Chibuisi. Gideon. Alimba

Chibuisi. Gideon. Alimba
University of Ibadan · Department of Zoology

PhD

About

90
Publications
63,291
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,212
Citations
Introduction
Lecture Cell Biology and Genetics courses in Department of Zoology, University of Ibadan, Nigeria.

Publications

Publications (90)
Article
Full-text available
Emissions (mainly leachates and landfill gases) from solid waste facilities are laden with mixtures of dangerous xenobiotics implicated with significant increase in various pathophysiological disorders including cancer, and eventual mortality in exposed wildlife and humans. However, the molecular mechanisms of solid waste leachates induce pathophys...
Conference Paper
Full-text available
Mushrooms are undeniably rich in nutritive and therapeutic compounds; nevertheless, they are excellent bio-accumulators of hazardous substances in contaminated conditions. This study aims at investigating the potential human health risk associated with the consumption of mushrooms from two locations in Ibadan, Nigeria. The concentrations of Pb,...
Article
Full-text available
This study aimed at determining in animal model the health effects of in situ exposure to landfill chemicals. We evaluated metal concentrations in tissues and cytogenetic and clinico-biochemical effects in Wistar rats (Rattus norvegicus) exposed in situ at Olusosun landfill in Lagos, Nigeria. Male rats (n = 30/point) were exposed at three different...
Article
Full-text available
Landfill soil leachates, containing myriad of xenobiotics, increase genotoxic and cytotoxic stress–induced cell death. However, the underlying mechanism involved in the elimination of the damaged cells is yet to be fully elucidated. This study investigated the apoptotic processes induced in lymphoma (Jurkat) cells by landfill soil leachates from Ol...
Article
Full-text available
Background Combination of different antimalarials has become the popular method of care for malaria morbidity in conventional and traditional treatment approaches due to the need to increase the efficacy and reduce the selection of drug resistance. A worrisome concern is the critical gaps with regards to the information available on antimalarial he...
Article
Full-text available
Discovering and developing the desired antimalarials continue to be a necessity especially due to treatment failures, drug resistance, limited availability and affordability of antimalarial drugs and costs especially in poor malarial endemic countries. This study investigated the efficacies of two plant cocktails; CtA and CtB, selected based on the...
Article
Full-text available
Contamination of aquatic environment is increasing and has been associated with indiscriminate discharge of solid wastes and effluents generated from industrial, domestic and agricultural activities. These wastes and effluents contain harmful substances, such as metals, which constitute a major problem on the quality of the Nigerian coastal water....
Article
Full-text available
Micro(nano)-plastics (MP/NPs) ubiquity in the environment constitutes the global environmental and toxicological related issues of the 21st century. MP/NPs are now constantly observed in all components of the environment including many human consumer products; sea food, milk, beer, honey, bottle and tap water, salts, tea, drinks, and in human feace...
Preprint
Full-text available
Discovering and developing the desired antimalarials continue to be a necessity especially due to treatment failures, drug resistance, limited availability and affordability of pharmaceutical antimalarials, costs and logistical problems especially in poor malarious countries. This study investigated the efficacies of two plant cocktails; CtA and Ct...
Article
Medicinal plants contain active compounds usually present as complex mixtures though at low concentrations, which accounts for the medicinal properties. Therefore it is important to identify and characterize these compounds. This study aims to quantify and characterize the physicochemical and phytochemical compositions of six plants commonly used i...
Article
Full-text available
Nature. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 mo...
Article
Full-text available
Rapid population growth and poor waste management practice are among the main drivers of plastic pollution in modern times, thus making Africa a hotspot for plastic pollution both now and in the future. This study is a review of plastic pollution reports from the African aquatic environment with regard to causes, current status, toxicological impli...
Article
Full-text available
Chlorfenapyr is a new formulated insecticide targeted against insecticide resistant species. Its application in targeting harmful aquatic insects may potentially contaminate aquatic environment. This study is to evaluate its genotoxic effects on non-targeted aquatic biota. The study assessed the genotoxic potentials of chlorfenapyr in African catfi...
Article
Full-text available
Existing studies have shown the systemic damage of titanium dioxide (TiO2) or zinc oxide (ZnO) nanoparticles (NPs), but there is little or no existing knowledge on the potential adverse toxic effects of the mixture of the two. In order to investigate the in vivo toxic effect of the mixture of TiO2 NPs and ZnO NPs, the acute toxicities of TiO2 NPs,...
Article
The application of titanium dioxide (TiO 2 ) nanoparticles (NPs) in the manufacturing of consumer products has increased tremendously and with the potential to induce deleterious effects on aquatic biota. There have been reports on metal oxide NP toxicity in aquatic organisms, however, information on cytotoxicity and genotoxicity of TiO 2 NPs on th...
Article
In this study, Swiss male mice were intraperitoneally administered with titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) and their mixture (1:1) at doses between 9.38 and 75 mg/kg for 5 weeks to evaluate reproductive toxicity. Both NPs and their mixture significantly (p < .001) altered sperm motility, reduced sperm numbers and incre...
Article
Full-text available
Mixture of xenobiotics in Olusosun landfill leachates (OSL) induced somatic and germ cell genotoxicity in eukaryotic cells. However, whether the DNA-damaged germ cells can increase reproductive failure, embryotoxicity and/or teratogenicity during fertilization remained unclear. The study herein investigated reproductive toxicity and embryotoxic eff...
Article
Full-text available
Exposure to lead (Pb) is a major risk factor in reproductive toxicity, somatic, and germ cell genotoxicity. Exposure via deteriorating Pb paints and contaminated air, soil, and water had been the primary routes. However, with increasing reports of Pb accumulation in mushrooms and other food items may increase the etiology of Pb poisoning. The study...
Article
Full-text available
The combination of antiretroviral (ARV) drugs: lamivudine, tenofovir disoproxil fumarate (TDF) and efavirenz is among the preferred first-line regimens for adolescents and adults infected with HIV. However, knowledge on in vivo genetic and reproductive toxicity of each of these drugs and their combination is limited. We evaluated the genotoxicity o...
Article
Full-text available
Pollution of aquatic ecosystems from anthropogenic activities has heightened in recent times and this has elicited national and international concern on the impacts on aquatic biota. This study investigated the genotoxic effects in C. nigrodigitatus from two polluted lagoons. Micronuclei (MN) test, as an index of chromosomal damage, is widely appli...
Article
The extensive production and utilisation of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) in consumable items may enhance significant increase in fauna and flora exposure. Studies showing the interactive effect of NPs in biological systems are limited. Herein, we showed the cytogenotoxic effects of TiO2 and ZnO NPs, and their mix...
Article
Full-text available
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translate...
Article
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translate...
Article
Full-text available
Concurrent occurrence of chromium (Cr), copper (Cu) and arsenic (As) from chromated copper arsenate (CCA) wood preservative in aquatic ecosystems demands that their joint-actions in eliciting toxic effects be assessed for adequate understanding of the health risk they may pose to biota. Clarias gariepinus was exposed to As2O3, CrO3 and CuO and t...
Article
Full-text available
Unanticipated increase in the use of silver (Ag) and copper oxide (CuO) nanoparticles (NPs) due to their antimicrobial properties is eliciting environmental health concern because of their coexistence in the aquatic environment. Therefore, we investigated the genetic and systemic toxicity of the individual NPs and their mixture (1:1) using the pisc...
Article
Full-text available
Napoleona vogelii is used in traditional medicine for the management of pain, inflammatory conditions and cancer. This study was conducted to investigate the modulatory mechanisms of methanol stem bark extract of N. vogelii on induction of micronuclei, apoptotic biomarkers and in vivo antioxidant enzymes in mice. Forty male albino mice were randoml...
Article
Heavy metals are ubiquitous environmental and occupational genotoxicants with different absorbability and toxicokinetics towards increasing genetic damage, neoplasm and cell death. Aquatic organisms are exposed to individuals and/or mixtures of these metals. This study investigated the potentials for cadmium(II) (Cd), lead(II) (Pb), manganese(II) (...
Article
The global plastics production has increased from 1.5 million tons in the 1950s to 335 million tons in 2016, with plastics discharged into virtually all components of the environment. Plastics rarely biodegrade but through different processes they fragment into microplastics and nanoplastics, which have been reported as ubiquitous pollutants in all...
Article
Full-text available
Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information is relatively scarce on the po...
Article
Full-text available
Pollution of environment due to increased exploitation of minerals has been on the rise, and vanadium, a metal in the first transition series essential for mammalian existence, is a major component of air pollution. This study investigated the clinico-pathological, hepato-renal toxicity, and cytogenotoxicity of intraperitoneal exposure of African g...
Article
Full-text available
Amphibians are increasingly being used as bio-indicator of contamination in ecosystems due to their sensitivity to xenobiotics in the environment. Cadmium and lead compounds, ubiquitous mutagens and carcinogens, are capable of eliciting genome instability in adult toads which may enhance amphibian decline. Micronucleus cytome (MN-cyt) assay, a comp...
Chapter
Full-text available
Oil exploration and exploitation, the major anthropogenic activities in the Niger Delta region since the discovery of crude oil in 1956, have caused the spill of at least 9-13 million barrels of crude oil, making the region one among the five most severely damaged ecosystems in the world. The biodiversity richness of the Niger Delta, which was desc...
Article
Full-text available
Hospital effluents contain myriad of mutagens and genotoxins capable of increasing DNA damage in aquatic biota. African mudfish, Clarias gariepinus, are exposed to genotoxins when cultured in swamps and derelict water bodies often contaminated by effluents. Moreover, its DNA is susceptible to xenobiotic-induced lesions since it lacks L-gulonolacton...
Conference Paper
This study was designed to investigate the genotoxicity and nephrotoxicity of Titanium dioxide (TiO2) nanoparticles (NPs), Zinc oxide (ZnO) NPs and their mixture (1:1) in mice. Only TiO2 NPs induced a significant (p < 0.05) increase in micronucleated polychromatic erythrocytes. Both NPs and their mixture induced a significant increase in the urea l...
Conference Paper
Full-text available
Increasing occupational and residential exposure to pollutants from municipal landfills has become national and international issue due to unsanitary landfills cum unplanned settlements. The study herein investigated genome instability in rats exposed in-situ to underground water and ambient air emission from Olusosun landfill in Lagos, Nigeria. Ma...
Article
Full-text available
Effets protecteurs de la vitamine C sur les reins, le foie et le cerveau: une étude chez des rats de souche Wistar intoxiqués au mercure Résumé: La présente étude a été conçue pour étudier les effets néfastes de l'intoxication chronique du mercure sur le rein, le foie et le cerveau et les possibilités allégeantes probables de l'acide ascorbique (vi...
Article
Landfill soils are sources of emerging carcinogens, teratogens and mutagens in the environment. There is inadequate information on its possible health risk and cytogenotoxicity. This study evaluated chemical characterization of four simulated landfill leachates with their cytotoxicity and DNA damage in human cells. Hepatocarcinoma (HepG2), lymphoma...
Article
Full-text available
Indiscriminate consumption of herbal drugs with the assumption that herbs translate to safety can increase exposure to deleterious phytochemicals and probable contaminants in plants, leading to serious health issues. The cytogenotoxic and hematotoxic effects of a tri-herbal pill claimed to cure hemorrhoids and other related sicknesses among Nigeria...
Article
Full-text available
Titanium dioxide nanoparticles (TiO2-NPs) have recently been of public health and scientific concern due to their widespread use in industrial and household applications. However, there is limited information concerning its in vivocytogenotoxicity. In this study, the cytogenotoxic effects of TiO2-NPs on the somatic tissue using the mouse bone marro...
Article
Full-text available
The in vivo micronucleus (MN) test, a standard test for the genotoxicity screening of xenobiotics, was used to evaluate the cytotoxic and genotoxic activities of landfill leachates in Clarias gariepinus, Coturnix coturnix japonica and Rattus norvegicus. These organisms were exposed to various sub-lethal concentrations (1-50 %) of Olusosun and Aba E...
Conference Paper
Full-text available
Individual and mixture of formaldehyde (FA) and propionic acid (PA) are used in poultry farming to reduce the incidence of Salmonella contamination of feeds and as fumigants against bacterial and helminth infections. They exhibit systemic toxicity in mammals with FA being described as probable carcinogen, but information is scarce on their potentia...
Conference Paper
Full-text available
Chromate copper arsenate (CCA), a widely used wood preservative, has been restricted by environmental regulatory agencies due to ecosystem contamination by the component metals. Indiscriminate use of CCA in many countries is worrisome, due to possible interactions among individual metals in the induction of mutagenesis and carcinogenesis. In this s...
Article
Full-text available
Heavy metal exposure or dietary deficiency is associated with increased genetic damage, cancer and age-related diseases. Folate (vitamin B9) required for DNA repair and synthesis may increase cellular susceptibility to metal induced genotoxicity. This study investigated the interactive effects of folic acid deficiency and sufficiency on genome inst...
Article
Full-text available
The study investigated the effects of 2.45 GHz microwave radiation on rats' chromosomes. Thirty mature male and female Sprague Dawley rats of sixteen weeks old, weighing between 160-190 g were used. They were divided into five groups of six each; Control (group A) were not exposed to radiation (Group B-E) were exposed to various values of SAR from...
Article
Full-text available
White rot fungi (Pleurotus species) are edible mushrooms known for their ability to bioaccumulate contaminants including metals from the environment. There is scarcity of information on the toxic effects of the bioaccumulated metals on organisms at higher trophic levels. In this study, we investigated alterations in haematological indices and eryth...
Article
Full-text available
Brain damage induced by Olusosun and Aba-Eku municipal landfill leachates was investigated in Wistar rats. Male rats were orally exposed to 1–25% concentrations of the leachates for 30 days. Catalase (CAT) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) concentrations in the brain and serum of rats were evaluated; body and brai...
Conference Paper
Full-text available
Interest in the production of micro-livestock to supply the required protein has resulted in the intensive production of Snails. Wild and domesticated snails fed on contaminated feed may accumulate heavy metals which may be injurious to the consumers. Although toxicity and the resulting threat to human health of any contaminant are, of course, a fu...
Article
Full-text available
The cytogenotoxic potential of abattoir effluent from Bodija, Nigeria, was investigated using micronucleus test in Clarias gariepinus . Fish was exposed to five different concentrations: 0.2, 0.4, 0.8, 1.6, and 3.1% of the effluent for 7, 14, and 28 days. Tap water and 0.02 mL/L of benzene were used as negative and positive controls, respectively....
Article
Full-text available
There is scarcity of information on the possible mechanisms of pharmaceutical effluent induced genotoxicity and systemic toxicity. This study investigated the genotoxicity and systemic toxicity of a pharmaceutical effluent in Wistar rats. Rats were orally treated with 5–50% concentrations of the effluent for 28 days. At post-exposure, blood, liver,...