Chloe BracisGrenoble Alpes University
Chloe Bracis
PhD
About
30
Publications
17,312
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Introduction
My research uses models to understand complex systems across a range of scales and contexts. These vary from intra-host modeling exploring the mechanisms of potential HIV treatment on viral dynamics to epidemiological models investigating the effect of interventions and vaccine properties on the COVID19 pandemic to simulation models examining how animals make decisions about where to move and then carry out these movements.
Additional affiliations
September 2007 - December 2014
Publications
Publications (30)
Background
In late March 2020, a “Stay Home, Stay Healthy” order was issued in Washington State in response to the COVID-19 pandemic. On May 1, a 4-phase reopening plan began. We investigated whether adjunctive prevention strategies would allow less restrictive physical distancing to avoid second epidemic waves and secure safe school reopening.
Me...
Trial results for two COVID-19 vaccines suggest at least 90% efficacy against symptomatic disease (VEDIS). It remains unknown whether this efficacy is mediated by lowering SARS-CoV-2 infection susceptibility (VESUSC) or development of symptoms after infection (VESYMP). We aim to assess and compare the population impact of vaccines with different ef...
The ability of wild animals to navigate and survive in complex and dynamic environments depends on their ability to store relevant information and place it in a spatial context. Despite the centrality of spatial memory, and given our increasing ability to observe animal movements in the wild, it is perhaps surprising how difficult it is to demonstr...
Spatial capture–recapture (SCR) models have emerged as a robust method to estimate the population density of mobile animals. However, model evaluation has generally been based on data simulated from simplified representations of animal space use. Here, we generated data from animal movement simulated from a mechanistic individual‐based model, in wh...
The rapid spread of highly transmissible SARS-CoV-2 variants combined with slowing pace of vaccination in Fall 2021 created uncertainty around the future trajectory of the epidemic in King County, Washington, USA. We analyzed the benefits of offering vaccination to children ages 5–11 and expanding the overall vaccination coverage using mathematical...
Background: The mass rollout of COVID vaccination in early 2021 allowed local and state authorities to relax mobility and social interaction regulations in spring 2021 including lifting all restrictions for vaccinated people and restoring in-person schooling. However, the emergence and rapid spread of highly transmissible variants combined with slo...
Predator reintroductions are often used as a means of restoring the ecosystem services that these species can provide. The ecosystem consequences of predator reintroduction depend on how prey species respond. Yet, to date, we lack a general framework for predicting these responses. To address this knowledge gap, we modeled the impacts of predator r...
SARS-CoV-2 vaccine clinical trials assess efficacy against disease (VEDIS), the ability to block symptomatic COVID-19. They only partially discriminate whether VEDIS is mediated by preventing infection completely, which is defined as detection of virus in the airways (VESUSC), or by preventing symptoms despite infection (VESYMP). Vaccine efficacy a...
Despite decades of extensive animal movement research, we still lack an integrated, process-based understanding behind the movement decisions that individuals make, which ultimately lead to the emergence of home-ranges. Here, we advance toward a more holistic understanding of HR formation, by developing a theoretical model integrating two key proce...
The goals of SARS-CoV-2 vaccination programs are to maximally reduce cases and deaths, and to limit the amount of time required under lockdown. Using a mathematical model calibrated to data from King County Washington but generalizable across states, we simulated multiple scenarios with different vaccine efficacy profiles, vaccination rates, and ca...
Background
Several COVID-19 vaccine candidates are in the final stage of testing. Interim trial results for two vaccines suggest at least 90% efficacy against symptomatic disease (VE DIS ). It remains unknown whether this efficacy is mediated predominately by lowering SARS-CoV-2 infection susceptibility ( VE SUSC ) or development of symptoms after...
Ongoing SARS-CoV-2 vaccine trials assess vaccine efficacy against disease (VE DIS ), the ability of a vaccine to block symptomatic COVID-19. They will only partially discriminate whether VE DIS is mediated by preventing infection as defined by the detection of virus in the airways (vaccine efficacy against infection defined as VE SUSC ), or by prev...
There is growing interest in using mechanistic ecosystem models for ecosystem-based management, as they have the advantage of capturing both bottom-up and top-down processes as well as system interactions from food web structure, spatial constraints, and human activities. However, they have the disadvantage of requiring many parameters, many of whi...
Background
In late March 2020, a "Stay Home, Stay Healthy" order was issued in Washington State in response to the COVID-19 pandemic. On May 1, a 4-phase reopening plan began. If implemented without interruptions, all types of public interactions were planned to resume by July 15. We investigated whether adjunctive prevention strategies would allow...
Studying nomadic animal movement across species and ecosystems is essential for better understanding variability in nomadism. In arid environments, unpredictable changes in water and forage resources are known drivers of nomadic movements. Water resources vary temporally but are often spatially stationary, whereas foraging resources are often both...
Conservation of nomadic species presents significant conservation challenges because of unpredictability in their movements and space use. Long‐term studies on nomadic species offering insights into the variability in space use within and between years are largely missing but are necessary to develop effective conservation strategies.
We examined t...
Aim
Animal movement is an important determinant of individual survival, population dynamics and ecosystem structure and function. Nonetheless, it is still unclear how local movements are related to resource availability and the spatial arrangement of resources. Using resident bird species and migratory bird species outside the migratory period, we...
Predator–prey interactions are central to fitness as animals simultaneously avoid death and consume resources to ensure growth and reproduction. Along with direct effects, predators can also exert strong non-consumptive effects. For example, prey shift habitat use in the presence of predators, a potentially learned behavior. The impact of cognition...
Animals regularly return to locations such as foraging patches, nests, dens, watering holes, or movement corridors, and these revisited locations are often sites of ecological significance. Analyzing the temporal and spatial pattern of revisitation can lead to important insights into the life history and ecology of populations. We introduce the R p...
Restrictions on roaming
Until the past century or so, the movement of wild animals was relatively unrestricted, and their travels contributed substantially to ecological processes. As humans have increasingly altered natural habitats, natural animal movements have been restricted. Tucker et al. examined GPS locations for more than 50 species. In ge...
One of the key questions regarding the underlying mechanisms of mammalian land migrations is how animals select where to go. Most studies assume perception of resources as the navigational mechanism. The possible role of memory that would allow forecasting conditions at distant locations and times based on information about environmental conditions...
An individual's choices are shaped by its experience, a fundamental property of behavior important to understanding complex processes. Learning and memory are observed across many taxa and can drive behaviors, including foraging behavior. To explore the conditions under which memory provides an advantage, we present a continuous-space, continuous-t...
Movement data provide a window – often our only window – into the cognitive, social and biological processes that underlie the behavioural ecology of animals in the wild. Robust methods for identifying and interpreting distinct modes of movement behaviour are of great importance, but complicated by the fact that movement data are complex, multivari...
The oceanic distribution of Columbia River spring-summer Chinook Salmon Oncorhynchus tshawytscha is essentially unknown, as they are first detected in the fishery at the mouth of the river and then at Bonneville Dam, located 235 km upstream of the river mouth. Although the composite run timing to Bonneville Dam varies interannually, earlier studies...
Although evidence indicates that salmon could use geomagnetic cues in their high seas homing migration, the underlying behavioral strategy salmon apply to navigation cues is poorly understood. In one hypothesis, salmon imprint on the magnetic field when entering the ocean as juveniles and use the difference between the local and imprinted fields to...