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Introduction
Skills and Expertise
Publications
Publications (76)
Background/purpose
The clinical features of dihydropyridine-induced gingival overgrowth (DIGO), including extracellular matrix accumulation and cell hyperplasia, are regulated by inflammatory factors (e.g., Interleukin-1β [IL-1β]) in combination with calcium channel blockers (e.g., nifedipine [Nif]). We speculated that IL-1β and Nif (IL-1β/Nif) may...
When the size of a liquid crystal display (LCD) increases, the light guiding plate (LGP) as the main part of the LCD must adopt a wedge-shaped plate to reduce its weight (the thickness of the LGP decreases because of this) and guide the light to the LCD screen. Micro-injection molding (MIM) is commonly used to manufacture LGPs. During the filling p...
Minimally invasive procedures were introduced in periodontics, which could enhance clinical outcomes and reduce post-operative discomfort. However, minimally invasive non-surgical periodontal therapy (MINST) as an alternative modality of conventional non-surgical root surface debridement has not been clearly evaluated by randomized controlled clini...
In this study, we determined the effects of design and processing parameters of precision injection molding (PIM) to minimize warpage phenomena of micro-sized parts using various plastics (polyoxymethylene (POM), acrylonitrile-butadiene-styrene (ABS), polypropylene (PP), polyamide (PA), and ABS+ polycarbonate (PC)). We applied a numerical simulatio...
In this study, we designed and fabricated transmission parts for a flapping-wing micro-aerial vehicle (FW-MAV), which was fabricated by precision injection molding, and analyzed its warpage phenomena. First, a numerical simulation (Moldflow) was used to analyze the runner balance and temperature, pressure, and stress distributions of the base, gear...
Periodontitis and chronic kidney disease are both chronic inflammatory diseases and share some common risk factors. This 3-month pilot study aimed to clarify whether non-surgical periodontal therapy is beneficial in clinical, biochemical, and microbiological conditions in patients with periodontitis and kidney failure. Kidney failure patients with...
The ability of Pluronic F127 (PF127) conjugated with tetrapeptide Gly-Arg-Gly-Asp (GRGD) as a sequence of Arg-Gly-Asp (RGD) peptide to form the investigated potential hydrogel (hereafter referred to as 3DG bioformer (3BE)) to produce spheroid, biocompatibility, and cell invasion ability, was assessed in this study. The fibroblast cell line (NIH 3T3...
In the original publication, there was a mistake in Figure 2a as published [...]
This study examined the uniformity of illuminance field distributions of light guide plates (LGPs). First, the authors designed microstructural patterns on the surface of an LGP. Then, a mold of the LGP with the optimal microstructural design was fabricated by a photolithography method. Micro-injection molding (μIM) was used to manufacture the mold...
This study evaluated color stability and staining susceptibility of five direct resin-based composites (RBCs) subjected to light-activated in-office bleaching with 40% hydrogen peroxide (HP). The test materials included 5 RBCs, which consisted of one nano-filled, one sub-micron, one bulk-filled, and two nano-hybrid RBC types. Ten disc-shaped specim...
This study applied poly-ε-caprolactone (PCL), a biomedical ceramic powder as an additive (nano-hydroxyapatite (nHA) or β-tricalcium diphosphate (β-TCP)), and sodium chloride (NaCl) and ammonium bicarbonate ((NH4)HCO3) as porogens; these stuffs were used as scaffold materials. An improved solvent-casting/particulate-leaching method was utilized to f...
In the present study, the as-cast Ti5Ge (wt%) (AS-TG) alloy was used to evaluate the effect of solution heat-treatment temperatures on the microstructure, phase transformation, and biocompatibility. The AS-TG specimen was subjected to different solution heat-treatment temperatures from 700 °C to 1000 °C for 30 min, and then characterized using a fi...
Objectives
This study analyzed the role of the interleukin (IL)‐6/signal transducer and activator of transcription 3 (STAT3) pathway in dihydropyridine‐induced gingival overgrowth (DIGO) fibroblasts.
Materials and methods
Tissue samples were obtained through surgical dissection from five DIGO patients and five healthy individuals. Cell cultures we...
This study emphasizes the warpage phenomenon of thin-walled parts using acrylonitrile-butadiene styrene (ABS) plus polycarbonate (PC) plastics for optimal processing by thin-wall injection molding. The authors first employed the Moldflow software to analyze the runner’s balance on multicavities for thin-walled parts and to simulate the warpage of t...
This study aimed to elucidate the local effect and micro-computed tomographic (μ-CT) assessment following bone implantation of an innovative bioceramic (α-calcium sulfate hemihydrate; α-CSH) on femur lateral condyle cortical bone of rabbit models. The innovative α-CSH bioceramic was synthesized through a green processing technology (microwave irrad...
The accuracy of static guided implant surgery (sGIS) using conventional planning workflow has been extensively examined; however, more information is required to justify the application of fully digital planning protocol. The purpose of this study was to investigate the clinical accuracy of sGIS with a fully digital planning workflow. Twenty-one pa...
Background/purpose
Early diagnosis of vertical root fracture (VRF) has been a great challenge. Since there is no single specific etiology identified, prevention of VRFs in endodontically treated teeth is quite difficult. The study aimed to evaluate the clinical associated factors of VRFs.
Materials and methods
A retrospective observational study o...
This study was to elucidate the surface characteristics and in vitro cell behaviors of biomedical titanium (Ti) with the biofunctional surface (nanostructured rutile-Ti dioxide (NanoR-TiO2) layer combined with amino-groups (NH2) and albumin). Biofunctional surface features were analyzed via scanning electron microscopy, atomic force microscopy, and...
The surface of Ti6Al4V substrate was modified by two ways: micro-powder blasting and co-blast technique. Micro-powder blasting was done using Al2O3 (of three different sizes) or SiC particles. Co-blast technique was done using the same particles co-blasted with hydroxyapatite (HA) particles. The morphology, roughness, deep impact and contact angle...
Background/purpose:
Diagnosis of vertical root fractures (VRFs) can often be challenging due to the similarity of signs and symptoms with other common dental infectious diseases. This study was aimed at evaluating the potential relationship between VRFs and commonly used clinical diagnostic factors.
Methods:
330 root-filled teeth with endodontic...
Oxygen plasma with different treatment powers and durations was utilized to modify the biomedical pure titanium (Ti) surface in the present study. The superficial, microstructural and biological properties of the plasma-oxidized samples were investigated using the electron microscopy, X-ray photoemission spectroscopy, grazing incidence X-ray diffra...
OBJECTIVES:
The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant.
MATERIALS AND METHODS:
The surface characteristic, biomechanical behavior and hemocompatibil...
In this study, the microstructural, mechanical and biological characterizations of the Ti-25Ta (wt.%) alloy were investigated by means of optical microscope, X-ray diffraction, electron microscope, microhardness test, contact angle goniometer and in vitro cytotoxicity assay. As the alloy underwent heat-treatment at temperatures between 700 °C and 1...
Objectives:
The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant.
Materials and methods:
The surface characteristic, biomechanical behavior and hemocompati...
This study investigates the results of cell cultures on aluminum (Al) templates with flat-structures, micro-structures, nano-structures and micro/nano-structures. An Al template with flat-structure was obtained by electrolytic polishing; an Al template with micro-structure was obtained by micro-powder blasting; an Al template with nano-structure wa...
Endosseous oral implant is applied for orthodontic anchorage in subjects with multiple tooth agenesis. Its effectiveness under orthodontic loading has been demonstrated clinically and experimentally. This study investigates the deformation and stress on the bone and implant for different bite forces by three-dimensional (3D) finite element (FE) met...
[This corrects the article DOI: 10.1155/2016/2617868.].
Background:
Recent studies have shown evidence that higher adiposity in the infrapatellar fat pad (IFP) induces inflammatory phenotypes in the knee joint and thereby contributes to the development and progression of osteoarthritis (OA). In particular, IFP adipocyte-derived inflammatory cytokines participate in pathological events. Our previous res...
Antrodia camphorata
has previously demonstrated the efficacy in treating cancer and anti-inflammation. In this study, we are the first to evaluate
Antrodia camphorata
alcohol extract (ACAE) for osteoporosis recovery
in vitro
with preosteoblast cells (MC3T3-E1) and
in vivo
with an osteoporosis mouse model established in our previous studies, ovariec...
Female SAMP 8 mice were ovariectomized at 4 months after birth to induce osteoporosis. The operation was performed on a SHAM-operated group of SAMP8 female mice at 4 months of age excluding removal of the ovaries. For 0 month non-induced ovaiectomy and after 4 months with or without ACAE treatment following the ovariectomy operation OVX-SAMP8 mice...
Background/purpose: The comprehensive periodontal treatment project (CPTP) is being implemented in Taiwan since 2010. This retrospective study compared the periodontal status, compliance rates, and influence of risk factors for periodontal recurrence and tooth loss among groups of patients who accepted CPTP and conventional periodontal treatment (C...
The objective of the present research was to investigate the thermal injury in the brain after minimally invasive electrosurgery using instruments with copper-doped diamond-like carbon (DLC-Cu) surface coating. The surface morphologies of DLC-Cu thin films were characterized using scanning electron microscopy and atomic force microscopy. Three-dime...
Microtia is characterized as an incomplete auricular development and surgical reconstruction for microtia is still limited even with emerging developments. This study aimed to apply bionanomaterials (PRP/collagen scaffold) for human auricular neocartilage reconstruction by using microtia chondrocytes. The results showed that PRP (TGF-β1 750 pg/mL a...
Nanoporous anodic aluminum oxide (AAO) templates are fabricated using an anodization method. The mean diameter of the nanoporous AAO templates is 100 nm. A molded plastic thin film with nanostructure is fabricated using AAO template as a mold insert by nanoimprint. The surface properties of the molded plastic thin film obtained using various proces...
Antibacterial bioceramics were successfully fabricated by adding 0.5 wt% silver to yttria-stabilized zirconia (YSZ) and their surface antibacterial properties were investigated. Silver-containing YSZ bioceramics exhibited superior antibacterial rate against both Staphylococcus aureus (99.9%) and Escherichia coli cells (88.6%) compared with non-dope...
To evaluate the cell responses of titanium oxide layer with the nanoporous micro-structure, an electrochemical anodization approach was proposed to create a nanoporous structure that superimposed onto the moderately rough sand-blasted, large-grit, acid-etched (SLA) Ti surface (denoted as SLAffinity-Ti). The osteoblast-like cells were cultured on SL...
Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/emb...
Background/Purpose
Traumatic injury often results in pulp necrosis of immature permanent incisors in children. This study compared clinical outcomes for 40 necrotic immature permanent incisors treated with calcium hydroxide [Ca(OH)2] or mineral trioxide aggregate (MTA) apexification/apexogenesis.
Methods
Forty necrotic open-apex incisors from 40 c...
Nanoporous anodic aluminum oxide (AAO) templates are fabricated using an nodization method. The mean diameters of nanoporous anodic aluminum oxide templates are 100 nm and 200 nm by various processing parameters of the anodization method. A molded plastic thin film nanostructure is fabricated by nanoimprinting using the AAO template as a mold inser...
This study indicates the micropattern of molded plastic film from a mold insert using ultrasonic micro embossing. A mold insert and plastic film are heated above the glass transition temperature of plastic, and the softened plastic is flowed into the micropattern of a mold insert by applying pressure via a conventional technique. A longitudinal ult...
Repigmentation variably occurs with different treatment methods in patients with gingival pigmentation. A systemic review was conducted of various treatment modalities for eliminating melanin pigmentation of the gingiva, comprising bur abrasion, scalpel surgery, cryosurgery, electrosurgery, gingival grafts, and laser techniques, to compare the recu...
Hydroxyapatite (HA) coating of hard tissue implants is widely employed for its biocompatible and osteoconductive properties as well as its improved mechanical properties. In this study, a novel micro-blasting process has been used to successfully modify a titanium alloy substrate with a HA treatment using a dopant/abrasive regime. The impact of a s...
Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with specific recognition to GRP78 can act as a guiding probe to direct conjugated imaging agents to localized cancers. Based on this rationale, GRP78-guided polymeric m...
Background/Purpose
Restriction endonuclease is found in bacteria and can precisely cut off the DNA sequence specificity invaded from outside. Using the restriction endonuclease to cleave the double-stranded DNA at specific recognition nucleotide sequences is regarded as important biotechnology. However, traditional approaches cannot directly observ...
This study photo-etches micropatterns on mold inserts and manufactures a light guide plate with microstructures using microinjection molding. The single parameter method is used to investigate flatness and replication with different process parameters for microinjection molding. Mold temperature is the most important factor for plate flatness and m...
In this paper, we are investigating the different cultured structures scale in micrometer and nanometer. The experiment have been fabricated four types aluminum substrate structures which included none-structure, micro-structure, nano-structure, and combined micro/nano structure to fulfill the research in osteoblast-like cell (MG 63). Finally we pe...
Compliance with recommended infection control practices in East Asia has not been clearly documented. To investigate changes in compliance with recommended infection control practices over a eleven-year period and to identify affecting factors, two nationwide cross-sectional surveys of dentists in Taiwan were conducted in 1999 and 2010. An anonymou...
Vascular cell adhesion molecule (VCAM-1) plays a critical role in the inflammatory processes by stimulating the recruitment, extravasation, and migration of leukocytes. Its expression and regulation in the dental pulp is not well elucidated.
Primary dental pulp cells were exposed to prostaglandin E(2) (PGE(2)), prostaglandin F(2α) (PGF(2α)), or int...
Although the risks of needlestick and sharps injuries (NSIs) for dentists are well recognized, most papers published only described the frequency of occupational exposure to NSIs. Less has been reported assessing factors contributing to exposure to NSIs. The purpose of this study was to update the epidemiology of NSIs among dentists in Taiwan and i...
This study develops an improved method for generating aluminum mold inserts used in the replication of polymer-based microfluidic chip. Since molding masters that are suitable for microfluidic chip replication must have features whose dimensions are of the order of tens to hundreds of microns, micro electrical discharge machining is employed herein...
Nanoporous anodic aluminum oxide (AAO) templates are fabricated using an
anodization method. The mean diameter of the nanoporous anodic aluminum
oxide templates is 100 nm. A molded plastic thin film with
nano-structure is fabricated using AAO template as a mold insert by
nanoimprint. The surface properties of the molded plastic thin film
obtained u...
This study investigates warpage of electronic dictionary battery covers fabricated using thin-wall injection molding as a
replacement for conventional insert molding. The primary concern is the molding window in thin-wall injection molding for
acrylonitrile–butadiene styrene (ABS) and polycarbonate (PC)+ABS plastics. Finally, the process parameters...
This study investigates the flow characteristics of microinjection-molded lightguiding plates. This study also analyzes the position of melt fronts on lightguiding plates. Viscous heating, temperature and velocity distribution are utilized to analyze delay or advancement of the melt front experimentally and using three-dimensional (3D) numerical si...
The as-quenched (AQ) microstructure of the Ag-containing alloys was found to be essentially a mixture of austenite (γ) and Ag phases. The Ag phase precipitates had a face-centered-cubic structure and lattice parameter a = 4.09 Å. When the alloy contained Ag ≥0.2 wt%, the mechanical properties were slightly enhanced because of the precipitate streng...
This work reports a novel and effective procedure for manufacturing the mold insert of microlens arrays. First, the microlens arrays master is formed using room-temperature imprint lithography and photoresist reflow process. Next, electroforming is carried out to fabriccate the metal mold insert from the master. Finally, microinjection molding is u...
The biocompatibility and microstructural variation of Fe–Al–Mn (FAM)-based alloys have been investigated clearly. The ((Fe,Mn)3AlCx) carbide (κ′-carbide) and Fe0.6Mn5.4C2 carbide (κ-carbide) as well as Cr7C3 (Cr-carbide) were formed on FAM alloy, following phase transformation by heat treatment and surface functionalization. These carbides have imp...
This study describes the brightness field distributions of microlens arrays fabricated by micro injection molding (μIM) and micro injection-compression molding (μICM). The process for fabricating microlens arrays used room-temperature imprint lithography, photoresist reflow, electroforming, μIM, μICM, and optical properties measurement. Analytical...
In this study, master of the microlens arrays is fabricated using micro dispensing technology, and then electroforming technology is employed to replicate the Ni mold insert of the microlens arrays. Finally, micro hot embossing is performed to replicate the molded microlens arrays from the Ni mold insert. The resin material is used as the dispensin...
A mixture of hospital post-commercial polymer waste (LDPE/HDPE/PP/PS) was pyrolyzed over various catalysts using a fluidized-bed reactor operating isothermally at ambient pressure. The yield of volatile hydrocarbons with zeolitic catalysts (ZSM-5>MOR>USY) were higher than with non-zeolitic catalysts (MCM-41>ASA). MCM-41 with large mesopores and ASA...
This investigation elucidated the effects of C and Cr content on the high-temperature microstructures of Fe–9Al–30Mn–xC–yCr alloys by means of optical microscopy and transmission electron microscopy. With increasing Cr content, the phase transition sequence within the α phase was found to be α+B2→α+B2+DO3→α+DO3. And with increasing C content, a γ→(...
This research points out the brightness field and luminance distribution of the microstructure of a light guiding plate by micro injection molding (MIM) and micro injection-compression molding (MICM). The process of a light guiding plate includes photo-etching, micro molding techniques (MIM and MICM), and optical field measurement. The results show...
This investigation elucidates the phase transformations of the Fe–8.7Al–28.3Mn–1C–5.5Cr alloy using optical microscopy (OM), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy-dispersive X-ray spectrometer (EDS). As the alloy was solution heat treated and then quenched, a (γ+Cr7C3)→γ→(γ+(α+B2+DO3)) phase transitio...
The process of micro-powder blasting is the high speed gas flow which mixed the micro-particle and gas to impact the brittle substrate by the specialized nozzle. This paper combined various diameters Al2O3 eroding particle with a novel masking technique to fabricate the pattern channels in soda glass with a width to 2000 μm and depth down to 1631 μ...
This study investigated the feasibility of using oxygen plasma discharging on titanium for forming a biocompatible layer between the bone plate and bone tissue. Plasma discharging formed a nanostructural oxidation layer on the titanium bone plate. The nanostructural oxidation layer revealed oxygen and titanium bonding states following oxygen plasma...
This research investigates the luminance and the brightness field distribution of the microstructure of a light guiding plate (LGP) by micro injection molding (MIM) and micro injection-compression molding (MICM). The process of manufacturing a LGP includes photo-etching, MIM, MICM, and optical field measurement. The results show that the luminance...
The effectiveness of titanium plates with Ar and oxygen plasma treatment in producing a biocompatible layer between the plate and bone tissue has been investigated. An amorphous-like oxide layer was found to form on the surface of the titanium bone plate after oxygen plasma treatment. Oxygen and titanium bonding states were observed for the titaniu...
Precision injection molding is the most important technology in Bio-MEMS/NEMS industry for the necessary of scale, velocity and cost by the development of Bio-MEMS/NEMS industry and the innovation of Bio-MEMS/NEMS industry. It has the advantage of low cost, low interface and small volume in Bio-MEMS/NEMS industry. This paper emphasizes the analysis...
Micro-injection molding is the most important technology in optical MEMS/NEMS industry for the necessary of scale, velocity and cost by the development of optical MEMS/NEMS industry and the innovation of optical MEMS/NEMS industry. It has the advantage of low cost, low interface and small volume in optical MEMS/NEMS industry. This paper emphasizes...
This investigation studies how nano-(
,
, and
) phases affect the formation of multi-nano-titania film by anodization and cathodic pretreatment. Nano-titanium hydrides
and substoichiometric nano-titanium hydrides were formed during cathodization. A multi-nanoporous titania film was formed
on the titanium during anodization. The nanohydrides ar...
This study demonstrates the replication property and surface roughness for metal micro-mold that combines the replica molding (REM) and electroforming techniques. The micro-mold firstly uses the silicon wafer to fabricate the master mold by UV-LIGA method, and then uses the sputtering method to sputter the Ni element as the seed layer on the surfac...
This study succeeds to replicate a micro-feature by ultrasonic nanoimprint.
The conjunction effect of the pressure and the ultrasonic vibration enables flowing of
plastic into a more precise micro-feature of the metal mold. The longitudinal wave
generated by an ultrasonic system of the frequency 35KMz and output power 900W.
The micro-feature of the...
Aluminum nitride thin films were fabricated as stress biosensors for biosensing cell attachment. The features and capacitance of AlN films following cell culture were detected via leakage current density and biocompatibility testing. Analytical results demonstrate that the failure of the capacitors produced slit-like microvoids to form on the AlN f...
The surface of implantable biomaterials directly contacts the host tissue and is critical in determining biocompatibility. To improve implant integration, interfacial reactions must be controlled to minimize nonspecific adsorption of proteins, and tissue-healing phenomena can be controlled. The purpose of this study was to develop a new method of f...
