Chien-Chang LiaoTaipei Medical University | TMU · Department of Anesthesiology
Chien-Chang Liao
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154
Publications
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Publications
Publications (154)
Objective
Sustained hyperlipidemia contributes to fatty liver and liver cirrhosis. Red yeast rice (RYR) effectively improved the lipid profile; however, the effects of RYR on the risk of incident liver cirrhosis remain to be elucidated. We aimed to evaluate the beneficial effects of RYR use on the risk and outcome of liver cirrhosis.
Patients and...
Objective
To evaluate the postoperative complications and mortality among patients with chronic kidney disease.
Methods
Biochemical measurements, diagnosis codes for CKD and comorbid conditions for surgical patients aged ≥20 years were obtained from electronic medical records of three large hospitals in Taiwan in 2009–2017. We conducted this retro...
Background
Both the size of the older population and the use of complementary and alternative medicine are increasing worldwide. This study evaluated the long-term trend in utilization of traditional Chinese medicine (TCM) and associated factors among older people in Taiwan.
Methods
Using the database of population-based interview surveys, we eval...
Objective
To evaluate the complications and mortality after noncardiac surgeries in patients who underwent previous coronary artery bypass grafting (CABG).
Methods
We used insurance data and identified patients aged ≥20 years undergoing noncardiac surgeries between 2010 and 2017 in Taiwan. Based on propensity-score matching, we selected an adequat...
Background
Previous observational studies have shown that people with dental scaling (DS) had decreased risk of stroke. However, limited information is available on the association between DS and poststroke outcomes. The present study aimed to evaluate the effects of regular DS on the complications and mortality after stroke.
Methods
We conducted...
Background
The influence of recent influenza infection on perioperative outcomes is not completely understood.
Method
Using Taiwan’s National Health Insurance Research Data from 2008 to 2013, we conducted a surgical cohort study, which included 20,544 matched patients with a recent history of influenza and 10,272 matched patients without. The main...
Background:
The incidence of chronic kidney disease is increasing, but most cases are not diagnosed until the accidental finding of abnormal laboratory data or the presentation of severe symptoms. Patients with chronic kidney disease are reported to have an increased risk of postoperative mortality and morbidities, but previous studies mainly targ...
Objective
To evaluate the risk of obesity in preschool children with prolonged screen time in Taiwan.
Methods
Using a nationwide survey with random sampling, we collected information on 8378 preschool children aged 2–6 years among 206 preschools in Taiwan from 2016 to 2019. Socioeconomic data, body mass index, and lifestyle of the preschool childr...
Background
The influence of alcoholic liver disease (ALD) on the postoperative outcomes is not completely understood. Our purpose is to evaluate the complications and mortality after nonhepatic surgeries in patients with ALD.
Methods
We conducted a retrospective cohort study included adults aged 20 years and older who underwent nonhepatic elective...
Cigarette smoking is associated with surgical complications, including wound healing and surgical site infection. However, the association between smoking status and postoperative wound complications is not completely understood. Our objective was to investigate the effect of smoking on postoperative wound complications for major surgeries. Data we...
Objective
The beneficial effect of influenza vaccination (IV) in patients with diabetes was not completely understood.
Methods
Using the research data of health insurance, we performed a cohort study of patients aged ≥ 20 years who were admitted to inpatient care due to diabetes in 2008-2013 in Taiwan. We performed the propensity score matching an...
Patients who previously suffered a stroke have increased risks of mortality and complications after surgeries, but the optimal anesthesia method is not fully understood. We aimed to compare the outcomes after surgeries for stroke patients who received general anesthesia (GA) and neuraxial anesthesia (NA). Using health insurance research data, we id...
Gastroenteritis promotes the development of systemic inflammation and a hypercoagulable state. There are limited data regarding the association between gastroenteritis and acute myocardial infarction (AMI). We aimed to evaluate the risk of AMI after an episode of gastroenteritis. In this nested case-control study, we selected patients who were hosp...
Background and aims
The effects of influenza vaccination (IV) on the outcomes of patients with kidney disease (KD) are not completely understood. We aimed to evaluate and compare the outcomes during admission of KD between elderly patients who did or did not receive an IV within the previous 12 months.
Methods
We used health insurance research dat...
The influence of physician specialty on the outcomes of kidney diseases (KDs) remains underexplored. We aimed to compare the complications and mortality of patients with admissions for KD who received care by nephrologists and non-nephrologist (NN) physicians. We used health insurance research data in Taiwan to conduct a propensity-score matched st...
The association between pancreatitis and acute myocardial infarction or stroke remains incompletely understood. This study aimed to evaluate the long-term risk of acute atherosclerotic cardiovascular disease (ASCVD) in people with acute and chronic pancreatitis. Using research database of Taiwan's National Health Insurance, we identified 2678 patie...
Whether aortic stenosis (AS) increases perioperative risk in noncardiac surgery remains controversial. Limited information is available regarding adequate anesthetic techniques for patients with AS. Using the reimbursement claims data of Taiwan’s National Health Insurance, we performed propensity score matching analyses to evaluate the risk of adve...
The risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we identified 2854 patients with newly diagnosed epilepsy in 2000–2008 from the research data of National Health Insurance in Taiwan. Using Propen...
Background
Little was know about the association between the CHA2DS2-VASc score and postoperative outcomes. Our purpose is to evaluate the effects of CHA2DS2-VASc score on the perioperative outcomes in patients with atrial fibrillation (AF).
Methods
We identified 47,402 patients with AF over the age of 20 years who underwent noncardiac surgeries b...
The impact of heart failure (HF) on postoperative outcomes is not completely understood. Our purpose is to investigate complications and mortality after noncardiac surgeries in people who had HF. In the analyses of research data of health insurance in, we identified 32,808 surgical patients with preoperative HF and 32,808 patients without HF underg...
Background:
The optimal dose and concentration of analgesic efficacy of ropivacaine (RPV) and bupivacaine (BPV) for postoperative pain relief in paediatric abdominal surgery patients is still unclear. Therefore, this meta-analysis compared the efficacy of these analgesics, their administered modes (ultrasound-guided RSB versus LAI) for postoperati...
Background
The utilization of traditional Chinese medicine is a common therapeutic approach for stroke patients in Chinese population, but little is known about the effect of Bu Yang Huan Wu Tang (BYHWT) on post-stroke diabetes.
Purpose
We aimed to evaluate the risk of diabetes in stroke patients who used BYHWT.
Study design
A retrospective cohor...
Objective
To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF).
Methods
We used research data from Taiwan’s National Health Insurance Program from 2000 to 2005 and identified 20,072 adults aged ≥30 years who were newly diagnosed with HF. Frequency matching based on age and sex was used to sel...
Background and aims
Limited information is available regarding the association between statins and pressure ulcers. The purpose of this study is to evaluate the beneficial effects of statins on pressure ulcers in stroke patients.
Methods
Using the claims data of Taiwan's National Health Insurance, we conducted a retrospective cohort study and iden...
Introduction
Limited information was available regarding the perioperative outcomes in patients with and without use of metformin. This study aims to evaluate the complications and mortality after major surgery in patients with diabetes who use metformin.
Research design and methods
Using a real-world database of Taiwan’s National Health Insurance...
Aim
To evaluate outcomes after major surgery in children and adolescents with intellectual disability.
Method
We used 2004 to 2013 claims data from Taiwan's National Health Insurance programme to conduct a nested cohort study, which included 220 292 surgical patients aged 6 to 17 years. A propensity score matching procedure was used to select 2173...
Background: Little was know about the association between the CHA2DS2-VASc score and postoperative outcomes. Our purpose is to evaluate the effects of CHA2DS2-VASc score on the perioperative outcomes in patients with atrial fibrillation (AF).
Methods: We identified 47,402 patients with AF over the age of 20 years who underwent noncardiac surgeries...
Aim:
We aimed to evaluate the long-term risk of dementia in patients with periodontitis and its associated factors.
Materials and methods:
Using Taiwan's National Health Insurance Database, we identified 56018 patients aged ≥50 years with newly diagnosed periodontitis in 2000-2008. A cohort of 56018 adults without periodontitis was selected for...
Background and aims
The effects of physician specialty on the outcome of heart disease remains incompletely understood because of inconsistent findings from some previous studies. Our purpose is to compare the admission outcomes of heart disease in patients receiving care by cardiologists and noncardiologist (NC) physicians.
Methods
Using reimburs...
[This corrects the article DOI: 10.1371/journal.pone.0231374.].
Background and aims
Because the sex difference in outcomes of fracture was incompletely understood, we evaluated the post-fracture complications and mortality of female and male patients.
Methods
We conducted a nationwide study of 498,586 fracture patients who received inpatient care using Taiwan’s National Health Insurance Research Database 2008–...
Objectives:
In the Asian population, patterns and risk factors for de novo malignancies after solid-organ transplant are not well understood.
Materials and methods:
Insurance claims from Taiwan's National Health Institute Research Database from 1997 to 2011 revealed 687 deceased-donor heart transplant recipients, 5038 kidney transplant recipient...
Background:
The impact of liver cirrhosis on the outcomes of admission to intensive care unit (ICU) is not completely understood. Our purpose is to identify risk factors for mortality in ICU patients with liver cirrhosis.
Methods:
Using reimbursement claims from Taiwan's National Health Insurance Research Database from in 2006-2012, 1,250,300 pa...
Objective
This study aimed to evaluate the risk of incident diabetes between people who used lovastatin and red yeast rice (RYR) prescriptions.
Methods
A retrospective cohort study was performed to analyze the real-world database of Taiwan’s National Health Insurance. We identified the RYR cohort, which included 34,504 persons age 20 years or olde...
Background: The impact of liver cirrhosis on the outcomes of admission to intensive care unit (ICU) is not completely understood. Our purpose is to identify risk factors for mortality in ICU patients with liver cirrhosis.
Methods: Using reimbursement claims from Taiwan’s National Health Insurance Research Database from in 2006-2012, 1,250,300 patie...
Objective
Urticaria is a mast cell-related disease caused severe itching and the lifetime prevalence of urticaria is about 20% in general population. Our purpose is to evaluate risk of urticaria in geriatric stroke patients received influenza vaccination (IV).
Methods
In a cohort of 192,728 patients with newly diagnosed stroke aged over 65 years o...
Although previous studies have shown that health checks may improve several risk factors for chronic diseases, the effect of preoperative health checks on postoperative recovery in surgical patients remains unknown. We aimed to investigate the association between preoperative use of mammography and the risk of perioperative complications. We conduc...
Objective
To evaluate the complications, mortality, and medical expenditures after nonurological surgical procedures in patients with chronic kidney disease (CKD).
Methods
Using claims data of Taiwan’s National Health Insurance, we conducted a matched cohort study of 35,643 patients with CKD who underwent nonurological surgeries in 2008–2013. By u...
Background: The association between physician gender and the outcomes of stroke patients is not yet fully understood. The aim of this study was to evaluate outcomes after stroke hospitalization between patients who received female physicians’ care (FPC) vs male physicians’ care (MPC). Methods: We used Taiwan’s National Health Insurance Research Dat...
Background: The impact of liver cirrhosis on the outcomes of admission to intensive care unit (ICU) is not completely understood. Our purpose is to identify risk factors for mortality in ICU patients with liver cirrhosis. Methods: Using reimbursement claims from Taiwan’s National Health Insurance Research Database from in 2006-2012, 1,250,300 patie...
Background:
The association between acupuncture treatment and post-stroke urinary tract infection (UTI) remains incompletely understood.
Objective:
To compare the long-term risks of UTI among stroke patients treated with or without acupuncture treatment.
Methods:
This retrospective cohort study was based on data from the National Health Insura...
Background and aims:
The effects of influenza vaccination (IV) on stroke outcomes are unclear. The purpose of this study is to evaluate the outcomes after stroke in elderly individuals who have received an IV.
Methods:
We used Taiwan's National Health Insurance Research Database 2000-2009 claims data to conduct a nested stroke cohort study inclu...
The impact of diabetes on perioperative outcomes remains incompletely understood. Our purpose is to evaluate post-operative complications and mortality in patients with diabetes. Using the institutional and clinical databases of three university hospitals from 2009–2015, we conducted a matched study of 16,539 diabetes patients, aged >20 years, who...
Objective
To compare the long-term risk of epilepsy in stroke patients who use Bu Yang Huan Wu Tang (BYHWT) and those who do not.
Methods
In the Taiwanese national insurance claims data, we identified newly diagnosed stroke patients receiving inpatient care in the years 2000–2004. Using propensity score-matched pairs to balance the baseline charac...
Background:
The influence of red yeast rice (RYR) on perioperative outcome remains unknown.
Aim:
We aimed to compare the complications and mortality after surgery between patients treated with and without RYR prescription.
Design:
In this surgical cohort study of 3.6 million surgical patients who underwent major inpatient surgeries, 2581 patie...
Background and aims:
The risk of stroke in epileptic patients and the impact of epilepsy history on stroke patients' outcome have not been studied completely. Our purpose is to evaluate whether patients with epilepsy have increased risk of stroke or post-stroke mortality.
Methods:
In Study I, we conducted a retrospective cohort study of 6746 pat...
Background:
The relationship between chronic obstructive pulmonary disease (COPD) and perioperative outcomes remains incompletely understood. Our purpose is to evaluate the features of postoperative adverse outcomes for geriatric surgical patients with chronic obstructive pulmonary disease (COPD) receiving non-thoracic surgeries.
Methods and proc...
Background and aims
Because the risk and outcomes of stroke in patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD) were unclear, we evaluated these risks using a retrospective cohort study and a nested cohort study.
Methods
We used Taiwan’s National Health Insurance Research Database to identify 1378 patients aged ≥20 year...
Background:
Limited information is available on the association between a influenza vaccination and postoperative outcomes.
Methods:
Using Taiwan's National Health Insurance Research Database reimbursement claims data from 2008 to 2013, we conducted a matched cohort study of 16,903 patients over age 66 who received influenza vaccinations and lat...
Limited information is available on the risks of epilepsy after surgery in patients receiving general or neuraxial anaesthesia. Using Taiwan's National Health Insurance Research Database, we identified 1,478,977 patients aged ≥ 20 years who underwent surgery (required general or neuraxial anaesthesia with hospitalisation for more than one day) betw...
Objective
The aim of this study is to evaluate fracture risk and post-fracture outcomes in patients with and without liver cirrhosis (LC).
Design
Retrospective cohort study and nested fracture cohort study.
Setting
This study was based on Taiwan’s National Health Insurance Research Database that included information on: (1) 3941 patients aged 20...
Objective
The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations.
Methods
We identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with C...
Background & aims:
The relationship between stroke and diabetes is not completely understood. This study evaluated diabetes risk and post-diabetes adverse events in patients with stroke.
Methods:
We identified 10,255 adults, newly diagnosed with stroke from 2000 to 2005, using the Taiwan's National Health Insurance Research Database. A compariso...
Objective
To validate the comprehensive features of adverse outcomes after surgery for patients with myasthenia gravis.
Methods
Using reimbursement claims from Taiwan’s National Health Insurance Research Database, we analyzed 2290 patients who received major surgery between 2004 and 2010 and were diagnosed with myasthenia gravis preoperatively. Su...
Objective
To investigate the risk of dementia in patients with stroke who did and did not receive acupuncture treatment.
Design
Retrospective cohort study.
Setting
This study was based on Taiwan’s National Health Insurance Research Database that included patients with stroke hospitalised between 1 January 2000 and 31 December 2004.
Participants...
Background & aims
The association between liver cirrhosis (LC) and stroke is not completely understood. Our purpose is to evaluate stroke risk and post-stroke outcomes in patients with LC.
Methods
We identified 6944 adults aged 20 years and older, newly diagnosed with LC, using the Taiwan's National Health Insurance Research Database from 2000 to...
[This corrects the article DOI: 10.1371/journal.pone.0133064.].
Background
The objective of this study was to investigate the prevalence and factors associated with purchasing Chinese herbal medicine (CHM) without a physician?s prescription among adults. Methods
Using data from the 2005 National Health Interview Survey and National Health Insurance, we identified 16,756 individuals aged 20 years and older. Soci...
Background
The risk and outcomes of stroke in patients with chronic obstructive pulmonary disease exacerbations (COPDe) remain unclear. We examined whether patients with COPDe faced increased risk of stroke or post-stroke outcomes.
Methods
Using Taiwan’s National Health Insurance Research Database, we identified 1918 adults with COPDe and selected...
Objective:
To evaluate outcomes after nonobstetric surgical procedures in pregnant patients.
Methods:
We conducted a retrospective cohort study of 5591 pregnant women who underwent nonobstetric surgical procedures using Taiwan's National Health Insurance Research Database 2008-2012 claims data. Using a propensity score matching procedure, 22,364...
Outcomes after surgeries involving physicians as patients have not been researched. This study compares postoperative adverse events between physicians as surgical patients and nonhealth professional controls.
Using reimbursement claims data from Taiwan's National Health Insurance Program, we conducted a matched retrospective cohort study of 7973 p...
Objective
To investigate the risk of epilepsy in stroke patients receiving and not receiving acupuncture treatment.
Design
Retrospective cohort study.
Setting
This study was based on Taiwan's National Health Insurance Research Database that included information on stroke patients hospitalised between 1 January 2000 and 31 December 2004.
Particip...
Background
An individual's birth month has been associated with allergic diseases, but little is known about the association between birth month and atopic dermatitis (AD). Objective
The aim of this study was to investigate the risk of AD in children born in various months. Methods
Using Taiwan's National Health Insurance Research Database, we cond...
Objective:
Patients with cardiac arrhythmia were more likely to develop stroke than general population. The therapeutic effect of traditional Chinese medicine (TCM) on the risk of stroke in patients with cardiac arrhythmia was unknown. The aim of this study is to investigate the risk of stroke in patients with cardiac arrhythmia receiving TCM.
Me...
Patients with Parkinson disease (PD) were known to have increased risk of complications during hospitalization. The purpose of this study is to validate the global features of postoperative adverse outcomes for patients with PD.
Using reimbursement claims from Taiwan's National Health Insurance Research Database, we conducted a nationwide retrospec...
Outcome after surgery in patients with asthma remains unknown. The purpose of this study is to investigate postoperative major complications and mortality in surgical patients with asthma.
Using reimbursement claims from the Taiwan National Health Insurance Research Database, the authors identified 24,109 surgical patients with preoperative asthma...
Several limitations existed in previous studies which suggested that diabetic patients have increased risk of stroke. We conducted this study to better understand the stroke risk and poststroke outcomes in patients with diabetes.
From the claims data of Taiwan's National Health Insurance, we identified 24,027 adults with new-diagnosed diabetes and...
Ethnopharmacological relevance:
The use of traditional Chinese medicine (TCM) was high in stroke patients but limited information was available on whether TCM is effective on post-stroke outcomes. The aim of this study is to compare the outcomes of stroke patients with and without receiving adjuvant TCM therapy.
Materials and methods:
Using Taiw...