Chinedu Imo

• Doctor of Philosophy
• Senior Lecturer at Federal University Wukari, Taraba State, Nigeria.

Background: Aluminium chloride is a widely distributed element with a well-established toxicity. The study aimed at evaluating ameliorative effects of active fractions and ethanolic fruits extracts of Raphia hookeri on AlCl3-induced toxicity in male rats. The objectives included; determination of liver and kidney function biomarkers, lipid profile,...

This study evaluated the proximate and phytochemical constituents of ethanolic seeds extracts of Cola nitida and Cola acuminata. The seeds of C. acuminata and C. nitida were purchased and air-dried at room temperature. The dried seeds were pulverized to ground sample. The sample was weighed and used for the proximate and phytochemical analysis. The...

Research has indicated that consumption of whole grain foods can significantly reduce the risk of some chronic health conditions such as type II diabetes, cardiovascular disease, and cancer Therefore, the present study evaluated the proximate constituents and the levels of phytochemicals in rice, maize and millet procured from Wukari Local Governme...

Aluminium (AL) is the third most abundant element in the earth's crust and constitutes about 8% of the total mineral components. The availability of AL has recently drawn more attention to its bio-toxicity. Hence the effects of aluminium chloride (AlCl 3) toxicity on haematological profile administered active fractions and ethanolic fruits extract...

This research study assessed the body weight, pulse and blood pressure of some staff and students of Federal University Wukari, Taraba State, Nigeria. A total of eighty-six people were used for the purpose of this research. They comprised of forty-three members of staff and forty-three students of Federal University Wukari, Nigeria. The members of...

1. Abstract This study investigation the effects of methanolic and aqueous extracts of seeds of Datura metel on liver of Wistar rats. Datura metel seed is believed to be a medicinal plant widely used in phy-tomedicine to cure diseases such as asthma, cough, convulsion and insanity. Various parts of the plant (leaves, seeds, roots and fruits) are us...

Acacia nilotica and Calotropis procera parts are used for various purposes in traditional medicine. Because of their acclaimed medicinal uses, this study investigated the lipid profile of albino rats fed with ethanolic extracts of Acacia nilotica fruit and Calotropis procera flower after aspirin-induced toxicity. Twenty-one (21) male Wistar rats we...

This study evaluated the effects of ethanolic extracts of fruits of Dennettia tripetala on liver function of male albino rats. Dennettia tripetala is an endemic plant of west tropical Africa that is known as pepper fruit. The fruit is known for its numerous medicinal properties such as antioxidant, anti-inflammatory and antidiarrhea. The plant mate...

This study compared the chemical compositions of two local varieties of rice in Wukari, Taraba state. The two local varieties of rice analyzed were, Jambawo and Faro, both cultivated in Wukari. The samples were analyzed for proximate composition on dry matter basis, mineral and phytochemical compositions. Gross energy composition was determined the...

In order to assess the total antioxidant capacity (TAC), total polyphenol content (TPC), and total flavonoid content (TFC) in ethanol fruit extract, as well as to ascertain the relationship between the antioxidant effects and phytochemical levels, this study looked at all three variables. 11 groups of 10 rats each were formed out of the experimenta...

Most agricultural products in Nigeria are often susceptible to environmental pollution due to anthropogenic activities and mode of preservation. As a case study, this work was aimed at evaluating the levels of heavy metals (Pb, Hg, As, Cd, Zn and Fe) depositions on selected agricultural products that are either stored at the rooftop of local Nigeri...

Environmental pollution due to anthropogenic activities and mode of preservation has posed great menace on agricultural products. As a case study, this work was aimed to investigate the levels of heavy metals PAHs (Pyrene, Benzo(a)pyrene, Benzo(b)fluoranthene, Fluoranthene, Indo(1,2,3-cd)pyrene and Dibenzo(a,h)anthracene) depositions on selected ag...

Dennettia tripetala fruit is commonly used as spices and in traditional medicine,it is employed for the treatment of various ailments. The phytochemical composition of both riped and unriped fruits of Dennettia tripetala were evaluated in this study. Fresh matured fruit of Dennettia tripetala used in this study were purchased at Nsukka, Enugu S...

This study examined the effects of ethanolic extracts of fruits of Dennettia tripetala on kidney function of healthy male albino rats. Dennettia tripetala is commonly also referred to as pepper fruit. Antioxidant, anti-inflammatory, and antidiarrheal characteristics are only a few of the fruit's many known therapeutic benefits. Fifty healthy adult...

Aim: This study examined the histological effect of ethanolic extracts of fruits of Acacia nilotica and flowers of Calotropis procera on aspirin-induced stomach ulcer in male albino rats. Acacia nilotica fruits and Calotropis procera flowers are among the plant parts which are used in the treatment of ulcers by local folks in Wukari, Nigeria. Study...

Background and Objective: This study investigated the influence of beers of different alcohol content on haematological indices of male albino rats. Materials and Methods: Three brands of beers commonly consumed within Nigeria were purchased and administered to the experimental animals for 21 days. Group 1 was the control. Group 2 and group 3 were...

Ezeonu CS, Tatah SV, Imo C, Yakubu OE, Garba QH, Arowora K, Umaru IJ, Abah MA, Abu MS, Yohanna ER, Timothy M. 2022. Antioxidant potential of ginger extract on metals (lead, cadmium, and boron) induced oxidative stress in maize plant. Asian J Trop Biotechnol 19: 45-51. Plants have a high potential to accumulate heavy metals, which may have a toxic e...

Background and Objective: Cajanus cajan is traditionally used for the treatment of various ailments due to its antioxidant properties. The present study investigated the effect C. cajan crude aqueous leaf extract (CCLE ) in rats with acetaminophen (APAP)-induced acute renal injury. Materials and Methods: Preliminary acute toxicity testing of the ex...

Blood groups are determined by a set of alternative genes and are based on heredity, a fact that is occasionally used to resolve issues of contested parentage. They were once used to show paternity tests and are now employed in forensic science. There are various types of blood groups, but the most prevalent is the ABO blood group system, which inc...

Background The fruits of Xylopia aethiopica and seeds and leaves of Piper guineense are commonly used as spices. Due to their wide use in nutrition and traditional medicine, there is need to examine the biochemical and histological effects of ethanolic extracts of fruits of Xylopia aethiopica and seeds and leaves of Piper guineense on liver and kid...

Liver plays crucial roles in transforming and clearing toxic chemical substances ingested into the body and thus needs to be investigated for wide spectrum of protective and ameliorative therapeutic agents that are readily available and affordable. In this study, ameliorative effects of fractionated crude methanol extract of Ficus glumosa leaves ag...

Abstract Liver plays crucial roles in transforming and clearing toxic chemical substances ingested into the body and thus needs to be investigated for wide spectrum of protective and ameliorative therapeutic agents that are readily available and affordable. In this study, ameliorative effects of fractionated crude methanol extract of Ficus glumosa...

This study investigated the effects of palm kernel oil, olive oil, crude oil and honey on renal function of male albino rats. These chemical substances are used in traditional medicine for various purposes, including as antidote for poisons. Thirty healthy male albino rats were purchased and used in this research study. The animals were randomly pl...

Background and Objectives: This study evaluated the haematological effects of palm kernel oil, olive oil, crude oil and honey in malealbino rats. The chemical substances are commonly used as antidote for poisons. Materials and Methods: Thirty healthy male albino ratswere used in this study. They were randomly placed into five groups of six animals...

The chemical constituents of crude oil were evaluated in this study. Crude oil is used for many purposes. It is commonly used for production of fuel and in traditional medicine for various purposes. Some people also use crude oil as antidote for poisons. Analysis of the chemical constituents of crude oil was carried out with the use of GC (model No...

This study evaluated the phytochemical constituents of palm oil. Palm oil is commonly used in nutrition for many reasons. Some people use it as antidote for certain types of poisons. The phytochemical analysis of was carried out with the use of GC (model No. 7890B) and MS detector (model 5977A). Some phytochemical constituents detected in palm oil...

This study investigated the haematological and hepatological effects of selected locally brewed beers in albino rats. Three locally brewed beers were purchased from locally brewed beer joint in Wukari, Nigeria. Twenty male albino rats were used and were randomly distributed into four groups of five rats each. Group 1 served as normal control, while...

Background and Objective: Crops sold in Nigeria has a great impact on health, different types of crops have varying nutritional values.Therefore, this study evaluated the proximate composition and total aflatoxins levels in some selected grain crops in Taraba and Benue States of Nigeria. The crops evaluated were maize, rice, groundnut and acha. Mat...

Comparative effects of palm kernel oil, olive oil, crude oil and honey on lipid profile, body weight and hearts of male albino rats was evaluated in this study. This is because they are widely used for various reasons in traditional medicine. Thirty-five male albino rats were used and randomly placed into five groups. Six animals were placed in eac...

Background: Comparative effects of palm kernel oil, olive oil, crude oil and honey on liver function of male albino rats was evaluated in this study because of their wide use in traditional medicine. Methods:A total of 35 healthy male albino rats were used in this study. The rats were randomly placed into 5 groups with 6 rats in each group. The rat...

This study investigated the nutritional composition and pesticide residue levels in cereal grains sold in Wukari market, Taraba State, Nigeria. Standard methods of AOAC were used for the nutrient analysis of the samples (wheat, sorghum, millet and maize). The organophosphate pesticide residue analysis was based on QuEchERs (Quick, easy, cheap, effe...

Background and Objectives: This study evaluated the haematological effects of palm kernel oil, olive oil, crude oil and honey in male albino rats. The chemical substances are commonly used as antidote for poisons. Materials and Methods: Thirty healthy male albino rats were used in this study. They were randomly placed into five groups of six animal...

Combretum paniculatum (combretaceae), has been used widely in ethnomedicine in the treatment of chronic diarrhea and dysentery, flatulence, vomiting, colic, and enlarge spleen and liver. The leaf and root of C. paniculatum were pulverized and extracted by serial exhaustive method with solvents i.e chloroform, ethyl acetate and ethanol in order of i...

Phoenix dactylifera fruit, Cyperus esculentus nut and Cocos nucifera nut are plant materials that are commonly consumed by man in many parts of the world. This research evaluated the liver function and haematological effects of extracts of date fruit, coconut and tiger nut in albino rats. Healthy male albino rats (20) were used and distributed rand...

This study investigated the nutritional composition of Cucumis sativus L. fruit and Solanum melongena L. fruit. The fruits where purchased in Wukari, Nigeria. They were sun-dried and processed for the various analysis. The amino acids analyses were carried out with the use of HPLC, while vitamin and proximate analyses were carried out with the use...

Effects of ethanolic extracts of leaf, seed and fruit of Datura metel on kidney function of male albino rats was investigated in this study. The result showed a non-significant (p > 0.05) increase of urea concentration in groups 2 and 3 administered low (300 mg/kg bw) and high (600 mg/kg bw) dose of leaf extract respectively and a non-significant (...

Background and objective: The processing and preservation of Irish potato tubers like many other crops has been affected by various pathogens like fungi (particularly storage rot) which causes a major constraint to Irish potato production in Nigeria resulting to enormous post-harvest spoilage. The inhibitory effect of aqueous and ethanolic extract...

This study investigated the chemical composition of Cyperus esculentus nut and Phoenix dactylifera fruit. The nuts and fruits were purchased as commonly sold in Wukari, Nigeria. They were cleaned, sorted for healthy parts, sun-dried and milled into fine powder. The AOAC, AAS and GC-MS methods were adopted for the proximate, mineral and phytochemica...

This research investigated the effects of soft drinks on some biochemical research parameters and histological study on liver in wistar rats. Effects of vitamin C on brix content of these soft drinks were also considered. This research was necessitated by the ruling of the high Court at Igbosere, Lagos , Nigeria which stated that NAFDAC should enfo...

This study reviewed the medicinal properties of ginger and garlic. Ginger and garlic are commonly used spices which are important in medicine due to the presence of many important phytochemical constituents and nutrients which are biologically active substances. Some chemical constituents of these medicinal plants have been reported in various lite...

Background and Objective: Phoenix dactylifera fruit, Cyperus esculentus nut and Cocos nucifera nut are widely consumed as food in many parts of the world and are also the major ingredients in the preparation of certain drinks. This study examined the effects of ethanolic extracts of Phoenix dactylifera fruit, Cyperus esculentus nut and Cocos nucife...

Background and Objective: Piper guineense seeds and leaves are among the plant parts commonly used as spices and also in herbal medicine for the treatment and management of different conditions. The proximate, mineral and phytochemical composition of Piper guineense seeds and leaves were evaluated in this study. Materials and Methods: Piper guineen...

Background: Fungal rot diseases of white yam (Discorea rotundata) tubers and cocoyam (Colocasia esculenta) are the major post-harvest challenges in the availability of these root tubers. The use of biological extract of plants will prevent post-harvest losses without any negative health challenge. Methods: Microwave-assisted method of extraction wa...

Aim: Chemical composition of Xylopia aethiopica fruits was evaluated in this study. Materials and Methods: Xylopia aethiopica fruits were purchased as commonly sold at the new market in Wukari, Taraba State, Nigeria. The fruits were sorted for healthy parts, air-dried, and pulverized using manual blender. The AOAC method and AAS were used for proxi...

Background and objective: Cocos nucifera nut is widely consumed in different forms by indigenes of many countries. It is used in preparation of some drinks and oil. Cocos nucifera nut is believed to have many potential nutritional, medicinal and pharmaceutical uses. This study evaluated the proximate, mineral and phytochemical composition of Cocos...

This research was necessitated by the quest to create a useful product from wastes (bio-ethanol from rice husk). This if successful will serve two purposes; first, help reduce wastes in the environment and to create wealth from waste. Separated isolates of Trichophyton soudanense, Trichophyton rubrum, Trichophyton mentagrophyte, Aspergillus oryzae,...

This study investigated the effects of various volumes of red wine on liver function of male Wistar rats. The essence of this research is to determine, if the potential toxicity observed in consumption of red wine can be reduced by lowering the volume of red wines consumed using experimental animals. Thirty (30) male Wistar rats (weighing 190 ± 5.0...

Background and Objective: Phoenix dactylifera fruit, Cyperus esculentus nut and Cocos nucifera nut are widely consumed as food in many parts of the world and are also the major ingredients in the preparation of certain drinks. This study examined the effects of ethanolic extracts of Phoenix dactylifera fruit, Cyperus esculentus nut and Cocos nucife...

Objectives: This study was carried out to evaluate the nutritional compositions of polished rice (Royal stallion) and local varietal rice (sipi) procured in Wukari, Taraba state, Nigeria. Methods: Proximate composition of the samples were determined by Standard Methods of Association of Analytical Chemists (AOAC), while Atomic Absorption Spectropho...

Purpose: This study investigated the effects of orally administered extracts of Datura metel (leaf, seed and fruit) on blood sugar and serum protein levels. Methods: Thirty-five (35) male Wistar rats were randomly allotted into seven (7) groups and each group had five rats. Each group was administered orally varying amounts of Datura metel for one...

The study investigated the levels of protein, energy, and moisture content as well as amino acid composition in some oilseed samples, using High Performance Liquid Chromatographic (HPLC) Technique, while other analysis were carried out using the standard methods of Association of official analytical chemists. All the samples were procured from Wuka...

This study investigated the effects of ethanolic extracts of Datura metel parts on liver function of male albino rats. The plant parts are used for several reasons, including its medicinal and psychoactive activities. Thirty-five albino rats were used and distributed into 7 groups of 5 rats each. The extracts were administered to the test animals f...

Abstract This study was conducted to determine the protein and energy levels, and also amino acids content in some leafy vegetables. Amino acids composition was determined using High Performance Liquid Chromatography (HPLC) method, energy determination was by the bomb calorimetric method while other analyses carried out on the vegetables were adapt...

This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl3. The rats were distributed into six g...

This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl3. The rats were distributed into six g...

This study examined the protective effects of ethanolic leaf extract of Gongronema latifolium on selected antioxidant indices of acetaminophen-induced toxicity in albino rats. Fifty healthy male albino rats were used in this study and were randomly placed into five groups with ten rats in each group. The leaf extract was administered accordingly to...

In the current study, the biochemical changes in haematological and liver function parameters in Intoxicated Male Albino Rats treated with Hymenocardia acida leaves ethanolic extract on AlCl3-toxicity was investigated. Twenty albino rats assigned to four groups of five each were used. Exactly 100 mg/kg bw of the plant extract was administered to gr...

Water lily (Nymphaea lotus) bulbs from Mankhanwa River in Ibi – Nigeria were quantified for their biochemical composition. Proximate composition, anti-nutritional factors, minerals, vitamins and phytochemical contents in the plant bulb were assayed using Association of Official Analytical Chemists (AOAC) standard methods. Values were obtained in du...

ABSTRACT Background: This study was carried out to investigate the effects of Datura metel (leaf, seed and fruit) on blood lipid profile of male albino rats. Methods: Thirty-five albino rats (8 weeks old) weighing between 66g and 84g were purchased and randomly allotted into 7 groups. The normal control (group 1) received normal saline, while gro...

The present study was designed to evaluate the effects of Senna occidentalis in alloxan-induced diabetic and its complications in Wistar rats. Thirty male Wistar rats with body weight ranging from 180–250 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Treatment was c...

This study investigated the fundamental scientific basis for the use of three common cucurbits (two cultivars of Cucurbita pepo (smooth-rind and coarse-rind varieties) and Citrullus lanatus) by screening and quantifying the percentage of selected phytochemical constituents in thesun-dried and oven-dried fruit pulps. Qualitative analysis revealed th...

Background: This study investigated the effect of unripe Musa paradisiaca (plantain) supplemented diet on serum blood glucose, lipid peroxidation, cholesterol and some antioxidant enzymes on alloxan induced-diabetic albino rats. Materials and Methods: Fifty healthy male albino rats weighing between 86-110 g and aged 6 weeks were used for the study....

This study examined the comparative effect of exposure to inhalation of Kerosene, Diesel, Petrol and a mixture of kerosene, diesel and petrol on liver function of male albino rats. The serum liver enzymes ALT, AST and ALP increased in all the test animals exposed to inhalation of the petroleum products when compared to the control. ALT increased si...

We examined the lipid profile and haematological effects of ethanolic leaf extract of Gongronema latifolium against acetaminophen-induced toxicity in albino rats. The serum concentrations of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein were determined using auto-analizer, while the haematological parameters...

This study examined the histological and hepatoprotective effects of ethanolic leaf extract of Gongronema latifolium Benth in acetaminophen-induced hepatic toxicity in male albino rats. The serum liver enzymes ALT, AST and ALP decreased significantly (p≤0.05) in all the test animals treated with the leaf extract compared to the negative control. AL...

This paper examined the influence of Lokpa cattle market waste on soil properties. Soil samples were collected from the Central, 3 and 6 m Northwards, Southwards, Eastwards and Westwards of Lokpa cattle market, Umuneochi Local Government Area of Abia State, Nigeria at a depth of 0 to 25 cm (Sample A) and 26 to 50 cm (Sample B) from each spot while...

This paper examined the influence of Lokpa cattle market waste on soil properties. Soil samples were collected from the Central, 3 and 6 m Northwards, Southwards, Eastwards and Westwards of Lokpa cattle market, Umuneochi Local Government Area of Abia State, Nigeria at a depth of 0 to 25 cm (Sample A) and 26 to 50 cm (Sample B) from each spot while...

The effect of aqueous extract of Piper guineense seeds on some liver enzymes, antioxidant enzymes and some hematological parameters in albino rats was investigated. Thirty female albino rats, aged 7 weeks and weighing between 128g to 142g were randomly placed into three groups of 10 animals each. Group1 served as control and received no extract exc...

Heavy metal concentration of soil and selected root crops cassava, yam, cocoyam and potato from three mining areas of Ishiagu, Ebonyi State were Evaluated. Heavy metals were analysed using Atomic absorption spectrophotometer (AAS). Results showed that lead (Pb) concentration of soil samples raged from 1.12±0.01a - 2.05±0.01c, Cadmium 0.46±0.02a – 0...

This paper aimed to study the antioxidant properties of two Nigerian plants Psidium guajava (guava) Myrtaceae and Aloe vera Liliaceae plants which have a broad application in phytomedicine. The plants were assessed by quantifying their individual chemical contents and their 1:1 (mass/mass) homogenous combination (guava+A. vera) simultaneously. The...

This study examined the biochemical effects and antioxidant activities of methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymes ALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. ALT decreased from 35.38...