Christian Beste

Universitätsklinikum Carl Gustav Carus Dresden · Kognitive Neurophysiologie

The ability to plan and carry out goal-directed behavior presupposes knowledge about the contingencies between movements and their effects. Ideomotor accounts of action control assume that agents integrate action-effect contingencies by creating action-effect bindings, which associate movement patterns with their sensory consequences. However, the...

Understanding the neural mechanisms underlying metacontrol and conflict regulation is crucial for insights into cognitive flexibility and persistence. This study employed electroencephalography (EEG), EEG-beamforming and directed connectivity analyses to explore how varying metacontrol states influence conflict regulation at a neurophysiological le...

Metacontrol” refers to the ability to find the right balance between more persistent and more flexible cognitive control styles, depending on task demands. Recent research on tasks involving response conflict regulation indicates a consistent link between aperiodic EEG activity and task conditions that demand a more or less persistent control style...

A major concept in cognitive neuroscience is that brains are “prediction machines”. Yet, conceptual frameworks on how perception and action become integrated still lack the concept of predictability and it is unclear how neural processes may implement predictive coding during dynamic perception-action integration. We show that distinct neurophysiol...

Functional movement disorders (FMD) are amongst the most common and disabling neurological conditions, placing a significant burden on the healthcare system. Despite the frequency and importance of FMD, our understanding of the underlying pathophysiology is limited, hindering the development of causal treatment options. Traditionally, FMD was consi...

Introduction: Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing in...

Understanding the neural mechanisms underlying metacontrol and conflict regulation is crucial for insights into cognitive flexibility and persistence. This study employed electroencephalography (EEG), EEG-beamforming and directed connectivity analyses to explore how varying metacontrol states influence conflict regulation at a neurophysiological le...

Deficiencies in inhibitory control are one of the hallmarks of attention-deficit-(hyperactivity) disorder (AD(H)D). Response inhibition demands can become increased through additional conflicts, namely when already integrated representations of perception-action associations have to be updated. Yet, the neural mechanisms of how such conflicts worse...

Importance New anti-tumor treatments, such as immune checkpoint inhibitors and CAR T-cell therapy, are associated with an increasing number of neurological issues linked to tumors not arising from nervous system such as neurological and neuropsychological side effects that can significantly impair quality of life in the short or long term. The scie...

Adaptive behavior is based on flexibly managing and integrating perceptual and motor processes, and the reconfiguration thereof. Such adaptive behavior is also relevant during inhibitory control. Although research has demonstrated local activity modulations in theta and alpha frequency bands during behavioral adaptation, the communication of brain...

In this paper, we outline why a recent conceptualization by Egner (2024, Nat Rev Psychol) that metacontrol persistence and flexibility are independent functions is premature. We outline why this view has a problem of a logical fallacy and does not sufficiently consider available neurobiological evidence and evidence from psychopathologies to substa...

How do we make sense of our surroundings? A widely recognized field in cognitive psychology suggests that many important functions like memory of incidents, reasoning, and attention depend on the way we segment the ongoing stream of perception (Zacks & Swallow, 2007). An open question still is, how the structure generated from a perceptual stream...

An in-depth investigation of the structure, neuronal mechanisms, and computations of the frontal lobe that enable higher-level thought. Experts from neurobiology, neuroanatomy, evolutionary biology, cognitive neuroscience, computational neuroscience, and clinical science examine how the neuronal structure of the frontal lobes enables unique aspects...

During our everyday life, the constant flow of information is divided into discrete events, a process conceptualized in Event Segmentation Theory (EST). How people perform event segmentation and the resulting granularity of encapsulated segments likely depends on their metacontrol style. Yet, the underlying neural mechanisms remain undetermined. Th...

Background: "Metacontrol" describes the ability to maintain an optimal balance between cognitive control styles that are either more persistent or more flexible. Recent studies have shown a link between metacontrol and aperiodic EEG patterns. The present study aimed to gain more insight into the neurobiological underpinnings of metacontrol by using...

Action planning can be construed as the temporary binding of action features to form a representation known as an action file. This file is distinct from other possible, but currently not required actions of the behavioral repertoire. To further this action file approach, we investigated what happens with an initially planned action, which however,...

Background Internalizing disorders in children and adolescents are about as frequent as externalizing disorders in the US, but three times more prevalent than externalizing disorders in China. Aims To examine why and how mental predispositions and stress lead to psychopathology in general and manifest as internalizing or externalizing problems in...

Adaptive behavior is fundamental to cognitive control and executive functioning. This study investigates how cognitive control mechanisms and episodic feature retrieval interact to influence adaptiveness, focusing particularly on theta (4 to 8 Hz) oscillatory dynamics. We conducted two variations of the Simon task, incorporating response-incompatib...

Substance use disorders (SUDs) are seen as a continuum ranging from goal‐directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (Re...

That younger individuals perceive the world as moving slower than adults is a familiar phenomenon. Yet, it remains an open question why that is. Using event segmentation theory, electroencephalogram (EEG) beamforming and nonlinear causal relationship estimation using artificial neural network methods, we studied neural activity while adolescent and...

Background The occurrence of tics is the main basis for the diagnosis of Gilles-de-la-Tourette syndrome (GTS). Video-based tic assessments are time-consuming. Objectives To assess the potential of automated video-based tic detection for discriminating between videos of adults with GTS and healthy control (HC) participants. Methods The amount and...

Gilles de la Tourette syndrome (GTS) is a disorder characterised by motor and vocal tics, which may represent habitual actions as a result of enhanced learning of associations between stimuli and responses (S‐R). In this study, we investigated how adults with GTS and healthy controls (HC) learn two types of regularities in a sequence: statistics (n...

Executive functions are essential for adaptive behavior. One executive function is the so-called ‘interference control’ or conflict monitoring another is inhibitory control (i.e., action restraint and action cancellation). Recent evidence suggests an interplay of these processes, which is conceptually relevant given that newer conceptual frameworks...

We delve into the human brain's remarkable capacity for adaptability and sustained cognitive functioning, phenomena traditionally encompassed as executive functions or cognitive control. The neural underpinnings that enable the seamless navigation between transient thoughts without detracting from overarching goals form the core of our article. We...

Interacting with our environment happens on different levels of complexity: While there are individual and simple actions like an isolated button press, most actions are more complex and involve sequences of simpler actions. The degree to which multiple simple actions are represented as one action sequence can be measured via so-called response-res...

Background Attention-deficit/hyperactivity disorder (ADHD) is one of the most frequently diagnosed psychiatric conditions in children and adolescents. Although the symptoms appear to be well described, no coherent conceptual mechanistic framework integrates their occurrence and variance and the associated problems that people with ADHD face. Aims...

Background The principle of gain control determines the efficiency of neuronal processing and can be enhanced with pharmacological or brain stimulation methods. It is a key factor for cognitive control, but the degree of how much gain control may be enhanced underlies a physical limit. Methods To investigate whether MPH and tDCS share common underl...

Goal-directed acting requires the integration of sensory information but can also be performed without direct sensory input. Examples of this can be found in sports and can be conceptualized by feedforward processes. There is, however, still a lack of understanding of the temporal neural dynamics and neuroanatomical structures involved in such proc...

Catecholamines and amino acid transmitter systems are known to interact, the exact links and its impact on cognitive control functions is unclear. Using a multi-modal imaging approach combining EEG and Proton-magnetic resonance spectroscopy (1H-MRS), we investigated the effect of different degrees of pharmacological catecholaminergic enhancement on...

Methamphetamine (METH, “Crystal Meth”) and 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) share structural-chemical similarities but have distinct psychotropic profiles due to specific neurochemical actions. Previous research has suggested that their impact on social cognitive functions and social behaviour may differ significantly, however, d...

Cognitive-control theories assume that the experience of response conflict can trigger control adjustments. However, while some approaches focus on adjustments that impact the selection of the present response (in trial N), other approaches focus on adjustments in the next upcoming trial (N+1). We aimed to trace control adjustments over time by qua...

The ability to find the right balance between more persistent and more flexible cognitive-control styles is known as "metacontrol". Recent findings suggest a relevance of aperiodic EEG activity and task conditions that are likely to elicit a specific metacontrol style. Here we investigated whether individual differences in aperiodic EEG activity ob...

The retina has been considered a "window to the brain" and shares similar innervation by the dopaminergic system with the cortex in terms of an unequal distribution of D1 and D2 receptors. Here, we provide a comprehensive overview that Optical Coherence Tomography (OCT), a non-invasive imaging technique, which provides an "in vivo" representation o...

To facilitate goal-directed actions, effective management of working memory (WM) is crucial, involving a hypothesized WM "gating mechanism". We investigate the underlying neural basis through behavioral modeling and connectivity assessments between neuroanatomical regions linked to theta, alpha, and beta frequency bands. We found opposing, threshol...

Coping with distracting inputs during goal-directed behavior is a common challenge, especially when stopping ongoing responses. The neural basis for this remains debated. Our study explores this using a conflict-modulation Stop Signal task, integrating group independent-component analysis (Group-ICA), multi-variate pattern analysis (MVPA), and EEG...

In the literature on human action control, it is assumed that features of stimuli (S) and responses (R) are integrated into internal representations (so-called event files) that are involved in the execution of an action. Experimentally, the impact of this integration on action control is typically analyzed via S-R binding effects. Recent theorizin...

Our everyday activities require the maintenance and continuous updating of information in working memory (WM). To control this dynamic, WM gating mechanisms have been suggested to be in place, but the neurophysiological mechanisms behind these processes are far from being understood. This is especially the case when it comes to the role of oscillat...

In stimulant use and addiction, conflict control processes are crucial for regulating substance use and sustaining abstinence, which can be particularly challenging in social-affective situations. Users of methamphetamine (METH, “Ice”) and 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) both experience impulse control deficits, but display diff...

In recent years, there has been many efforts to establish a comprehensive theoretical framework explaining the working mechanisms involved in perception-action integration. This framework stresses the importance of the immediate past on mechanisms supporting perception-action integration. The present study investigates the neurophysiological princi...

Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by motor and vocal tics. GTS is associated with enhanced processing of stimulus-response (S-R) associations, including a higher propensity to learn probabilistic S-R contingencies (i.e., statistical learning), the nature of which is still elusive. In this study, we...

The literature on action control is rife with differences in terminology. This consensus statement contributes shared definitions for perception-action inte- gration concepts as informed by the framework of event coding.

At present, clinical practice and research in movement disorders focus on the “normalization” of altered movements. In this review, rather than concentrating on problems and burdens people with MDs undoubtedly have, we highlight their hidden potentials. Starting with current definitions of Parkinson’s disease, dystonia, chorea, and tics, we outline...

Background The catecholaminergic system influences response inhibition, but the magnitude of the impact of catecholaminergic manipulation is heterogeneous. Theoretical considerations suggest that the voluntary modulability of theta band activity can explain this variance. The study aimed to investigate to what extent interindividual differences in...

According to action control theories, responding to a stimulus leads to the binding of response and stimulus features into a common representation, that is, an event file. Repeating any component of an event file retrieves all previously bound information, leading to performance costs for partial repetitions measured in so-called binding effects. A...

Individuals organize the evolving stream of events in their environment by partitioning it into discrete units. Event segmentation theory (EST) provides a cognitive explanation for the process of this partitioning. Critically, the underlying time-resolved neural mechanisms are not understood, and thus a central conceptual aspect of how humans imple...

Fatigue is one of the most disabling symptoms of Multiple Sclerosis (MS), affecting more than 80% of patients over the disease course. Nevertheless, it has a multi-faceted and complex nature, making its diagnosis, evaluation, and treatment extremely challenging in clinical practice. In the last years, digital supporting tools have emerged to suppor...

Fatigue is one of the most disabling symptoms of Multiple Sclerosis (MS), affectingmore than 80% of patients over the disease course. Nevertheless, it has a multi-faceted and complex nature, making its diagnosis, evaluation, and treatmentextremely challenging in clinical practice. In the last years, digital supporting toolshave emerged to support t...

Opioid use disorder (OUD) is a critical problem in China and is accompanied by depression and deficits in cognitive control. In China, the most successful intervention for OUD is the community drug rehabilitation where methadone maintenance treatment (MMT) plays a key role. Even though methadone for the treatment of OUD can be helpful, it can cause...

Response inhibition is an important instance of cognitive control and can be complicated by perceptual conflict. The neurophysiological mechanisms underlying these processes are still not understood. Especially the relationship between neural processes directly preceding cognitive control (proactive control) and processes underlying cognitive contr...

Neurofilaments (NFs) are not only important for axonal integrity and nerve conduction in large myelinated axons but they are also thought to be crucial for receptor and synaptic functioning. Therefore, NFs may play a critical role in cognitive functions, as cognitive processes are known to depend on synaptic integrity and are modulated by dopaminer...

Evidence is accumulating that the Coronavirus disease (COVID-19) can bring forth deficits in executive functioning via alterations in the dopaminergic system. Importantly, dopaminergic pathways have been shown to modulate how actions and perceptions are integrated within the brain. Such alterations in event file binding could thus underlie the cogn...

Behavioral flexibility and goal-directed behavior heavily depend on fronto-striatal networks. Within these circuits, gamma-aminobutyric acid (GABA) and glutamate play an important role for (motor) response inhibition, but it has remained largely unclear whether they are also relevant for cognitive inhibition. We hence investigated the functional ro...

The chronic intake of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") bears a strong risk for sustained declarative memory impairments. Although such memory deficits have been repeatedly reported, their neurofunctional origin remains elusive. Therefore, we here investigate the neuronal basis of altered declarative memory in recurrent MDMA users...

Reward and cognitive control play crucial roles in shaping goal-directed behavior. Yet, the behavioral and neural underpinnings of interactive effects of both processes in driving our actions towards a particular goal have remained rather unclear. Given the importance of inhibitory control, we investigated the effect of reward prospect on the modul...

Objective In attention deficit/hyperactivity disorder (ADHD), impaired response inhibition is frequently observed. A promising non-pharmacological treatment is electroencephalography (EEG)-neurofeedback (NF) training. However, the widely used theta-down/beta-up regulation (↓θ↑β) NF protocol may not be optimal for targeting these deficits. We examin...

The binding of stimuli and responses is an important mechanism in action control. Features of stimuli and responses are integrated into event files. A re-encounter with one or more of the stored features leads to automatic retrieval of the previous event file including the previously integrated response. The distractor-response binding effect evide...

European clinical guidelines recommend the use of Exposure and Response Prevention (ERP) and Comprehensive Behavioral Intervention for Tics (CBIT) as first-line treatment for tic disorders. Although ongoing efforts in research are being made to understand the mechanisms underlying these behavioral approaches, as yet the neurophysiological mechanism...

Background: 3,4-Methylenedioxymethamphetamine (MDMA) is a widely used recreational substance inducing acute release of serotonin. Previous studies in chronic MDMA users demonstrated selective adaptations in the serotonin system, which were assumed to be associated with cognitive deficits. However, serotonin functions are strongly entangled with gl...

Monitoring actions is essential for goal-directed behaviour. However, as opposed to short-lasting, and regularly reinstating monitoring functions, the neural processes underlying continuous action monitoring are poorly understood. We investigate this using a pursuit-tracking paradigm. We show that beta band activity likely maintains the sensorimoto...

Sensorimotor integration processes play a central role in daily life and require that different sources of sensory information become integrated. That is, the information related to the object being under control of the agent (i.e., indicator), and the information about the goal of acting. Yet, how this is accomplished on a neurophysiological level...

Background: Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor processes, essential for the control of goal-directed behavior, is altered in patients with FMD is less clear. A detailed investigati...

Goal-directed behavior requires integrated mental representations of perceptions and actions. The neurophysiological underpinnings of these processes, however, are not yet understood. It is particularly undetermined, which oscillatory activities in which brain regions are involved in the management of perception-action representations. We examine t...

Data privacy is typically particularly difficult to achieve in medical applications of machine learning, despite its importance in this area. The datasets are often small, which is why machine learning models such as neural networks tend to memorize information about the training data. This allows confidential and sensitive information about patien...

Everyday tasks and goal-directed behavior involve the maintenance and continuous updating of information in working memory (WM). WM gating reflects switches between these two core states. Neurobiological considerations suggest that the catecholaminergic and the GABAergic are likely involved in these dynamics. Both of these neurotransmitter systems...

Background Video based tic detection and scoring is useful to independently and objectively assess tic frequency and severity in patients with Tourette syndrome. In trained raters, inter-rater reliability is good. However, video ratings are time-consuming and cumbersome, particularly in large-scale studies. Therefore, we developed two machine learn...

Inhibitory control processes are an important aspect of executive functions and goal-directed behavior. However, the mostly correlative nature of neurophysiological studies was not able to provide insights which aspects of neural dynamics can best predict whether an individual is confronted with a situation requiring the inhibition of a response. T...

It seems natural that motor responses unfold smoothly and that we are able to easily concatenate different components of movements to achieve goal-directed actions. Theoretical frameworks suggest that different motor features have to be bound to each other to achieve a coherent action. Yet, the nature of the “glue” (i.e., bindings) between elements...

Adaptive behaviour requires interaction between neurocognitive systems. Yet, the possibility of concurrent cognitive control and incidental sequence learning remains contentious. We designed an experimental procedure of cognitive conflict monitoring that follows a pre-defined sequence unknown to participants, in which either statistical or rule-bas...

(1) Background: 1-2% of children and adolescents are affected by Obsessive-Compulsive Disorder (OCD). The rigid, repetitive features of OCD and an assumed disability to inhibit recent mental representations are assumed to lead to a paradoxical advantage that the Backward Inhibition (BI) effect was recently found to be lower in adolescents with OCD...