Christian Beste

Christian Beste
Universitätsklinikum Carl Gustav Carus Dresden · Kognitive Neurophysiologie

Prof. Dr. rer. nat.

About

472
Publications
100,121
Reads
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9,491
Citations
Additional affiliations
April 2016 - December 2017
National Institute of Mental Healt, Klecany, Czech Republic
Position
  • Researcher
June 2014 - present
Technische Universität Dresden
Position
  • Professor (Associate)
October 2013 - present
Universitätsklinikum Dresden, Medical Faculty
Position
  • Professor (Full)

Publications

Publications (472)
Article
Numerous studies demonstrate that moment-to-moment neural variability is behaviorally relevant and beneficial for tasks and behaviors requiring cognitive flexibility. However, it remains unclear whether the positive effect of neural variability also holds for cognitive persistence. Moreover, different brain variability measures have been used in pr...
Article
The representation of incoming information, goals and the flexible processing of these are required for cognitive control. Efficient mechanisms are needed to decide when it is important that novel information enters working memory (WM) and when these WM 'gates' have to be closed. Compared to neural foundations of maintaining information in WM, cons...
Article
Full-text available
Premonitory urges preceding tics are a cardinal feature of Gilles de la Tourette syndrome (GTS), a developmental disorder usually starting during middle childhood. However, the temporal relation between urges and tics has only been investigated in adults. In 25 children and adolescents with GTS (8-18 years), we assess urge-tic associations, includi...
Article
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The conflict monitoring theory postulates that conflict detection is initiated in the anterior cingulate cortex (ACC), indexed by midfrontal theta oscillations in the electroencephalogram (EEG). Recent research suggested that distractor detection (in the Eriksen flanker task) can be initiated relatively early by attentional control processes in the...
Article
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3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a serotonin- and noradrenaline-releasing substance, currently among the most widely used illicit substances worldwide. In animal studies, repeated exposure to MDMA has been associated with dendritic but also axonal degeneration in the brain. However, translation of the axonal findings, specific...
Article
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An efficient integration of sensory and motor processes is crucial to goal-directed behavior. Despite this high relevance, and although cognitive theories provide clear conceptual frameworks, the neurobiological basis of these processes remains insufficiently understood. In a double-blind, randomized placebo-controlled pharmacological study, we exa...
Article
The functions of nonsuicidal self-injury (NSSI) consist of social and emotional aspects (Social influence, Sensation seeking, Internal and External emotion regulation). Previous studies have indicated that dysfunction in reward-related brain structures especially the striatum might drive this habitual behavior. However, no studies to date have inve...
Article
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The integration of perception and action has long been studied in psychological science using overarching cognitive frameworks. Despite these being very successful in explaining perception-action integration, little is known about its neurophysiological and especially the functional neuroanatomical foundations. It is unknown whether distinct brain...
Article
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Dopa-responsive dystonia (DRD) is caused by impaired dopamine biosynthesis due to a GTP-cyclohydrolase-1 (GCH1) deficiency, resulting in a combination of dystonia and parkinsonism. However, the effect of GCH1 mutations and levodopa treatment on motor control beyond simple movements, such as timing, action preparation and feedback processing, have n...
Article
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Importance: Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence. Objective: To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanis...
Article
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The diagnostic process of attention deficit hyperactivity disorder (ADHD) is complex and relies on criteria sensitive to subjective biases. This may cause significant delays in appropriate treatment initiation. An automated analysis relying on subjective and objective measures might not only simplify the diagnostic process and reduce the time to di...
Article
Even simple actions like opening a door require integration/binding and flexible re-activation of different motor elements. Yet, the neural mechanisms underlying the processing of such ‘embedded response plans’ are largely elusive, despite theoretical frameworks, such as the Theory of Event Coding, describing the involved cognitive processes. In a...
Article
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Goal-directed behavior often requires concatenating different actions to achieve a goal. The neural correlates of such multi-component behavior have extensively been investigated. However, it is still enigmatic whether it is possible to predict, using single-trial EEG data and on a single-subject level, that an individual is confronted with a situa...
Article
Goal-directed behavior often requires the inhibition of prepotent automatic responses. Response inhibition encompasses several top-down cognitive operations embedded in a neural network extending from fronto-cortical regions to subcortical nuclei. Yet, it has remained unclear whether the early allocation of cognitive resources also modulates respon...
Article
Actions can fail – even though this is well-known, little is known about what distinguishes neurophysiological processes preceding errors and correct actions. In this study, relying on the Theory of Event Coding, we test the assumption that only specific aspects of information coded in EEG activity are relevant for understanding processes leading t...
Article
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Alcohol use disorder (AUD) is a relapsing-remitting condition characterized by excessive and/or continued alcohol consumption despite harmful consequences. New adjuvant tools, such as non-invasive brain stimulation techniques, might be helpful additions to conventional treatment approaches or even provide an alternative option for patients who fail...
Article
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Standard clinical and psychiatric thinking follows a unipolar logic ranging from “normal” conditions that are characterized by optimal performance in everyday life to atypical conditions that deviate from “normality” in systematic ways. A similar logic has been used to describe cognitive control, assuming that optimal control abilities are characte...
Article
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The electroencephalogram (EEG) is one of the most widely used techniques in cognitive neuroscience. We present a protocol showing how to combine a temporal signal decomposition approach (RIDE, Residue iteration decomposition) with multivariate pattern analysis (MVPA) to obtain insights into the temporal stability of representations coded in distinc...
Article
Efficient response selection is essential to flexible, goal-directed behavior. Prominent theoretical frameworks such as the “Theory of Event Coding” (TEC) and “Binding and Retrieval in Action Control” (BRAC) have provided insights regarding the dynamics of perception-action integration processes. According to TEC and BRAC, encoded representations o...
Article
Inhibition of inappropriate behavior is relevant in many everyday situations. Nevertheless, the mechanisms that induce response inhibition based on sensory information and what influences these mechanisms are not entirely understood. We examined neurophysiological processes of perception-action integration in response inhibition and the impact of t...
Article
Obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) are multi-faceted neuropsychiatric conditions that in many aspects appear to be each other's antipodes. We suggest a dimensional approach, according to which these partially opposing disorders fall onto a continuum that reflects variability regarding alterations...
Article
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The neurophysiological processes underlying the inhibition of impulsive responses have been studied extensively. While also the role of theta oscillations during response inhibition is well examined, the relevance of resting-state theta activity for inhibitory control processes is largely unknown. We test the hypothesis that there are specific rela...
Article
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Standard accounts of mental health are based on a “deficit view” solely focusing on cognitive impairments associated with psychiatric conditions. Based on the principle of neural competition, we suggest an alternative. Rather than focusing on deficits, we should focus on the cognitive potential that selective dysfunctions might bring with them. Our...
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High-dose alcohol intoxication is commonly associated with impaired inhibition, but the boundary conditions, as well as associated neurocognitive/neuroanatomical changes have remained rather unclear. This study was motivated by the counterintuitive finding that high-dose alcohol intoxication compromises response inhibition performance when working...
Article
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Goal-directed actions frequently require a balance between antagonistic processes (e.g., executing and inhibiting a response), often showing an interdependency concerning what constitutes goal-directed behavior. While an inter-dependency of antagonistic actions is well described at a behavioral level, a possible inter-dependency of underlying proce...
Article
The ability to inhibit responses is central for situational behavior. However, the mechanisms how sensory information is used to inform inhibitory control processes are incompletely understood. In the current study, we examined neurophysiological processes of perception-action integration in response inhibition using the Theory of Event Coding (TEC...
Article
Alcohol use disorder (AUD) is characterized by excessive habitual drinking and loss of control over alcohol intake despite negative consequences. Both of these aspects foster uncontrolled drinking and high relapse rates in AUD patients. Yet, common interventions mostly focus on the phenomenological level, and prioritize the reduction of craving and...
Article
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Background Pursuing goals is compromised when being confronted with interfering information. In such situations conflict monitoring is important. Theoretical considerations on the neurobiology of response selection and control suggest that auricular transcutaneous vagus nerve stimulation (atVNS) should modulate conflict monitoring. However, the neu...
Article
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Impairment of cognitive performance is often observed in time-on tasks. Theoretical considerations suggest that especially prefrontal cortex cognitive control functions is affected by time-on-task effects, but the role of effort/task engagement is not understood. We examine time-on-task effects in cognitive control on a neurophysiological level usi...
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Performance impairment as an effect of prolonged engagement in a specific task is commonly observed. Although this is a well-known effect in everyday life, little is known how this affects central cognitive functions such as working memory (WM) processes. In the current study we ask how time-on-task affects WM gating processes and thus processes re...
Chapter
There is growing evidence that besides the motor system alterations in the somatosensory system including sensorimotor and cognitive processing play an important role in the pathophysiology of Gilles de la Tourette syndrome. Therefore, a broader framework integrating motor, perceptual as well as cognitive components seems useful for a better explan...
Article
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The ability to inhibit a prepotent response is a crucial prerequisite of goal-directed behavior. So far, research on response inhibition has mainly examined these processes when there is little to no cognitive control during the decision to respond. We manipulated the ‘context’ in which response inhibition has to be exerted (i.e., a controlled or a...
Article
Inhibitory control has multiple facets, and one possible distinction can be made between ‘inhibition of interferences’ and the ‘inhibition of actions’. Both facets of inhibitory control show an interdependency. Even though some neurophysiological processes underlying this interdependency have been examined, the role of neuro-modulatory processes in...
Preprint
Full-text available
The diagnostic process of attention deficit hyperactivity disorder (ADHD) is complex and relies on criteria sensitive to subjective biases. This may cause significant delays in appropriate treatment initiation. An automated analysis relying on subjective and objective measures might not only simplify the diagnostic process and reduce the time to di...
Article
Full-text available
To achieve higher-level goals, cognitive flexibility is essential. Cognitive theories assume that the activation/deactivation of goals and task rules is central to understand cognitive flexibility. However, how this activation/deactivation dynamic is implemented on a neurophysiology level is unclear. Using EEG-based MVPA methods, we show that activ...
Article
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Efficient transfer of concepts and mechanistic insights from the cognitive to the health sciences and back require a clear, objective description of the problem that this transfer ought to solve. Unfortunately, however, the actual descriptions are commonly penetrated with, and sometimes even motivated by cultural norms and preferences, which has co...
Article
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Tics in Tourette syndrome are often difficult to discern from single spontaneous movements or vocalizations in healthy people. In the present study, videos of patients with Tourette syndrome and healthy controls were taken and independently scored according to the Modified Rush Videotape Rating Scale. We included n=101 patients with Tourette syndro...
Article
Cognitive control and working memory (WM) processes are essential for goal-directed behaviour. Cognitive control and WM are probably based on overlapping neurophysiological mechanisms. For example, theta-band activity (TBA) plays an important role in both functions. For cognitive control processes, it is known that different aspects of information...
Article
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Multi-component behavior is a form of goal-directed behavior that depends on the ability to execute various responses in a precise temporal order. Even though this function is vital for any species, little is known about how non-mammalian species accomplish such behavior and what the underlying neural mechanisms are. We show that humans and a non-m...
Article
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Tourette syndrome is a common neurodevelopmental disorder defined by multiple motor and phonic tics. Tics in Tourette syndrome resemble spontaneously occurring movements in healthy controls and are therefore sometimes difficult to distinguish from these. Tics may in fact be mis-interpreted as a meaningful action, i.e. a signal with social content,...
Article
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Background Currently, there is a marked increase of young people with sudden onset of tic-like behaviors resembling movements and vocalizations presented on social media videos as “Tourette syndrome”. Objectives To delineate clinical phenomenology of tic-like behaviors following social media exposure in comparison to clinical features of Tourette...
Article
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There has been a fascination for centuries surrounding drivers of human behavior and the relationship between the ‘mind’ and the brain. However, there is an ongoing disconnection between different research communities aiming to provide a mechanistic understanding about what underlies behavior, psychology and neuroscience. This comment outlines why...
Article
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Restless legs syndrome (RLS) is a common neurological disorder characterized by a sensorimotor condition, where patients feel an uncontrollable urge to move the lower limbs in the evening and/or during the night. RLS does not only have a profound impact on quality of life due to the disturbed night-time sleep, but there is growing evidence that unt...
Article
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The investigation of action control processes is one major field in cognitive neuroscience, and several theoretical frameworks have been proposed. One established framework is the “Theory of Event Coding” (TEC). However, only rarely, this framework has been used in the context of response inhibition and how stimulus-response association or binding...
Article
Full-text available
It is a common phenomenon that somatosensory sensations can trigger actions to alleviate experienced tension. Such “urges” are particularly relevant in patients with Gilles de la Tourette (GTS) syndrome since they often precede tics, the cardinal feature of this common neurodevelopmental disorder. Altered sensorimotor integration processes in GTS a...
Article
Full-text available
Cognitive flexibility is an essential prerequisite for goal-directed behavior and daily observations already show that it deteriorates when one is engaged in a task for (too) long time. Yet, the neural mechanisms underlying such fatigability effect in cognitive flexibility are poorly understood. We examined how theta, alpha and beta frequency event...
Article
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Gilles de la Tourette syndrome (GTS) can be characterized by enhanced cognitive functions related to creating, modifying and maintaining connections between stimuli and responses (S-R links). Specifically, two areas, procedural sequence learning and, as a novel finding, also event file binding show converging evidence of hyperfunctioning in GTS. In...
Article
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Humans differ in their capacity for integrating perceived events and related actions. The “Theory of event coding” (TEC) conceptualizes how stimuli and actions are cognitively bound into a common functional representation (or “code”), known as the “event file”. To date, however, the neural processes underlying the development of event file coding m...
Article
Full-text available
Premonitory urges are a cardinal feature in Tourette syndrome (GTS) and are commonly viewed as a driving force of tics. However, inter-individual differences in experimentally measured urges, tics and urge-tic associations, as well as possible relations to clinical characteristics and abnormal perception-action processing recently demonstrated in t...
Article
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Behavioral automatization usually makes us more efficient and less error-prone, but may also foster dysfunctional behavior like alcohol abuse. Yet, it has remained unclear whether alcohol itself causes the shift from controlled to habitual behavior commonly observed in alcohol use disorder (AUD). We thus investigated how the acute and post-acute ef...
Article
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Depression is the leading cause of disability worldwide, making antidepressant drugs the most used psychiatric drugs in the USA. Withdrawal effects and rebound symptoms frequently occur after reduction and/or discontinuation of these drugs. Although these phenomena have been investigated with respect to the clinical symptomatology, no studies have...
Article
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Die Schädigung der Myelinscheiden und der Axone bei der Multiplen Sklerose führt zu heterogenen neurologischen Defiziten. Die Krankheit kann durch eine individuell optimierte Therapie gebremst werden, muss dazu aber zunächst messbar gemacht werden. Zur Krankheitserfassung im klinischen Alltag gibt es verschiedene Ansätze, die in einer Serie von 14...
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This study aimed to provide a currently missing link between general intoxication-induced changes in overall brain activity and the multiple cognitive control deficits typically observed during acute alcohol intoxication. For that purpose, we analyzed the effects of acute alcohol intoxication (1.1‰) on the four archetypal electroencephalography (EE...
Article
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Patients with attention deficit/(hyperactivity) disorder (AD(H)D) show increased intra-individual variability (IIV) in behavioral performance. This likely reflects dopaminergic deficiencies. However, the precise performance profile across time and the pattern of fluctuations within it have not yet been considered, partly due to insufficient methods...
Article
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Objectives: Goal-direct actions requires and integrating processing of stimuli and responses, which is why close stimulus-response bindings have to be created. However, the strength of these bindings can be modified. The metacontrol state model (MSM) hypothesizes that this can be achieved through mindfulness meditation. Yet, the cognitive processes...
Article
Full-text available
Conflict monitoring processes are central for cognitive control. Neurophysiological correlates of conflict monitoring (i.e. the N2 ERP) likely represent a mixture of different cognitive processes. Based on theoretical considerations we hypothesized that effects of anodal tDCS (atDCS) in superior frontal areas affect specific subprocesses in neuroph...