Chiara Dall'Asta

Chiara Dall'Asta
Università di Parma | UNIPR · Department of Food Sciences

Chemistry

About

262
Publications
49,039
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Introduction
Current Position: Assistant Professor in Food Chemistry, University of Parma Education: PhD in Food Chemistry (2004) Expertise: bioactive compounds; mycotoxins; mass spectrometry; supramolecular chemistry; chemosensing. Main Research Topics: - MS based methods for xenobiotics/bioactive compounds - Mycotoxins and masked mycotoxins in food - Metabolomics - Plant/Pathogen interaction More at http://www.ls9.it
Education
January 2001 - December 2003
Università di Parma
Field of study
  • Food Science
September 1994 - April 2000
Università di Parma
Field of study
  • Chemistry

Publications

Publications (262)
Article
Full-text available
The on-going shift from traditional diets to plant-based meat alternatives is governed by the friendly-character related to consumers’ health and environment. However, the beneficial aspects of meat alternatives overshadow the possible adverse effects that accompany them. The present systematic review shows that the contamination of the most common...
Article
Full-text available
Plant biodiversity preservation is one of the most important priorities of today’s agriculture. Wheat (Triticum spp. L.) is widely cultivated worldwide, mostly under a conventional and monovarietal farming method, leading to progressive biodiversity erosion. On the contrary, the evolutionary population (EP) cultivation technique is characterized by...
Article
Full-text available
Several Alternaria mycotoxins are believed to act as endocrine disruptive chemicals (EDCs), since they are reported to bind estrogen receptors in several experimental models. After ingestion of contaminated food commodities, the mycotoxins reach the intestine, where they come into direct contact with food constituents as well as the gut microbiota....
Article
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Thirty-seven red yeast rice (RYR) food supplements were screened for their mycotoxin and natural statin content. Products included pure RYR capsules and multi-ingredient formulations with standardized amounts of monacolin K (MK), marketed both online and retail in the European Union. In terms of mycotoxins, citrinin (CIT) was found in all the monit...
Poster
Full-text available
Fusarium head blight (FHB) is a devasting fungal disease in many parts of the world and the subsequent accumulation of its mycotoxins, especially deoxynivalenol (DON) represents one of the most important threats to food safety. FHB has harmful effects on human and animal health as well as economic losses. Among the strategies developed for reducing...
Article
This study aimed to evaluate the impact of breads made with two different wheat evolutionary populations (EPs), in comparison with a modern variety, on postprandial blood glucose and insulin responses. A randomized controlled crossover postprandial study involving twelve healthy subjects was conducted. Seven non-commercial breads produced with flou...
Article
Fusaric acid is a secondary metabolite produced by various Fusarium fungi, present with relatively high incidence in Fusarium-contaminated foods. It was already described as phytotoxic and cytotoxic. However, the understanding of its molecular mechanisms is still fragmentary and further data are needed to ensure an informed assessment of the risk r...
Article
Full-text available
Fumonisin-contaminated maize (Zea mays L.) products are a major health concern because of their toxic effects in humans and animals. Breeding maize for increased mycotoxin resistance is one of the key sustainable strategies for mitigating the effects of fumonisin contamination. Recent studies suggest a link between fumonisin accumulation and plant...
Article
Extra virgin olive oil (EVOO) is frequently adulterated by mixing it with soft refined oils (SROO). The differentiation of EVOO from its blends with SROO is not possible with the most common approaches, and, for this reason, the discriminating power of liquid chromatography-high resolution mass spectrometry (LC-MS), gas-chromatography ion mobility...
Article
Milk freshness is an important parameter for both consumers' health and quality of milk-based products. Up to now there have been neither analytical methods nor specific parameters to uniquely define milk freshness from a complete and univocal chemical perspective. In this study, 8 molecules were selected and identified as responsible for milk agin...
Article
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The human gut microbiota plays an important role in the maintenance of human health. Factors able to modify its composition might predispose the host to the development of pathologies. Among the various xenobiotics introduced through the diet, Alternaria mycotoxins are speculated to represent a threat for human health. However, limited data are cur...
Article
Harmful algal bloom and marine toxins are actual and overgrowing problems. Okadaic acid (OA) is the main toxin responsible for diarrheic shellfish poisoning in humans, while Tetrodotoxin (TTX) is a tremendously strong neurotoxin. Given their high toxicity, strategies to obtain a mitigation of these toxins are every day more fundamental, in the opti...
Article
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Fusarium mycotoxins represent a major threat for cereal crops and food safety. While previous investigations have described plant biotransforming properties on mycotoxins or metabolic relapses of fungal infections in plants, so far, the potential consequences of radical exposure in healthy crops are mostly unknown. Therefore, we aimed at evaluating...
Article
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In 2017–2018, extensive symptoms of sudden decline and fruit rot were observed on date palms in southern Tunisia. Samples of diseased plants were randomly collected in six localities. Based on morphological identification, Fusarium was the most frequent fungal genus detected. A sequencing of translation elongation factor, calmodulin, and second lar...
Article
Nowadays, most of the screening methods in food manufacturing are based on spectroscopic techniques. Ambient Mass Spectrometry is a relatively new field of analytical chemistry which has proven to offer similar speed and ease-of-use when compared to other fingerprinting techniques, alongside the advantages of good selectivity, sensitivity and chemi...
Article
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While aflatoxin metabolism in animals has been clarified, very limited information is so far available on the possible biotransformation occurring in plants. Therefore, this work aimed at investigating whether AFB1 metabolites could occur in field-grown infected maize and the putative role of Zea mays L. metabolism in their production. For such sco...
Article
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To cope with the presence of unfavorable compounds, plants are capable to biotransform xenobiotics, translocate both parent compounds and metabolites, perform compartmentation and segregation at cellular or tissue level. Such a scenario also applies to mycotoxins, fungal secondary metabolites with a preeminent role in plant infection. In this work,...
Article
Alternariol is a mycotoxin produced by Alternaria spp. relevant to the food safety area due to its abundance in certain foods. The shortage of data on its toxicology, also as a part of chemical mixtures, prevents setting regulation to limit its abundance in food. To extend knowledge on the possible mechanisms underpinning alternariol toxicology in...
Article
Full-text available
The aim of this study is to review the innovative techniques based on bioprocessing, thermal or physical treatments which have been proposed during the last few decades to convert rice bran into a valuable food ingredient. Rice bran (Oryza sativa) is the main by-product of rice grain processing. It is produced in large quantities worldwide and it c...
Article
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In the present study, we have characterized for the first time the volatile fraction of 20 pomegranate juices from fruits harvested in Northern Italy and southern Montenegro, by means of headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography–mass spectrometry technique (GC–MS). The volatile profile accounted for 57 compound...
Article
Scope Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aimed at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups o...
Article
Full-text available
This work presents a non-targeted high-resolution mass spectrometry inter-laboratory study for the detection of new chemical markers responsible of soft refined oils addition to extra virgin olive oils. Refined oils (soft deodorized and soft deacidified) were prepared on a laboratory scale starting from low-quality olive oils and analyzed together...
Article
Full-text available
In the present work, the provenance discrimination of Argentinian honeys was used as case study to compare the capabilities of three spectroscopic techniques as fast screening platforms for honey authentication purposes. Multifloral honeys were collected among three main honey-producing regions of Argentina over four harvesting seasons. Each sample...
Article
Full-text available
Molds of the genus Alternaria produce several mycotoxins, some of which may pose a threat for health due to their genotoxicity. Due to the lack of adequate toxicological and occurrence data, they are currently not regulated. Interactions between mycotoxins, gut microbiota and food constituents might occur after food ingestion, modifying the bioavai...
Article
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Emodin, a widespread natural anthraquinone, has many biological activities including health-protective and adverse effects. Amongst beneficial effects, potential antiviral activity against coronavirus responsible for the severe acute respiratory syndrome outbreak in 2002–2003 has been described associated with the inhibition of the host cells targe...
Article
The undeclared blending of EVOO with soft-refined oils is one of the main issue in the olive oil sector. Despite the efforts, reliable markers related to soft-refinement processes have not been found yet. In the present work, two rapid headspace-based techniques, namely gas-chromatography ion mobility spectrometry and flash gas chromatography elect...
Article
Scope Urolithin A and B are gut metabolites of ellagic acid and ellagitannins associated with many beneficial effects. Evidence in vitro pointed to their potential as estrogenic modulators. However, both molecular mechanisms and biological targets involved in such activity are still poorly characterized, preventing a comprehensive understanding of...
Article
Coffee is an important source of bioactive compounds, including caffeine, trigonelline, and phenolic compounds. Several studies have highlighted the preventive effects of coffee consumption on major cardiometabolic diseases, but the impact of coffee dosage on markers of cardiometabolic risk is not well understood. Moreover, the pool of coffee-deriv...
Article
Full-text available
Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biological targets underlying the activi...
Article
Full-text available
Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and found as a contaminant in various foods. OTA causes kidney toxicity in different animal species and kidney tumours in rodents. OTA is genotoxic both in vitro and in vivo; howev...
Article
Full-text available
Ochratoxin A (OTA), a mycotoxin that is of utmost concern in food and feed safety, is produced by fungal species that mainly belong to the Aspergillus and Penicillium genera. The development of mitigation strategies to reduce OTA content along the supply chains is key to ensuring safer production of food and feed. Enzyme-based strategies are among...
Article
Full-text available
The xenoestrogenic mycotoxin zearalenone is a common food contaminant produced by Fusarium strains. The modified mycotoxin zearalenone-14-sulfate (Z14S) is formed in both fungi and mammals during the biotransformation of zearalenone. Cyclodextrins (CD) are cyclic oligosaccharides which can form host-guest type complexes with some mycotoxins, includ...
Article
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The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by Alternaria alternata fungi, pr...
Article
Full-text available
Maize is the principal staple food/feed crop exposed to mycotoxins, and the co-occurrence of multiple mycotoxins and their metabolites has been well documented. This review presents the infection cycle, ecology, and plant-pathogen interactions of Aspergillus and Fusarium species in maize, and current knowledge on maize chain management to mitigate...
Article
Enniatin B is an emerging mycotoxin known to present biological activity because of its ionophoric characteristics. This compound has demonstrated strong in vitro cytotoxicity against different cancer cells, also at low molecular concentrations. Its natural occurrence in food commodities and feed is highly reported world-wide, but few information i...
Article
Rice (Oryza sativa L.) bran is an important by‐product produced during cereal milling process, rich in several valuable compounds, such as lipids. Moreover, considering the valorisation potential of these material, the application of innovative and low‐impact techniques can improve the overall quality of by‐products for their future exploitation in...
Article
Full-text available
Listeria monocytogenes is a widespread foodborne pathogen of high concern and internalin A is an important virulence factor that mediates cell invasion upon the interaction with the host protein E-cadherin. Nonsense mutations of internalin A are known to reduce virulence. Although missense mutations are largely overlooked, they need to be investiga...
Chapter
The structural identification of phase-I and phase-II metabolites of mycotoxins is a difficult task, mostly due to the lack of standards and because of the large number of isomeric forms. Here, we describe the use of ion mobility-mass spectrometry to analyze cereal extracts and how structural information on newly discovered mycotoxins metabolites c...
Article
Mycotoxins are toxic compounds mainly produced by fungi of the genera Aspergillus , Penicillium and Fusarium . They are present, often as mixtures, in many feed and food commodities including cereals, fruits and vegetables. Their ubiquitous presence represents a major challenge to the health and well being of humans and animals. Hundreds of compoun...
Article
Full-text available
The volatile fraction investigated by means of HS-SPME/GC–MS technique, the extractable color in terms of ASTA units, and the pungency measured on the Schoville scale of different experimental Capsicum annuum powders, designed for food industry, were evaluated in this study. In particular, six Capsicum annuum cultivars were included; fresh fruits w...
Article
Wheat (Triticum spp. L.) is an important source of nutrients and bioactive compounds with recognized beneficial effects. Wheat undergoes several processes with the final aim of separating the endosperm from the outer layers, usually discarded. In this study, free and bound phenolic acids (PAs) profile, betaine and choline contents were quantified i...
Article
Full-text available
The mycotoxins zearalenone and alternariol may contaminate food and feed raising toxicological concerns due to their estrogenicity. Inter-species differences in their toxicokinetics and toxicodynamics may occur depending on evolution of taxa-specific traits. As a proof of principle, this manuscript investigates the comparative toxicodynamics of zea...
Article
This study aimed to investigate the potential of in vitro wheat model as biofactory for masked mycotoxin production. Micropropagated durum wheat organs (leaves and roots) were treated during a 14-day time span on a proper medium spiked with deoxynivalenol (DON). After the treatment, DON absorption from culture media was evaluated while roots and le...
Article
Full-text available
Mycotoxins are low-molecular weight compounds produced by diverse genera of molds that may contaminate food and feed threatening the health of humans and animals. Recent findings underline the importance of studying the combined occurrence of multiple mycotoxins and the relevance of assessing the toxicity their simultaneous exposure may cause in li...
Article
Full-text available
The present study aimed at elucidating the uptake and biotransformation of T2 and HT2 toxins in five cultivars of durum wheat, by means of cultured plant organs. An almost complete absorption of T2 toxin (up to 100 µg) was noticed after 7 days, along with the contemporaneous formation of HT2 in planta, whereas HT2 showed a slower uptake by uninfect...
Article
Wheat bran, a by-product produced in huge amount during cereal milling, is today largely unexploited because of its poor suitability as food ingredient. Solid-state fermentation (SSF) using a Lactobacillus rhamnosus strain was applied to wheat bran and its influence on bioactive compounds (free and bound phenolic acids) and antioxidant activity wer...
Article
Full-text available
Insects are considered a suitable alternative feed for livestock production and their use is nowadays regulated in the European Union by the European Commission Regulation No. 893/2017. Insects have the ability to grow on a different spectrum of substrates, which could be naturally contaminated by mycotoxins. In the present work, the mycotoxin upta...
Article
Full-text available
Zearalenone (ZEN) is a Fusarium-derived xenoestrogenic mycotoxin. In plants, zearalenone-14-O-β-d-glucoside (Z14G) is the major conjugated metabolite of ZEN, and is a masked mycotoxin. Masked mycotoxins are plant-modified derivatives, which are not routinely screened in food and feed samples. Cyclodextrins (CDs) are cyclic oligosaccharides built up...
Article
Full-text available
Alternariol (AOH) is a mycotoxin produced by Alternaria species. In vitro studies suggest the genotoxic, mutagenic, and endocrine disruptor effects of AOH, and an increased incidence of esophageal cancer has been reported related to higher AOH exposure. Human serum albumin (HSA) is the most abundant plasma protein in the circulation, it is able to...
Article
Mycotoxins in food may threat public health at a global scale. However, for most of them, the current body of knowledge does not support a proper risk assessment and more data are needed to clarify their toxicity. In particular, the assessment of “personalized” action may succeed in understanding and counteracting the effects of many toxicants. The...
Article
A sensitive UHPLC-ESI-MS/MS method, coupled with a suitable extraction protocol, was developed and validated for the rapid detection of four tropane alkaloids (anisodamine, atropine, homatropine, scopolamine) in herbal teas and herbal extracts. The method offers good sensitivity, accuracy and precision. The protocol is suitable for routine determin...
Chapter
Whole grain cereals are the major contributors to the daily energy intake of human and animal diet. Given their importance as food and feed, the assurance of their safety is crucial. Despite of this, food industry has the responsibility to implement good safety management system in order to contrast the potential contamination of possible hazards....
Article
The present field study offers new insights into the role played by plant lipid pathways in the modulation of fumonisin accumulation in maize Untargeted metabolomics was applied to better understand the multifactorial plant-pathogen interaction mechanisms, including host resistance. Our results showed a significant influence of the hybrid genotype,...
Article
Mycotoxins are one of the most important contaminants in cereal grains. Besides parent forms, the presence and identification of structurally modified mycotoxins is nowadays recognized as a challenging food safety-related issue and contribute to increase the human and animal exposure. The aim of this study was to follow the distribution of Fusarium...
Article
This study aimed to investigate the possible correlation between 5-n-alkylresorcinols and hydroxycinnamic acids on mycotoxin accumulation in grains under field conditions. At this purpose, ten different grain varieties characterized by different degree of ploidy (hexaploid, tetraploid, diploid) were chosen, among them common and durum wheat, einkor...
Article
Full-text available
St. John’s Wort (Hypericum perforatum L.) flowers are commonly used in ethnomedical preparations with promising outcomes to treat inflammation both per os and by topical application. However, the underlying molecular mechanisms need to be described toward a rational, evidence-based, and reproducible use. For this purpose, the aptitude of the promin...
Poster
Full-text available
Honey is the natural substance produced by Apis mellifera bees from the plant nectar or excretions of plant-sucking insects. In the supply and distribution chain, mono-floral and mono-geographic honeys usually command a premium price. Argentina is on the main honey producers in the world and methods to autenticate specific regions are needed. Purpo...