Chi Zhang

Chi Zhang
Nanyang Technological University | ntu · School of Chemical and Biomedical Engineering

PhD

About

42
Publications
2,827
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1,819
Citations

Publications

Publications (42)
Article
Full-text available
Checkpoint immunotherapies have been combined with other therapeutic modalities to increase patient response rate and improve therapeutic outcome, which however exacerbates immune-related adverse events and requires to be carefully implemented in a narrowed therapeutic window. Strategies for precisely controlled combinational cancer immunotherapy c...
Article
Full-text available
Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by the lack of efficient sonosensitizers and “always‐on” pharmacological activities of therapeutic agents. Herein, we report the development of semiconducting polymers as efficient sonosensitizers and further development of...
Article
Full-text available
Optical nanoparticles are promising diagnostic tools; however, their shallow optical imaging depth and slow clearance from the body have impeded their use for in vivo disease detection. To address these limitations, we develop activatable polyfluorophore nanosensors with biomarker-triggered nanoparticle-to-molecule pharmacokinetic conversion and ne...
Article
Activatable phototheranostics holds promise for precision cancer treatment owing to the “turn‐on” signals and therapeutic effects. However, most activatable phototheranostic probes only possess photodynamic therapy (PDT) or photothermal therapy (PTT), which suffer from poor therapeutic efficacy due to deficient cellular oxygen and complex tumor mic...
Article
Activatable phototheranostics holds promise for precision cancer treatment owing to the “turn‐on” signals and therapeutic effects. However, most activatable phototheranostic probes only possess photodynamic therapy (PDT) or photothermal therapy (PTT), which suffer from poor therapeutic efficacy due to deficient cellular oxygen and complex tumor mic...
Article
Combination photoimmunotherapy holds promise for tumor suppression; however, smart phototherapeutic agents that only activate their immunotherapeutic action in tumor have been rarely developed, which have the potential advantage of reduced side effect. Herein, we report a semiconducting polymer nano-regulator (SPN T ) with cascading activation for...
Article
Combination photoimmunotherapy holds promise for tumor suppression; however, smart phototherapeutic agents that only activate their immunotherapeutic action in tumor have been rarely developed, which have the potential advantage of reduced side effect. Herein, we report a semiconducting polymer nano-regulator (SPN T ) with cascading activation for...
Article
Immunosuppressive tumor microenvironment (TME) has been one of the major hurdles to cancer immunotherapy. Protease inhibitors have emerged to be a potential way to modulate intratumoral metabolic processes to reprogram TME, which however suffer from the limited efficacy and off-targeted side effects. We herein report smart nano-proteolysis targetin...
Article
Immunosuppressive tumor microenvironment (TME) has been one of the major hurdles to cancer immunotherapy. Protease inhibitors have emerged to be a potential way to modulate intratumoral metabolic processes to reprogram TME, which however suffer from the limited efficacy and off-targeted side effects. We herein report smart nano-proteolysis targetin...
Article
Despite the importance of rapid and accurate detection of SARS-CoV-2 in controlling the COVID-19 pandemic, current diagnostic methods are static and unable to distinguish between viable/nonviable virus or directly reflect viral replication activity. Real-time imaging of protease activity specific to SARS-CoV-2 can overcome these issues but remains...
Article
Nanomedicine offers an effective way to regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for cancer immunotherapy. We herein report a charge-reversal polymer nano-modulator (SPDMCN) activated by tumor microenvironment (TME) for photodynamic immunoth...
Article
Charge-reversal polymer nano-modulators that can be specifically activated by acidic tumor microenvironment to release immunomodulator and enhance tumor penetration are developed for combinational photodynamic cancer immunotherapy. Abstract Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T ly...
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Full-text available
Immunometabolic intervention has been applied to treat cancer via inhibition of certain enzymes associated with intratumoral metabolism. However, small-molecule inhibitors and genetic modification often suffer from insufficiency and off-target side effects. Proteolysis targeting chimeras (PROTACs) provide an alternative way to modulate protein home...
Article
Gout, a common type of inflammatory arthritis resulting from chronic elevation of uric acid (UA) level, is usually accompanied with hyperuricemia. The current clinical drugs for the treatment of gout and hyperuricemia are greatly restricted by their limited therapeutic efficacy, off-target toxicity and severe side effects. Here, a neutrophil membra...
Article
Full-text available
Tumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, and thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation of immunometabolism to boost cancer immunotherapy is mostly based on small‐molecule inhibitors, which often encounter the issues of off‐target adverse effects, drug resis...
Article
Tumor metabolism generally involves in the generation of immunosuppressive metabolites, which contribute to the dysfunction of immune cells. Thus, immunometabolic interventions targeting the metabolic circuits and reducing immunosuppressive metabolites have been developed to invigorate antitumor immunity and attenuate cancer immune evasion. Althoug...
Article
With the booming development of smartphones in our routine lives, the integration of advanced medical technologies and mobile health (mHealth) to manage disease has become an irresistible trend. To extend quality tumour treatment into daily lives, a mHealth platform was developed by using ferroelectric BiFeO3 nanomaterials (BFO) modified with TAT p...
Article
Cancer immunotherapy is an emerging treatment strategy that modulates the immune system to fight against cancer. Although several immunotherapeutic agents have been utilized in the clinic for cancer treatment, low patient response rates and potential immune-related adverse events remain two major challenges. With the merits of delivery controllabil...
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Full-text available
Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) a...
Article
Here, a protein farnesyltransferase (PFTase)-driven plasma membrane (PM)-targeted chimeric peptide PpIX-C6-PEG8-KKKKKKSKTKC-OMe (PCPK) was designed for PM-targeted photodynamic therapy (PM-PDT) and enhanced immunotherapy via tumor cell PM damage and fast release of damage-associated molecular patterns (DAMPs). The PM targeting ability of PCPK is or...
Article
Redox homeostasis inside malignant cells is a defense mechanism against the reactive oxygen species (ROS)-induced therapy means, but little importance has been paid to this innate barrier. The present study intends to make cancer cells more sensitive to the ROS-induced therapy by disturbing cellular redox homeostasis. To verify this concept, a poro...
Article
Full-text available
Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial “super neutrophils” are proposed with excellent inflammation targeting and hypochlorous acid (HClO)...
Article
The only treatment for cataract in clinic is the clouded lens removal combined with artificial lens implantation. In this study, nifedipine (NFP), a classic vasodilator, was loaded in a U.S. FDA-approved polymer PLA-PEG to form NFP-loaded PLA-PEG micelles as a novel eye drop to prevent oxidative cataract formation and progression at the early stage...
Article
Photodynamic therapy (PDT) has become an effective antibiosis method for overcoming antibiotic resistance. In this study, we developed a versatile bacterial membrane-binding chimeric peptide PpIX-[PEG8-(KLAKLAK)2]2 (denoted as PPK) by conjugating a photosensitizer protoporphyrin IX (PpIX) with the antimicrobial peptide (KLAKLAK)2 (KLA) for effectiv...
Article
Full-text available
During the last decade, peptide‐based nanomaterials are recognized as upcoming biomedical materials for tumor imaging and therapy. The rapid expansion of peptides and peptide derivatives is almost owing to their excellent biocompatibility, diverse bioactivity, potential biodegradability, specific biological recognition ability, and easy chemical mo...
Article
This paper reported on a two-photon excited nanocomposite FCRH to overcome tumor hypoxia for enhanced photodynamic therapy (PDT). Through modified by ruthenium (Ⅱ) complex (Ru(bpy)3²⁺) and hyperbranched conjugated copolymer with poly (ethylene glycol) arms (HOP), the water-splitting mediated O2 generation can be triggered via two-photon irradiation...
Article
During the past decades, functionalized nano-systems were believed in holding the bright future of the nanomaterials in biomedical applications. Due to their excellent biocompatibility, biodegradation capability, and biological activity, functional peptides have been vastly used solitary or employed as functional components in nano-systems for dise...
Article
Chemotherapy is well recognized to induce immune responses during some chemotherapeutic drugs-mediated tumor eradication. Here, a strategy involving blocking programmed cell death protein 1 (PD-1) to enhance the chemotherapeutic effect of a doxorubicin nanoprodrug HA-Psi-DOX is proposed and the synergetic mechanism between them is further studied....
Article
Nowadays, cell membrane targeting therapy has drawn much attention for its high anti-tumor effect by avoiding the cellular barriers. In this study, therapeutic agent conjugated chimeric peptide (Cp) was anchored in cracked cancer cell membranes (CCCM) to construct a self-delivery membrane system (M-Cp), which could relize precise cell membrane targ...
Article
To overcome drug resistance, efficient cancer therapeutic strategies using combination of small-molecule drugs and macromolecule drugs are highly desired. However, due to their significant differences in molecular weight and size, it is difficult to load them simultaneously in one vector and to release them individually. Here, a biodegradable organ...
Article
Multidrug resistance (MDR) remains one of the biggest obstacles in chemotherapy of tumor mainly due to P-glycoprotein (P-gp)-mediated drug efflux. Here, a transformable chimeric peptide is designed to target and self-assemble on cell membrane for encapsulating cells and overcoming tumor MDR. This chimeric peptide (C16-K(TPE)-GGGH-GFLGK-PEG8, denote...
Article
Conventional photodynamic therapy (PDT) has limited applications in clinical cancer therapy due to the insufficient O2 supply, inefficient reactive oxygen species (ROS) generation, and low penetration depth of light. In this work, a multifunctional nanoplatform, upconversion nanoparticles (UCNPs)@TiO2@MnO2 core/shell/sheet nanocomposites (UTMs), is...
Article
The cell membrane is the most important protective barrier in living cells and cell membrane targeted therapy may be a high-performance therapeutic modality for tumor treatment. Here, a novel charge reversible self-delivery chimeric peptide C16–PRP–DMA is developed for long-term cell membrane targeted photodynamic therapy (PDT). The self-assembled...
Article
Geometrical shape of nanoparticles plays an important role in cellular internalization. However, the applicability in tumor selective therapeutics is still scarcely reported. In this paper, we designed a tumor extracellular acidity-responsive chimeric peptide with geometrical shape switch for enhanced tumor internalization and photodynamic therapy....
Article
Conventional oxygen-dependent photodynamic therapy (PDT) has faced severe challenges because of the non-specificity of most available photosensitizers (PSs) and the hypoxic nature of tumor tissues. Here, an O2 self-sufficient cell-like biomimetic nanoplatform (CAT-PS-ZIF@Mem) consisting of the cancer cell membrane (Mem) and a cytoskeleton-like poro...
Article
Full-text available
Hydrogen peroxide (H2O2) detection in biological systems is of significant importance, which act as critical second messenger in fundamental biological processes. Here, we report on a chemoselective fluorescent naphthylimide peroxide probe (NPP) for the H2O2 detection in vitro and in vivo. NPP is a phenylboronic acid-caged chromophore that selectiv...
Article
A multifunctional prodrug, designated as TPP-L-GEM, is fabricated to realize image-guided in situ tumor photodynamic therapy (PDT) with red light activatable chemotherapy. Gemcitabine is conjugated with a fluorescent photosensitizer, meso-tetraphenylporphyrin (TPP), by a reactive oxygen species cleavable thioketal linker. Under the irradiation of l...
Article
Full-text available
Sialic acid is prominently situated at the outer ends of the glycoproteins and glycolipids in every vertebrate cell membranes, which collectively comprise the sialome. [1] This location advantage gives sialic acid the ability to mediate and/or modulate many cellular interactions emerged at the cell surface. [2] For example, sialic acid could act as...
Article
Intracellular thiols paly vital roles in living systems, the in situ monitoring of which is of great importance. Here, we report on a bioorthogonal chemistry based fluorescence probe, which is capable of monitoring intracellular thiols in living cells up to 36 hours with an obvious blue-to-green fluorescence change.

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Project (1)
Project
peptide, nanoparticle