Cheng-Jen Chang

Cheng-Jen Chang
Taipei Medical University Hospital | TMUH · Division of Plastic Surgery

MD, phD, FACS

About

43
Publications
3,396
Reads
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854
Citations
Citations since 2017
14 Research Items
298 Citations
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201720182019202020212022202301020304050
201720182019202020212022202301020304050

Publications

Publications (43)
Article
Full-text available
The objective of this study is to use imaging and histopathological analysis to characterize and monitor microvascular responses to photodynamic therapy (PDT). In vivo chicken chorioallantoic membranes (CAMs) and a stimulated malignant oral lesions animal model were used to determine the blood flow and the biological activities of Photofrin® (2.5 m...
Article
Purposes: The objectives of this study are to use diode lasers for low-level laser therapy (LLLT) and to assess its applicability and effects in adipose-derived stem cell (ADSC) growth processes. Methods: Studies were conducted on the diode laser with wavelengths of 622.7, 527.1, and 467.3 nm. The mechanism of action of LLL illumination was stud...
Article
Full-text available
Aim: Transconjunctival CO2 laser lower blepharoplasty is considered to be a safe and reliable approach. A retrospective review of transconjunctival approached CO2 laser lower blepharoplasty associated with fractional CO2 laser ablation or fractioned non-ablative Fraxel laser resurfacing for lower eyelid rejuvenation is presented for comparison. Met...
Article
Full-text available
The forehead flap is a dependable option for nasal reconstruction owing to its reliability and anatomic likeness to nasal skin. For patients with low hairlines, the vertical design of the paramedian forehead flap can intrude into the scalp, thus incorporating hair into the nasal reconstruction. The inadequate length of the forehead flap or shift to...
Article
Full-text available
When the cartilage on the prominent ears is reshaped, the arising stress returns the tissue to its initial configuration. Laser irradiation of areas of maximal stress leads to stress relaxation and results in a stable configuration. Sixty auricles were harvested from 30 New Zealand white rabbits and cut into a rectangle measuring 50 mm by 25 mm wit...
Article
Background: Lymphatic malformations remain a challenge for patients and plastic surgeons. Promising results have been reported using intralesional laser photocoagulation (ILP) for treating vascular anomalies. Background data: The objective of our study is to review the long-term results of a large series of lymphatic malformations in patients tr...
Article
Background: The objective of this study was to assess the efficacy and safety of endovenous laser photocoagulation (EVLP) at a wavelength of 810 nm for treating complicated venous insufficiency associated with venous ulcers. Materials and methods: A retrospective review of 110 patients with 180 legs having chronic venous insufficiencies associat...
Article
Objectives: The prognosis of patients suffering from malignant cutaneous neoplasms can be improved by early diagnosis. Exact demarcation of tumor margins could contribute to optimum results in surgical excision and reconstruction. The purpose of our study is to evaluate Photofrin® with a new diagnostic procedure, photodynamic diagnosis (PDD), for...
Article
The objective of this study was to compare the efficacy and safety of laser versus conventional endoforehead lifting. A retrospective review was conducted of 110 patients a 12-year period. Subjects’ ages ranged from 20 to 79 years; there were 84 females and 26 males. Patients (n=55) received conventional endoforehead lifting. Subsequent patients (n...
Article
Background: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. Methods: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided...
Article
Background: Reconstruction of postburn axillary contractures is difficult and particularly challenging without healthy adjacent soft tissue for axillary scar resurfacing. In this case, a free soft-tissue transfer is among the best treatment options. Here, we describe our experience with free anterolateral thigh (ALT) flap for reconstruction in pos...
Article
Full-text available
Background: The purpose of our study is to use a noninvasive tomographic imaging technique with high spatial resolution to characterize and monitor biological tissue responses associated with laser thermal injury. Methods: Optical doppler tomography (ODT) combines laser doppler flowmetry (LDF) with optical coherence tomography (OCT) to obtain high...
Article
Full-text available
Aim: A clinically useful treatment laser must generate stable and precise energy of low diffusivity. This study assessed the photothermal response of a Q-switched ruby laser (QSRL) in the treatment of oculodermal melanosis (Nevus of Ota). Methods: A two-year retrospective review of 40 patients with oculodermal melanosis treated with a QSRL (λ = 694...
Article
Background: Defects of the nasal ala and upper lip aesthetic subunits can be challenging to reconstruct when they occur in isolation. When defects incorporate both the subunits, the challenge is compounded as subunit boundaries also require reconstruction, and local soft tissue reservoirs alone may provide inadequate coverage. In such cases, we us...
Article
Full-text available
In medical cosmetology, laser energy must be properly controlled to avoid unnecessary thermal damage of normal tissue due to excessive irradiation. When a laser source is applied to a specific target that is very close to the surface tissue, residual heat can damage the surface tissue even after the laser treatment is halted. This study aims to det...
Article
Background: This study was performed to assess the photothermal response of highly focused laser energy using infrared thermal imaging instrument to detect and assess the actual temperature distribution during flash lamp pumped pulsed dye laser (FLPPDL) treatment for port wine stain (PWS) patients and avoiding its complications. Methods: A retro...
Article
Background: Carved autologous costal cartilage is widely used in different rhinoplasty procedures because of its availability and proven advantages. However, the usefulness of rib grafts is limited by warping postoperatively. The chimeric autologous costal cartilage graft is proposed. "Chimeric" means the combining of two different tissues (bone a...
Article
Background and objective: The objective of this study was to compare the efficacy and safety of Endovenous Laser Photocoagulation (EVLP) at wavelengths of 1064 nm versus 810 nm for chronic venous insufficiency (varicose veins) in a large series of patients. Study design/materials and methods: A retrospective review was conducted of 108 patients...
Article
Full-text available
Sentinel lymph node biopsy (SLNB) is a standard procedure in the management of clinically node-negative melanoma. However, few studies have been performed on SLNB in Asia, which is an acral melanoma-prevalent area. This study evaluated the clinicopathologic prognostic factors of disease-free survival (DFS) and overall survival (OS) in Taiwanese pat...
Article
Many surgeons have to face the challenge of the sophisticated management of catastrophic high-voltage injuries to upper extremities. These patients present with both vast soft tissue defects and varied segmental main artery defects with compromised circulation of the distal limb. This study is a first attempt to analyze the outcome of the flow-thro...
Article
Thermal energy must be properly controlled to avoid the extensive thermal damage of the normal bio tissue during the medical laser therapy. In the process of the laser surgery, laser heat sources may apply as the multiple-points around the specific target that the distance among these multiple-points are very close. The thermal energies may accumul...
Article
Background and objectives: Hemangiomas remain a challenge for patients and plastic surgeons. Promising results have been reported using intralesional photocoagulation (ILP) for treatment. The objective of our study is to review the long term results of a large series of hemangiomas in patients treated by ILP. Materials (Subjects) and Methods: A re...
Article
Background and aims: Currently, the method of choice for the treatment of port-wine stains is laser photocoagulation. Because of evolving treatment options, it is no longer enough for port-wine stains merely to be lightened through laser treatment. The best course of management consists of the most appropriate laser that will produce the most comp...
Article
The objective of this study was to improve port wine stain (PWS) therapeutic outcome in response to laser therapy. Our specific aim was to determine whether the combined use of pulsed dye laser (PDL) therapy and topical Imiquimod versus PDL alone can improve PWS therapeutic outcome. This pilot study involved a retrospective review of 20 subjects, a...
Article
Full-text available
Vascular ectasia observed in port wine stain (PWS) birthmarks might be secondary to localized reduction of neural innervation and associated loss of autonomic stimulation. Our objective was to investigate this theory and evaluate nerve density, blood vessel density, and average blood vessel size in untreated and pulsed dye laser with cryogen spray...
Article
The object of the present study was to evaluate the feasibility of photodynamic therapy (PDT) for malignant melanomas through in vivo and in vitro processes. Photofrin (porfimer sodium) was evaluated through in vitro processes with human malignant melanoma cells (MMCs). The in vitro absorption and photosensitizing activity of Photofrin was examined...
Article
Background and objective: The object of our study is to evaluate the feasibility of photodynamic therapy (PDT) for complicated hemangiomas. The photosensitizing activities of Photofrin(®) have been used in vivo models for our goal of evaluation. Study design/materials and methods: The in vivo biological activities of Photofrin(®) exposed to the...
Article
Using laser scanning imaging microscopy, our previous studies have demonstrated visible laser irradiation induced significant generation of mitochondrial reactive oxygen species (mROS) and apoptosis. In addition, photodynamic therapy (PDT) with a mitochondrion-targeted photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA), significant...
Article
Early diagnosis improves oral cancer prognosis. Exact demarcation of tumor margins improves surgical outcomes. This study evaluates Photofrin® fluorescence: a new diagnostic procedure for detection of oral neoplasms in animal models. Fourteen male Golden Syrian hamsters were used. 0.5% D.M.B.A (9,10 dimethyl1-1,2-benzanethracene) was brushed onto c...
Article
The aim of this study was to provide a retrospective analysis of treatment that combines the laser and the endoscope. Previously, surgeons faced many complications arising from endoscope-assisted surgery in the region of the forehead. In order to reduce the incidence of complications, such as swelling and hematoma, the CO2 laser is added to endosco...
Article
Full-text available
The prognosis of patients with oral cancer can be improved by early diagnosis. Exact demarcation of tumor margins could contribute to optimum results in surgical excision and reconstruction. Therefore, the purpose of this study was to evaluate Photofrin (Quadra Logic Technologics, Inc., Vancouver, British Columbia, Canada) with protoporphyrin IX fl...
Article
Recently, the mitochondrion has been considered as a novel pharmacological target for anticancer therapy due to its crucial role involved in arbitrating cell apoptosis. We have previously demonstrated that 488-nm laser irradiation induced a specific mitochondrial reactive oxygen species (mROS) formation and apoptotic death. In this study, we used a...
Conference Paper
Photofrin<sup>®</sup> distributes dynamically in A431 cells; the plasma membranes and Golgi complex are the main target sites of Photofrin<sup>®</sup> after a brief (3 h) and prolonged (24 h) incubation, respectively. Cells with differentially localized Photofrin<sup>®</sup> displayed distinct death phenotypes in response to PDT.
Conference Paper
Light-induced fluorescence detection using Photofrin<sup>®</sup> topically provides a sensitive, noninvasive technique for the early identification of malignant neoplasms in the oral cavity. The development of an endoscopic fluorescence imaging system that could be used for real-time, noninvasive and diagnosis in clinical application.
Article
High spatial resolution noninvasive techniques for in vivo blood flow imaging are currently not available as a diagnostic tool in clinical medicine. Such techniques could have a significant impact for biomedical research and clinical diagnosis. The rationale for using Optical Doppler Tomography (ODT) to characterize the underlying microvasculature...
Article
The objective of our research was to use a noninvasive tomographic imaging technique with high spatial resolution (2-15 microm) to characterize and monitor fluid flow and the microvasculature in highly scattering biological tissues at user-specified discrete locations. The technique of optical Doppler tomography (ODT) combines laser Doppler flowmet...
Article
Photodynamic therapy (PDT) is a kind of photochemo-therapeutic treatment that exerts its effect mainly through the induction of cell death. Distinct types of cell death may be elicited by different PDT regimes. In this study, the mechanisms involved in the death of human epidermoid carcinoma A431 cells triggered by PDT with Photofrin (a clinically...
Article
The objective of this study was to compare the efficacy and safety of cryogen spray cooled laser treatment (CSC-LT) at wavelengths of 585 nm vs. 595 nm for port wine stain (PWS) birthmarks in a large series of patients. A retrospective review was conducted of 64 patients with PWS treated with the ScleroPLUS [Candela (Wayland, MA)] pulsed dye laser...
Article
Background and objectives: Untreated varicose veins have significant morbidity and potential mortality. Treatment aims to relieve symptoms, improve appearance, and to prevent deterioration. Current therapeutic options include graduated compression stockings, sclerotherapy, ambulatory phlebectomy, surgical ligation, and stripping. Results of laser...
Article
Full-text available
When a cryogen spurt is applied to the skin surface for an appropriately short period of time (on the order of milliseconds), the cooling remains localized in the epidermis, while leaving the temperature of the deeper vessels of hemangiomas unchanged. The purpose of our study is to examine the effectiveness of dynamic cooling in protecting superfic...

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