Chris Wohlgamuth

University of Texas at Dallas | UTD · Physics

Much remains to be understood about the kinetics and thermodynamics of DNA helicase binding and activity. Here, we utilize probe-modified DNA monolayers on multiplexed gold electrodes as a sensitive recognition element and morphologically responsive transducer of helicase-DNA interactions. The electrochemical signals from these devices are highly s...

Electrochemistry of self-assembled DNA monolayers represents an attractive strategy for understanding the intrinsic properties of DNA and for developing DNA-based sensors. Thus, there is much interest in the discovery and characterization of new redox-active probes for application in DNA-based technologies. Herein, we report a detailed study of the...

Functional nanowires and nanoelectronics are sought for their use in next generation integrated circuits, but several challenges limit the use of most nanoscale devices on large scales. DNA has great potential for use as a molecular wire due to high yield synthesis, near-unity purification, and nanoscale self-organization. Nonetheless, a thorough u...

Charge transfer through DNA is of interest both as the quintessential biomolecule of all living organisms and as a self-organizing element in bioelectronic circuits and sensing applications. Here we report the temperature-dependent properties of DNA charge transport in an electronically-relevant arrangement of DNA monolayers on gold under biologica...

The field of surface bound electrochemistry is important in a variety of applications specifically sensing. A fundamental understanding of the processes involved could help to improve detection limits, optimize rates of detection and direct changes in device design. Accurate extraction of electrochemical kinetic parameters such as the rate constant...

Charge transport (CT) through DNA has been extensively studied, and yet the mechanism of this process is still not yet fully understood. Besides the benefits of understanding charge transport through this fundamental molecule, further understanding of this process will elucidate the biological implications of DNA CT and advance sensing technology....

Achieving charge transport (CT) through DNA comlements its inherent biological recognition capabilities and its unmatched capacity to be patterned into precise, nanoscale shapes. We have probed the length and temperature dependence of DNA charge transport with DNA-mediated electrochemistry. Cyclic voltammetry of 100-mer and 17-mer DNA monolayers on...

Charge transport (CT) through DNA has been extensively studied, and yet the mechanism of this process is still not yet fully understood. DNA CT has been utilized in sensing proteins and DNA fragments, and it has been postulated that it may assist DNA damage prevention and repair. Besides the benefits of understanding charge transport through this f...