Chong Zhou

Swinburne University of Technology · Department of Civil and Construction Engineering

Background Inhibiting secondary inflammatory damage caused by glial cells and creating a stable microenvironment is one of the main strategies to investigate drugs for the treatment of spinal cord injury. Acetyl‐11‐keto‐beta‐boswellic acid (AKBA) is the active component of the natural drug boswellia, which has anti‐inflammatory and antioxidant effe...

The reasonable design of atomically dispersed Ni-Nx sites in porous carbon nanostructures is an efficient strategy to enhance the electrochemical CO2 reduction reaction (CO2RR) catalytic activity. In this work, atomically dispersed Ni-Nx sites on hierarchically porous carbon catalysts (HP-Ni-NC) were fabricated by a facile NaCl template-assisted py...

In this multicenter, single-arm phase 2 trial (ChiCTR1900024428), patients with locally advanced gastric/gastroesophageal junction cancers receive one cycle of sintilimab (anti-PD1) and chemotherapy (S-1 and nab-paclitaxel), followed by 5 weeks of concurrent chemoradiotherapy and sintilimab, and another cycle of sintilimab and chemotherapy thereaft...

Boswellia is a traditional medicine for bruises and injuries. Its main active ingredient, Acetyl-11-keto-beta-boswellic acid (AKBA), has antioxidant and anti-apoptotic effects. In this experiment, we used SD rats to make a sciatic nerve injury model to detect the Nrf2/HO-1 signaling pathway and apoptosis, combined with clinical indicators, for test...

The existing studies by our team demonstrated the pro-recovery effect of 3-Acetyl-11-keto-beta-boswellic acid (AKBA) on a sciatic nerve injury. To further investigate the role of AKBA in peripheral nerve injury repair, The TMT quantitative proteomics technique was used to obtain differentially significant proteins in a Sham group, Model group, and...

Background: Aristolochic acid I (AA-I) can damage the structure and function of kidney, but there are few prevention strategies at present. In this study, we investigated the protective effects and mechanism of Rehmannia glutinosa extract-catalpol (CAT) on renal injury caused by AA-I. Methods: In vitro, NRK-52E cells were administered with AA-I (40...

Previous studies showed that acetyl-11-keto-beta-boswellic acid (AKBA), the active ingredient in the natural Chinese medicine Boswellia, can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation. However, the underlying molecular mechanism remains poorly understood. In this study, we performed genomic sequencing in a rat mo...

Background: Radiation resistance remains the leading cause of radiotherapy (RT) failure. The development of tumor-specific targeted sensitizers is key to overcoming radiation resistance. Our early data showed that cancer cell penetration was simulated by internalizing arginine-glycine-aspartic acid (iRGD), and the irradiation efficacy was improved...

Rational design and synthesis of carbon nanostructures doped with atomically dispersed metal sites is an effective method to improve electrocatalytic oxygen reduction reaction (ORR) performance. Introducing mesopores into substrate carbon materials would help expose more active sites and improve mass/charge transfer in the microenvironments near ac...

Background: Dragon's blood is a natural medicine with hemostatic and blood-activating effects and is used to promote wound healing. Dracorhodin perchlorate (DP) is a stable form of dracarhod and is used as a substitute for cochinchinenin. DP promotes the proliferation of rat fibroblasts and promotes wound healing in rats. Methods: DP ointment (0...

Resistance to irradiation (IR) remains a major therapeutic challenge in tumor radiotherapy. The development of novel tumor-specific radiosensitizers is crucial for effective radiotherapy against solid tumors. Here, we revealed that remodeling tumor tissue penetration via tumor penetrating peptide internalizing RGD (iRGD) enhanced irradiation effica...

A proton therapy facility is under development at Huazhong University of Science and Technology (HUST). To meet the need for fast energy changes during treatments, a beamline control system (BCS) has been designed and implemented. The BCS coordinates and controls various beamline devices by adopting a distributed architecture divided into three lay...

Cancer-associated adipocytes (CAAs), which are adipocytes transformed by cancer cells, are of great importance in promoting the progression of breast cancer. However, the underlying mechanisms involved in the crosstalk between cancer cells and adipocytes are still unknown. Here we report that CAAs and breast cancer cells communicate with each other...

A proton therapy (PT) facility with multiple treatment rooms based on the superconducting cyclotron scheme is under development at Huazhong University of Science and Technology (HUST). This paper attempts to describe the design considerations and implementation of the PT beamline from a systematic viewpoint. Design considerations covering beam opti...

Mecobalamin is commonly used in the adjuvant intervention of various peripheral nerve injuries. Actin cytoskeleton plays a role in the regeneration of myelin and axon. Therefore, the purpose of this study was to explore the possibility of mecobalamin regulating actin cytoskeleton in repairing nerve injury. In this study, a crush injury on the right...

Aristolochic acid (AA) are persistent soil pollutants in the agricultural fields of the Balkan Peninsula. Preparations containing aristolochic acid are widely used for anti-inflammatory, diuretic, etc. To study the hepatotoxicity of aristolochic acid, 80 healthy SD rats were selected and divided into 20mg/kg- AA group, 4mg/kg- AA group, and 2mg/kg-...

A proton therapy facility (HUST-PTF) based on a 250 MeV isochronous superconducting cyclotron is under construction in the Huazhong University of Science and Technology. An energy degrader is used to modulate the beam energy from 70 to 230 MeV in HUST-PTF, and then transports the proton beams to one fixed-beamline room and two gantry rooms for clin...

A proton therapy facility based on spot scanning technique requires a fast ON/OFF beam switch during beam spots and energy modulation procedures. At HUST, a proton therapy facility (HUST-PTF) with multiple treatment rooms is under development. For HUST-PTF, this beam switch function is implemented by a fast kicker magnet and downstream beam dump. T...

Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression, yet the underlying mechanisms and functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associate...

Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. H...

In computer networks, Denial-of-Service (DoS) attacks attempt to make computers or network resources unavailable for their intended use. DoS attacks are difficult to detect and mitigate since they normally do not attempt to access the private data of their intended victim, but rather intend to disrupt the publicly available resources their victims...

Outlier detection is an important topic in machine learning and has been used in a wide range of applications. In this paper, we approach outlier detection as a binary-classification issue by sampling potential outliers from a uniform reference distribution. However, due to the sparsity of data in high-dimensional space, a limited number of potenti...

Rotor is a widely used and easily defected mechanical component. Thus, it is significant to develop effective techniques for rotor fault diagnosis. Fault signature extraction and state classification of the extracted signatures are two key steps for diagnosing rotor faults. To complete the accurate recognition of rotor states, a novel evaluation in...

Anomalies and outliers are common in real-world data, and they can arise from many sources, such as sensor faults. Accordingly, anomaly detection is important both for analyzing the anomalies themselves and for cleaning the data for further analysis of its ambient structure. Nonetheless, a precise definition of anomalies is important for automated...

Anomalies and outliers are common in real-world data, and they can arise from many sources, such as sensor faults. Accordingly, anomaly detection is important both for analyzing the anomalies themselves and for cleaning the data for further analysis of its ambient structure. Nonetheless, a precise definition of anomalies is important for automated...

Fault diagnosis of rolling bearings is important for ensuring the safe operation of industrial machinery. How to effectively extract the fault features and select a classifier with high precision is the key to realizing the fault recognition of bearings. Accordingly, a new fault diagnosis method of rolling bearings based on improved fast spectral c...

Outlier detection is an important topic in machine learning and has been used in a wide range of applications. In this paper, we approach outlier detection as a binary-classification issue by sampling potential outliers from a uniform reference distribution. However, due to the sparsity of data in high-dimensional space, a limited number of potenti...

The impulsive fault feature signal of rolling bearings at the early failure stage is easily contaminated by the fundamental frequency (i.e., the rotation frequency of the shaft) signal and background noise. To address this problem, this paper puts forward a rolling bearing weak fault diagnosis method with the combination of optimal notch filter and...

When rolling bearing failure occurs, vibration signals generally contain different signal components, such as impulsive fault feature signals, background noise and harmonic interference signals. One of the most challenging aspects of rolling bearing fault diagnosis is how to inhibit noise and harmonic interference signals, while enhancing impulsive...

Efficient trafficking of lymphocytes to the tumor microenvironment is crucial for the success of an effective antitumor immunotherapy. A major challenge to achieve effective adoptive immunotherapy is poor tumor penetration and inefficient migration of T cells to the tumor site. Several approaches to facilitate the trafficking of lymphocytes to the...

Gene expression analysis provides genome-wide insights into the transcriptional activity of a cell. One of the first computational steps in exploration and analysis of the gene expression data is clustering. With a number of standard clustering methods routinely used, most of the methods do not take prior biological information into account. In thi...

Deep autoencoders, and other deep neural networks, have demonstrated their effectiveness in discovering non-linear features across many problem domains. However, in many real-world problems, large outliers and pervasive noise are commonplace, and one may not have access to clean training data as required by standard deep denoising autoencoders. Her...

In order to improve the drawbacks of DE algorithm with DE/best/1 such as the rapid convergence speed and local optimum, this paper proposes an improved DE algorithm. Based on the DE/best/1 mutation operator, a new mutation operator is constructed. The best M individuals are summed as a new individual to replace the base individual of the DE/best/1....

Differential Evolution (DE) algorithm is known in evolutionary computation. However, DE with DE/best/1 mutation has some drawbacks such as premature convergence and local optimum. To address these drawbacks, we improve the DE/best/1 mutation operator and propose a sine cosine mutation based differential evolution algorithm, named SCDE. In the propo...

This paper presents the modification, validation and application of the system code ATHLET for Sodium-cooled Fast Reactors. The ATHLET code is developed by Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) in Germany for Light Water Reactors application. The code structure is modified that it can be easily extended to different fluids. For the...

With the electromagnetic spectrum becoming significantly crowded, it is highly challenging to satisfy the tightening wireless specifications with the increasingly shrinking RF components in mobile equipment. High performance and miniature acoustic resonator is crucial to build the critically important RF components such as RF filters, RF duplexers...

Since the existing thermal-hydraulic computer codes for light water reactors are not applicable to supercritical water cooled reactors (SCWRs) owing to the limitation of physical models and numerical treatments, the development of a reliable thermal-hydraulic computer code is very important to design analysis and safety assessment of SCWRs. Based o...

This paper presents the application of the modified ATHLET code to the dynamic behavior analysis of a supercritical water cooled system. A small scale fuel assembly under the “evaporator” condition of the HPLWR core design concept, with a supercritical water cooled experiment loop, is about to be tested in the LVR-15 research reactor of the Nuclear...

The sodium-cooled fast reactor (SFR) is gathering worldwide attention for its features of the fast-spectrum reactor and closed fuel recycle system. This paper presents the modification of the ATHLET code for application to SFRs. The thermal-hydraulic computer code ATHLET is developed by Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) in Germa...

In this paper, a new approach is proposed to rapidly and accurately measure the electromechanical coupling constant K(t)(2) of thin film piezoelectric material, which is critically important for real-time quality control of the piezoelectric film growth in mass production. An ideal lossy bulk acoustic resonator (LBAR) model is introduced and the th...

This work presents the design methodologies and simulation results of a GSM900/DCS1800 dual-band filter based on bulk acoustic wave coupled resonator filter (BAW CRF) technology. The dual-band filter is featured with a unified input port, thus eliminating the need for a RF switch to route the GSM/DCS receiver signals in a GSM/DCS handset. The filte...

Satellite radio equipments require efficient radio-frequency (RF) filtering solutions to solve issues such as narrow bandwidth, small size, frequency of temperature independence, and etc. A band pass filter based on temperature stable bulk acoustic wave resonator has been designed, fabricated and tested. The filter presents decent insertion loss, v...

To explore the influence of knock-down of miR-21 expression on the radiosensitivity of radioresistant glioma SHG-44 cells and its mechanism. Radioresistant cell line SHG-44(R) cells were established from radiosensitive parental SHG-44 glioma cells. Then the expression levels of miR-21 in SHG-44(R) and SHG-44 were determined by quantitative real-tim...

Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumors or its metastases. Many techniques have been developed in the recent years to identify CTCs in breast cancer patients, and trials have proved the prognostic significance of CTCs. In this study, we validated...

Multi-mode mobile equipments requires efficient radio-frequency (RF) filtering solutions to solve interference problems in a UMTS system integrated with a mobile television function. We designed and fabricated a pair of RF filters consisting of a band-pass and a band-stop filter, based on temperature-stable bulk acoustic wave resonator (BAW) techno...

Google and other products have revolutionized the way we search for information. There are, however, still a number of research challenges. One challenge that arises specifically in desktop search is to exploit the structure and semantics of documents, as defined by the application program that generated the data (e.g., Word, Excel, or Outlook). Th...

This paper presents the design methods and simulation results of an unbalanced filter and a balanced filter for RF signal filtering in the receiver path of a TD-SCDMA handset. Film bulk acoustic resonator (FBAR) technology is employed in the filters. Transmission line model has been built to emulate the behaviors of an FBAR, which is then used in t...

This study investigates the experiences of a group of Mainland Chinese students studying at South Australian secondary schools. It focuses on the cultural challenges faced by these students and provides some insider's knowledge about the underlying causes for these challenges and the students' coping strategies in the process of adjusting to living...

Current search engines such as Google and Yahoo! are prevalent for searching the Web. Search on dynamic client-side Web pages is, however, either inexistent or far from perfect, and not addressed by existing work, for example on Deep Web. This is a real impediment since AJAX and Rich Internet Applications are already very common in the Web. AJAX ap...

The current commercial Web search engines do a good job at ranking web pages with hyperlink information. However, there are also many common documents such as PowerPoint files or Flash files which do not have enough hyperlink information. We call such documents weak-linked documents. Current search engines return therefore either completely irrelev...

The existing so-called semantic XML document clustering algorithms usually use a synonymous word library to calculate semantic similarities among XML documents. However, when people create their own XML documents, they name the element randomly and often use lots of abbreviations. Many tags are not real words at all. The XML documents created by di...

A closed form solution for elastic global buckling of twin girder systems interconnected with cross frames is derived. Current design specifications for such systems only consider individual girder buckling between cross frames. The solution, which is suitable for design specifications, was developed for a uniform moment loading condition. Finite-e...

Current search engines such as Google and Yahoo! are prevalent for searching the Web. Search in dynamic pages, however, is ei- ther inexistent or far from perfect. AJAX and Rich Internet Ap- plication are such applications. They are increasingly frequent on the Web (in YouTube, Amazon, GMail, Yahoo!Mail) or mobile de- vices and are offering a high...

Current search engines such as Google and Yahoo! are prevalent for searching the Web. Search in dynamic pages, however, is either inexistent or far from perfect. AJAX and Rich Internet Application are such applications. They are increasingly frequent on the Web (in YouTube, Amazon, GMail, Yahoo!Mail) or mobile devices and are offering a high degree...

Four steel bridges in Texas have been designed and will be constructed using lean-on bracing systems where individual cross-frames provide bracing to multiple girders. The detailing used in these bridges includes top and bottom lateral struts in girder bays adjacent to a cross-frame to allow several girders to lean on the cross-frame. Utilization o...

Histogram and Wavelet synopses provide useful tools in query optimization and approximate query answering. Traditional wavelet synopsis construction algorithms treat the construction algorithms as the wavelet coefficients selection problem which is called Coefficient Thresholding. However, all these algorithms just focus on the selection of best wa...

XML language is widely used as a standard for data representation and exchange among Web applications. In recent years, many efforts have been spent in querying, integrating and clustering XML documents. Measuring the similarity among XML documents is the foundation of such applications. In this paper, we propose a new similarity measure method amo...

Skyline queries have caused much attention for it helps users make intelligent decisions over complex data. Unfortunately, too many or too few skyline objects are not desirable for users to choose. Practically, users may be interested in the skylines in the subspaces of numerous candidate attributes. In this paper, we address the important problem...

Skyline queries have caused much attention for it helps users make intelligent decisions over complex data. Unfortunately, too many or too few skyline objects are not desirable for users to choose. Practically, users may be interested in the skylines in the subspaces of numerous candidate attributes. In this paper, we address the important problem...

Frequent subtree pattern mining is an important data mining problem with broad applications. Most existing algorithms, such as Apriori-like algorithms, are based on candidate-generation-and-test framework, except for Chopper and XSpanner [8]. Unfortunately, candidate pattern generation and test used in Apriori-like algorithms are always time and sp...

In this study, the researcher intends to make some contributions to the research literature regarding the analysis of secondary students' cross-cultural adjustment through investigating a group of Mainland Chinese students' experiences in secondary schools in South Australia. The study explores the perceptions of Chinese students in a more naturali...

This study investigates the experiences of a group of Mainland Chinese students studying at South Australian secondary schools. It explores the perceptions of these students in a more naturalistic way through conversations with them in their own language. It focuses on the cultural challenges they faced and provides an insider's knowledge about the...