Chenyu Sun

AMITA Health Saint Joseph Hospital Chicago · Internal Medicine

Objective: While some individual studies have suggested an association between periodontal disease and breast cancer, there has not been a formal meta-analysis that collates the existing evidence supporting the hypothesis that periodontal disease leads to a higher risk of developing breast cancer. Accordingly, this meta-analysis was conducted. Meth...

Introduction: The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. Objective: In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable...

Background: Research into the effects of breast cancer on delivery outcomes has generated inconsistent findings. Objectives: To pool data from existing observational studies of the effect of breast cancer on preterm delivery and low delivery weight. Search strategy: A systematic literature search of PubMed, Embase, and Web of Science databases...

目的 运用Meta 分析方法评价中国人群中血清胸腺激酶1 (TKl) 与乳腺疾病的相关性. 方法 通过计算机检索中国知网(CNKI), 万方, 维普, PubMed 数据库, 结合文献追溯和采用公共搜索引擎(www. baidu. com; scholar. google. com) 网上检索, 收集所有关于中国人群中血清TKl 与乳腺疾病的相关性的研究. 以血清TK1 与乳腺疾病的相关性的相对危险度(RR) 值及标化均数差(SMD) 值为效应指标, 各资料间进行一致性检验, 以确定采用固定或随机效应模型进行合并分析. 发表偏倚通过漏斗图和Egger'S 线性回归检验进行评估. 统计分析应用 RevMan5. 1 软件进行, Egger'S 线性回归检验选用STATA10. 0 软件计算...

An amendment to this paper has been published and can be accessed via the original article.

Background Colorectal cancer (CRC) is the third most common diagnosed cancer and the third leading cause of all cancer deaths in the USA. Some evidences are shown that aspirin can reduce the morbidity and mortality of different cancers, including CRC. Aspirin has become a new focus of cancer prevention and treatment research so far; clinical studie...

Background: The critical role of vascular health on brain function has received much attention in recent years. At the single-cell level, studies on the developmental processes of cerebral vascular growth are still relatively few. Techniques for constructing gene regulatory networks (GRNs) based on single-cell transcriptome expression data have ma...

The present meta-analysis was performed to evaluate the efficacy of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC) patients. A systematic literature search was conducted of online databases prior to February 21, 2021. Eleven articles involving 8429 patients were included. The pooled hazard...

The contributions of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) to breast cancer are critical areas of investigation. In this study, we identified a novel lncRNA RP11-283G6.5 which was lowly expressed in breast cancer and whose low expression was correlated with poor overall survival and disease-free survival of breast cancer patients. F...

Gastric cancer (GC) is the fifth most common cancer globally. Secreted frizzled-related proteins (SFRP) are important elements associated with the Wnt signaling pathway, and its dysregulated expression is found in multiple cancers. However, the function of distinct SFRPs in GC remains poorly understood. We investigated the differential expression,...

Previous researches on the association between proton pump inhibitors (PPIs) use and the treatment and prevention of COVID-19 has generated inconsistent findings. Therefore, this meta-analysis was conducted to clarify the outcome in patients who take PPIs. Eight articles with more than 268,683 subjects were included. PPI use was not associated with...

Disclosures Research Funding: None Background:

e16235 Background: Diabetes mellitus (DM), a paraneoplastic phenomenon, can develop earlier than other symptoms in pancreatic cancer (PaC) patients. Enhanced surveillance is encouraged on all elderly patients with new-onset DM. However, it is a challenge to differentiate newly developed PaCDM from type 2 DM (T2DM). Thus, we investigated the differe...

Disclosures Research Funding: None Background:

e15609 Background: Colorectal cancer (CRC) is one of the most diagnosed cancers and the second leading cause of cancer-related death worldwide. Globally, more than 1.8 million people are diagnosed of colorectal cancer (CRC) in 2018. In advanced CRC patients, bevacizumab plus 5-fluorouracil-based or platinum-based therapy has become one of the stand...

Introduction: Coronavirus disease 2019 (COVID-19) has been spreading globally for more than half a year. Previous studies remain controversial regarding whether metformin is associated with reduced risk for COVID-19 diabetic patients. Thus, this meta-analysis is performed. Method: A comprehensive literature search on PubMed and Web of Science was c...

Introduction: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Dipeptidyl peptidase-4 (DPP-4) is a multi-expressed glycoprotein that is speculated to be a functional SARS-CoV-2 receptor. Previous studies remain controversial regarding whether DPP-4 use is associated with reduced risk for...

A 44-year-old woman with ER+/Her2(-)/PI3K positive met-astatic breast cancer was started on alpelisib. Previously, HbA1C was 5.4%. Hyperglycemia developed and HbA1c rose to 9.0% within 6 months of alpelisib 300mg daily. She started metformin and empagliflozin, which she was unable to tolerate due to nausea and vomiting. Her self-monitored blood glu...

The association between radioactive iodine (RAI) therapy and reduced fertility has remained controversial, in part because no large-scale randomized clinical trials or prospective studies have been done in this regard. Hence, we performed this meta-analysis to investigate the association between radioactive iodine therapy and birth rates in female...

hemoglobin between T1 and T4 which was estimated at 2.5 g/dl, we defined two groups (N = 15). The rate of falls of preoperative fib-rinogen concentration between the two groups was not statistically significant contrary to preoperative hemoglobin level and postopera-tive bleeding volume at 24 hours. However, there was an inverse correlation between...

Background Phelan-McDermid syndrome (PMS), also known as 22q13.3 deletion syndrome, is a rare neurodevelopmental syndrome resulting from a deletion of the distal long arm of chromosome 22. Case presentation We report a case of a 21 months old Chinese girl presenting with global developmental delay, regression of language skills, unable to understa...

Background: Surgical stainless wire has been widely used to stabilize pectus bar and ribs in Nuss procedure for pectus excavatum correction. However, wire fracture and its secondary complications are problems easily to be ignored but very important. The purpose of this article was to describe a series of cases with wire breakage, hoping to arouse...

Background Famotidine was reported to potentially provide benefits to Coronavirus Disease 2019 (COVID-19) patients. However, it remains controversial whether it is effective in treating COVID-19.AimsThis study aimed to explore whether famotidine use is associated with reduced risk of the severity, death, and intubation for COVID-19 patients.Methods...

Background: Some evidence shown that aspirin can reduce the morbidity and mortality of different cancers, including breast cancer. Aspirin has become a new focus of cancer prevention and treatment research at present, however clinical studies found conflicting conclusions of its anticancer characteristics. Materials and Methods: A systematic litera...

PurposePrevious research on the association between proton pump inhibitor (PPI) use and the risk of progression to high-grade dysplasia (HGD)/esophageal adenocarcinoma (EAC) in Barrett’s Esophagus (BE) patients has generated inconsistent findings. This meta-analysis was performed to clarify the association.Methods We performed a comprehensive searc...

Introduction: The highly infectious coronavirus disease 2019 (COVID-19) has now rapidly spread around the world. This meta-analysis was strictly focused on the influence of smoking history on the severe and critical outcomes on people with COVID-19 pneumonia. Methods: A systematic literature search was conducted in eight online databases before 1 F...

Background: During the current Coronavirus Disease 2019 (COVID-19) pandemic, diabetic patients face disproportionately more. Anti-inflammatory effects of hypoglycemic agents have been reported, and their beneficial or harmful effects in patients with diabetes and COVID-19 remain controversial. Purpose: This study was performed to clarify this assoc...

ACKGROUND Paragonimiasis is a parasitic disease that has multiple symptoms, with pulmonary types being common. According to our clinical practices, the pleural effusion of our patients is full of fibrous contents. Drainage, praziquantel, and triclabendazole are recommended for the treatment, but when fibrous contents are contained in pleural effusi...

190 Background: Globally, more than 570,000 people are diagnosed of esophageal cancer each year. Shift-work involving circadian disruption was designated as a probable cause of cancer by The International Agency for Research on Cancer. Previous studies investigating the relationship between shift-work and esophageal cancer among showed controversia...

Background: Previous researches on the association between proton pump inhibitors (PPIs) use and the treatment and prevention of COVID-19 have generated inconsistent findings. Therefore, this Meta-analysis was conducted to clarify the outcome in patients who take PPIs. Methods: We carried out a systematic search to identify potential studies until...

Background Based on the status of the COVID-19 global pandemic, there is an urgent need to systematically evaluate the effectiveness of wearing masks to protect public health from COVID-19 infection. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement was consulted to report this systematic review. We c...

Objective: We aimed to compare the characteristics of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, Italy, and South Korea. Materials and methods: Detailed national epidemiological information of COVID-19 was retracted from the latest statistics reports from China, Italy, and Sou...

Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic. Hospitalized patients of COVID-19 suffer from a high mortality rate, motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients. Here, we have developed a risk score using clinical data from 1479 inpatients admitted...

Objective Colorectal cancer (CRC) is a commonly diagnosed cancer. Previous studies investigating the relationship between periodontal disease (PD) and CRC showed controversial conclusions. This meta‐analysis is to explore the association between PD and CRC. Methods Observational studies that explore the association between CRC and PD were included...

Background: Phelan-McDermid syndrome (PMS), also known as 22q13.3 deletion syndrome, is a rare neurodevelopmental syndrome resulting from a deletion of the distal long arm of chromosome 22. Case presentation: We report a case of a 21 months old Chinese girl presenting with global developmental delay, absence of speech, unable to understand a few wo...

Objectives The evidence of whether the obstructive sleep apnea (OSA) could increase the risk of Parkinson disease (PD) remains controversial. This meta-analysis was conducted in hopes of providing evidence of associations between the OSA and the risk of PD incidence. Methods Relevant studies published until 7 September, 2020 were retrieved from 6...

Background Based on the current status of the COVID-19 global pandemic, there is an urgent need to systematically evaluate the effectiveness of wearing masks to protect public health from COVID-19 infection. Methods We conducted a systematic review and meta-analysis to evaluate the effectiveness of using face masks to prevent the spread of SARS-Co...

BACKGROUND Breast diseases pose increasing threat to women health as peoples lifestyle changes. The aim of this study was to investigate the clinical application value of Palpation Imaging (PI) in the diagnosis of breast diseases. MATERIAL AND METHODS From October 2019 to February 2020, 184 patients with 225 breast lesions were examined by using PI...

PurposeThe association between antibiotics and colorectal cancer (CRC) risk has drawn increasing attention but remains controversial. This study was performed to clarify the association.MethodsA systematic review and meta-analysis was performed on seven electronic databases. The pooled odds ratios (OR) with a 95% confidence interval (CI) were calcu...

Introduction: Colorectal cancer (CRC) is a commonly diagnosed cancer, ranking third in prevalence among men and second among women. In the United States, CRC is the second leading cause of cancer-related deaths. Periodontal disease (PD), affecting a large number of adults, may increase cancer risk by the prolonged release of inflammatory mediators...

COVID‐19 pandemic has made the medical situation of HIV‐infected individuals more complicated in low‐income countries especially those with high incidence of acquired immunodeficiency syndrome (AIDS). Besides, the COVID‐19 pandemic may also have an impact on acquired immunodeficiency syndrome (AIDS) patients' access to medical services. Although th...

Background Although the effects of seasonal variations and ambient temperature on the incidence of tuberculosis (TB) have been well documented, it is still unknown whether ambient temperature change is an independent risk factor for TB. The aim of this study was to assess the association between ambient temperature change and the risk of TB admissi...

Coronavirus Disease 2019 (COVID-19) has become a world-wide pandemic. Hospitalized patients of COVID-19 suffer from a high mortality rate, motivating the development of convenient and practical methods for clinicians to promptly identify high-risk patients. Here we developed a risk score using clinical data from 1,479 inpatients admitted to Tongji...

Background The effect of using Angiotensin-converting enzyme inhibitors (ACEIs) and Angiotensin-receptor blockers (ARBs) on the risk of coronavirus disease 2019 (COVID-19) is a topic of recent debate. Although studies have examined the potential association between them, the results remain controversial. This study aims to determine the true effect...

Background: Urolithiasis is a prevalent health issue all over the world,To evaluate the diagnostic accuracy of low-lose computed tomography(LDCT) for detecting urolithiasis. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed, EMBASE and The Cochrane Library were searched for original diagnostic...

Background Conflicting recommendations exist related to whether masks have a protective effect on the spread of respiratory viruses. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement was consulted to report this systematic review. Relevant articles were retrieved from PubMed, Web of Science, ScienceD...

Background: Conflicting recommendations exist related to whether masks have a protective effect on the spread of respiratory viruses. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement was consulted to report this systematic review. Relevant articles were retrieved from PubMed, Web of Science, Science...

Purpose The aim of this study was to explore the relationship between proton pump inhibitors use and the risk of dementia. Methods A comprehensive literature search was conducted in English and Chinese databases from origination to December 2018. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a random-effect...

The relationship between hypertension and risk of colorectal cancer (CRC) is unclear. This meta-analysis aims to explore the association between them. Six databases were searched for studies published before August 2019. The pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated to estimate the association between the hyperten...

Previous epidemiological investigations have evaluated the association between gout, serum uric acid levels, and obstructive sleep apnea syndrome (OSAS), but with inconsistent results. We conducted this meta-analysis aiming at providing clear evidence about whether OSAS patients have higher serum uric acid levels and more susceptible to gout. Relev...

Purposes: Many studies have indicated that orthostatic hypotension (OH) may be a risk factor for dementia and stroke, but the results have been inconsistent. To further ascertain the links between OH and cognition or stroke, a meta-analysis was performed. Methods: The Chinese Biomedical Database, PubMed, Web of Science, and the Cochrane Library dat...

Objective: To evaluate the association between periodontitis and the incidence and mortality of gastrointestinal cancer. Methods: A comprehensive literature search was conducted to identify all relevant studies published prior to April 2019 according to the established inclusion criteria. The pooled hazard ratios (HRs) and 95% confidence interva...

We performed this meta-analysis to assess the association between intensive systolic blood pressure (SBP)-lowering strategies and heart failure (HF). A comprehensive literature review was conducted using English and Chinese databases from their origination through April 2018. Random-effects models were used to calculate pooled relative risks and 95...

Recently, emerging studies on the relationship between insomnia, the most common sleep disorder, and cancer have been published, but with inconsistent results. With the development of society and the accelerated pace of life, more and more people experience insomnia. Therefore, it is important to clarify the association. Relevant literature was obt...

The relationships between orthostatic hypotension (OH) and some kinds of cardiovascular disease are inconsistent among studies. This updated meta‐analysis was conducted in hopes of producing progress on this topic. A systematic database search was performed in electronic databases, including the Chinese Biomedical Database (CBM), PubMed, Web of Sci...

Background: Caveolin-1 (CAV1) polymorphisms have been shown to correlated with breast cancer risk in previous studies. However, the role of CAV1 polymorphisms still remained indecisive, and dual functions of CAV1 was demonstrated in breast cancer development. Consequently, a meta-analysis to evaluate and summarize the association of the CAV1 polym...

Here, we present a case of a 25-year-old Chinese female who was diagnosed with non-functional adrenocortical adenoma containing myelolipoma with hypertension as the only symptom. Serum levels of cortisol, aldosterone, angiotensin I/II and renin activity were normal. Myelolipoma is a benign, non-functioning retroperitoneal tumour occurring predomina...

Recently published studies on the association between depression and hip fracture (HF) are inconsistent. Therefore, we performed this meta-analysis with the main aim to clarify the association between depression and HF, and also to identify possible susceptible groups. Relevant literature published until February 2019 was obtained and screened acco...

Objective The aim of this study was to explore the relationship between statin use and the risk of pancreatic cancer. Methods Electronic databases were searched to identify relevant studies published until January 2018. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated with random-effects model. Subgroup analyses a...

NEK5, a contraction of NIMA Related Kinase 5, has been shown to regulate the centrosome integrity of cells though; it has been little described in cancer. Herein, to explore the clinicopathological meaning of NEK5 expression in breast cancer, immunohistochemistry was performed to detect the expression of NEK5 on tissue blocks, totaling 203 cases. Q...

As a part of the central nervous system, the optic nerve goes through the comparatively independent intraocular and retrobulbar pressurized cerebrospinal fluid cavity. Additionally, the central retinal vein and artery pass from the optic nerve head through the optic nerve and the orbital cerebrospinal fluid (CSF) space. The CSF pressure, as the cou...

已有诸多研究者试图从不同角度阐述医患关系紧张的原因和解决方法，但医患关系紧张情况一直没有得到有效地缓解。对医患关系的深层探索和分析可为有效地解决医患关系紧张问题提供精准可靠的策略和方法，其中"加州女儿综合征"现象作为导致部分医患矛盾案例发生的深层原因应引起重视。对"加州女儿综合征"这一现象背后原因及相关应对方法的深入探索，将有助于医护人员避免和应对此类医患纠纷的发生。 The escalating tension in doctor-patient relationship has not been well solved yet. Researchers have tried to explain its reasons and how to solve this problem. An...