Chetana Chandrashekar

Chetana Chandrashekar
Manipal Academy of Higher Education | MAHE · Department of Oral Pathology and Microbiology

About

24
Publications
2,748
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184
Citations
Citations since 2016
16 Research Items
154 Citations
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
Introduction
Skills and Expertise

Publications

Publications (24)
Article
Full-text available
Purpose: Odontogenic cysts and tumors comprise a major component of lesions of the oral and maxillofacial region. The pathogenesis of these lesions involves the interaction between the odontogenic epithelium and the ectomesenchyme. However, the clinical behavior of these biological entities is unpredictable. The aim of this study was to evaluate th...
Article
BACKGROUND: Spalt-like transcription factor 4 (SALL4) is a stem cell marker that plays a critical role in maintaining the pluripotency and self-renewal of embryonic and hematopoietic stem cells. Only a few studies have been done to apprehend the expression of SALL4 in the potentially malignant oral lesion (leukoplakia with dysplasia) and oral squam...
Article
Unicytic ameloblastoma is a variant of ameloblastoma encompassing about 6% of ameloblastomas. They represent cystic lesions that reveal clinical and radiographic features of a cyst, but the histopathological features demonstrate a typical ameloblastomatous epithelium lining the cyst. Plexiform unicystic ameloblastoma, a variant of unicystic amelobl...
Article
Full-text available
Objectives: Oral epithelial dysplasia (OED) is characterized by cellular alterations which have the proclivity of progressing to squamous cell carcinoma. Excision repair cross-complement group 1 (ERCC1) is one of the key proteins involved in nucleotide excision repair (NER) pathway. The expression of ERCC1 has been studied in colorectal, esophagea...
Article
Background: Odontogenic keratocyst (OKC) is a clinical entity with characteristic microscopic features, high growth potential and propensity to recur. Aggressive behavior and higher tendency for recurrence have been attributed to greater proliferative activity of epithelial lining. The incidence of recurrence in various reported series ranges from...
Article
Full-text available
Objectives: To determine the prevalence of odontogenic cysts and tumors along with age range, sex distribution, site of presentation and also to identify the most common type of odontogenic cyst and tumor among the population of coastal Karnataka over a 10-year period. Methods: Data was collected from patient records and histologically diagnosed...
Article
Aim: The occurrence of oropharyngeal candidiasis (OPC) may be influenced by oral candidal carriage (OCC). Although OPC is strongly associated with low CD4+ cell count (400-700 cells/mm3 ) and a lack of highly active antiretroviral therapy (HAART), the effect of these two parameters on OCC is debatable. We investigated the oral candidal carriage, s...
Article
Full-text available
Botryomycosis has emerged as a multifaceted entity caused by both the aerobes as well as the anaerobes, however, the exact nature of this entity is not understood in entirety as there are varying reports pertaining to its association with other conditions, clinical presentations and the host's immune status. In the present report we describe a case...
Article
Full-text available
We appraise a case of central odontogenic fibroma (COF) with unusual histologic features of entrapped neural elements and mast cells. The presence of mast cells attributed to the release of stem cell factor, the principal growth and activating factor of mast cells. A putative role for C-kit and mast cells in the pathogenesis of COF is described.
Article
Laser capture microdissection (LCM) is a high end research and diagnostic technology that helps in obtaining pure cell populations for the purpose of cell or lesion specific genomic and proteomic analysis. Literature search on the application of LCM in oral tissues was made through PUBMED. There is ample evidence to substantiate the utility of LCM...
Article
Giant-cell fibroma is a localized, benign fibrous mucosal mass, which clinically mimics any other fibroepithelial growth, and its distinction from other lesions is on the basis of its peculiar histopathology. A case of giant-cell fibroma with stroma strewn with brown pigment-laden cells is presented herewith. Immunohistochemical staining aided with...
Article
Background Determining margin status is the key in management of oral squamous cell carcinoma, indicating risk of local recurrence and guiding the use of adjuvant therapy. Frozen sections are commonly employed intraoperatively to assess the adequacy of resections. There is however no standard approach as to how frozen sections are used. A practice...
Article
Objectives: To determine the oral candidal carriage (OCC), activity of virulent factors and fluconazole susceptibility in subjects with type 2 diabetes mellitus (T2DM) and investigate their association with HbA1c measurements. Materials and methods: A cross sectional study was conducted on 100 diabetics and 100 healthy volunteers. The virulence...
Article
Full-text available
Oral squamous cell carcinomas comprise a heterogeneous tumor cell population with varied molecular characteristics, which makes prognostication of these tumors a complex and challenging issue. Thus, molecular profiling of these tumors is advantageous for an accurate prognostication and treatment planning. This is a retrospective study on a cohort o...
Article
Full-text available
Salivary duct carcinoma (SDC) is a high-grade adenocarcinoma arising from the ductal epithelium of salivary glands which rarely involves the minor salivary glands. The varied histological presentation in the minor salivary gland tumors makes them the most heterogeneous group of neoplasms, making the diagnosis a challenge. This report highlights the...
Article
About 20% of the world's population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2...
Article
Full-text available
Epithelial-mesenchymal transition (EMT), a key developmental program has been shown to occur in wound healing, organ fibrosis and in the initiation of metastasis for cancer progression. EMT is a process that describes the development of motile, mesenchymal-like cells from non-motile parent epithelial cells. Plasticity of the cells enable significan...
Article
Full-text available
Purpose: The clinical behavior of unicystic ameloblastoma varies according to its subtype. The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol. Methods: 18 cases of clinically and histologically confirmed unicystic ameloblastoma, cate...
Article
Vascularized ameloblastoma is a bewildering entity whose existence is questionable from its origin to nosology and its very characterization as a distinct variant of ameloblastoma. This uncertainty is largely because of a fewer number of documented cases and loss of long-term follow-up. The current paper describes two cases of ameloblastoma in the...
Article
Full-text available
To assess the expression of β-catenin in benign and malignant salivary gland tumors and to investigate the possible role of β-catenin in the behavior of salivary gland tumors. Paraffin embedded tissues from 45 salivary gland tumors were studied immunohistochemically for expression of β-catenin. Reduced/aberrant β-catenin expression was seen in beni...
Article
Full-text available
β-Catenin acts as a structural protein at cell-cell adherens junctions and as a transcription activator mediating Wnt signal transduction. Altered β-catenin expression has been associated with loss of cell differentiation and acquisition of an invasive phenotype. In the present study, β-catenin expression was compared immunohistochemically between...
Article
Teeth have been extensively used as a source of information in human identification, especially when the soft tissue cannot provide reliable information. Dental enamel is the most mineralized tissue, and resists post-mortem changes. The enhanced probability of personal identification from histological stress markers is said to be due to the pattern...

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Projects (2)
Project
Elucidate, Refine, Reformulate, Classify the Hallmarks of Cancer