Christian Beste

Christian Beste
Universitätsklinikum Carl Gustav Carus Dresden · Kognitive Neurophysiologie

Prof. Dr. rer. nat.

About

519
Publications
110,913
Reads
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11,251
Citations
Citations since 2017
310 Research Items
8363 Citations
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201720182019202020212022202305001,0001,500
Additional affiliations
April 2016 - December 2017
National Institute of Mental Healt, Klecany, Czech Republic
Position
  • Researcher
June 2014 - present
Technische Universität Dresden
Position
  • Professor (Associate)
October 2013 - present
Universitätsklinikum Dresden, Medical Faculty
Position
  • Professor (Full)

Publications

Publications (519)
Article
Opioid use disorder (OUD) is a critical problem in China and is accompanied by depression and deficits in cognitive control. In China, the most successful intervention for OUD is the community drug rehabilitation where methadone maintenance treatment (MMT) plays a key role. Even though methadone for the treatment of OUD can be helpful, it can cause...
Article
According to action control theories, responding to a stimulus leads to the binding of response and stimulus features into a common representation, that is, an event file. Repeating any component of an event file retrieves all previously bound information, leading to performance costs for partial repetitions measured in so-called binding effects. A...
Article
Full-text available
Response inhibition is an important instance of cognitive control and can be complicated by perceptual conflict. The neurophysiological mechanisms underlying these processes are still not understood. Especially the relationship between neural processes directly preceding cognitive control (proactive control) and processes underlying cognitive contr...
Article
Neurofilaments (NFs) are not only important for axonal integrity and nerve conduction in large myelinated axons but they are also thought to be crucial for receptor and synaptic functioning. Therefore, NFs may play a critical role in cognitive functions, as cognitive processes are known to depend on synaptic integrity and are modulated by dopaminer...
Article
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Evidence is accumulating that the Coronavirus disease (COVID-19) can bring forth deficits in executive functioning via alterations in the dopaminergic system. Importantly, dopaminergic pathways have been shown to modulate how actions and perceptions are integrated within the brain. Such alterations in event file binding could thus underlie the cogn...
Article
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Behavioral flexibility and goal-directed behavior heavily depend on fronto-striatal networks. Within these circuits, gamma-aminobutyric acid (GABA) and glutamate play an important role for (motor) response inhibition, but it has remained largely unclear whether they are also relevant for cognitive inhibition. We hence investigated the functional ro...
Article
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The chronic intake of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") bears a strong risk for sustained declarative memory impairments. Although such memory deficits have been repeatedly reported, their neurofunctional origin remains elusive. Therefore, we here investigate the neuronal basis of altered declarative memory in recurrent MDMA users...
Article
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Reward and cognitive control play crucial roles in shaping goal-directed behavior. Yet, the behavioral and neural underpinnings of interactive effects of both processes in driving our actions towards a particular goal have remained rather unclear. Given the importance of inhibitory control, we investigated the effect of reward prospect on the modul...
Article
Objective In attention deficit/hyperactivity disorder (ADHD), impaired response inhibition is frequently observed. A promising non-pharmacological treatment is electroencephalography (EEG)-neurofeedback (NF) training. However, the widely used theta-down/beta-up regulation (↓θ↑β) NF protocol may not be optimal for targeting these deficits. We examin...
Article
The binding of stimuli and responses is an important mechanism in action control. Features of stimuli and responses are integrated into event files. A re-encounter with one or more of the stored features leads to automatic retrieval of the previous event file including the previously integrated response. The distractor-response binding effect evide...
Article
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Background: 3,4-Methylenedioxymethamphetamine (MDMA) is a widely used recreational substance inducing acute release of serotonin. Previous studies in chronic MDMA users demonstrated selective adaptations in the serotonin system, which were assumed to be associated with cognitive deficits. However, serotonin functions are strongly entangled with gl...
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European clinical guidelines recommend the use of Exposure and Response Prevention (ERP) and Comprehensive Behavioral Intervention for Tics (CBIT) as first-line treatment for tic disorders. Although ongoing efforts in research are being made to understand the mechanisms underlying these behavioral approaches, as yet the neurophysiological mechanism...
Article
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Monitoring actions is essential for goal-directed behaviour. However, as opposed to short-lasting, and regularly reinstating monitoring functions, the neural processes underlying continuous action monitoring are poorly understood. We investigate this using a pursuit-tracking paradigm. We show that beta band activity likely maintains the sensorimoto...
Article
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Sensorimotor integration processes play a central role in daily life and require that different sources of sensory information become integrated. That is, the information related to the object being under control of the agent (i.e., indicator), and the information about the goal of acting. Yet, how this is accomplished on a neurophysiological level...
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Background: Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor processes, essential for the control of goal-directed behavior, is altered in patients with FMD is less clear. A detailed investigati...
Article
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Goal-directed behavior requires integrated mental representations of perceptions and actions. The neurophysiological underpinnings of these processes, however, are not yet understood. It is particularly undetermined, which oscillatory activities in which brain regions are involved in the management of perception-action representations. We examine t...
Conference Paper
Data privacy is typically particularly difficult to achieve in medical applications of machine learning, despite its importance in this area. The datasets are often small, which is why machine learning models such as neural networks tend to memorize information about the training data. This allows confidential and sensitive information about patien...
Article
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Everyday tasks and goal-directed behavior involve the maintenance and continuous updating of information in working memory (WM). WM gating reflects switches between these two core states. Neurobiological considerations suggest that the catecholaminergic and the GABAergic are likely involved in these dynamics. Both of these neurotransmitter systems...
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Background Video based tic detection and scoring is useful to independently and objectively assess tic frequency and severity in patients with Tourette syndrome. In trained raters, inter-rater reliability is good. However, video ratings are time-consuming and cumbersome, particularly in large-scale studies. Therefore, we developed two machine learn...
Article
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Inhibitory control processes are an important aspect of executive functions and goal-directed behavior. However, the mostly correlative nature of neurophysiological studies was not able to provide insights which aspects of neural dynamics can best predict whether an individual is confronted with a situation requiring the inhibition of a response. T...
Article
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It seems natural that motor responses unfold smoothly and that we are able to easily concatenate different components of movements to achieve goal-directed actions. Theoretical frameworks suggest that different motor features have to be bound to each other to achieve a coherent action. Yet, the nature of the “glue” (i.e., bindings) between elements...
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Adaptive behaviour requires interaction between neurocognitive systems. Yet, the possibility of concurrent cognitive control and incidental sequence learning remains contentious. We designed an experimental procedure of cognitive conflict monitoring that follows a pre-defined sequence unknown to participants, in which either statistical or rule-bas...
Article
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(1) Background: 1-2% of children and adolescents are affected by Obsessive-Compulsive Disorder (OCD). The rigid, repetitive features of OCD and an assumed disability to inhibit recent mental representations are assumed to lead to a paradoxical advantage that the Backward Inhibition (BI) effect was recently found to be lower in adolescents with OCD...
Article
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Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stim-ulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigat-ed the immediate effects of single-session 1Hz rTMS and sham...
Article
In substance use and addiction, inhibitory control is key to ignoring triggers, withstanding craving and maintaining abstinence. In amphetamine-type stimulant (ATS) users, most research focused on behavioral inhibition, but largely neglected the equally important subdomain of cognitive interference control. Given its crucial role in managing consum...
Article
Higher-level cognitive functions are mediated via complex oscillatory activity patterns and its analysis is dominating cognitive neuroscience research. However, besides oscillatory (period) activity, also aperiodic activity constitutes neural dynamics, but its relevance for higher-level cognitive functions is only beginning to be understood. The pr...
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Background The common club drug 3,4-methylendioxymethamphetamine (MDMA, “Ecstasy”) enhances mood, sensory perception, energy, sociability, and euphoria. While MDMA has been shown to produce neurotoxicity in animal models, research on its potential neurotoxic effects in humans is inconclusive and has focused primarily on the serotonin system. Metho...
Article
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Probabilistic sequence learning supports the development of skills and enables predictive processing. It remains contentious whether visuomotor sequence learning is driven by the representation of the visual sequence (perceptual coding) or by the representation of the response sequence (motor coding). Neurotypical adults performed a visuomotor sequ...
Article
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Long COVID, the postviral disorder caused by SARS-CoV-2 is expected to become one of the leading causes of disability in Europe. The cognitive consequences of long COVID have been described as “brain fog” and characterized by anxiety and depression, and by cognitive deficits. Long COVID is assumed to be a complex condition arising from multiple cau...
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Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder. Since motor signs are the defining feature of GTS, addressing the neurophysiology of motor processes is central for the understanding of GTS. The integration of voluntary motor processes is subject to so-called “binding problems”, i.e. how different aspects of an action are integr...
Article
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Information processing in the brain is governed by oscillatory activity. Activity oscillations in specific frequency bands (theta, alpha, beta and gamma) have been associated with various cognitive functions. A drawback of this is that the plethora of findings led to considerable uncertainty as to the functional relevance of activity in different f...
Article
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In addition to the core symptoms defining ADHD, affected children often experience motor problems; in particular, graphomotor movements including handwriting are affected. However, in clinical settings, there is little emphasis on standardized and objective diagnosing and treatment of those difficulties. The present study investigated for the first...
Article
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High dose alcohol intoxication reduces cognitive control, including inhibition. Although inhibition deficits may contribute to the behavioral deficits commonly observed in alcohol use disorders (AUD), many questions about potentially modulating factors have remained unanswered. We examined the effects of experimentally induced high-dose alcohol int...
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In daily life, sensorimotor integration processes are fundamental for many cognitive operations. The pursuit tracking paradigm is an ecological and valid paradigm to examine sensorimotor integration processes in a more complex environment than many established tasks that assess simple motor responses. However, the analysis of pursuit tracking perfo...
Article
Cognitive flexibility is an essential facet of everyday life, for example, when switching between different tasks. Neurophysiological accounts on cognitive flexibility have often focused on the task switch itself, disregarding preceding processes and the possible impact of ‘brain states’ prior to engaging in cognitive flexibility. In a combined wor...
Article
Inhibitory control plays an indispensable role in cognitive flexibility. Nevertheless, the neurophysiological principles underlying this are incompletely understood. This owes to the fact that the representational dynamics, as coded in oscillatory neural activity of different frequency bands has not been considered until now – despite being of conc...
Article
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Response inhibition and the ability to navigate distracting information are both integral parts of cognitive control and imperative to adaptive behavior in everyday life. Thus far, research has only inconclusively been able to draw inferences regarding the association between response stopping and the effects of interfering information. Using a nov...
Article
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There is growing consensus that stimulus-response bindings (event-files) play a central role in human action control. Here, we investigated how the integration and the retrieval of event-files are affected by the predictability of stimulus components of event-files. We used the distractor-response binding paradigm, in which nominally task-irrelevan...
Article
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The occurrence of motor/vocal tics, i.e. “extra‐movements” and/or “extra‐vocalizations”, is the leading diagnostic criterion for tic disorders. We show that extra‐movements are common also in healthy controls, so that a surplus of movements per se is not indicative of the presence of a tic disorder. This questions the usefulness of DSM‐5 criteria f...
Article
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When facing particular combinations of stimuli and responses, people create temporary event-files integrating the corresponding stimulus and response features. Subsequent repetition of one or more of these features retrieves the entire event-file, which impairs performance if not all features are repeated (partial-repetition costs). In the literatu...
Article
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Cognitive neuroscience comes in many facets, and a particularly large branch of research is conducted in individuals with mental health problems. This article outlines why it is important that cognitive neuroscientists re-shape their role in mental health research and re-define directions of research for the next decades. At present, cognitive neur...
Article
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Neurofeedback (NF) is an important treatment for attention deficit/hyperactivity disorder (ADHD). In ADHD, cognitive control deficits pose considerable problems to patients. However, NF protocols are not yet optimized to enhance cognitive control alongside with clinical symptoms, partly because they are not driven by basic cognitive neuroscience. I...
Article
Full-text available
The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic versus controlled processing during response inhibition in participants with mild to moderate AUD...
Article
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Numerous studies demonstrate that moment-to-moment neural variability is behaviorally relevant and beneficial for tasks and behaviors requiring cognitive flexibility. However, it remains unclear whether the positive effect of neural variability also holds for cognitive persistence. Moreover, different brain variability measures have been used in pr...
Article
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Inhibitory control processes have intensively been studied in cognitive science for the past decades. Even though the neural dynamics underlying these processes are increasingly better understood, a critical open question is how the representational dynamics of the inhibitory control processes are modulated when engaging in response inhibition in a...
Article
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The representation of incoming information, goals and the flexible processing of these are required for cognitive control. Efficient mechanisms are needed to decide when it is important that novel information enters working memory (WM) and when these WM 'gates' have to be closed. Compared to neural foundations of maintaining information in WM, cons...
Preprint
The conflict monitoring theory postulates that conflict detection is initiated in the anterior cingulate cortex (ACC), indexed by midfrontal theta oscillations in the electroencephalogram (EEG). Recent research suggested that distractor detection (in the Eriksen flanker task) can be initiated relatively early by attentional control processes in the...
Article
Full-text available
Premonitory urges preceding tics are a cardinal feature of Gilles de la Tourette syndrome (GTS), a developmental disorder usually starting during middle childhood. However, the temporal relation between urges and tics has only been investigated in adults. In 25 children and adolescents with GTS (8-18 years), we assess urge-tic associations, includi...
Article
Full-text available
The conflict monitoring theory postulates that conflict detection is initiated in the anterior cingulate cortex (ACC), indexed by midfrontal theta oscillations in the electroencephalogram (EEG). Recent research suggested that distractor detection (in the Eriksen flanker task) can be initiated relatively early by attentional control processes in the...
Article
Full-text available
3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a serotonin- and noradrenaline-releasing substance, currently among the most widely used illicit substances worldwide. In animal studies, repeated exposure to MDMA has been associated with dendritic but also axonal degeneration in the brain. However, translation of the axonal findings, specific...
Article
Full-text available
An efficient integration of sensory and motor processes is crucial to goal-directed behavior. Despite this high relevance, and although cognitive theories provide clear conceptual frameworks, the neurobiological basis of these processes remains insufficiently understood. In a double-blind, randomized placebo-controlled pharmacological study, we exa...
Article
The functions of nonsuicidal self-injury (NSSI) consist of social and emotional aspects (Social influence, Sensation seeking, Internal and External emotion regulation). Previous studies have indicated that dysfunction in reward-related brain structures especially the striatum might drive this habitual behavior. However, no studies to date have inve...
Article
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The integration of perception and action has long been studied in psychological science using overarching cognitive frameworks. Despite these being very successful in explaining perception-action integration, little is known about its neurophysiological and especially the functional neuroanatomical foundations. It is unknown whether distinct brain...
Article
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Dopa-responsive dystonia (DRD) is caused by impaired dopamine biosynthesis due to a GTP-cyclohydrolase-1 (GCH1) deficiency, resulting in a combination of dystonia and parkinsonism. However, the effect of GCH1 mutations and levodopa treatment on motor control beyond simple movements, such as timing, action preparation and feedback processing, have n...
Article
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Importance: Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence. Objective: To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanis...
Article
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The diagnostic process of attention deficit hyperactivity disorder (ADHD) is complex and relies on criteria sensitive to subjective biases. This may cause significant delays in appropriate treatment initiation. An automated analysis relying on subjective and objective measures might not only simplify the diagnostic process and reduce the time to di...
Article
Even simple actions like opening a door require integration/binding and flexible re-activation of different motor elements. Yet, the neural mechanisms underlying the processing of such ‘embedded response plans’ are largely elusive, despite theoretical frameworks, such as the Theory of Event Coding, describing the involved cognitive processes. In a...
Article
Full-text available
Goal-directed behavior often requires concatenating different actions to achieve a goal. The neural correlates of such multi-component behavior have extensively been investigated. However, it is still enigmatic whether it is possible to predict, using single-trial EEG data and on a single-subject level, that an individual is confronted with a situa...
Article
Goal-directed behavior often requires the inhibition of prepotent automatic responses. Response inhibition encompasses several top-down cognitive operations embedded in a neural network extending from fronto-cortical regions to subcortical nuclei. Yet, it has remained unclear whether the early allocation of cognitive resources also modulates respon...
Article
Actions can fail – even though this is well-known, little is known about what distinguishes neurophysiological processes preceding errors and correct actions. In this study, relying on the Theory of Event Coding, we test the assumption that only specific aspects of information coded in EEG activity are relevant for understanding processes leading t...
Article
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Alcohol use disorder (AUD) is a relapsing-remitting condition characterized by excessive and/or continued alcohol consumption despite harmful consequences. New adjuvant tools, such as non-invasive brain stimulation techniques, might be helpful additions to conventional treatment approaches or even provide an alternative option for patients who fail...
Article
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Standard clinical and psychiatric thinking follows a unipolar logic ranging from “normal” conditions that are characterized by optimal performance in everyday life to atypical conditions that deviate from “normality” in systematic ways. A similar logic has been used to describe cognitive control, assuming that optimal control abilities are characte...
Article
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The electroencephalogram (EEG) is one of the most widely used techniques in cognitive neuroscience. We present a protocol showing how to combine a temporal signal decomposition approach (RIDE, Residue iteration decomposition) with multivariate pattern analysis (MVPA) to obtain insights into the temporal stability of representations coded in distinc...
Article
Efficient response selection is essential to flexible, goal-directed behavior. Prominent theoretical frameworks such as the “Theory of Event Coding” (TEC) and “Binding and Retrieval in Action Control” (BRAC) have provided insights regarding the dynamics of perception-action integration processes. According to TEC and BRAC, encoded representations o...
Article
Inhibition of inappropriate behavior is relevant in many everyday situations. Nevertheless, the mechanisms that induce response inhibition based on sensory information and what influences these mechanisms are not entirely understood. We examined neurophysiological processes of perception-action integration in response inhibition and the impact of t...
Article
Obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) are multi-faceted neuropsychiatric conditions that in many aspects appear to be each other's antipodes. We suggest a dimensional approach, according to which these partially opposing disorders fall onto a continuum that reflects variability regarding alterations...
Article
Full-text available
The neurophysiological processes underlying the inhibition of impulsive responses have been studied extensively. While also the role of theta oscillations during response inhibition is well examined, the relevance of resting-state theta activity for inhibitory control processes is largely unknown. We test the hypothesis that there are specific rela...
Article
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Standard accounts of mental health are based on a “deficit view” solely focusing on cognitive impairments associated with psychiatric conditions. Based on the principle of neural competition, we suggest an alternative. Rather than focusing on deficits, we should focus on the cognitive potential that selective dysfunctions might bring with them. Our...