Chien-Yeh Hsu

Taipei Medical University | TMU

Patients with chronic obstructive pulmonary disease (COPD) are at higher risk of stroke. This study aimed to investigate the clinical factors of stroke risk in COPD and allied conditions patients and associations between medications for treating COPD and allied conditions. The population-based study cohort comprised 24,173 patients diagnosed with C...

Patients at risk of chronic kidney disease (CKD) must be identified early and precisely in order to prevent complications, save lives, and limit expenditures for patients and health systems. This study aimed to develop a simple, high-precision machine learning model to identify individuals at risk of developing CKD in the near future, using a novel...

Many people suffer from Chronic Kidney Disease (CKD). Nowadays, CKD is one of the top ten causes of death. CKD should via invasive examination to understand participants health status. If a non-invasive identification model can be established, it can provide users with self-assessment which let users quickly understand their physical condition. Thi...

In the analysis of medical data, it is now important to use “Real-World Data (RWD)”. In the past, clinical research in the medical field was often completed by clinical trials. Clinical trials are a kind of use of listed drugs and comfort according to research objectives. The process of comparing drugs or other medical treatments on subjects as a c...

In Taiwan, diseases with cardiovascular include heart disease and cerebrovascular disease among the top ten causes of death. With the development of data mining in the medical field, it can be used to establish the risk prediction models of disease as a tool to assist physicians in decision-making in diagnosis.The purpose of this study is taking Ta...

Unhealthy diet and inappropriate lifestyle contribute to an imbalance in cardiometabolic profiles among postmenopausal women. This research aimed to analyze the association between dietary pattern and changes in cardiovascular risk factors among postmenopausal Taiwanese women using binary logistic regression. This cross-sectional study involved 568...

Anemia and dyslipidemia often occurs in premenopausal women. This study investigated the association between dietary patterns and anemia among dyslipidemic women in Taiwan. This study recruited 22,631 dyslipidemic women aged 20–45 years between 2001 and 2015. The dietary assessment was collected by a validated food frequency questionnaire. The bioc...

Background : Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson's disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension. Methods : This retrospective coho...

(1) Background: Nutritional intake is fundamental to human growth and health, and the intake of different types of nutrients and micronutrients can affect health. The content of the diet affects the occurrence of disease, with the incidence of many diseases increasing each year while the age group at which they occur is gradually decreasing. (2) Me...

(1) Background: Cancer has been the leading cause of death in Taiwan for 39 years, and among them, pancreatic cancer has been ranked seventh in the top ten cancer mortality rates for the past three years. While the incidence rate of pancreatic cancer is ranked at the bottom of the top 10 cancers, the survival rate is very low. Pancreatic cancer is...

Pancreatic cancer is one of the cancers that are not easy to detect early due to the lack of obvious disease characteristics in the early stage, the tumor is mostly located in the posterior abdominal cavity, and the lack of early diagnosis tools. Therefore, when it is diagnosed, it is often approaching the late stage. In recent years, the studies o...

Background and objectives: Insulin resistance (IR) is frequently associated with chronic low-grade inflammation and has an important role as a mediator in the development of liver disease. Thus, this study aimed to explore the relationship between two indexes of IR and abnormal liver function parameters. Materials and Methods: This cross-sectional...

Background and Objective COVID-19, a serious infectious disease outbreak started in the end of 2019, has caused a strong impact on the overall medical system, which reflects the gap in the volume and capacity of medical services and highlights the importance of clinical data ex-change and application. The most important concerns of medical records...

Background Anemia and electrolyte disturbances are adverse outcomes of chronic kidney disease (CKD). This study explored the association between metabolic parameters with anemia and electrolyte and mineral disorders among CKD patients in Taiwan. Methods This cross-sectional study with a total of 2176 CKD stages 3–5 patients were collected from the...

While diet and lifestyle are independently implicated in the etiology of liver disease, the interaction of diet and lifestyle may be more helpful for determining the risk of liver abnormality. Thus, our study aimed to evaluate the interaction between the dietary pattern associated with liver biomarkers and lifestyle factors among Taiwanese adults w...

Background: The Coronavirus Disease 2019 (COVID-19) is an ongoing global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2). As of June 2021, five emergency vaccines are available for COVID-19 prevention and with the improvement of vaccination rates and the resumption of activities in each country, verification of...

BACKGROUND COVID-19 is an ongoing global pandemic caused by SARS-CoV-2. As of June 2021, 5 emergency vaccines were available for COVID-19 prevention, and with the improvement of vaccination rates and the resumption of activities in each country, verification of vaccination has become an important issue. Currently, in most areas, vaccination and rev...

Objectives The aim of this study was to investigate the association of lifestyle factors with the risk of anemia among adults in Taiwan. Methods This cross sectional study included 118,924 (43,055 men and 75,869 women) participants aged 20–45 years, who had health examination including blood tests, anthropometric measurements, and questionnaires t...

Recently, the role of lifestyle factors in testicular function has developed into a growing area of interest. Based on cross-sectional data on 3283 Taiwanese men, we investigated whether interactive effects of unhealthy lifestyle behaviors were associated with testicular function. The men were recruited from a private screening institute between 20...

Background and Objectives The nursing assessment in the psychiatric department differ from those used in other departments considerably. We developed a psychiatric knowledge-based clinical decision support system (Psy-KBCDSS), which may aid nurses in solving patients’ problems in the psychiatric department. In addition, we compared the sensitivity...

Inadequate dietary intake, poor nutritional status, heavy smoking, and alcohol consumption are associated with the risk of anemia. The objective of this study was to investigate the associations between dietary patterns, lifestyle, nutritional status, and anemia-related biomarkers among adults using a multivariable regression model. Taiwanese adult...

We investigated the association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting glucose in Taiwan. A total of 15,005 subjects (5452 men and 9553 women) aged 35–69 years were selected. Two major dietary patterns were identified by principal component analysis: Western dietary pattern and Medi...

Background The use of dihydropyridine calcium channel blockers (DCCBs) was proposed to reduce the risk of Parkinson's disease (PD). This study aimed to evaluate the association between DCCB and its dose effect and the risk of PD in patients with newly diagnosed hypertension. Methods This population-based retrospective cohort study enrolled 107,207...

Cancer is the leading cause of death in Taiwan. According to the Cancer Registration Report of Taiwan’s Ministry of Health and Welfare, a total of 13,488 people suffered from lung cancer in 2016, making it the second-most common cancer and the leading cancer in men. Compared with other types of cancer, the incidence of lung cancer is high. In this...

We evaluated the interactive effects of nutrition education (NE) and lifestyle factors on kidney function parameters and cardiovascular risk factors among chronic kidney disease (CKD) patients. This cross-sectional cohort study recruited 2176 CKD stages 3–5 patients aged > 20 years from Integrated Chronic Kidney Disease Care Network, Shuang Ho Hosp...

Diets could play an important role in testicular function, but studies on how adherence to the dietary patterns that influence human testicular function in Asian countries are scarce. Herein, we examined the association between testosterone-related dietary patterns and testicular function among adult men in Taiwan. This cross-sectional study recrui...

Personal health records (PHRs) have lots of benefits for things such as health surveillance, epidemiological surveillance, self-control, links to various services, public health and health management, and international surveillance. The implementation of an international standard for interoperability is essential to accessing personal health record...

This study explored the association between dietary patterns and kidney function parameters in adults with metabolic syndrome in Taiwan. This cross-sectional study was undertaken in 56,476 adults from the health screening centers in Taiwan from 2001 to 2010. Dietary intake and dietary patterns were assessed using a food frequency questionnaire and...

Background COVID-19 has affected more than 180 countries and is the first known pandemic to be caused by a new virus. COVID-19’s emergence and rapid spread is a global public health and economic crisis. However, investigations into the disease, patient-tracking mechanisms, and case report transmissions are both labor-intensive and slow. Objective...

Background Dietary patterns were associated with the risk of chronic disease development and outcome-related diseases. In this study, we aimed to compare the correlation between dietary patterns and metabolic syndrome (MetS) using two methods for identifying dietary patterns. Methods The participants ( n = 25,569) aged ≥40 years with impaired kidn...

BioScience Trends (BST) is a peer-reviewed journal belongs to the International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA) Group of Japan. Despite a decade of existence, no study was performed to measure the bibliometric profile of the journal. The objective of this study was to investigate the bibliometri...

Cancer is the leading cause of death in Taiwan, according to the Ministry of Health and Welfare (2017), with cancers of the trachea, bronchus, and lung being the most prevalent. Thus, it is critically important to study this disease. By using Taiwan’s National Health Insurance Research Database (NHIRDB), which covers 99.9% of residents, we are capa...

Because of the increasing adoption and use of technology in primary health care (PHC), public health informatics competencies (PHIC) are becoming essential for public health workers. Unfortunately, no studies have measured PHIC in resource-limited setting. This paper describes the process of developing and validating Public Health Informatics Compe...

BACKGROUND COVID-19 has affected more than 180 countries and is the first known pandemic to be caused by a new virus. COVID-19’s emergence and rapid spread is a global public health and economic crisis. However, investigations into the disease, patient-tracking mechanisms, and case report transmissions are both labor-intensive and slow. OBJECTIVE...

Background: Dietary patterns were associated with the risk of chronic disease development and outcome-related diseases. In this study, we aimed to compare the correlation between dietary patterns and metabolic syndrome (MetS) using two methods for identifying dietary patterns. Methods: The participants (n = 25,569) aged ≥ 40 years with impaired kid...

Background: Dietary patterns were associated with the risk of chronic disease development and outcome-related diseases. In this study, we aimed to compare the correlation between dietary patterns and metabolic syndrome (MetS) using two methods for identifying dietary patterns. Methods: The participants (n = 25,569) aged ≥ 40 years with impaired kid...

Background Dietary patterns were associated with the risk of chronic disease development and outcome-related diseases. In this study, we aimed to compare the correlation between dietary patterns and metabolic syndrome (MetS) using two methods for identifying dietary patterns. Methods The participants (n = 25,569) aged ≥ 40 years with impaired kidne...

Background Hypokalemia is a common clinical problem. The association between urinary tract infection (UTI) and hypokalemia is not clear. Hypokalemia is common in patients with UTI in clinical observation. The aim of the study is to determine if UTI is associated with hypokalemia. Methods Patients hospitalized with UTI and the control group were re...

According to the health promotion administration ministry of health and welfare, Taiwan latest cancer registration report in 2016, 2,202 people were diagnosed with pancreatic cancer and 1,996 died of pancreatic cancer. It ranks 8th in the male and 5th in the female of cause of cancer death. Compared with other cancers, the incidence of pancreatic c...

Until the present moment, most of the medical records are only stored in hospitals. The hospital systems are still in Electronic Medical Records and haven’t developed into Personal Health Records yet to let people manage their own health records. If there is no medical record exchange between hospitals, it may cause a lot of medical resources waste...

The proportion of China’s 65-year-old population has increased year by year. As we enter old age, people’s average life expectancy increases year by year. The risk of disease in the elderly population increases. According to the statistics of the Ministry of Health and Welfare of Taiwan, most people over the age of 65 suffer from cancer and heart d...

Background: The increasing prevalence of obesity has become a pandemic problem, and dietary patterns are one of the important factors causing obesity. Although the correlation between dietary patterns and obesity has been well explored, the gender difference on the association between dietary patterns and obesity remains unclear. The objective of...

Background: Lifestyle factors were associated with an increased risk of cardiovascular disease (CVD) occurrence. We explored the associations between lifestyle factors and CVD risk factors, and assessed the interactive effects of lifestyle factors on CVD risk factors. Methods: A cross-sectional data of 114,082 (57,680 men and 56,402 women) middl...

BACKGROUND PHR security, correctness and protection is essential to health and medical services. Blockchain architecture can provide efficiency of data retrieval and security requirements. Exchangeable PHR and self-management of health by patient can offer many benefits to the traditional medical service, allowing people to manage their own health...

Background Personal health record (PHR) security, correctness, and protection are essential for health and medical services. Blockchain architecture can provide efficient data retrieval and security requirements. Exchangeable PHRs and the self-management of patient health can offer many benefits to traditional medical services by allowing people to...

Dyslipidemia, anemia, and inflammation are associated with declined kidney function. This study investigated the association of inflammatory dietary pattern with dyslipidemia, anemia, and kidney function biomarkers among middle-aged and older Taiwanese adults with declined kidney function. Biochemical data and food frequency questionnaire were obta...

The study determined the association of sleep duration and insomnia symptoms with the components of metabolic syndrome and inflammation in middle-aged and older adults with metabolic syndrome in Taiwan. This cross-sectional study used the database compiled in Taiwan between 2004–2013. A total of 26,016 volunteers aged 35 years and above were select...

Background: Chronic Kidney Disease (CKD), characterized by an impaired kidney function, is associated with low testosterone levels. This study investigated the association between dietary patterns, testosterone levels, and severity of impaired kidney function among middle-aged and elderly men. Methods: This cross-sectional study used the databas...

Background Lifestyle factors were associated with an increased risk of cardiovascular disease (CVD) occurrence. We explored the associations between lifestyle factors and CVD risk factors, and assessed the interactive effects of lifestyle factors on CVD risk factors. Methods A cross-sectional data of 114,082 (57,680 men and 56,402 women) middle-age...

Background/objectives: Aging is an imperative problem for many countries in this century, and presents several challenges for the maintenance of good nutritional status. This study aims to assess the impact of socio-demographic factors, lifestyle and health status on the nutritional status among the elderly in Taiwan. Subjects/methods: A cross-s...

Low adherence to leprosy treatment is the main challenge in Indonesia. This is a quasi-experimental observational study in a real setting of a leprosy control program in Indonesia. The study is aimed at evaluating an e-leprosy framework in increasing the rate of on-time attendance at primary health care and on-time completion of treatment of lepros...

According to statistics of the Ministry of Health and Welfare (Taiwan) in 2016, the first of Top Ten causes of death was cancer. In this category, percentages of trachea, bronchus and lung cancer were the highest. Thus, it is particularly important to study the disease. Coverage rate of national health insurance in Taiwan is up to 99.6%. Database o...

Abstract Background Chronic Kidney Disease (CKD), characterized by impaired kidney function, affects over 1.5 million individuals in Taiwan. Cardiovascular disease (CVD) is commonly found in patients with CKD, and the increased prevalence of obesity can have some implications for the risk of both CKD and CVD. Since diet plays an important role in t...

Dietary patterns have been proposed to be related to dyslipidemia and hyperglycemia. This study investigated the correlation of dietary patterns with components of dyslipidemia and fasting plasma glucose (FPG) among young and middle-aged adults (aged between 20 and 50 years) with dyslipidemia and abnormal FPG in Taiwan. This cross-sectional study u...

BACKGROUND Nursing assessments used in the psychiatry department considerably differ from those used in other departments. OBJECTIVE We developed a psychiatric knowledge-based clinical decision support system (Psy-KBCDSS) to help nurses in assessing patients’ problems. In addition, we evaluated the sensitivity and specificity of the Psy-KBCDSS and...

Abstract Background Metabolic syndrome is commonly associated with inflammation. The underlying factors of inflammation in metabolic syndrome are not fully understood. The objective of the study was to determine the association of dietary patterns, anthropometric measurements, and metabolic parameters with inflammatory markers in middle-aged and ol...

Osteoporosis and atrial fibrillation (AF) are common in post-menopausal women. Vitamin D and bisphosphonates are widely used to treat osteoporosis, and these may have different effects on the risk of AF.The goal of this study was to evaluate whether different agents for treating osteoporosis modulate the risk of AF in a population-based database.We...

Leprosy is one of the listed neglected tropical diseases which is continuing as a major health problem in Indonesia. Low adherence to Multi-Drug Therapy (MDT) against leprosy is still a significant obstacle in disease control, as the defaulters with incomplete cure remain as potential sources of infection, lead to patients' irreversible complicatio...

Background: Whether renal transplantation (RT) influences the risk of cardiovascular events remains controversial. Methods: This nationwide population-based study investigated the risk of major adverse cardiac events (MACEs) and stroke after RT in patients with end-stage renal disease (ESRD), using data obtained from the National Health Insuranc...

Since the first ambulance has been introduced to Taiwan, the members of fire departments have been dedicating themselves to emergency service training. Though all the emergency rescue measures have been improved, the causes and problems of Out-of Hospital-cardiac Arrest (OHCA) caused are still actively being explored by the experts from emergency m...

Since the National Health Insurance was applied in 1995, the main goal was to offer better medical care to the general public, and to reduce the medical fare as well. Even with the general influenza, the general public would rather choose large medical center instead of local clinic since large hospital is recognized as better and more accurate. As...

This study examined the correlation of dietary patterns with components of metabolic syndrome (MetS) and inflammation among middle-aged and older adults with MetS in Taiwan. This cross-sectional study used data from the Mei Jau International Health Management Institution in Taiwan between 2004 and 2013. A total of 26,016 subjects aged 35 years and...

Physically and mentally disabled citizens are just like the general population who have independent human rights, but outside assistance is frequently needed to achieve independency due to the disabilities. An independent life for people with disabilities has gradually become the goal of social promotion. Under the circumstances, the support strate...

Taiwan has been confronted with a serious problem of aging in recent years. The prevalence of the chronic diseases caused by aging is increased continuously, which has led to a high percentage of comorbidity and polypharmacy. The proportion of the elderly people with polypharmacy (over three to five kinds of drugs) is 81%. Under the situation of hi...