Chia-Huang Chang

Taipei Medical University | TMU · School of Public Health

Attention-deficit hyperactivity disorder (ADHD) is diagnosed in ~7% of school-aged children. The role of endocrine-disrupting chemicals (EDC) and oxidative stress in ADHD etiology are not clear. Assessment of the associations between simultaneous exposure to multiple compounds and ADHD in children. The case-control study included 76 clinically diag...

We determined the urinary levels of acrylamide (AA) metabolites of the general Taiwanese population, explore the association between AA internal exposure and dietary intake frequency, and assess the health risk. Urine samples and dietary questionnaires were collected from the subjects of the Nutrition and Health Survey in Taiwan. AA metabolite [N-a...

The Taiwan Maternal and Infant Cohort Study (TMICS) was launched with the aim to assess the effects of prenatal exposure to phthalic acid esters (PAEs) on infant health. A total of 1102 pregnant women were enrolled in this study from 2012 to 2015. All participants completed a structured questionnaire, and provided urine specimens. The urinary conce...

Prenatal exposure to bisphenol A (BPA) may increase the risk of abnormal birth outcomes, and DNA methylation might mediate these adverse effects. This study aimed to investigate the effects of maternal BPA exposure on maternal and fetal DNA methylation levels and explore whether epigenetic changes are related to the associations between BPA and low...

This study will help to clarify the relationship between organophosphate pesticides (OPs) and attention deficit/hyperactivity disorder (ADHD) related to oxidative stress and paraoxonases (PON) polymorphisms to further characterize the gene-environment interaction. This case-control study enrolled 85 children with ADHD and 96 control subjects. Urina...

The present study assessed the association between phthalate exposure and mitochondrial DNA (mtDNA) polymerase γ (POLG) methylation along with the potential effect on the characteristics of body fat in children. A total of 152 children were enrolled. The urinary concentrations of phthalate metabolites were measured using ultraperformance liquid chr...

This chapter provides a general introduction to bisphenols and alkylphenols in toxicity, exposure assessment, biomonitoring, and epidemiological studies. Both bisphenols and alkylphenols are applied intensively to the majority of consumer products and are ubiquitous in environmental matrices. Bisphenol A (BPA), nonylphenol (NP), octylphenol (OP), t...

Background: Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host's redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities (including the plaque index (PlI), bleeding on pr...

Parabens are a group of esters of parahydroxybenzoic acid and are utilized as antimicrobial preservatives in the majority of personal care products (PCPs). Epidemiological studies regarding the adverse effects of parabens on fetuses are still limited. The aim of this study was to determine the association between maternal paraben exposure and birth...

This study determined whether maternal bisphenol A (BPA) exposure influences birth outcomes through oxidative stress and estimated the daily intake of BPA through breast milk for infants. One hundred and eighty-six pregnant women without pregnancy complications were enrolled and maternal urine was collected in the third trimester. Postnatal breast...

The aim of this study was to evaluate the associations between cigarette use and five salivary oxidative stress biomarkers, copper-zinc superoxide dismutase (Cu/Zn SOD), manganese superoxide dismutase (MnSOD), catalase, thioredoxin-1 (TRX1), and peroxiredoxin-2 (PRX2), to assess the effectiveness of non-surgical periodontal therapy. Materials and...

Objective: The aim of this study was to evaluate the association between cigarette use and the effectiveness of five biomarkers of oxidative stress, including copper-zinc superoxide dismutase (Cu/Zn SOD), manganese superoxide dismutase (MnSOD), catalase, thioredoxin-1 (TRX1), and peroxiredoxin-2 (PRX2), in periodontal infection control. Methods: In...

Objective: The aim of this study was to clarify the association between organophosphate pesticides (OPs) and attention-deficit/hyperactivity disorder (ADHD) related to oxidative stress and genetic polymorphisms. Methods: This case-control study enrolled 93 children with ADHD and 112 control children in north Taiwan. Six dialkyl phosphate (DAP) m...

The contamination of a clouding agent with di(2-ethylhexyl) phthalate (DEHP), a substitute emulsifier-containing compound used in a variety of foods was announced on May 23, 2011. The aims of this study were as follows (1) compare the urine phthalates (PAE) metabolites concentration and estimate the daily intake (DI) of PAEs in pregnant women befor...

Background: Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates. Objectives: To assess which time point maternal arsenic exposure may influence the fetus during preg...

Prenatal exposure to phenols, phthalates (PAEs), and organophosphate (OP) pesticides may increase the risk of abnormal birth outcomes. However, many previous studies have examined exposure to a limited number of chemical classes or exposure profiles limited to a specific stage of pregnancy. This study aims to characterize the concurrent exposure sc...

Objectives: The purpose of this study was to assess relationships among periodontal conditions, salivary antioxidant levels, and patients' satisfaction with their prostheses. Methods: This study was conducted at the Division of Prosthodontics, Department of Dentistry, Taipei Medical University Hospital. The periodontal condition of patients was...

Table and figure dataset. (DBF)

Objective: Fetal nuchal translucency (NT) thickness is an important marker for prenatal screening; however, studies focusing on the correlation between maternal trace element levels and NT thickness are limited. The aim of this study was to evaluate maternal trace element levels during the first trimester and to investigate the association between...

Prenatal exposure and the health effects of that exposure have been intensively studied for a variety of environmental pollutants and trace elements. However, few studies have compared susceptibilities among the three trimesters of gestation. Manganese (Mn) is a naturally occurring and abundant trace element in the environment. Although the effects...

Background: Chronic imbalance is common in patients with vestibular dysfunction. Vestibular rehabilitation is effective in improving upright balance control. Vestibular rehabilitation exercises, such as Cawthorne-Cooksey exercises, include simple repetitive movements and have limited feedback and adaptive training protocols. Interactive systems ba...

Background Nonylphenol (NP) has been proven as an endocrine disrupter and had the ability to interfere with the endocrine system. Though the health effects of NP on pregnant women and their fetuses are sustained, these negative associations related to the mechanisms of regulation for estrogen during pregnancy need to be further clarified. The objec...

Objectives Patients with Ménière’s disease (MD) may suffer from chronic imbalance problem that cannot be cured by surgery or medication. For these patients, vestibular rehabilitation is another treatment option. Three-dimensional (3D), virtual reality (VR) technology may be applied to facilitate rehabilitation exercise. In this study we report outc...

Dizziness is a major consequence of chronic imbalance and vestibular dysfunction, which prevents people performing their routine tasks and affects their quality of life. It may lead to severe injuries caused by unexpected falling. Medicine treatment can alleviate the syndrome of dizziness and past research shows that dizziness can be further reduce...

Background: Nonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intrauterine NP exposure on neonates. Methods: A cohort...

In this paper we present a fall detection system using a triaxial accelerometer module for the prevention of falls and fall-related injuries among patients with vertigo. We recruited 26 healthy control subjects and 12 patients with vertigo for the study. The fall detection system used a triaxial accelerometer module (ADXL33; Analog Devices, Inc., N...

In this paper we present a fall detection system using a triaxial accelerometer module for the prevention of falls and fall-related injuries among patients with vertigo. We recruited 26 healthy control subjects and 12 patients with vertigo for the study. The fall detection system used a triaxial accelerometer module (ADXL33; Analog Devices, Inc., N...

Dizziness caused by peripheral vestibular nerve disease might lead to the imbalance of center of gravity, which in turn might affect the quality of daily life. Vestibular function rehabilitation exercise is thought to be able to improve the symptom of dizziness effectively. However, since rehabilitation process is boring, lacks of challenges and ad...

Objective: People with chronic vestibular dysfunction can be treated with balance rehabilitation. Virtual reality (VR) technology may serve as a useful therapeutic tool to facilitate rehabilitation. The aim of this pilot study was to investigate the clinical applicability of VR technology in treating patients with vestibular dysfunction. Method: Fi...

To control the workflow for surgical patients, we in-cooperate radio-frequency identification (RFID) technology to develop a Patient Advancement Monitoring System (PAMS) in operation theater. The web-based PAMS is designed to monitor the whole workflow for the handling of surgical patients. The system integrates multiple data entry ports Across the...

Background: The sterilization method is a concern as the application of RFID (radio frequency identification) technology is getting its popularity in healthcare industry. In this study we investigate the feasibility and cost-effectiveness in using different sterilization methods for active RFID wrist band. Methods: We compare the completeness of bi...

Objectives: To improve management competency and to enhance patient safety, we in-cooperate radio-frequency identification (RFID) and web-based database technologies to develop a Patient Advancement Monitoring System (PAMS) in the operation theater. Methods: A web-based SQL database (PAMS) is designed with partial links to hospital information syst...

Objectives: Disease management for chronic condition is evolving into a major entity of healthcare quality in an aging society. The issues regarding the care guideline compliance, long term follow-up, and complication prevention are becoming critical in diabetes management. Methods: A web-based diabetes management system is developed for automatic...