Christelle Crampon

Christelle Crampon
Aix-Marseille Université | AMU · M2P2 UMR 7340

Doctor of Engineering

About

45
Publications
9,860
Reads
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1,156
Citations
Citations since 2017
20 Research Items
833 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (45)
Article
This study reports A. platensis capacity to capture and convert CO2 into biomass. The cyanobacterium was cultivated under controlled conditions with a 5 % v/v CO₂-enriched atmosphere at different photoperiods (light/dark): 12 h/12 h, 20 h/4 h, and 24 h (continuous light). The photoperiod influence on biomass growth and its effect on CO₂ uptake was...
Article
The capability of supercritical CO2 to extract edible oil from handmade Argan press cake was investigated. The aim is to enable Moroccan cooperatives to improve their economic situation by valuing the handmade argan press cake, which is nowadays considered as a waste, applying a clean extraction process. Extraction experiments were conducted at 300...
Article
The effects of process parameters: pressure (200 – 400 bar), temperature (313 – 333 K), and flow rate (0.11 – 0.27 kg/h) on the efficiency of extraction process of Argan oil by supercritical CO2 were investigated using response surface methodology and mathematical modelling (Sovová’s mathematical model). The fastest extraction kinetics correspondin...
Article
Hypothesis It is particularly noteworthy to study interfacial tension behavior under pressurized carbon dioxide for supercritical processes such as crystallization or fractionation. For the latter, a liquid phase and a supercritical phase are in contact, and interfacial properties influence mass transfer phenomena and hydrodynamics. Ethanol-water m...
Article
Experimental and modelling investigations of supercritical CO2 extraction of oil from Argania spinosa L. kernels were conducted at pressure range from 200 to 400 bar, temperature range of 313–333 K at a CO2 flow rate of 0.14 kg/h. Regardless of the pressure and the temperature, the highest achievable yield was estimated at 0.63 kgoil / kgbiomass. T...
Article
Supercritical fractionation is a unit operation which allows separation and purification of liquid mixtures and is of particular interest for low-volatility and thermosensitive mixtures. This process is an environmentally friendly alternative to conventional methods which use organic solvents or require rather high temperature, and it presents a gr...
Article
Supercritical CO2 extraction experiments were conducted to investigate the effects of pretreatment and process parameters on neutral lipids, chlorophylls and carotenoids recovery on two species of Nannochloropsis. For Nannochloropsis maritima, a factorial experimental design was performed (P: [100 - 300] bar, T: [313 - 333] K). The highest extracti...
Article
The aim of this study was to model experimental results obtained for the supercritical CO2 fractionation of a liquid mixture containing 24% of sclareol in order to recover a raffinate with increased sclareol content. First, supercritical CO2 fractionation experiments were carried out at pressures (10–12) MPa, and temperatures (313–338) K. Secondly,...
Article
Full-text available
β-carotene (BC) is one of the best known and used bioactive compounds with antioxidant activity. In this work coprecipitation of BC with polyvinylpyrrolidone (PVP) by Supercritical Assisted Atomization (SAA) has been studied, to enhance BC bioavailability and to provide its protection against oxidation. Two solvents have been used: ethanol and a mi...
Article
Supercritical carbon dioxide has been used to develop two methods for the impregnation of porous silica beads with a natural antioxidant, quercetin. These methods involved batch and semi-continuous supercritical impregnations. The first experiments performed in batch mode helped to understand the influence of pressure, temperature, duration, and the...
Article
Supercritical fluid (SCF) technology has been applied to drug product development over the last thirty years and drug particle generation using SCFs appears to be an efficient way to carry out drug formulation which will form end-products meeting targeted specifications. This article presents an overview of drug particle design using SCFs from a ra...
Article
Experimental and modelling investigations of supercritical CO2 extraction of oil from Jatropha curcas were conducted at a pressure range of 20-40MPa and a temperature range of 313-333K at a CO2 flow rate of 0.4kg/h. The extraction yield was estimated to be about 0.6kgoil/kgbiomass for all experiments. The model of broken and intact cells published...
Article
Full-text available
To evaluate the potential recovery rate of volatile terpenes from pulp mills, different extraction methods were performed on fir, spruce and maritime pine, and the extracts were analyzed by gas chromatography-flame ionization detector/mass spectroscopy (GC-FID/MS). The results obtained by traditional solvent extraction in the Soxhlet and the accele...
Article
Full-text available
Rifampicin-loaded submicron-sized particles were prepared through supercritical anti-solvent process using ethyl cellulose as polymeric encapsulating excipient. Ethyl acetate and a mixture of ethyl acetate/dimethyl sulfoxide (70/30 and 85/15) were used as solvents for both drug and polymeric excipient. When ethyl acetate was used, rifampicin was cr...
Article
The implementation and optimization of continuous supercritical CO2 fractionation of a clary sage extract containing 25 wt% of sclareol were performed in order to increase its sclareol content. After preliminary experiments confirming the feasibility of the process, different operating conditions were studied: CO2-over-feed mass ratio from 25 up to...
Article
Full-text available
This article deals with the extraction of neutral lipids and antioxidants from enriched Spirulina platensis microalgae using supercritical carbon dioxide (CO2), and more particularly with the influence of experimental conditions on extraction yields and kinetics at laboratory and pilot scales. Preliminary studies were carried out at laboratory scal...
Article
In this work, the supercritical fractionation of fatty acid ethyl esters derived from fish oil was carried out with carbon dioxide at 333 K and 14.5 MPa. The feed mixture is very complex, with over 80 different compounds detected by GC. Among them, the EicosaPentaenoic Acid (EPA) and DodecaHexaenoic Acid (DHA) ethyl esters are of major industrial i...
Article
This study investigates the effects due to the water content and to the drying pre-treatment on the extraction kinetics of solutes extracted from _Dunaliella salina_ microalgae by supercritical CO2. The extraction experiments were conducted at pressure range from 20 up to 40 MPa at a temperature of 333 K on crushed samples with water content varyin...
Article
The present study deals with the determination of optimal values of operating parameters such as temperature and pressure leading to the best yield of a supercritical CO2 extraction of essential oil from local rosemary plants, using the response surface methodology (RSM). The maximum of essential oil recovery percentage relative to the initial mass...
Article
The present article describes the production of oil from autotrophic microalgae grown in raceways in France, and presents the bench test results of a Diesel monocylinder engine with the derived biodiesel (methyl ester). The cultivation of Nannochloropsis has been performed under nitrogen limitation in order to increase the lipid content of the micr...
Article
The present work deals with the application of the supercritical fluid extraction process to extract essential oils from the leaves of an Algerian myrtle plant (Myrtus communis L.). Using the surface response methodology, an optimization of the extraction recovery was carried out, varying the pressure in the range of [10-30 MPa], the temperature wi...
Article
This work demonstrates that supercritical carbon dioxide extraction is efficient for the complete recovery of neutral lipids from microalgae with a water content up to 20 wt%, allowing thus a further full characterization of this oil. This is a first useful step in the framework of lipid production from microalgae either for nutraceutical, food or...
Article
The aim of this work is to show that the equations developed by Sovová, based on the concept of broken and intact cells for describing the supercritical extraction curves from plants and vegetables, can be applied for the modelling of the supercritical CO2 extraction curves obtained with microalgae. Experimental and modelling results of supercritic...
Article
A new process called Continuous Anti-Solvent (CAS) process was developed for the production of liposomes using supercritical CO2. Unlike the current dense gas technologies, CAS method is a single step and continuous process. Preliminary experiments were conducted in semi-batch mode to determine the most suitable operating conditions (stirring speed...
Article
The purpose of this paper is to guide lectors in the extraction of algal (microalgae and seaweeds) compounds using supercritical carbon dioxide (SC-CO2) from dry biomass. It proposes a review of 30 articles dealing with the SC-CO2 extraction of molecules of interest from microalgae and seaweeds. Among these papers, 20 are devoted to microalgae. The...
Article
Two methods to produce liposomes encapsulating a fluorescent marker were compared: the supercritical anti-solvent (SAS) method and a conventional one (Bangham). Liposome size and encapsulation efficiency were measured to assess the methods. Micronized lecithin produced by the SAS process was characterized in terms of particle size, morphology and r...
Article
The aim of this review is to explain the various phenomena involved in liposome formation using dense gas processes and especially supercritical CO2. Before liposome formation, the review focuses on the phase behavior of CO2/water/surfactant ternary systems. First of all, the two main cases of CO2/water/surfactant fluid phase behavior are studied:...
Article
In this work, a revision of a predictive model previously proposed by Coniglio for the calculation of pure component vapor pressures by means of the Peng–Robinson equation of state is presented. A new expression for the shape factor m, more suitable for heavy components, has been suggested by Trassy and a simplification of the group contributions i...
Article
Full-text available
The synthetic method was applied to measure the phase equilibrium of binary mixtures involving CO2 and the following alcohols: undecan-2-ol, undecan-6-ol, undec-10-en-1-ol, and 2-methylpentan-2,4-diol. Measurements were performed at three different temperatures: 313.15, 323.15, and 333.15K. The bubble points were measured at carbon dioxide mole fra...
Article
Full-text available
Very recently, Jaubert et al. proposed a purely predictive model for the phase equilibria computation of mixtures involving fatty acid esters (FAE) and supercritical carbon dioxide (SC−CO2). In this research note, the capability of the model to predict the isothermal phase diagrams of three binary systems recently measured by Crampon et al. is chec...
Article
Starting from a screw-type manual pump, a high-pressure variable-volume view cell was designed to perform static measurements of equilibria involving CO2 and fatty acid esters. Though the design of the cell allows both the upper and the lower phases to be sampled, the synthetic method was chosen for this study. The efficiencies of both the apparatu...

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