Chris Course

Chris Course
Cardiff University | CU · Department of Child Health

BSc MBBCh MRCPCH

About

23
Publications
585
Reads
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60
Citations
Introduction
Chris Course is a specialist registrar in neonatology currently practicing in South Wales, UK. He also works as a Clinical Research Fellow at the Department of Child Health, School of Medicine, Cardiff University, UK His areas of clinical and research interest concern the respiratory pathology of infants born both prematurely and at term, and it’s management, as well as the long-term respiratory consequences of premature birth.
Additional affiliations
March 2021 - present
Cardiff University
Position
  • Fellow
Description
  • I am currently working in two main projects: Undertaking 1 year and 2 year following up for infants enrolled in AZTEC Trial (azithromycin for chronic lung disease if prematurity) Ongoing analysis of data obtained from RHiNO Trial (Respiratory Outcomes in Neonates) focussing on cardiovascular outcomes and metabolomic/proteomic profiles.
August 2011 - April 2021
National Health Service
Position
  • Neonatal Grid Registrar
Education
September 2005 - June 2011
Cardiff University
Field of study
  • Medicine

Publications

Publications (23)
Article
Full-text available
Background Decreased lung function is common in preterm‐born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm‐born children and adults who did or did not have chronic lung...
Article
Full-text available
Respiratory Distress Syndrome (RDS) is the commonest diagnosis after premature birth. We aimed to audit clinical practices before and after introduction of a national guideline in Wales on RDS management. Anonymised, prospective data on all infants born at <34 weeks of gestation and cared for at one of the participating neonatal units in Wales were...
Article
Objective Wales has an immunoreactive trypsin (IRT)-DNA cystic fibrosis (CF) newborn screening (NBS) programme. Most CF NBS false negative cases are due to an IRT concentration below the screening threshold. The accuracy of IRT results is dependent on the quality of the dried bloodspot (DBS) sample. The aim of this study was to determine the cause...
Article
Full-text available
Volatile organic compounds (VOC) detected in human breath, urine, stool, sweat, saliva, and blood result from metabolic processes in the body during health or disease. Using sophisticated measurement systems, small amounts of these compounds can be detected in the above bodily fluids. Multiple studies in adults and children have shown the potential...
Article
Full-text available
Importance: Although preterm birth is associated with later deficits in lung function, there is a paucity of information on geographical differences and whether improvements occur over time, especially after surfactant was introduced. Objective: To determine deficits in percentage predicted forced expiratory volume in 1 second (%FEV1) in preterm...
Article
Full-text available
Background Preterm birth, especially at less than 30 weeks’ gestation, is significantly associated with respiratory, neurodevelopmental and growth abnormalities. The AZTEC study has recruited 799 infants born at < 30 weeks’ gestation to determine if a ten-day intravenous treatment with azithromycin improves survival without development of chronic l...
Preprint
Background: Preterm birth, especially at less than 30 weeks’ gestation, is significantly associated with respiratory, neurodevelopmental and growth abnormalities. The AZTEC study has recruited 799 infants born at <30 weeks’ gestation to determine if a ten-day intravenous treatment with azithromycin improves survival without development of chronic l...
Article
Cystic fibrosis (CF) is the most common life-limiting inherited condition in Caucasians. It is a multisystem autosomal recessive disorder caused by variants in the gene for cystic fibrosis transmembrane conductance regulator (CFTR) protein, a cell-surface localised chloride channel that regulates absorption and secretion of salt and water across ep...
Article
Research is vital to paediatrics; however, many trainees feel there is a deficit in their opportunities, experience and exposure in this area. Three training regions in the UK, the West Midlands, Wales and Peninsula, have recently started region-wide, trainee-led research and governance collaboratives aimed at improving trainee access and education...
Article
Newborn screening for cystic fibrosis (CF) has become a widely accepted and endorsed public health strategy in economically developed countries, although there is little consensus on optimal screening methods and gene panels. Increasing understanding of CFTR genetics and consequent unpredictability of phenotypic and clinical outcomes lead to diagno...
Article
Background: Timely diagnosis and management of neonatal hypoglycaemia is important due to associated short and long-term sequelae including neurodevelopmental delay. Hyperinsulinism should be distinguished from other causes of hypoglycaemia as management and acceptable glycaemic parameters may be different. Aims: To characterize admissions with hy...
Article
A 4-year-old girl attends with a 3-day history of cough, breathlessness and fever. She is started on antibiotics but fails to improve over the subsequent 48 hours. A chest X-ray and ultrasound of the thorax reveals a large, loculated pleural effusion amenable to drainage. In managing children with a large empyema (patient), does a pleural drain wi...
Conference Paper
Introduction Bruising is a common finding among children, arising from both accidental and non-accidental injury (NAI). Paediatricians are often asked for an opinion on causation, or to discern the difference between bruises and innocuous skin lesions. NICE guidance on ‘thresholds’ for suspecting child maltreatment exist, but there is only a limite...
Article
Context This is a trainee-led, multi-centre project incorporating all Paediatric and Neonatal units across Wales, aiming to improve trainee research and education experience; promote a collaborative to audit, research and quality improvement; and ultimately benefit paediatric and neonatal care across Wales. Problem Paediatric trainees in Wales have...
Article
Respiratory failure is the commonest morbidity of newborn infants, often necessitating support. While respiratory support of newborn infants is life-saving, it is strongly associated with long-term sequelae. Modes of support for newborn infants, especially preterm infants, have been evolving over the last four decades. Key developments have ensured...

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