Chinwe Chukwudi

University of Nigeria | UNN · Department of Veterinary Pathology and Microbiology

https://theconversation.com/molecular-research-could-help-nigeria-solve-a-host-of-health-problems-183366

Molecular research and researchers engage in studies that seek to understand the structures, functions, and interactions of biomolecules as the basis for cellular and systemic effects in living organisms. This research approach was made possible by considerable technological advancements that equip researchers with tools to view biomolecules. Altho...

Objective: PPR is a highly contagious trans boundary viral disease of small ruminants, with high morbidity and mortality especially in young animals. Infections are easily spread by close contact in natural settings, and clinically characterized by erosive stomatitis, enteritis and pneumonia. It is endemic in many countries/regions, and poses a maj...

Background Cadmium (Cd) is a known metallohormone which mimics the action of steroid hormones with adverse effect on testicular function. It is highly toxic and a prevalent environmental contaminant with no conventional antidote. This study investigates the possible ameliorative effects of Thymus vulgaris extract on testicular toxicity induced by C...

Background: Pregnancy involves complex biological interaction and communication between the developing conceptus and maternal uterus, which may alter the blood cellular elements. The present investigation evaluated the hematological changes associated with pregnancy in domestic sows. Methods: Blood samples were collected by auricular venipuncture f...

Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub-Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxopla...

Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub‐Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxopla...

This study evaluated the possible ameliorative effect of hydromethanol extract of Thymus vulgaris on hepatorenal toxicity induced by cadmium in male rats. The experimental animals were divided into four groups and treated as follows: A (control-0.5ml of 2% tween 80 in distilled water per os) for 3 weeks and a single subcutaneous dose of phosphate b...

The diagnosis of mange is problematic in the absence of mites in skin scrapings because many skin diseases present similar gross features as mange. The study evaluated the stepwise procedure for herd diagnosis of mange in the West African Dwarf (WAD) and Red Sokoto (RS) goats with greater specificity and sensitivity. Twenty-seven WAD goats (n = 27)...

The antibacterial efficacy of the tetracycline antibiotics has been greatly reduced by the development of resistance, hence a decline in their clinical use. The hok/sok locus is a type I toxin/antitoxin plasmid stability element, often associated with multi-drug resistance plasmids, especially ESBL-encoding plasmids. It enhances host cell survivabi...

Eggs are readily consumed and have been associated with several nutritional benefits in man. This study evaluated the comparative effect of feeding quail egg or chicken egg on the lipid profile, total proteins and blood parameters of male albino rats. Male albino rats (36) weighing between 100 and 120 g were used for this study. They were randomly...

The antibacterial efficacy of the tetracycline antibiotics has been greatly reduced by the development of resistance, hence a decline in their clinical use as antibiotics. The hok/sok locus is a type I toxin/antitoxin plasmid stability element, often associated with multi-drug resistance plasmids, especially ESBL-encoding plasmids. It enhances host...

In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking the mature rRNAs, and not necessarily by the nucleotide sequences. Inhibition of this cleavage would...

The hok/sok locus has been shown to enhance the growth of bacteria in adverse growth conditions such as high temperature, low starting-culture densities and antibiotic treatment. This is in addition to their well-established plasmid-stabilization effect via post-segregational killing of plasmid-free daughter cells. It delays the onset of growth by...

The tetracycline antibiotics are known to be effective in the treatment of both infectious and non-infectious disease conditions. The 16S rRNA binding mechanism currently held for the antibacterial action of the tetracyclines do not explain their activity against viruses, protozoa that lack mitochondria and non-infectious conditions. Also, the mech...

The 16S rRNA binding mechanism proposed for the antibacterial action of the tetracyclines does not explain their mechanism of action against non-bacterial pathogens. In addition, several contradictory base pairs have been proposed as their binding sites on the 16S rRNA. This study investigated the binding of minocycline and doxycycline to short dou...