Chia-Hung Chien

Taiwan Food And Drug Administration

In mid-2022, the COVID-19 cases have reached close to 562 million, but its overall infection rate is hard to confirm. Even with effective vaccines, break-through infections with new variants occur, and safe and reliable testing still plays a critical role in isolation of infected individuals and in control of an outbreak of a COVID-19 pandemic. In...

Miscanthus in Taiwan occupies a cline along altitude and adapts to diverse environments, e.g., habitats of high salinity and volcanoes. Rhizospheric and endophytic bacteria may help Miscanthus acclimate to those stresses. The relative contributions of rhizosphere vs. endosphere compartments to the adaptation remain unknown. Here, we used targeted m...

Purpose The aim of this study is to examine how aesthetic devices are defined and managed. Regulation discrepancies between clinical use and home use in four regions are also described. Methods The official websites and databases of US, European, Chinese, and Taiwanese authorities were used to collect regulation information for aesthetic devices....

The aim of this study was to establish a web-based platform for exchanging medical device management and maintenance experiences to enhance the professional competency of clinical engineers (CEs), which ensures the quality of medical devices and increases patients’ satisfaction with medical services. Medical devices play an essential role in diagno...

Diverse soil microbial community is determinant for sustainable agriculture. Rich microbial diversity has presumably improved soil health for economic crops to grow. In this work, the benefits of paddy-upland rotation on soil microbial diversity and specific microbes are thus intensively explored. The microbiome from multiple factor experiment (thr...

Background: Transcription factors (TFs) play essential roles during plant development and response to environmental stresses. However, the relationships among transcription factors, cis-acting elements and target gene expression under endo- and exogenous stimuli have not been systematically characterized. Results: Here, we developed a series of...

The medical device industry is an industry dealing with multiple types of products covering a wide range of applications. As the safety and effectiveness of medical devices are vital to human health, the products must be managed by strict regulations according to the different risk levels. A total product life cycle regulatory system including prod...

Next generation sequencing (NGS) has become the mainstream approach for monitoring gene expression levels in parallel with various experimental treatments. Unfortunately, there is no systematical webserver to comprehensively perform further analysis based on the huge amount of preliminary data that is obtained after finishing the process of gene an...

Transcription factors (TFs) are sequence-specific DNA-binding proteins acting as critical regulators of gene expression. The Plant Promoter Analysis Navigator (PlantPAN; http://PlantPAN2.itps.ncku.edu.tw) provides an informative resource for detecting transcription factor binding sites (TFBSs), corresponding TFs, and other important regulatory elem...

In general, the expression of gene alters conditionally to catalyze a specific metabolic pathway. Microarray-based datasets have been massively produced to monitor gene expression levels in parallel with numerous experimental treatments. Although several studies facilitated the linkage of gene expression data and metabolic pathways, none of them ar...

Compared with animal microRNAs (miRNAs), our limited knowledge of how miRNAs involve in significant biological processes in plants is still unclear. AtmiRNET is a novel resource geared toward plant scientists for reconstructing regulatory networks of Arabidopsis miRNAs. By means of highlighted miRNA studies in target recognition, functional enrichm...

Noncoding, endogenous microRNAs (miRNAs) are fairly well known for regulating gene expression rather than protein coding. Dysregulation of miRNA gene, either upregulated or downregulated, may lead to severe diseases or oncogenesis, especially when the miRNA disorder involves significant bioreactions or pathways. Thus, how miRNA genes are transcript...

The additional file provides the expression profile of hsa-miR-122 and its 261 co-expressed genes among 17 human normal tissues (Figure S1 and S2), and full list of TSSs, the number of co-expressed gene groups, and putative TFs of human miRNAs (Table S1-S3).

Background: Algae are important non-vascular plants that have many research applications, including high species diversity, biofuel sources, and adsorption of heavy metals and, following processing, are used as ingredients in health supplements. The increasing availability of next-generation sequencing (NGS) data for algae genomes and transcriptom...

This paper proposes a quantum switching on crossed cube, the diameter of the crossed cube is almost half of that of the hypercube, to execute quantum walks. Quantum walks can be implemented in the hypercube and general graphs. Hypercube is a regular graph. According to quantum walk algorithm, the system can preserve unitary property of quantum walk...

Quantum walks can be implemented in the hypercube and general graphs, where hypercube is a regular graph. According to quantum walk algorithm, unitary property of quantum walks can be preserved. In the regular graph, to develop quantum walks algorithm is focused on quantum search algorithm. Quantum switching is the reversible and parallel computati...

This paper designs quantum testing circuit to detect intermediate malicious node and achieve message integrity in the distributed quantum computing. The proposed mechanism has several improvements shown as follows. The random key generation between Alice and Bob such that an attack cannot break this deriving process. Local unitary operations and qu...

Blind quantum computation is an appealing use of quantum information technology because it can conceal both the client's data and the algorithm itself from the server. However, problems need to be solved in the practical use of blind quantum computation and fault-tolerance is a major challenge. On an example circuit, the computational cost measured...

In the hospital, the management of medical equipments is a series of activities from budget planning to equipment disposing. The overall activities focus on issues such as quality, safety, performance, cost, and profit. An efficient and effective management system is necessary for supervising these goals. In this study, we show an equipment service...

This paper designs quantum circuit to detect the fault components in the Byzantine generals problem. This circuit is verification circuit that can investigate the equivalence of quantum input particles. In this problem, reach agreement and liar detection are two major issues. In the quantum field, quantum secret sharing can support a special correl...

We propose a protocol based on quantum teleportation and measurement-based computation allowing clients to conduct blind computation on the server with less information of input, output and computation revealed. Our protocol also requires less quantum resources on clients. There are two phases in our protocol, i.e., preparation and computation. Sin...

In the wireless communication networks, quantum message integrity can be applied with quantum authentication and quantum signature if the source and destination are indirect communication. Eavesdroppers and malicious nodes may exist in the routing path from the source to the destination. There is major threat in the indirect communication. Based on...

For vehicular networks, the security and privacy face two major challenges. One is the open wireless medium and the other is the high-speed mobility of the vehicles. For the open wireless medium, eavesdropping and man-in-the-middle attacks may exist in the communication path. This is called an unsafe routing path. Based on quantum nature, quantum c...

MicroRNAs (miRNAs) are critical small non-coding RNAs that regulate gene expression by hybridizing to the 3'-untranslated regions (3'-UTR) of target mRNAs, subsequently controlling diverse biological processes at post-transcriptional level. How miRNA genes are regulated receives considerable attention because it directly affects miRNA-mediated gene...

This paper proposes a novel work to design reversible quantum circuits. The function of this circuit is to investigate quantum transmission integrity in the quantum communication networks. This work is to verify quantum transmission sequence of a quantum frame by using reversible quantum model. This model designs control module to derive the correl...

In this paper, we use the technique of entanglement swapping to exchange quantum message among sharing parties. For Bell measurements, quantum teleportation can provide long-distance quantum transmission when sharing parties are disconnected. The proposed mutual authentication protocol has the capability to securely identify each other under an uns...

hsa-let-7a can target on FOXA1. The previous research [67] shows the duplex structure of let-7a and the transcript of FOXA1. For the standard seed criteria, only one wobble base pair is allowed in it. The duplex structure in this figure, however, there are too many wobble base pairs (shows in yellow color) in the seed region (shows in green color)...

MicroRNAs (miRNAs) are small non-coding RNA molecules that are ~22-nt-long sequences capable of suppressing protein synthesis. Previous research has suggested that miRNAs regulate 30% or more of the human protein-coding genes. The aim of this work is to consider various analyzing scenarios in the identification of miRNA-target interactions, as well...

The major role of disaster recovery management is to rapidly restore the chaotic condition to normal, which includes mitigation, preparedness, response, and recovery. To reduce secondary damage and loss, the recovery process must be facilitated. Information technologies (including network, web-based, computer, and related software tools) speed up t...

Intelligent management of medical equipments is vital to hospital. Most hospitals spend large budgets in purchasing medical equipments, but there is no perfect monitoring mechanism to immediately understand the benefits of these devices and their designated goals. Today the hospital is operated in a serious competitive environment. It needs to have...

MicroRNAs (miRNAs), i.e. small non-coding RNA molecules (∼22 nt), can bind to one or more target sites on a gene transcript to negatively regulate protein expression, subsequently controlling many cellular mechanisms. A current and curated collection of miRNA–target interactions (MTIs) with experimental support is essential to thoroughly elucidatin...

Medical equipment management is an important issue for safety and cost in modern hospital operation. In addition, the use of an efficient information system effectively promotes the managing performance. In this study, we designed a framework of medical equipment management system used for in-house clinical engineering department. The system was we...

The aim of this work is to develop a new technique of two-dimensional (2D) bowel sound magnitude map (BSMM) with multichannel electronic stethoscopes to evaluate the location, intensity, and track of intestinal motility from the abdominal surface in real time. The static BSMM, obtained from the interpolation of captured one-dimensional (1D) signals...

The traditional processes for designing and verifying a new device need a long time. First, the customized requirement is converted to a prototype which would be followed a series of tests to verify the specifications. Then the software system is added to the prototype and re-verify. When all functions of the system hardware and software are valida...

This paper is to present a new noninvasive measurement medical device for helping doctor to evaluate the function of digestion system. Accelerator sensors are used to detect vibration signals on the abdominal surface. Here some standard measuring processes are established. These will provide health index factors to evaluate the function of digestio...

Numerous regulatory structural motifs have been identified as playing essential roles in transcriptional and post-transcriptional regulation of gene expression. RegRNA is an integrated web server for identifying the homologs of regulatory RNA motifs and elements against an input mRNA sequence. Both sequence homologs and structural homologs of regul...

The centralized and information management are in common use technique of modern management. The management of the medical equipment emphasized in the purchase and the maintenance management in early days,and cost down now is import factor for medical equipment management because the health insurance system causes the hospital budget reduced, so in...

Judging from the continuous increase in population suffering from chronic illnesses in the past 30 years in Taiwan, we can predict that the number of diabetes victims will reach 1.5 million in 15 years. This increase is global. According to an estimate provided by WTO, one out of two diabetes sufferers is not identified as the illness victim. An es...

The ways of angiography are divided into two kinds at present: the invasive type and the non invasive type. Because the magnetic resonance angiography (MRA) has advantages of the non invasive type, thus people can accept MRA more easily. Presently, to diagnoses for the initial stage triage of the blood vessel on clinic by MRA mostly. We to be allow...