Chiara Moretti

Chiara Moretti
University of Gothenburg | GU · Department of Molecular and Clinical Medicine

Doctor of Philosophy

About

10
Publications
1,405
Reads
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148
Citations
Citations since 2017
10 Research Items
148 Citations
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Introduction
My research is focused on Tryptophan metabolism by gut microbiota and its role in cardiometabolic disease and gut motility.
Education
November 2016 - December 2020
Karolinska Institutet
Field of study
  • Nitric Oxide physiology and pharmacology
October 2013 - July 2015
University of Ferrara
Field of study
  • Molecular and Cellular Biology
October 2010 - October 2013
University of Ferrara
Field of study
  • Biological Sciences

Publications

Publications (10)
Article
Full-text available
Aim: Studies in the past 15 years have highlighted the role of the gut microbiota in modulation of host metabolism. The observation that germ-free (GF) mice are leaner than conventionally raised (CONV) mice and their apparent resistance to diet-induced obesity (DIO), sparked the interest in dissecting the possible causative role of the gut microbio...
Article
Full-text available
It is becoming increasingly clear that commensal bacteria inhabiting our body surfaces interact closely with the host to modulate a vast number of physiological functions. Metabolism of dietary components by gut microbiota can result in formation of a variety of reactive compounds associated with both favorable and unfavorable health effects. N-nit...
Article
Full-text available
Aging is associated with decreased nitric oxide (NO) bioavailability and signalling. Boosting of a dietary nitrate-nitrite-NO pathway e.g. by ingestion of leafy green vegetables, improves cardiometabolic function, mitochondrial efficiency and reduces oxidative stress in humans and rodents, making dietary nitrate and nitrite an appealing interventio...
Article
Full-text available
Background/purpose: Unhealthy dietary habits contribute to the increasing incidence of metabolic syndrome and type 2 diabetes (T2D), which is accompanied by oxidative stress, compromised nitric oxide (NO) bioavailability and increased cardiovascular risk. Apart from lifestyle changes, biguanides such as metformin are the first-line pharmacological...
Article
Aging is associated with decreased nitric oxide (NO) bioavailability and signalling. Boosting of a dietary nitrate-nitrite-NO pathway e.g. by ingestion of leafy green vegetables, improves cardiometabolic function, mitochon-drial efficiency and reduces oxidative stress in humans and rodents, making dietary nitrate and nitrite an appealing interventi...
Article
Nitric oxide (NO) is a key signalling molecule in the regulation of cardiometabolic function and impaired bioactivity is considered to play an important role in the onset and progression of cardiovascular and metabolic disease. Research has revealed an alternative NO-generating pathway, independent of NO synthase (NOS), in which the inorganic anion...
Article
Full-text available
Significance Liver steatosis, or fatty liver, is the most common liver disease in the world, affecting up to 25% of all Americans. There is currently no approved drug available for this condition, which may progress to serious disease, including steatohepatitis, fibrosis, and cirrhosis. Here, we show in rodent and human models of metabolic syndrome...

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