Chengzhou Zhu

Chengzhou Zhu
Central China Normal University · College of Chemistry

Professor

About

255
Publications
61,815
Reads
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19,818
Citations
Introduction
Dr. Zhu is a professor at Central China Normal University. He has coauthored over 200 peer-reviewed publications, with citations of ∼22000, h-index 75. His scientific interests focus on atomic scale nanomaterials for catalysis and biosensing. Web:https://www.x-mol.com/groups/zhulab_ccnu
Additional affiliations
April 2018 - present
Central China Normal University
Position
  • Professor
June 2014 - April 2018
Washington State University
Position
  • Professor
March 2013 - April 2014
Technische Universität Dresden
Position
  • Humboldt Research Fellow

Publications

Publications (255)
Article
The conventional cathodic electrochemiluminescence (ECL) always requires a more negative potential to trigger strong emission, which inevitably damages the bioactivity of targets and decreases the sensitivity and specificity. In this work, iron single-atom catalysts (Fe-N-C SACs) were employed as an efficient co-reaction accelerator for the first t...
Article
Developing enzyme-mimicking catalysts with high catalytic activity and specificity has been a long-standing challenge. Herein we report efficient laccase-mimicking catalysts (His-Cys-Cu) that consist of atomic Cu active centers and dipeptide-organized electron transfer pathway by simulating the catalytic process of natural enzymes, exhibiting high...
Article
Compared with traditional laboratory-based tests, lateral flow immunoassay (LFA) has been developed as one of the emergent and popularly used rapid detection technology. Due to unique physical and chemical properties, novel nanomaterials have been widely used as the signal label in LFA for the detection of analytes, but these assays merit further d...
Article
Ammonia (NH 3) is mainly produced through the traditional Haber-Bosch process under harsh conditions with huge energy consumption and massive carbon dioxide (CO 2) emission. The nitrogen electroreduction reaction (NERR), as an energy-efficient and environment-friendly process of converting nitrogen (N 2) to NH 3 under ambient conditions, has been r...
Article
The elaborate design and fabrication of nanomaterials to mimic natural enzyme-catalyzed active sites is a promising approach to significantly improve catalytic performances, which is beneficial to the signal amplification for biosensing applications. Metal−organic frameworks (MOFs) with tailorable components, structures and well-distributed metal s...
Article
Cell-free enzymatic catalysis (CFEC) is emerging biotechnology that simulates biological transformations without living cells. However, the high cost of separation and preparation of the enzyme has hindered the practical application of the CFEC. Enzyme immobilization technologies using solid supports to stabilize enzymes have been regarded as an ef...
Preprint
Although great progress has been made in nanozymes, their large-scale application still remains a huge challenge due to their unsatisfactory catalytic performances. Featuring unique electronic structure and coordination environment, single atoms nanozymes provide great opportunities to vividly mimic the specific metal catalytic center of natural en...
Article
Full-text available
Dual-band electrochromism is a phenomenon where materials can independently regulate the transmittance of visible (VIS) and near-infrared (NIR) light. Owing to their bistability, low energy consumption, and independent control over VIS and NIR regions, dual-band electrochromic (EC) devices have been of great significance to fully harnessing VIS and...
Article
Full-text available
Photoelectrochemical (PEC) enzymatic biosensors integrate the excellent selectivity of enzymes and high sensitivity of PEC bioanalysis, but the drawbacks such as high cost, poor stability, and tedious immobilization of natural enzymes on photoelectrodes severely suppress their applications. AgCu@CuO aerogel-based photoelectrode materials with both...
Article
Full-text available
Fe-based single-atomic site catalysts (SASCs), with the natural metalloproteases-like active site structure, have attracted widespread attention in biocatalysis and biosensing. Precisely, controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’ performance. In this work, we use a facile ion-imprinting metho...
Article
Metal-organic framework (MOF)-based materials are regarded as potential electrocatalysts for oxygen evolution reaction (OER) resulting from the abundant pore structures, large surface area and atomically dispersed metal centers, while their coordinately saturated metal nodes are inert to electrocatalysis. In this work, creating active sites while a...
Article
Due to the high stability, various synthesis strategies, low cost, and tunable performance, nanozymes have gained much attention as the replacement of natural enzymes. To widen the application, highly active, specific, and robust nanozymes are in need. Recently, defects in nanomaterials have been verified to play a significant role in enhancing cat...
Article
The development of highly active biomimetic catalysts with peroxidase (POD)-like activity and realization of vivid mimicking of the active sites of natural enzymes still remains a huge challenge. Herein, atomically dispersed Fe atoms on hierarchically S/N co-doped porous carbon (FeSNC) featured with the unsymmetrically coordinated Fe-N3S1 as active...
Article
Full-text available
Single‐atom alloys (SAAs) have ignited a surge of unprecedented interest as the advanced nanomaterials and opened many opportunities for wide applications. Herein, 3D porous aerogels comprising ionic liquid (IL) functionalized PdBi SAA building blocks with atomically dispersed Bi on Pd nanowires (IL/Pd50Bi1) are synthesized with accelerated gelatio...
Article
In recent years, a new type of quasi-one-dimensional graphene-based material, graphene nanoribbons (GNRs), has attracted increasing attention. The limited domain width and rich edge configurations of GNRs endow them with unique properties and wide applications in comparison to two-dimensional graphene. This review article mainly focuses on the elec...
Article
Replacement of enzymes with nanomaterials such as atomically dispersed metal catalysts is one of the most crucial steps in addressing the challenges in biocatalysis. Despite the breakthroughs of single-atom catalysts in enzyme-mimicking, a fundamental investigation on the development of an instructional strategy is still required for mimicking biat...
Article
Though nanozymes are successfully applied in various areas, the increasing demands facilitate the exploitation of nanozymes possessing higher activity and more functions. Natural enzyme‐linked receptors (ELRs) are critical components for signal transductions in vivo by expressing activity variations after binding with ligands. Inspired by this, the...
Article
Although carbon nanozymes have attracted great interest due to their good biocompatibility, low cost, and high stability, designing high-active carbon nanozymes still faces great challenges. Herein, ultrathin nitrogen-doped carbon nanosheets with rich defects (d-NC) were prepared through a high-temperature annealing process, using potassium chlorid...
Article
Full-text available
Self‐powered sensing systems (SPSSs) are critical components in smart portable electronic devices. Zinc‐air batteries (ZABs) as promising energy devices provide a great opportunity to develop novel SPSS for sensing applications owing to the merit of high open‐circuit potential. Herein, hierarchically porous single‐atom iridium embedded nitrogen‐dop...
Article
Full-text available
Multiple enzymes-induced biological cascade catalysis guides efficient and selective substrate transformations in vivo. The biomimetic cascade systems, as ingenious strategies for signal transduction and amplification, have a wide range of applications in biosensing. However, the fragile nature of enzymes greatly limits their wide applications. In...
Article
The rational design of nanozymes with superior activities is essential for improving bioassay performances. Herein, nitrogen and boron co-doped graphene nanoribbons (NB-GNRs) are prepared by a hydrothermal method using urea as the nitrogen source and boric acid as the boron source, respectively. The introduction of co-doped and edge structures prov...
Article
The complex structure of nanomaterial causes great difficulty in identifying active sites of nanozymes and getting to the bottom of the catalytic mechanism. In this report, single-atom Bi-anchored Au ([email protected]) hydrogels were synthesized through a one-step reduction strategy, which enables the precise regulation of the nanozyme activity an...
Article
Graphite carbon nitride (g-C3N4) is a significant non-metal photocatalyst, but still challenging for photocatalytic degradation of pollutants because of its poor visible light utilization, easy recombination of photo-generated carriers and low surface reactive reaction sites. In this paper, perylene diimide (PDI), an electron-deficient building blo...
Article
At present, enzyme-mediated signal amplification strategies have been widely applied in photoelectrochemical (PEC) biosensing systems, while the introduction of natural enzymes onto the surface of photoelectrodes inevitably obstructs the electron transfer due to their insulating properties as proteins, leading to severe damage to photocurrent. In t...
Article
With great progress in the development of nanozymes, the effect of size, composition and structure on the catalytic activity of nanozymes have been studied extensively, while the effect of phase has rarely been reported. Herein, phase-engineered RuTe2 nanorods are synthesized with different phase structures and peroxidase (POD)-like activities, whi...
Article
Full-text available
The rational construction of advanced sensing platforms to sensitively detect H2O2 produced by living cells is one of the challenges in both physiological and pathological fields. Owing to the extraordinary catalytic performances and similar metal coordination to natural metalloenzymes, single atomic site catalysts (SASCs) with intrinsic peroxidase...
Article
Benefiting from the maximum atom-utilization efficiency and distinct structural features, single-atom catalysts open a new avenue for the design of more functional catalysts, whereas their bioapplications are still in their infancy. Due to the advantages, platinum single atoms supported by cadmium sulfide nanorods (Pt SAs-CdS) are synthesized to bu...
Article
Developing single-atomic site (SAS) catalysts for oxygen reduction reaction (ORR) with superior activities in the renewable-energy initiatives is critical but remains challenging. Herein, exceptional SAS Fe boosted by adjacent graphene-encapsulated Fe3C nanocrystals (Fe3[email protected] SAS) is constructed for ORR. Because of the strong synergisti...
Article
Full-text available
The development of electrocatalysts for the oxygen reduction reaction (ORR) with high activity and cost-effectiveness is indispensable for sustainable energy storage and conversion technologies. Featured with maximum atomic efficiency and well-defined structure characteristics, carbon-based single-atomic site (SAS) catalysts are regarded as the mos...
Article
Development of highly sensitive biosensors has received ever-increasing attention over the years. Due to the unique physicochemical properties, the functional nanomaterial-enabled signal amplification strategy has made some great breakthroughs in biosensing. However, the sensitivity and selectivity still need further improvement. Single-atom cataly...
Article
Enzyme cascade reactions in biological systems can effectively improve the catalytic performances owing to their high local concentration, efficient mass transfer and reduced intermediate decomposition. However, the disadvantages of high cost, low stability, and easy inactivation limit their practical applications in harsh environments. Nanozymes a...
Article
Nanomaterials with enzyme-like activities, i.e., nanozymes, have aroused wide concern in biocatalysis. Fe-N-C single-atom catalysts with atomically dispersed FeNx as active sites, defined as Fe-N-C single-atom nanozymes, have the structure similar to some heme enzymes and therefore can mimic the enzyme-like activities. However, they are still subje...
Article
Noble metal-based nanomaterials have been a hot research topic during the past few decades. Particularly, self-assembled porous architectures have triggered tremendous interest. At the forefront of porous nanostructures, there exists a research endeavor of noble metal aerogels (NMAs), which are unique in terms of macroscopic assembly systems and th...
Article
Full-text available
Carbon materials have been widely used as nanozymes in bioapplications, attributing to their intrinsic enzyme-like activities. Nitrogen (N)-doping has been explored as a promising way to improve the activity of carbon material-based nanozymes (CMNs). However, hindered by the intricate N dopants, the real active site of N-doped CMNs (N-CMNs) has bee...
Article
Design of highly-active carbon nanozymes and further establishment of ultrasensitive biosensors remains a challenge. Here-in, the hierarchically porous carbon nanozymes with sulfur (S) / nitrogen (N) co-doping (SNC) were developed. Compared with N-doped carbon (NC) nanozymes, SNC nanozymes have smaller Michaelis–Menten constant (Km) and higher spec...
Article
Full-text available
Although nanozymes have been widely developed, accurate design of highly active sites at the atomic level to mimic the electronic and geometrical structure of enzymes and the exploration of underlying mechanisms still face significant challenges. Herein, two functional groups with opposite electron modulation abilities (nitro and amino) were introd...
Article
Full-text available
In the electrochemiluminescence sensing platform, co-reaction accelerators are some specific materials to catalyze the dissociation of co-reactants into active radicals, which can significantly boost the ECL emission of luminophores. Deep insight into the correlation between the structure and ECL performance will guide to rationally design highly a...
Article
Full-text available
Single-atom catalysts (SACs) with nitrogen-coordinated nonprecious metal sites have exhibited inimitable advantages in electrocatalysis. However, a large room for improving their activity and durability remains. Herein, we construct atomically dispersed Fe sites in N-doped carbon supports by secondary-atom-doped strategy. Upon the secondary doping,...
Article
Generally, the photoactive materials are always tightly fixed on the photoelectrode of photoelectrochemical (PEC) sensors to produce excellent photocurrent response, while obvious and constant background currents will appear as well and then hamper the ultrasensitive sensing of target molecules. In this work, ultrasensitive detection of organophosp...
Article
Full-text available
Tuning electrocatalysts via interface engineering is widely adopted as a valid way to manipulate the electrocatalytic activity. Herein, the interface engineering of PdCu aerogels is successfully achieved by the integration of ionic liquid (IL), which not only accelerates the gelation kinetics but also leads to the modulation of interface electronic...
Article
In this work, Co-N-doped carbon nanosheet (Co-NCS) as an efficient ORR catalyst was reported through a self-assembly strategy and subsequent pyrolysis process. Coupling with the unique 2D architecture and high N-doping level, the optimized Co-NCS exhibits a superior ORR performance with more positive onset potential (0.96 V) and half-wave potential...
Article
Co single‐atom catalysts (SACs) with good aqueous solubility and abundant labelling functional groups were prepared in Co/Fe bimetallic metal‐organic frameworks by a facile solvothermal method without high‐temperature calcination. Different from traditional chemiluminescence (CL) catalysts, Co SACs accelerated decomposition of H2O2 to produce a lar...
Article
Despite the breakthroughs of transition metal catalysts in enzyme-mimicking, fundamental investigation on the design of efficient nanozymes at the atomic scale is still required for boosting their intrinsic activities to fill in gaps from enzymes to nanozymes. Herein, we report a general salt-template method for the preparation of isolated Fe atoms...
Article
Single-atom catalysts (SACs), a newcomer in the field of nanocatalysis, have sparked tremendous interest thanks to their high atomic utilization, unsaturated coordination environment, and attractive properties. Unfavorably, few studies have focused on the applications of the SACs in the biosensors. Herein, a reliable SiO2-templated strategy was ela...
Article
Developing efficient nonprecious metal electrocatalysts is urgently needed to promote the sluggish kinetics of oxygen evolution reaction (OER). Transition metals-based layered double hydroxides (LDH) have been considered as highly active OER catalysts, while low conductivity and limited active site exposures hinder their further applications. Herei...
Article
Ammonia (NH 3) is mainly produced through the traditional Haber-Bosch process under harsh conditions with huge energy consumption and massive carbon dioxide (CO 2) emission. The nitrogen electroreduction reaction (NERR), as an energy-efficient and environment-friendly process of converting nitrogen (N 2) to NH 3 under ambient conditions, has been r...
Article
Ammonia (NH3) is mainly produced through the traditional Haber–Bosch process under harsh conditions with huge energy consumption and massive carbon dioxide (CO2) emission. The nitrogen electroreduction reaction (NERR), as an energy-efficient and environment-friendly process of converting nitrogen (N2) to NH3 under ambient conditions, has been regar...
Article
A highly sensitive photoelectrochemical (PEC) sensing platform was constructed for Hg²⁺ determination based on the Schottky heterojunction between an emerging 2D material Ti3C2TX MXene and a promising semiconductor material BiVO4. Through simply spin-coating the single-layer Ti3C2TX onto the surface of BiVO4 film, the modified electrode exhibited s...
Article
In this work, a Z-scheme TiO2/Ti3C2Tx/Cu2O heterostructure was well designed and fabricated by in situ generating TiO2 NPs on Ti3C2Tx MXenes and subsequently introducing Cu2O via one-step hydrothermal reaction. The obtained heterojunction exhibits good photoelectrochemical (PEC) activity with dissolved O2 as electron scavenger, during which H2O2 is...
Article
Single-atom electrocatalysts (SAEs) can realize the target of low-cost by the maximum atomic efficiency. However, they usually suffer performance decay due to high energy states, especially in a harsh acidic water splitting environment. Here, we conceive and realize a double protecting strategy that ensures robust acidic water splitting on Ir SAEs...
Article
Single-atom nanozymes (SAzymes), as novel nanozymes with atomically dispersed active sites, are of great importance in the de-velopment of nanozymes for their high catalytic activities, the maximum utilization efficiency of metal atoms, and the simple mod-el of active sites. Herein, the peroxidase-like SAzymes with high-concentration Cu sites on ca...
Article
The establishment of advanced electrocatalysts with remarkable performance and cost effectiveness for the oxygen evolution reaction (OER) is an emerging need for the production of clean hydrogen fuel. In this work, three-dimensional (3D) amorphous NiFeIr x /Ni core-shell nanowire@nanosheets (NW@NSs) are successfully synthesized through a facile one...
Preprint
Full-text available
Ammonia (NH3) is mainly produced through the traditional Haber-Bosch process under the harsh conditions with huge energy consumption and massive carbon dioxide (CO2) emission. The nitrogen electroreduction reaction (NERR), as an energy-efficient and environment-friendly process converting nitrogen (N2) to NH3 under ambient conditions, has been rega...