnitus patients were compared to healthy controls while a comorbid psychiatric diagnosis was an exclusion criterion. Consequently, patients with severe tinnitus and psychiatric comorbidity were often neg...
Article
Full-text available
Chronic tinnitus, a symptom of high prevalence, is a persistent hearing sensation in the absence of an external sound source. Recent electrophysiological studies indicate that tinnitus generation is to a high degree the result of maladaptive plasticity in the central auditory pathway. The pitch of the tinnitus sensation can be assessed by performin...
Article
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Chronic tinnitus has been associated with brain structural changes in both the auditory system as well as limbic system. While there is considerable inconsistency across brain structural findings, growing evidence suggests that distress and other non-auditory symptoms modulate effects. In this study we addressed this issue, testing the hypothesis t...
Article
Recent electrophysiological evidence suggests a rapid acquisition of novel speaker representations during intentional voice learning. We investigated effects of learning intention on voice recognition, using a variant of the directed forgetting paradigm. In an old/new recognition task following voice learning, we compared performance and event-rela...
Article
Full-text available
At the interface between scene perception and speech production, we investigated how rapidly action scenes can activate semantic and lexical information. Experiment 1 examined how complex action-scene primes, presented for 150 ms, 100 ms, or 50 ms and subsequently masked, influenced the speed with which immediately following action-picture targets...
Data
Figures A—E illustrating interactions for all experiments. (DOCX)
Data
Linear mixed effect analyses for all experiments. (DOCX)
Article
Faces of one's own-age group are easier to recognize than other-age faces. Using behavioural measures and EEG, we studied whether an own-age bias (OAB) also exists in voice memory. Young (19 - 26 years) and old (60 - 75 years) participants studied young (18 - 25 years) and old (60 - 77 years) unfamiliar voices from short sentences. Subsequently, th...
Article
Full-text available
Tinnitus describes the subjective perception of a sound despite the absence of external stimulation. Being a sensory symptom the majority of studies focusses on the auditory pathway. In the recent years, a series of studies suggested a crucial involvement of the limbic system in the manifestation and development of chronic tinnitus. Regarding cogni...
Article
Full-text available
Objective: Considering the heterogeneity of the symptoms shown by patients suffering from chronic tinnitus, there are surprisingly few interdisciplinary treatments available, and mostly available only for inpatients. In order to provide an interdisciplinary treatment, we developed a day care concept in which each patient was treated by an ENT docto...
Article
Full-text available
Cochlear implants provide individuals who are deaf with access to speech. Although substantial advancements have been made by novel technologies, there still is high variability in language development during childhood, depending on adaptation and neural plasticity. These factors have often been investigated in the auditory domain, with the mismatc...
Data
Criteria for speech and language performance. (PDF)
Data
Results of speech intelligibility tests. (PDF)
Data
Subjective rating of hearing abilities. (PDF)
Article
Full-text available
Previous studies demonstrated that there is a significant change in speaking fundamental frequency after testosterone therapy in female-to-male gender dysphoric individuals. It is yet an open question how the satisfaction with voice alteration can be predicted because until now it is not clear whether a testosterone therapy is sufficiently effectiv...
Article
Objective: Deficits in basic numerical skills, calculation, and working memory have been found in children with developmental dyscalculia (DD) as well as children with attention-deficit/hyperactivity disorder (ADHD). This paper investigates cognitive profiles of children with DD and/or ADHD symptoms (AS) in a double dissociation design to obtain a...
Article
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The cortical correlates of speech and music perception are essentially overlapping, and the specific effects of different types of training on these networks remain unknown. We compared two groups of vocally trained professionals for music and speech, singers and actors, using recited and sung rhyme sequences from German art songs with semantic and...
Article
Some information about complex naturalistic scenes, such as the scene's gist (a beach, a restaurant) or the category of an object depicted in a scene, can be extracted within a fraction of a second. The present study focused on the rapid apprehension of scene coherence in action scenes involving two actors. Coherence was manipulated by either varyi...
Article
The aim of the present study was to investigate the cognitive profiles of primary school children (age 82-133 months) on a battery of basic number processing and calculation tasks. The sample consisted of four groups matched for age and IQ: Arithmetic disorder only (AD; N = 20), Reading disorder only (RD; N = 40), a comorbid group (N = 27) and an u...
Article
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In three experiments, participants named target pictures by means of German compound words (e.g., Gartenstuhl-garden chair), each accompanied by two different distractor pictures (e.g., lawn mower and swimming pool). Targets and distractor pictures were semantically related either associatively (garden chair and lawn mower) or by a shared semantic...
Article
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Persons suffering from anxiety disorders display facilitated processing of arousing and negative stimuli, such as negative words. This memory bias is reflected in better recall and increased amygdala activity in response to such stimuli. However, individual learning histories were not considered in most studies, a concern that we meet here. Thirty-...
Article
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In major depressive disorder (MDD), electrophysiological (EEG) and imaging studies suggest reduced neural activity in parietal and dorsolateral prefrontal cortex regions. In the present study, neural correlates of emotional processing in MDD were for the first time analyzed in a pre-/post-treatment design by means of magnetoencephalography (MEG) al...
Article
Auditory sensory memory is an important ability for successful language acquisition and processing. The mismatch negativity (MMN) in response to auditory stimuli has been proposed as an objective tool to measure the existence of auditory sensory memory traces. By increasing interstimulus intervals, attenuation of MMN peak amplitude and increased MM...
Article
Full-text available
There is a long tradition of investigating various disorders of musical abilities after stroke. These impairments, associated with acquired amusia, can be highly selective, affecting only music perception (i.e., receptive abilities/functions) or expression (music production abilities), and some patients report that these may dramatically influence...
Article
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Relative to healthy controls, anxiety-disorder patients show anomalies in classical conditioning that may either result from, or provide a risk factor for, clinically relevant anxiety. Here, we investigated whether healthy participants with enhanced anxiety vulnerability show abnormalities in a challenging affective-conditioning paradigm, in which...
Article
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Diffusion tensor imaging revealed that trait anxiety predicts the microstructural properties of a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex. Besides this particular pathway, it is likely that other pathways are also affected. We investigated white matter differences in persons featuring an anxious or...
Article
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Emotion regulation has an important role in child development and psychopathology. Reappraisal as cognitive regulation technique can be used effectively by children. Moreover, an ERP component known to reflect emotional processing called late positive potential (LPP) can be modulated by children using reappraisal and this modulation is also related...
Article
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Social anxiety disorder (SAD) is a commonly occurring and highly disabling disorder. The neuropeptide oxytocin and its receptor (OXTR) have been implicated in social cognition and behavior. The present study - for the first time applying a multi-level epigenetic approach - investigates the role of OXTR gene methylation in categorical, dimensional a...
Article
Purpose: L-dopa has been shown to improve outcome of moderate-intensity language training after stroke in acute aphasia. Given the critical role of training intensity we probed the effect of l-dopa in combination with high-intensity language training in chronic post-stroke aphasia. Methods: In this prospective, randomized, placebo-controlled, do...