Choon Fu GohUniversiti Sains Malaysia | USM · Discipline of Pharmaceutical Technology
Choon Fu Goh
Doctor of Philosophy
About
33
Publications
37,654
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264
Citations
Citations since 2017
Introduction
Choon Fu graduated with a B. Pharm. (First Class Honours) from Universiti Sains Malaysia (USM) in 2010 and completed his pre-registration training at Sibu Hospital, Sarawak (2011-2012). In 2012, he was offered the chance to study abroad for a PhD at the School of Pharmacy, University College London (UCL) under the academic training scheme by USM. Immediately after finishing his PhD, he was appointed as a lecturer in Pharmaceutical Technology in April 2016.
Personal site: https://gohchoonfu.wixsite.com/pharmaceutics
Additional affiliations
September 2012 - April 2016
Education
September 2012 - April 2016
Publications
Publications (33)
Atopic dermatitis (AD) is a complex, relapsing inflammatory skin disease with a considerable social and economic burden globally. AD is primarily characterized by its chronic pattern and it can have important modifications in the quality of life of the patients and caretakers. One of the fastest-growing topics in translational medicine today is the...
Nanotechnology has received a widespread application recently in the development of pharmaceutical, cosmeceutical and nutraceutical (PCN) products through utilizing nanomaterials in the formulation and/or shaping of the finished products at nanoscale. This study investigates factors influencing Malaysia consumer decisions in nano-based PCN products...
The advent of skin patch formulation design and technology has enabled the commercialisation of methyl salicylate (MS) as a topical patch. However, the most fundamental aspect of skin permeation is unknown at present. The study aims to investigate the effect of solvent choice on the skin permeation of MS in a neat solvent system and patch formulati...
Previously, we reported the use of Confocal Raman Spectroscopy (CRS) as a novel non-invasive approach to determine drug disposition in the skin in vivo. Results obtained by CRS were found to correlate with data from the well-established in vitro permeation test (IVPT) model using human epidermis. However, these studies used simple vehicles comprisi...
Hydrogels are an attractive platform for drug delivery to the skin. Current cellulose hydrogel developments commonly focus on readily available bleached woody cellulose. Considering the detrimental environmental impacts of bleaching reagents, unbleached non-woody biomass was proposed as an alternative. Herein, this study aims to develop hydrogel fr...
This book illustrates about COVID-19 and the situation in Malaysia. It uses picture illustrations and wording to educate the children about COVID-19.
Atopic dermatitis (AD) is a complex, relapsing inflammatory skin disease with a considerable social and economic burden globally. AD is primarily characterized by its chronic pattern and it can have important modifications in the quality of life of the patients and caretakers. One of the fastest-growing topics in translational medicine today is the...
Mitragynine is a promising candidate for pain relief and opiate replacement but the investigations for drug delivery are lacking. This study aims to investigate the potential of mitragynine to be delivered through the skin with an emphasis on developing and validating a gradient HPLC-UV analytical method to determine mitragynine in the samples coll...
The use of nanocrystalline cellulose (NCC) as a renewable and green biomaterial in diverse value-added applications has roused substantial interest. Sourcing NCCs from the abundantly available non-woody biomass becomes attractive due to its high cellulose content and low cost. Acid hydrolysis using mineral acids has been widely explored as a facile...
For effective topical and transdermal drug delivery, it is necessary for most actives to penetrate and permeate through the stratum corneum (SC). Extensive investigation of the thermal behaviour of mammalian SC has been performed to understand the barrier function of the skin. However, little attention has been paid to the related experimental vari...
The production of drug delivery systems fabricated at the nano scale comes with the challenges of identifying reliable characterisation tools, especially for solid dosage forms. A full understanding of physicochemical properties of solid-state systems at a high spatial resolution is essential to monitor their manufacturability, processability, perf...
The kapok (Ceibapentandra (L.) Gaertn) seed fibre is unicellular with length up to 35 mm, however, it is covered by a hydrophobic waxy layer that limits its application in paper production. In this study, the effect of various pulping methods namely mechanical, chemi-mechanical, semichemical and chemical pulping on kapok fibre properties was invest...
Buku Warna & Aktiviti COVID-19 merupakan hasil gabungan idea dan kreativiti beberapa orang ahli akademik yang cakna dengan masalah penyebaran penyakit COVID-19 yang telah atau sedang dihadapi oleh masyarakat di seluruh dunia. Di antara topik utama yang terkandung di dalam buku ini adalah pengenalan tentang penyakit COVID-19, cara-cara untuk membant...
Introduction:
At present, there is a lack of baseline data on the facial skin biophysical profile of women in Malaysia. The implications related to the daily habits and facial skincare product use on the skin biophysical condition are, thus, unknown. In this study, we aim to evaluate facial skin biophysical parameters of Malaysian women and examin...
Hydrogels are an attractive system for a myriad of applications. While most hydrogels are usually formed from synthetic materials, lignocellulosic biomass appears as a sustainable alternative for hydrogel development. The valorization of biomass, especially the non-woody biomass to meet the growing demand of the substitution of synthetics and to le...
Salicylates have a long history of use for pain relief. Salicylic acid and methyl salicylate are among the widely used topical salicylates namely for keratolytic and anti-inflammatory actions, respectively. The current review summarises both passive and active strategies, including emerging technologies employed to enhance skin permeation of these...
Drug crystallisation in the skin is recognised as a significant problem in topical and transdermal drug delivery. Our recent investigations provided new evidence of drug crystallisation in the skin, however, confirming the precise location of crystals remains challenging. Of note, most approaches used have required disruption of the membrane by tap...
Rice starch is a promising biomaterial for thin film development in buccal drug delivery, but the plasticisation and antiplasticisation phenomena from both plasticisers and drugs on the performance of rice starch films are not well understood. This study aims to elucidate the competing effects of sorbitol (plasticiser) and drug (antiplasticiser) on...
Polymer matrix composites (PMC) consist of different types of organic polymers which form the continuous phase with reinforced fibers as the dispersed phase. The continuous phase serves as the matrix to adhere the fibers together for the efficient transfer of load between them. The matrix serves as an important platform to distribute the fibers eve...
Chlorine dioxide plays a significant role in the industrial settings as disinfectants due to its broad antimicrobial property. Despite commonly use as germicide, chlorine dioxide demonstrates a good safety profile, rendering its suitability for use at water treatment and food preparation zones. Protein denaturation including envelope proteins is th...
Infection preventive practice of using disinfectants against SARS-CoV-2 has become the new normal due to the COVID-19 pandemic. Although disinfectants may not be applied directly to the human body, it remains at high risk of exposure including close skin contact on disinfected surfaces or during handling. This dermal contact, on a regular basis, ca...
Atovaquone (ATQ) is a poorly soluble drug. Therefore, formulating ATQ into its supersaturated state through solid dispersion for bioavailability enhancement can be of great value. However, due to fast crystallising properties of ATQ, the quantification of ATQ in a supersaturated solid dispersion system can be complicated. Therefore, in pursuit of a...
Background
Drug crystallization following application of transdermal and topical formulations may potentially compromise the delivery of drugs to the skin. This phenomenon was found to be limited to the superficial layers of the stratum corneum (~7 µm) in our recent reports and tape stripping of the skin samples was necessary. It remains a signific...
Hand sanitisers (also known as hand rub) and hand washing play important roles in fighting viral infections.
COVID-19 can be transmitted when someone touches a contaminated surface and then touches their mouth, nose or eyes, and contaminated hands can also transfer the virus to other surfaces.
The World Health Organization (WHO) recommends hand w...
Alcohol-based hand sanitisers can be made in the form of a gel, which allows the alcohol to remain in contact for the hands for longer while hand washing/hand rubbing.
This hand sanitiser gel is suitable for use by the public and can be prepared on a small scale at home or in a laboratory, using basic equipment. For the hand gel to be effective aga...
Rice starch is known to have an excellent film-forming behaviour in the packaging industry but inadequate attention was given to this biopolymer to be developed into thin films for drug delivery. Accordingly, rice starch thin films containing a model drug, paracetamol and plasticisers (glycerol or sorbitol) were developed using film casting techniq...
Background and purpose
The flipped classroom has not been fully exploited to improve tertiary education in Malaysia. A transformation in pharmacy education using flipped classrooms will be pivotal to resolve poor academic performance in certain courses. This study aimed to investigate the effectiveness of the flipped classroom in improving student...
Drug crystallization on and in the skin has been reported following application of topical or transdermal formulations. This study explored novel probe-based approaches including localized nano-thermal analysis (nano-TA) and photothermal microspectroscopy (PTMS) to investigate and locate drug crystals in the stratum corneum (SC) of porcine skin fol...
Nano-thermal analysis (nano-TA) is a localised thermal technique which maps a surface in terms of thermal transitions by combining atomic force microscopy with the use of thermal probes, allowing a spatial resolution of sub–100 nm. In this communication, we describe the application of a localised nano-TA approach, transition temperature microscopy...
Drug permeation through the intercellular lipids, which pack around and between corneocytes, may be enhanced by increasing the thermodynamic activity of the active in a formulation. However, this may also result in unwanted drug crystallisation on and in the skin. In this work, we explore the combination of ATR-FTIR spectroscopy and multivariate da...
The stratum corneum (SC) is the outermost skin layer and limits the penetration of most of drugs. Percutaneous absorption of drug is limited by not only the skin barrier itself, but also the thermodynamic of a formulation. For many formulations such as gels, creams and lotions, drug permeation usually slows down over time and drug is deposited in a...
Questions
Questions (13)
Recently I performed in vitro drug release for physical mixture and found the drug release (in 50 mL) already achieved almost 100% in 5 - 10 min and then to 200% over 2 h. We have repeated the study and it was the same. We're suspecting some unsolubilised drug may have extracted during 1st time point and accumulated at the filter which may dissolve during the next time point taken. Any idea or similar encounter?
It may be a dilemma for coauthorship invitation, especially when a manuscript is completed. Even though authorship should be discussed earlier before manuscript drafting, it may turn into a situation where coauthors can join at last without significant contribution. I would like to gather some opinions on planning coauthorship for different situations including article types (eg research article, review), as a cosupervisor, comments/opinions from experts etc.
We are doing ex vivo skin permeation studies for an easily degraded drug. Any suggestion for antioxidant/stabiliser to minimise degradation of drug while not affecting the skin integrity?
I have been recently trying to develop a method to separate the above compounds. Most methods tried were adapted from literature using RP C8 or C18 column with ACN/MeOH and buffered water at pH 2 - 7. However, the separation was not successful. My main target is methyl salicylate (MS) but interefering from others disallowed a proper quantification of MS. I knew GCMS is a more common way to separate the compounds. But I wonder if HPLC can also do the same.
Projects
Projects (7)
To develop mitragynine the next blockbuster drug for opiate replacement
To design an advanced dosage form that ultimately improve QoL of patient or user
