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Publications (145)
In this study, we utilize intraoral images for deep learning to provide valuable supports to dentists. This study unfolds in two main phases. Initially, ResNet152 is used to classify which part of the dental arch is captured in the intraoral image. Following that, we utilize YOLOv5s for teeth detection and tooth type classification. Additionally, t...
Primary malignant cardiac tumors rarely occur, and cardiac synovial sarcoma (SS) is especially rare among such tumors. Herein, we present the case of a 35-year-old female with primary cardiac SS treated with surgery, chemotherapy, and radiotherapy. She presented with chest symptoms and underwent imaging examinations. A cardiac tumor was suspected,...
Background
Herein, for the first time, we present a case with mixed invasive micropapillary and neuroendocrine mammary neoplasm.
Case
The patient, a 65‐year‐old postmenopausal woman, had become aware of a tumor in her right breast 11 months prior to presentation at our hospital. The cut surface of the mastectomy specimen contained a well‐circumscr...
Purpose: The purpose of our study was to analyze dental panoramic radiographs and contribute to dentists' diagnosis by automatically extracting the information necessary for reading them. As the initial step, we detected teeth and classified their tooth types in this study. Approach: We propose single-shot multibox detector (SSD) networks with a si...
It is desirable to have robust image interpretation support systems that can obtain the equivalent accuracy for images acquired with different imaging systems and at different facilities. However, these systems often do not adapt well to images with different characteristics, and it is expected that the performance will be improved by customization...
This article describes the summary of our research achievement on the function integrated diagnostic assistance based on multidisciplinary computational anatomy (MCA) models. The main purpose of our research was to develop computer-aided diagnosis (CAD) systems based on such anatomical models for organ and tissue functions. During FY2014 to FY2018,...
Purpose: The purpose of this study was to develop and evaluate lung cancer segmentation with a pretrained model and transfer learning. The pretrained model was constructed from an artificial dataset generated using a generative adversarial network (GAN).
Materials and Methods: Three public datasets containing images of lung nodules/lung cancers wer...
Purpose
To develop and evaluate a three-dimensional (3D) generative model of computed tomography (CT) images of lung nodules using a generative adversarial network (GAN). To guide the GAN, lung nodule size was used.
Materials and methods
A public CT dataset of lung nodules was used, from where 1182 lung nodules were obtained. Our proposed GAN mode...
Objective
The first aim of this study was to determine the performance of a deep learning object detection technique in the detection of maxillary sinuses on panoramic radiographs. The second aim was to clarify the performance in the classification of maxillary sinus lesions compared with healthy maxillary sinuses.
Methods
The imaging data for hea...
Objective
The aim of this study was to compare time and storage space requirements, diagnostic performance, and consistency among 3 image recognition convolutional neural networks (CNNs) in the evaluation of the relationships between the mandibular third molar and the mandibular canal on panoramic radiographs.
Study Design
Of 600 panoramic radiogr...
Training of a convolutional neural network (CNN) generally requires a large dataset. However, it is not easy to collect a large medical image dataset. The purpose of this study is to investigate the utility of synthetic images in training CNNs and to demonstrate the applicability of unrelated images by domain transformation. Mammograms showing 202...
Early detection of glaucoma is important to slow down progression of the disease and to prevent total vision loss. Retinal fundus photography is frequently obtained for various eye disease diagnosis and record and is a suitable screening exam for its simplicity and low cost. However, the number of ophthalmologists who are specialized in glaucoma di...
Objectives
Dental state plays an important role in forensic radiology in case of large scale disasters. However, dental information stored in dental clinics are not standardized or electronically filed in general. The purpose of this study is to develop a computerized system to detect and classify teeth in dental panoramic radiographs for automatic...
Erector spinae muscle (ESM) is an important muscle in the torso region. Changes of sizes, shapes and densities in the cross section of the spinal column muscles have been found in chronic low back pain, degenerative lumbar sclerosis and chronic obstructive pulmonary disease. However, the image features of the ESM are measured manually by the physic...
Computer-aided diagnosis systems for assisting the classification of various diseases have the potential to improve radiologists’ diagnostic accuracy and efficiency, as reported in several studies. Conventional systems generally provide the probabilities of disease types in terms of numerical values, a method that may not be efficient for radiologi...
Automated blood vessels detection on retinal images is an important process in the development of pathologies analysis systems. This paper describes about an automated blood vessel extraction using high-order local autocorrelation (HLAC) on retinal images. Although HLAC features are shift-invariant, HLAC features are weak to turned image. Therefore...
The pattern of blood vessels in the eye is unique to each person because it rarely changes over time. Therefore, it is well known that retinal blood vessels are useful for biometrics. This paper describes a biometrics method using the Jaccard similarity coefficient (JSC) based on blood vessel regions in retinal image pairs. The retinal image pairs...
We propose an approach to supporting pre-surgical planning for the uterus by integrating medical image analysis and physical model generation based on 3D printing. With our method, we first segment the patient-specific anatomy and lesions of the uterus on MR images; then, we create a 3D physical model, an exact replica of the patient’s uterus in te...
Dental records play an important role in forensic identification. To this end, postmortem dental findings and teeth conditions are recorded in a dental chart and compared with those of antemortem records. However, most dentists are inexperienced at recording the dental chart for corpses, and it is a physically and mentally laborious task, especiall...
Retinal arteriolar narrowing is decided based on the artery and vein diameter ratio (AVR). Previous methods segmented blood vessels and classified arteries and veins by color pixels in the centerlines of blood vessels. AVR was definitively determined through measurement of artery and vein diameters. However, this approach was not sufficient for cas...
Presentation of images similar to a new unknown lesion can be helpful in medical image diagnosis and treatment planning. We have been investigating a method to retrieve relevant images as a diagnostic reference for breast masses on mammograms and ultrasound images. For retrieval of visually similar images, subjective similarities for pairs of masse...
Purpose
Studies reported that the mandibular cortical width (MCW) measured on dental panoramic radiographs (DPRs) was significantly correlated with bone mineral density. However, MCW is not a perfect index by itself, and studies suggest the added utility of mandibular cortical index (MCI). In this study, we propose a method for computerized estimat...
[Purpose]
Elasticated is a essential for organ modeling in 3-D printing and the sense of softness may provide a new priory information for surgical planning in abdominal organs. Uterine fibroid removal is a major treatment option, and surgery planning guided by MR images is important. Instead of traditional MR image interpretation on 2-D sections a...
The word "Locomotive syndrome" has been proposed to describe the state of requiring care by musculoskeletal disorders and its high-risk condition. Reduction of the knee extension strength is cited as one of the risk factors, and the accurate measurement of the strength is needed for the evaluation. The measurement of knee extension strength using a...
The iliac muscle is an important skeletal muscle related to ambulatory function. The muscles related to ambulatory function are the psoas major and iliac muscles, collectively defined as the iliopsoas muscle. We have proposed an automated recognition method of the iliac muscle. Muscle fibers of the iliac muscle have a characteristic running pattern...
An automated blood vessel extraction using high-order local autocorrelation (HLAC) on retinal images is presented. Although many blood vessel extraction methods based on contrast have been proposed, a technique based on the relation of neighbor pixels has not been published. HLAC features are shift-invariant; therefore, we applied HLAC features to...
Early detection of glaucoma is important to slow down or cease progression of the disease and for preventing total blindness. We have previously proposed an automated scheme for detection of retinal nerve fiber layer defect (NFLD), which is one of the early signs of glaucoma observed on retinal fundus images. In this study, a new multi-step detecti...
Textural features can be useful in differentiating between benign and malignant breast lesions on mammograms. Unlike previous computerized schemes, which relied largely on shape and margin features based on manual contours of masses, textural features can be determined from regions of interest (ROIs) without precise lesion segmentation. In this stu...
CONCLUSION
Patient-specific 3D printing is likely the best way for supporting the surgery planning of uterine fibroid removal in the future. However, the high product cost of 3D printing prevents it from routine practice, and 3D visualization is still the practical method to support the surgery planning now.
Background
Uterine fibroid removal is a...
Architectural distortion is one of the most important findings when evaluating mammograms for breast cancer. Abnormal breast architecture is characterized by the presence of spicules, which are distorted mammary structures that are not accompanied by an increased density or mass. We have been developing an automated method for detecting spiculated...
Findings on dental panoramic radiographs (DPRs) have shown that mandibular cortical index (MCI) based on the morphology of mandibular inferior cortex was significantly correlated with osteoporosis. MCI on DPRs can be categorized into one of three groups and has the high potential for identifying patients with osteoporosis. However, most DPRs are us...
MIBG (iodine-123-meta-iodobenzylguanidine) is a radioactive medicine that is used to help diagnose not only myocardial diseases but also Parkinson’s diseases (PD) and dementia with Lewy Bodies (DLB). The difficulty of the segmentation around the myocardium often reduces the consistency of measurement results. One of the most common measurement meth...
Multimedia, including audio, image, and video, etc., is a ubiquitous part of modern life. Quality evaluation, both objective and subjective, is of fundamental importance for various multimedia applications. In this paper, a novel quality-aware feature is proposed for blind/no-reference (NR) image quality assessment (IQA). The new quality-aware feat...
Microaneurysm is one of diabetic retinopathy (DR) findings. Visual loss can be prevented by early detection and treatment of DR. The fundus examination is effective for early detection of DR. We also proposed an automated MAs detection method using double-ring filter and shape index based on Hessian matrix in the retinal fundus images. However, it...
Glaucoma is a leading cause of permanent blindness. Retinal imaging is useful for early detection of glaucoma. In order to evaluate the presence of glaucoma, ophthalmologists may determine the cup and disc areas and diagnose glaucoma using a vertical optic cup-to-disc (C/D) ratio and a rim-to-disc (R/D) ratio. Previously we proposed a method to det...
Glaucoma is a leading cause of permanent blindness. Retinal imaging is useful for early detection of glaucoma. In order to evaluate the presence of glaucoma, ophthalmologists may determine the cup and disc areas and diagnose glaucoma using a vertical optic cup-to-disc (C/D) ratio and a rim-to-disc (R/D) ratio. Previously we proposed a method to det...
Texture information of breast masses may be useful in differentiating malignant from benign masses on digital mammograms. Our previous mass classification scheme relied on shape and margin features based on manual contours of masses. In this study, we investigated the texture features that were determined in regions automatically selected from squa...
Detection of lacunar infarcts is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification is often hindered by the difficulty in distinguishing between lacunar infarcts and enlarged Virchow-Robin spaces. Therefore, we developed a computer-aided detection (CAD) scheme for the detect...
The purpose of this study was to improve an automated scheme for detecting carotid artery calcification (CAC) in dental panoramic radiographs (DPRs). Using 100 DPRs, the sensitivity of CAC detection employing our previous method was 90.0% with 5.0 false positives (FPs) per image. This study describes two enhancements. One is the adoption of a new f...
Glaucoma is one of the leading causes of blindness in Japan and the US. One of the indices for diagnosis of glaucoma is the cup-to-disc ratio (CDR). We have been developing a computerized method for measuring CDR on stereo fundus photographs. Although our previous study indicated that the method may be useful, cup determination was not always succe...
Several studies have reported the presence of carotid artery calcifications (CACs) on dental panoramic radiographs (DPRs) as a possible sign of arteriosclerotic diseases. However, CACs are not easily visible at the common window level for dental examinations, and dentists, in general, are not looking for CACs. Computerized detection of CACs may hel...
Periodontal disease is a kind of typical dental diseases, which affects many adults. The presence of alveolar bone resorption, which can be observed from dental panoramic radiographs, is one of the most important signs of the progression of periodontal disease. Automatically evaluating alveolar-bone resorption is of important clinic meaning in dent...
BACKGROUND
As digital mammography and monitor reading are becoming common practice, process for storing and retrieving images is much easier and faster. The vast data including diagnostic and pathologic images, clinical data, and treatment data can be effectively used as a reference and teaching materials. We have investigated an automatic retrieva...
PURPOSE
Previously diagnosed cases with known pathologies can be used as a reference for diagnosis of a new lesion. In order for reference images to be useful, they must be similar to and belong to the same pathologic group as the unknown lesion. In this study, precision of our new image retrieval method was evaluated.
METHOD AND MATERIALS
In our...
PURPOSE
To develop a new computer-aided diagnosis system with temporal subtraction technique for FDG-PET scans and to show the fundamental usefulness based on an observer performance study.
METHOD AND MATERIALS
The computerized system consists of the following steps: (1) Anatomical standardization of normal FDG-PET scans, (2) Normal model construc...
Diabetic retinopathy (DR) is the most frequent cause of blindness. Microaneurysm (MA) is an early symptom of DR. Therefore, the detection of MA is important for the early detection of DR. We have proposed an automated MA detection method based on double-ring filter, but it has given many false positives. In this paper, we propose an MA detection me...
Our purpose in this study is to develop a scheme to segment the rectus abdominis muscle region in X-ray CT images. We propose a new muscle recognition method based on the shape model. In this method, three steps are included in the segmentation process. The first is to generate a shape model for representing the rectus abdominis muscle. The second...
In this paper, we present a texture classification method based on
texton learned via sparse representation (SR) with new feature histogram
maps in the classification of emphysema. First, an overcomplete
dictionary of textons is learned via KSVD learning on every class image
patches in the training dataset. In this stage, high-pass filter is
introd...
For retrieving reference images which may be useful to radiologists in
their diagnosis, it is necessary to determine a reliable similarity
measure which would agree with radiologists' subjective impression. In
this study, we propose a new similarity measure for retrieval of similar
images, which may assist radiologists in the distinction between be...
When a computer-aided diagnosis (CAD) system is used in clinical
practice, it is desirable that the system is constantly and
automatically updated with new cases obtained for performance
improvement. In this study, the effect of different case selection
methods for the system updates was investigated. For the simulation, the
data for classification...
Inflammation in paranasal sinus sometimes becomes chronic to take long
terms for the treatment. The finding is important for the early
treatment, but general dentists may not recognize the findings because
they focus on teeth treatments. The purpose of this study was to develop
a computer-aided detection (CAD) system for the inflammation in
paranas...
Diagnostic imaging on FDG-PET scans was often used to evaluate
chemotherapy results of cancer patients. Radiologists compare the
changes of lesions' activities between previous and current examinations
for the evaluation. The purpose of this study was to develop a new
computer-aided detection (CAD) system with temporal subtraction
technique for FDG...
Presentation of similar reference images can be useful for diagnosis of new lesions. A similarity map which can visually present the overview of the relationship between the lesions with different types may provide the supplemental information to the reference images. A new method for constructing the similarity map by multidimensional scaling (MDS...
Computer-aided detection/diagnosis (CAD) is emerging as an innovative interdisciplinary technology for medical service. The traditional concept of automated computer diagnosis is encountered with a significant barrier because computerized medical systems cannot fully replace human doctors with the comparable level of performance. By contrast, CAD i...
PURPOSE
Computer-aided diagnosis for pulmonary emphysema is very important. The purpose of this study is to propose a reliable and high performance computational method for the classification of different kinds of pulmonary emphysema and normal pulmonary tissues.
METHOD AND MATERIALS
A novel pulmonary emphysema classification method is proposed in...
BACKGROUND
At today's diagnostic scenes, patients sometimes are shown their Computer Tomography (CT) by their doctors. Most patients are not capable to understand of CT slices shown by doctors, because, lay people usually do not have knowledge of anatomy and are not familiar to CT images. Patients hardly realize the spatial position of the their bo...
PURPOSE
In multimodality breast image reading, it may be advantageous to bring all the information including possible pathologic inference from mammograms for making diagnosis. The purpose of this study is to investigate a new method for selection of similar images to be used as a reference for pathologic classification of masses.
METHOD AND MATER...
PURPOSE
In Japan, the proportion of elderly people has been increasing. The volume of the skeletal muscle is an important issue for the elderly. Particularly, psoas major muscle and abdominal wall muscle is a major role on walking ability and posture. In addition, torso CT images are widely used for diagnosis. However, it has to utilize all the inf...
Purpose:
Mandibular cortical width (MCW) measured on dental panoramic radiographs (DPRs) was significantly correlated with bone mineral density. We developed a computer-aided diagnosis scheme that automatically measures MCW to assist dentists in describing a possible osteoporotic risk and suggesting further examinations.
Methods:
In our approach...
Computer-aided diagnosis has potential in improving radiologists' diagnosis, and presentation of similar images as a reference may provide additional useful information for distinction between benign and malignant lesions. In this study, we evaluated the usefulness of presentation of reference images in observer performance studies and compared the...
Glaucoma is the first leading cause of vision loss in Japan, thus developing a scheme for helping glaucoma diagnosis is important. For this problem, automated nerve fiber layer defects (NFLDs) detection method was proposed, but glaucoma risk assessment using this method was not evaluated. In this paper, computerized risk assessment for having glauc...
In multi-modality, multi-information breast cancer diagnosis framework, radiologists take into account all the information available in making diagnosis, one of which can be the information from reference cases. The purpose of this study is to investigate the relationship between pathological concordance and image similarity of breast masses for ex...
Microaneurysm in the retina is one of the signs of simple diabetic retinopathy. We have been investigating a computerized method for the detection of microaneurysms on retinal fundus images. In this study, the computerized scheme was developed by using twenty five cases. After image preprocessing, candidate regions for microaneurysms were detected...