Chih-Wei Peng

Chih-Wei Peng
Taipei Medical University | TMU · School of Biomedical Engineering, College of Biomedical Engineering

PhD

About

120
Publications
14,781
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1,359
Citations
Citations since 2017
64 Research Items
746 Citations
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2017201820192020202120222023050100150200

Publications

Publications (120)
Article
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Foot drop is a common clinical gait impairment characterized by the inability to raise the foot or toes during walking due to the weakness of the dorsiflexors of the foot. Lumbar spine disorders are common neurogenic causes of foot drop. The accurate prognosis and treatment protocols of foot drop are not well delineated in the scientific literature...
Preprint
Full-text available
Background After stroke, patients often experience lower limb motor deficits that interrupt their balance and gait functions and thereby lead to a high risk of falls. Sustained gait impairment can restrict participation in the activities listed in the International Classification of Functioning, Disability and Health model and poor quality of life....
Article
The problem of decreased balance caused by injury, illness, or aging is becoming increasingly prevalent in society. The traditional functional balance assessment method is highly time-consuming and inefficient, as well as being susceptible to measurement errors caused by personal subjective factors. This study proposes a system that can rapidly, co...
Article
Behavioral flexibility (or set-shifting), which is regulated by the prefrontal cortex (PFC), is often impaired in patients with attention-deficit/hyperactivity disorder (ADHD), which is characterized by poor inhibitory control and reinforcement learning. Transcranial direct current stimulation (tDCS) has been proposed as a means of noninvasive brai...
Article
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Background: Bladder dysfunction is a common non-motor disorder in Parkinson's disease (PD). This study attempted to determine the bladder dysfunction with disease progression in the PD rat model produced from unilateral/bilateral injections of 6-hydroxydopamine (6-OHDA). Methods: Cystometrographic (CMG) and external urethral sphincter electromyo...
Article
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Various infarct sizes induced by middle cerebral artery occlusion (MCAO) generate inconsistent outcomes for stroke preclinical study. Monitoring cerebral hemodynamics may help to verify the outcome of MCAO. The aim of this study was to investigate the changes in brain tissue optical properties by frequency-domain near-infrared spectroscopy (FD-NIRS...
Article
Background High-definition transcranial electrical theta burst superimposing direct current stimulation (HD-tDCS-eTBS) not only incorporates the therapeutic advantages of tDCS and TBS but enhances stimulation focality and practicality. However, the applicability of this innovative neuromodulatory device in post-stroke rehabilitation remains uncerta...
Article
Despite a single drug, Aducanumab, recently approved by the U.S. Food and Drug Administration for Alzheimer’s disease (AD)-modifying treatments, the development of non-invasive, highly sensitive, and early screening devices to halt the disease remains a critical challenge. In this study, an electrochemical biosensor for amyloid-β (42) oligomers (Aβ...
Article
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Almost one-fifth of the people in the world experience a decrease in quality of life due to overactive bladder (OAB) syndrome. The main bothersome symptoms are urgency accompanied by urinary frequency and nocturia. This chronic, disabling condition is first managed by reducing fluid intake and pelvic floor muscle training, supplemented with antimus...
Article
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Paired stimulation of the brain and spinal cord can remodel the central nervous tissue circuitry in an animal model to induce motor neuroplasticity. The effects of simultaneous stimulation vary according to the extent and severity of spinal cord injury. Therefore, our study aimed to determine the significant effects on an incomplete SCI rat brain a...
Article
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This systematic review and meta-analysis investigated the effect of phonophoresis when various gel types were used. Medline (using PubMed), EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) were used to search for relevant studies from the date of their inception to June 28, 2021. We included studies that were randomized controll...
Article
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The aims of this study were (1) to compare the effect of robot-assisted gait orthosis (RAGO) plus conventional physiotherapy with the effect of conventional therapy alone on functional outcomes, including balance, walking ability, muscle strength, daily activity, and cognition, in chronic stroke patients, and (2) to determine the association of adj...
Article
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Intermittent theta burst (iTBS) powered by direct current stimulation (DCS) can safely be applied transcranially to induce neuroplasticity in the human and animal brain cortex. tDCS-iTBS is a special waveform that is used by very few studies, and its safety needs to be confirmed. Therefore, we aimed to evaluate the safety of tDCS-iTBS in an animal...
Article
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Smart fabrics that can harvest ambient energy and provide diverse sensing functionality via triboelectric effects have evoked great interest for next‐generation healthcare electronics. Herein, a novel borophene/ecoflex nanocomposite is developed as a promising triboelectric material with tailorability, durability, mechanical stability, and flexibil...
Article
Background/Purpose Paired stimulation can cause neuroplasticity in corticospinal and spinal pathways in subjects with a chronic spinal cord injury (SCI). We aimed to know the effects of different waveforms using paired stimulations with bicycling in subjects with a chronic SCI. Methods Recruited subjects with an SCI underwent three treatment inter...
Article
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Objective Cortical electrical stimulation (CES) can modulate cortical excitability through a plasticity-like mechanism and is considered to have therapeutic potentials in Parkinson’s disease (PD). However, the precise therapeutic value of such approach for PD remains unclear. Accordingly, we adopted a PD rat model to determine the therapeutic effec...
Article
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Oxygen consumption (VO2) during strength training can be predicted through surface electromyography (sEMG) of local muscles. This research aimed to determine relations between VO2 and sEMG of upper and lower body muscles to predict VO2 from sEMG during moderate-intensity strength training exercises. Of the 12 participants recruited, 11 were divided...
Article
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Falls are the second leading cause of death from unintentional injuries in older adults. Although many systems have been used to detect falls, they are limited by the computational complexity of the algorithm. The images taken by the camera must be transmitted through a network to the back-end server for calculation. As the demand for Internet of T...
Article
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Transcranial temporal interference stimulation (tTIS) has been proposed as a new neuromodulation technology for non-invasive deep-brain stimulation (DBS). However, few studies have detailed the design method of a tTIS device and provided system validation. Thus, a detailed design and validation scheme of a novel tTIS device for animal brain stimula...
Article
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Repetitive transcranial magnetic stimulation (rTMS) is a popular noninvasive technique for modulating motor cortical plasticity and has therapeutic potential for the treatment of Parkinson’s disease (PD). However, the therapeutic benefits and related mechanisms of rTMS in PD are still uncertain. Accordingly, preclinical animal research is helpful f...
Article
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Energy expenditure through metabolic equivalent (MET) prediction during resistance exercises in humans can be modeled by using cardiorespiratory parameters. In this study, we aimed to predict MET during six moderate-intensity resistance training sessions consisting of three different exercises. Eleven participants were recruited into two groups; an...
Article
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Objective: Non-invasive brain stimulation has been promoted to facilitate neuromodulation in treating neurological diseases. Recently, high-definition (HD) transcranial electrical stimulation and a novel electrical waveform combining a direct current (DC) and theta burst stimulation (TBS)-like protocol were proposed and demonstrated high potential...
Preprint
Full-text available
Phonophoresis is an alternative treatment for knee osteoarthritis. However, evidence supporting the advantages of phonophoresis remains inconsistent. This systematic review and meta-analysis was conducted to illustrate the effect of phonophoresis. The PubMed, Cochrane Library, and Embase databases were searched for relevant studies from the date of...
Article
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Energy expenditure during weight training exercises produces great fitness and health benefits for humans, but few studies have investigated energy expenditure directly during weight training. Therefore, in this study, we aimed to determine energy costs during three training sessions consisting of three different exercises. Ten participants were ra...
Article
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Paired associative nerve stimulation (PANS) was proposed as a potential nerve rehabilitation treatment strategy. However, few relevant documents are available regarding the strategy, and only a few clinical studies have involved healthy people. To determine the feasibility of the neurorehabilitation treatment and to estimate the effect of PANS on n...
Article
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Background Transcranial direct current stimulation (tDCS) and intermittent theta burst stimulation (iTBS) were both demonstrated to have therapeutic potentials to rapidly induce neuroplastic effects in various rehabilitation training regimens. Recently, we developed a novel transcranial electrostimulation device that can flexibly output an electric...
Article
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The development of minimally invasive and easy-to-use sensor devices is of current interest for ultrasensitive detection and signal recognition of Alzheimer's disease (AD) biomarkers. Over the years, tremendous effort has been made on diagnostic platforms specifically targeting neurological markers for AD in order to replace the conventional, labor...
Article
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Traumatic brain injury leads to major brain anatomopathological damages underlined by neuroinflammation, oxidative stress and progressive neurodegeneration, ultimately leading to motor and cognitive deterioration. The multiple pathological events resulting from traumatic brain injury can be addressed not by a single therapeutic approach, but rather...
Article
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We investigated the effects of intermittent theta-burst stimulation (iTBS) on locomotor function, motor plasticity, and axonal regeneration in an animal model of incomplete spinal cord injury (SCI). Aneurysm clips with different compression forces were applied extradurally around the spinal cord at T10. Motor plasticity was evaluated by examining t...
Article
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Objective : Individuals with different severities of traumatic brain injury (TBI) often suffer long-lasting motor, sensory, neurological, or cognitive disturbances. To date, no neuromodulation-based therapies have been used to manage the functional deficits associated with TBI. Cortical electrical stimulation (CES) has been increasingly developed f...
Article
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Myofascial pelvic pain (MFPP) of pelvic floor muscles is a common cause of chronic pelvic pain (CPP). The pathological mechanisms and treatments of MFPP are complex and still unclear until now. The levator ani muscle (LAM) is the major pelvic floor muscle. The purpose of this study was to examine the fascia and attachment of LAM through the electro...
Article
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Background: A cylindrical piezoelectric element and a specific multi-channel circular microelectromechanical systems (MEMS)-transducer array of ultrasonic system were used for ultrasonic energy generation and ablation. A relatively long time is required for the heat to be conducted to the target position. Ultrasound thermal therapy has great poten...
Article
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The system designed in this study involves a three-dimensional (3D) microelectronic mechanical system chip structure using DNA printing technology. We employed diverse diameters and cavity thickness for the heater. DNA beads were placed in this rapid array, and the spray flow rate was assessed. Because DNA cannot be obtained easily, rapidly deployi...
Article
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Bladder dysfunction is a common phenomenon in Parkinson's disease (PD) patients. A research attempt was made to analyze the voiding efficiency (VE) and bladder functions in rats with PD induced by unilateral or bilateral injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. PD rats were divided into unilateral-and bilateral-inj...
Article
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In this study, a medical grade pulse rate (PR) instrument was used to monitor hemodialysis patients, and the wearable product was applied for the 4 h observation. Electrocardiogram (ECG) and photoplethysmography (PPG) data were simultaneously collected to observe physiological phenomena in patients undergoing hemodialysis. The analyzed results of 3...
Article
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Objective: Traumatic brain injuries (TBIs) are a prime public health challenge with a high incidence of mortality, and also reflect severe economic impacts. One of their severe symptoms is bladder dysfunction. Conventional therapeutic methods are not effective in managing bladder dysfunction. Henceforth, a research endeavor was attempted to explor...
Presentation
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This Scientific Report 2020-2021 presents the main research activities carried out by the Professors and research teams of the College of Biomedical Engineering at Taipei Medical University, Taipei, Taiwan. The report highlights the main research focus of the College in the fields of (a) Biomedical Materials and Tissue Engineering, (b) Nanomedicine...
Article
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Many mini-implantable devices have been developed and fabricated for diagnostic and treatment purposes. Wireless implantable biomicrosystems provide a desirable approach for long-term physiological signal monitoring. In this study, we implemented a wireless implantable biomicrosystem for bladder-cavity pressure measurements in a freely moving rabbi...
Article
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Background: This study aimed to evaluate the effectiveness of a customized interactive video game-based (IVGB) training on balance in older adults with mild-to-moderate Parkinson's disease (PD). Methods: In this 12-week crossover trial, PD patients ≥65 years of age were randomly divided into Group A (a 6-week intervention phase followed by a 6-w...
Article
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Parkinson’s disease (PD) is one of the common long-term degenerative disorders that primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals with PD and often present before motor symptoms. It has been found that gut dysbiosis to PD pathology is related to the severity of motor and non-motor symptoms in PD. Probiotic...
Article
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The neurorestorative efficacy of human platelet lysates in neurodegenerative disorders is still under investigation. Platelets prepared from standard and pathogen reduced platelet concentrates were pelletized, washed, concentrated, and subjected to freeze-thawing. The lysate was heated to 56°C for 30 min and characterized. Toxicity was evaluated us...
Article
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Background Transcranial direct current stimulation (tDCS) has been proven to be able to modulate motor cortical plasticity might have potential as an alternative, adjunctive therapy for Parkinson’s disease (PD). However, the efficacy of tDCS in PD is still uncertain. A disease animal model may be useful to clarify the existence of a treatment effec...
Article
Full-text available
Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help t...
Article
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Background/purpose: Few studies have investigated the effects of changing the amplitude of dorsal genital nerve stimulation (GNS) on the inhibition of neurogenic detrusor overactivity in individuals with spinal cord injury (SCI). The present study determined the acute effects of changes in GNS amplitude on bladder capacity gain in individuals with...
Article
Recently, a specific repetitive transcranial magnetic stimulation (rTMS) waveform, namely the theta burst stimulation (TBS) protocol, has been proposed for more efficiently inducing neuroplasticity for various clinic rehabilitation purposes. However, few studies have explored the feasibility of using the TBS combined with direct current (DC) wavefo...
Article
Full-text available
Purpose. This study evaluated the effects of interactive video game-based (IVGB) exercise on balance in diabetic patients with peripheral neuropathy. Materials and Methods. Twenty-four patients were randomly assigned to two groups (12 participants per group). Group A received IVGB training for the first 6 weeks, with no exercise in the subsequent 6...
Article
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Objective Traumatic brain injury (TBI) is a global scenario with high mortality and disability, which does not have an effectual and approved therapy till now. Bladder dysfunction is a major symptom after TBI, and this study deals with the alleviation of bladder function in TBI rats, with the aid of deep brain stimulations (DBS). Methods TBI was i...
Presentation
According to the Times Higher Education (THE) Asia University Ranking 2018, Taipei Medical University continues to improve its ranking to reach now the 83th place. Our College of Biomedical Engineering was for the first time listed in the top 150-200 biomedical engineering academic institutes in the world in the ARWU ranking, after only 3 years of...
Article
Introduction/Background Neurogenic bladder, a condition associated with spinal cord injury (SCI), is characterized by uninhibited bladder contractions in response to bladder filling; these contractions reduce bladder capacity and urinary continence. Few studies have investigated the amplitude-dependent effects of dorsal genital nerve stimulation (G...
Article
Full-text available
This study proposes a modular data glove system to accurately and reliably capture hand kinematics. This data glove system’s modular design enhances its flexibility. It can provide the hand’s angular velocities, accelerations, and joint angles to physicians for adjusting rehabilitation treatments. Three validations—raw data verification, static ang...
Article
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Falls are a major health concern leading cause of fatal and non-fatal injuries for neurological disorders. Balance dysfunction is one of the common factors to determine fall risk in neurological patients. Preventative measures may help to reduce the incidence and severity of falls for detecting balance function and fall risk factors. However, the o...
Presentation
Full-text available
There are exciting research topics at the College of Biomedical Engineering of Taipei Medical University for Foreign MS and PhD students.We have several international MS and PhD programs in Biomedical Engineering covering Biomedical Materials and Tissue Engineering, Nanotechnologies and Medical Engineering, and Bio-Optomechatronics. Teaching is 100...
Article
Traumatic brain injury (TBI) typically causes permanent brain tissue damage, which leads to permanent severe voiding dysfunction. Urinary retention is often refractory to standard therapies, and most patients require self-catheterization, which results in frequent urinary tract infections and reduces quality of life. Deep brain stimulation (DBS) mi...
Article
Objective: To evaluate the feasibility of deep brain stimulation (DBS) and compare the potential of four DBS targets in rats for regulating bladder activity: the periaqueductal gray (PAG), locus coeruleus (LC), rostral pontine reticular nucleus (PnO), and pedunculopontine tegmental nucleus (PPTg). Methods: A bipolar stimulating electrode was imp...
Article
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Objective Traumatic brain injury (TBI) is a major brain injury type commonly caused by traffic accidents, falls, violence, or sports injuries. To obtain mechanistic insights about TBI, experimental animal models such as weight-drop-induced TBI in rats have been developed to mimic closed-head injury in humans. However, the relationship between the m...