About
13
Publications
3,086
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
51
Citations
Introduction
Current institution
Additional affiliations
October 2016 - present
Institute of Pathological Physiology, 1st Faculty of Medicine, Charles University
Position
- PhD Student
Publications
Publications (13)
In bone marrow transplantation (BMT), hematopoiesis-reconstituting cells are introduced following myeloablative treatment, which eradicates existing hematopoietic cells and disrupts stroma within the hematopoietic tissue. Both hematopoietic cells and stroma then undergo regeneration. Our study compares the outcomes of a second BMT administered to m...
The immense regenerative power of hematopoietic tissue stems from the activation of the immature stem cells and the progenitor cells. After partial damage, hematopoiesis is reconstituted through a period of intense regeneration when blood cell production originates from erythro-myeloid progenitors in the virtual absence of stem cells. Since the dam...
Regeneration of severely damaged adult tissues is currently only partially understood. Hematopoietic tissue provides a unique opportunity to study tissue regeneration due to its well established steady-state structure and function, easy accessibility, well established research methods, and the well-defined embryonic, fetal, and adult stages of deve...
Conjugated linoleic acids (CLA) are a family of polyunsaturated fatty acids, there are mainly two CLA isomers: cis-9, trans-11 (c9, t11; CLA1) and trans-10, cis-12 (t10, c12; CLA2). So far, very little is known about the beneficial effects on memory related to CLA. Neurexin is a presynaptic protein, essential for the function of synaptogenesis. Neu...
The c-Kit expression level is decreased in regenerating bone marrow and such bone marrow performs poorly when co-transplanted with normal bone marrow. We asked whether diminished numbers of c-Kit receptors on HSPCs following their internalization induced by the binding of the cytokine stem cell factor (SCF) would jeopardize transplantability of HSP...
Extramedullary hematopoiesis (EMH) is a pathological process secondary to underlying bone marrow (BM) insufficiency in adults. It is characterized by the emergence of multipotent hematopoietic progenitors scattered around the affected tissue, most likely in the spleen, liver, and lymph node, etc. EMH in patients frequently receives less medical att...
A low-cost platform is proposed for the growth and real-time monitoring of biological cells. The main components of the platform include a polymethyl methacrylate (PMMA) cell culture microchip and a multi-channel lens-free CMOS (complementary metal-oxide-semiconductor) / light-emitting diode (LED) imaging system. The PMMA microchip comprises a thre...
Presence of the c-Kit tyrosine kinase receptor is a hallmark of the mouse hematopoietic stem cells (HSCs) and progenitors routinely used for their identification and separation. c-Kit is activated after binding of its ligand, the stem cell factor (SCF; c-Kit-ligand). c-Kit receptors with bound SCF form dimers that are rapidly internalized and degra...
Presence of the c-Kit tyrosine kinase receptor is a hallmark of the mouse hematopoietic stem cells (HSCs) and progenitors routinely used for their identification and separation. c-Kit is activated after binding of its ligand, the stem cell factor (SCF; c-Kit-ligand). c-Kit receptors with bound SCF form dimers that are rapidly internalized and degra...
The c-Kit tyrosine kinase receptor and its ligand, stem cell factor (SCF), have been reported to be an important control mechanism for cell survival, cell growth and cell proliferation in hematopoiesis, spermatogenesis and melanocytogenesis. In majority of studies referring to c-Kit positive cells, the studies included only c-Kithigh cells and omit...
