Chen Wang

• ANU College

Background: Alzheimer’s disease and other dementias (ADODs) severely threaten the wellbeing of older people, their families, and communities, especially with projected exponential growth. Understanding the macroeconomic implications of ADODs for policy making is essential but under-researched. Methods: We used a health-augmented macroeconomic model...

Background Clinical characteristics of patients with pulmonary thromboembolism have been described in previous studies. Although very old patients with pulmonary thromboembolism are a special group based on comorbidities and age, they do not receive special attention. Objective This study aims to explore the clinical characteristics and mortality...

The self-healing behavior has been extensively used in intelligent sensing systems capable of molecular recognition. However, most rigid crystalline frameworks, once collapsed under external stimuli like pressure, heat, or vacuum, could hardly recover to their crystalline phases under ambient conditions. Here, we report the self-healing of a new mi...

Preoperative localization of the tumor sites and intraoperative real-time monitoring are essential for precise surgery but are meanwhile challenging due to the lack of high-resolution, easy-to-operate, and fast visualization techniques. On the other hand, tumor recurrence and metastasis after surgery greatly reduce the survival rate of patients. In...

Introduction: Chronic obstructive pulmonary disease (COPD) is highly prevalent and underdiagnosed worldwide. The validity and reliability of COPD Population Screening (COPD-PS) questionnaire are not properly known in a large-sample Chinese population. Methods: This is a national multicenter prospective study that enrolled 1,824 outpatients from...

Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular diseases and brain injuries, are caused by various pathophysiological changes such as excessive or impaired angiogenesis, neuroinflammation, immune activation or suppression, neurodegenerative disorders, and neurovirulent protein deposition, which poses a serious heal...

Liquid biopsy has received increasing attention as a new disease detection modality because of its noninvasive, simple sampling, and reproducible assay advantages. Among the markers of liquid biopsy, extracellular vesicles (EVs) are considered as promising disease biomarkers because they contain a large amount of biological information and have a s...

Background Cigar prevalence is increasing year by year and is more and more harmful, but little is known about the prevalence of cigars in Chinese groups. Methods The data were divided from the 2018–2019 National Health Literacy Survey, which employed a rigorous multi-stage stratified sampling method. Finally, 86,701 individuals were included in t...

Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability, offering an alternative for reversing drug resistance in cancer therapy. Herein, a formulated nano-liposome that fabricated by hybridizing cisplatin-resistant A549 cell line (A549/cis) cancer cell membrane and phospholipids for co-de...

Background Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spirometry, and cardiopulmonary exercise test (CPET) features of COPD patients with cardiac AD and the association of AD with CT-derive...

The innate immune regulator stimulator of interferon genes (STING) mediates self-DNA sensing and leads to the induction of type I interferons and inflammatory cytokines, which promotes the progression of various inflammatory and autoimmune diseases. Innate immune system plays a critical role in regulating obesity-induced islet dysfunction, whereas...

Background and Purpose Pneumoconiosis, especially silicosis has emerged as a prominent occupational disease with remarkable global implications with no definitive cure available. While pirfenidone and nintedanib have been approved in treating idiopathic pulmonary fibrosis, their potential efficacy as anti-fibrotic agents in advanced silicosis warra...

Background High medication burdens are common in patients with chronic obstructive pulmonary disease (COPD). This study aimed to explore the associations of medication regimen complexity index (MRCI) with medication adherence and clinical outcomes among patients with acute exacerbations of COPD (AECOPD) after hospital discharge. Methods Data were...

Chemotherapy remains one of the most prevailing strategies for cancer treatment. However, its treatment effect is hampered by drug resistance, nonspecific tumor targeting, and severe toxic side effects. Combination chemotherapy with synergistic effect has become an attractive tumor therapy. N⁶-methyladenosine (m⁶A) regulators determine the fate of...

Precise synthesis of topologically predictable and discrete molecular crystals with permanent porosities remains a long‐term challenge. Here, we report the first successful synthesis of a series of 11 isoreticular multivariate hydrogen‐bonded organic frameworks (MTV‐HOFs) from pyrene‐based derivatives bearing −H, −CH3, −NH2 and −F groups achieved b...

Background Acute pulmonary embolism (APE) is a fatal cardiovascular disease, yet missed diagnosis and misdiagnosis often occur due to non-specific symptoms and signs. A simple, objective technique will help clinicians make a quick and precise diagnosis. In population studies, machine learning (ML) plays a critical role in characterizing cardiovascu...

Backgrounds To our knowledge, there is no available nationwide data on omicron symptom patterns in China mainland. We aim to determine the acute and long COVID-19 symptoms in the omicron-dominant period and to evaluate its association with age, sex and smoking status. Methods We designed a cross-sectional nationwide study and data about self-repor...

Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement of eosinophils in the development of emphysema. However, the precise mechanisms underlying the development of eosinophil-mediated emphysema...

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive condition characterized by the impairment of alveolar epithelial cells. Despite continued research efforts, the effective therapeutic medication is still absent due to an incomplete understanding of the underlying etiology. It has been shown that rhythmic alterations are of significan...

Background Recent studies have shown that the lung microbiota is altered in critically ill patients and predicts clinical outcomes. Primary graft dysfunction (PGD) is a common complication and a leading cause of death within 1 month of lung transplantation, but the clinical significance of changes in the lung bacterial community during PGD is uncle...

UHC embodies a global commitment to recognise health as a human right, which is pivotal for economic development, national security, social stability, social civilisation, and human wellbeing. The pursuit of UHC is not a burden or drain on the socioeconomic fabric, but rather an investment, serving as a vital pathway to achieving a people-centred a...

Background An increase in the prevalence of comorbidities has been reported in patients with chronic obstructive pulmonary disease (COPD). However, contemporary estimates of the overall prevalence of the sociodemographic correlates of COPD comorbidities are scarce and inconsistent in China. This study aimed to investigate the prevalence of sociodem...

Precise synthesis of topologically predictable and discrete molecular crystals with permanent porosities remains a long‐term challenge. Here, we report the first successful synthesis of a series of isoreticular multivariate hydrogen‐bonded organic frameworks (MTV‐HOFs) from pyrene‐based derivatives bearing ‐H, ‐CH3, ‐NH2 and ‐F groups achieved by a...

STING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune d...

Nanofibrous hydrogels are pervasive in load‐bearing soft tissues, which are believed to be key to their extraordinary mechanical properties. Enlighted by this phenomenon, a novel reinforcing strategy for polymeric hydrogels is proposed, where polymer segments in the hydrogels are induced to form nanofibers in‐situ by bolstering their controllable a...

Detecting CO2 in complex gas mixtures is challenging due to the presence of competitive gases in the ambient atmosphere. Photoelectrochemical (PEC) techniques offer a solution, but material selection and specificity remain limiting. Here, we constructed a hydrogen‐bonded organic framework material based on a porphyrin tecton decorated with diaminot...

Chronic myeloid leukemia (CML) is recognized as a classic clonal myeloproliferative disorder. Given the limited treatment options for CML patients in the accelerated phase (AP) and blast phase (BP), there is an evident need to develop new therapeutic strategies. This has the potential to improve outcomes for individuals in the advanced stages of CM...

Background Mobile phone–based cessation interventions have emerged as a promising alternative for smoking cessation, while evidence of the efficacy of mobile phone–based smoking cessation programs among young people is mixed. Objective This study aimed to determine the efficacy of mobile phone–based interventions compared to usual practice or asse...

Detecting CO2 in complex gas mixtures is challenging due to the presence of competitive gases in ambient atmosphere. Photoelectrochemical (PEC) techniques offer a solution, but material selection and specificity remain limiting. Here, we invented a hydrogen‐bonded organic framework material based on a porphyrin tecton decorated with diaminotriazine...

Purpose To quantitatively analyze lung elasticity in idiopathic pulmonary fibrosis (IPF) using elastic registration based on 3-dimensional pulmonary magnetic resonance imaging (3D-PMRI) and to assess its’ correlations with the severity of IPF patients. Material and Methods Thirty male patients with IPF (mean age: 62±6 y) and 30 age-matched male he...

Background Similar to influenza, coinfections and superinfections are common and might result in poor prognosis. Our study aimed to compare the characteristics and risks of coinfections and superinfections in severe COVID-19 and influenza virus pneumonia. Methods The data of patients with COVID-19 and influenza admitted to the intensive care unit...

Background Exacerbation of chronic obstructive pulmonary disease (ECOPD) is a complex phenomenon, with marked heterogeneity in the aetiology, pathophysiology and clinical manifestations. This study aimed to evaluate the clinical characteristics and long-term outcomes of patients with 30-day exacerbation among those hospitalised with ECOPD in China....

BACKGROUND Educational disparities in COVID-19 outcomes have been documented in numerous studies conducted in western countries. However, evidence from China is limited, and no study has yet explored the potential role of smoking on the disparities. OBJECTIVE To assess the association between educational status and hospitalization among cases with...

We have determined the binding strengths between ribonucleotides of adenine (A), guanine (G), uracil (U), and cytosine (C) in homogeneous single-stranded ribonucleic acids (ssRNAs) and homo-decapeptides consisting of 20 common amino acids. We use a bead-based fluorescence assay for these measurements in which decapeptides are immobilized on the bea...

Background: From November 2022 to February 2023, the Chinese mainland experienced a surge in COVID-19 infection and hospitalization, and the hospital-based healthcare workers (HCWs) might suffer serious psychological crisis during this period. This study aims to assess the depressive and anxiety symptoms among HCWs during the surge of COVID-19 pan...

Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We employed an integrative analytical pipeline to transform genetic associations to identify novel plasma proteins for VTE. Proteome-wide association studies (PWAS) were determined...

Background: Serum uric acid (SUA) levels have been associated with an increased risk and recurrence of venous thromboembolism (VTE) in European populations, but the potential causal relationship remains unclear. Large-scale studies on the association between SUA and VTE in East Asian populations are lacking, despite the high prevalence of hyperuri...

Background: Influenza and pneumococcal vaccination are a priority in patients with chronic obstructive pulmonary disease (COPD). However, limited information is available on vaccination coverage among patients with acute exacerbations of COPD (AECOPD) in China. This study aimed to determine the rates and associated factors of influenza and pneumoc...

Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and imposes a substantial economic burden. Gaining a thorough understanding of the economic implications of COPD is an important prerequisite for sound, evidence-based policy making. We aimed to estimate the macroeconomic burden of COPD for each co...

For human epidermal growth factor receptor 2‐positive metastatic colorectal cancer (HER2+ mCRC), anti‐HER2 therapy shows benefits, while current HER2 testing using tumor biopsy remains controversial. Noninvasive circulating tumor cells (CTCs) may achieve more accurate HER2 diagnosis . Herein, enumeration and HER2 phenotyping on CTCs (HER2(0/1+/2+/3...

An understanding of protein conformational ensembles is essential for revealing the underlying mechanisms of interpeptide recognition and association. However, experimentally resolving multiple simultaneously existing conformational substates remains challenging. Here, we report the use of scanning tunneling microscopy (STM) to analyze the conforma...

Deciphering the conformations and interactions of peptides in their assemblies offers a basis for guiding the rational design of peptide-assembled materials. Here we report the use of scanning tunneling microscopy (STM), a single-molecule imaging method with a submolecular resolution, to distinguish 18 types of coexisting conformational substates o...

We aimed to assess general fluid management in China and evaluate the association between fluid balance and survival outcomes in acute respiratory distress syndrome (ARDS) patients. A retrospective, multicenter study including ARDS patients was conducted. We described the fluid management of ARDS patients in China. Furthermore, clinical characteris...

Backgrounds To our knowledge, there is no available nationwide data on omicron symptom patterns in China mainland. We aim to determine the acute and long COVID-19 symptoms in the omicron-dominant period and to evaluate its association with age, sex and smoking status. Methods We designed a cross-sectional nationwide study and data about self-report...

Peptide-modified delivery systems are enabling the improvement of the targeting specificity, biocompatibility, stability, etc. However, the precise design of a peptide-decorated surface for a designated function has remained to be challenging due to a lack of mechanistic understanding of the interactions between surface-bound peptide ligands and th...

Background The association between periodontitis and post-bronchodilator lung function is unclear. We aimed to determine the associations between symptoms of severe periodontitis (SSP) and post-bronchodilator lung function in the Chinese population. Methods A cross-sectional study (China Pulmonary Health study) was conducted from 2012 to 2015 in a...

Background Chronic obstructive pulmonary disease (COPD) management in China is far from adequate; underdiagnosis and undertreatment are major barriers to optimal care and improved patient outcomes. Objective To generate reliable information on COPD management, outcomes, treatment patterns and adherence, and disease knowledge in China in a real-wor...

Objective To compare the clinical features and outcomes in patients with pre-chronic obstructive pulmonary disease (COPD) and COPD hospitalised for confirmed or suspected acute exacerbation of COPD (AECOPD). Design A multicentre, longitudinal observational cohort study. Setting Data were obtained from the AECOPD Inpatient Registry Study in China....

Chronic obstructive pulmonary disease (COPD) is a serious chronic respiratory disease. Improving the ability to identify patients with COPD in primary medical institutions is important to prevent and treat the disease. With the continuous development of medical digitization, the application of big data informatization in the medical and health fiel...

Background Coal worker’s pneumoconiosis (CWP) is a chronic occupational disease mainly caused by coal dust inhalation in miners. This study aimed to investigate the clinical value of Osteopontin (OPN), KL-6, Syndecan-4 and Gremlin-1 as serum biomarkers in CWP. Patients and Methods We integrated reported lung tissues transcriptome data in pneumocon...

Background: The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity. Methods: We did an ambidirectional cohort study of...

Background Tobacco cessation is proven to be the most effective and cost-effective strategy for smokers to reduce their risk of smoking-related disease and premature death. Providing effective, efficient, safe, and patient-centred tobacco cessation treatment to reach those who need them is a significant challenge. To date, only a few nationwide stu...

We propose and study a toy model for the quantum measurements that yield the Born's rule of quantum probability. In this model, the electrons interact with local photon modes and the photon modes are dissipatively coupled with local photon reservoirs. We treat the interactions of the electrons and photons with full quantum mechanical description, w...

Bacterial infections have become a serious threat to global public health. Nanomaterials have shown promise in the development of bacterial biosensing and antibiotic-free antibacterial modalities, but single-component materials are often less functional and difficult to achieve dual bacterial detection and killing. Herein, we report a novel strateg...

Objective To determine which early‐stage variables best predicted the deterioration of coronavirus disease 2019 (COVID‐19) among community‐isolated people infected with severe acute respiratory syndrome coronavirus 2 and to test the performance of prediction using only inexpensive‐to‐measure variables. Methods Medical records of 3145 people isolat...

Rationale: The diagnostic yields of traditional ultrasound-guided pleural biopsy remain unsatisfactory, especially when the pleural thickness is ≤ 5 mm and/or no pleural nodules are detected. Pleural ultrasound elastography has a better diagnostic yield than traditional ultrasound for malignant pleural effusion. However, studies of ultrasound elas...

Background A large proportion of pulmonary embolism (PE) heritability remains unexplained, particularly among the East Asian (EAS) population. Our study aims to expand the genetic architecture of PE and reveal more genetic determinants in Han Chinese. Methods We conducted the first genome-wide association study (GWAS) of PE in Han Chinese, then pe...

Background: Chronic obstructive pulmonary disease (COPD) management in China is inadequate and there is a need to improve care and outcomes for patients nationwide. Objectives: The REAL study was designed to generate reliable information on COPD management from a representative sample of Chinese patients with COPD. Here, we present study outcome...

Background:Idiopathic pulmonary fibrosis is a progressive and fatal lung disease that lacking effective therapeutics. Treatment with pirfenidone or nintedanib is recommended for patients to delay the progression of the disease. Anti-fibrosis drugs may cause adverse reactions, even interrupt the treatment, affecting the disease's progress. Objective...

Background: Underdiagnosis and undertreatment pose major barriers to optimal management of chronic obstructive pulmonary disease (COPD) in China. Objective: The REAL trial was performed to generate reliable information on real-world COPD management, outcomes and risk factors among Chinese patients. Here, we present study outcomes related to COPD...

Quantum heat transport is considered as an indispensable branch of quantum thermodynamics to potentially improve the performance of thermodynamic devices. We theoretically propose a dissipative qubit-photon system composed of multiple coupled resonators interacting with a single two-level qubit, to explore the steady-state heat transport by tuning...

Background and Objective Chronic thromboembolic pulmonary hypertension (CTEPH) is a lethal complication of pulmonary embolism involving pulmonary artery occlusion and microvascular disease. The glucose metabolism and reactive oxygen species (ROS) production may be perturbed in CTEPH, but the precise mechanisms are unclear. This study investigated g...

Objective: Our aim was to systematically investigate the efficacy of Tanreqing (TRQ) injection on in-hospital outcomes among inpatients with frequent or infrequent AECOPD. Methods: In this ongoing, nationwide multicenter registry designed to investigate clinical characteristics, management, and prognoses of Chinese patients admitted for AECOPD in r...

Thermoelectric rectification and amplification were investigated in an interacting quantum-dot circuit-quantum-electrodynamics system. By applying the Keldysh nonequilibrium Green’s function approach, we studied the elastic (energy-conserving) and inelastic (energy-nonconserving) transport through a cavity-coupled quantum dot under the voltage bias...

Evidence suggests that exposure to coal dust increases immunoglobulin concentration. However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers’ pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic biomarkers for the disease. CWP patients, dust-exposed workers without pneumoconiosi...

Vascular leakage and inflammation are pathological hallmarks of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Endothelial cells (ECs) serve as a semipermeable barrier and play a key role in disease progression. It is well known that fibroblast growth factor receptor 1 (FGFR1) is required for maintaining vascular integrity. How...

Background: It has been shown that glycolytic protein alpha-ENO1 (enolase) contributes to the pathogenesis of pulmonary hypertension through acting smooth muscle cells; however, the roles of ENO1-caused endothelial and mitochondrial dysfunctions in Group 3 pulmonary hypertension remain unexplored. Methods: PCR array and RNA sequencing were used...

Background: To clarify whether dynamic quantification of variables derived from chest high-resolution computed tomography (HRCT) can assess the progression of idiopathic pulmonary fibrosis (IPF). Methods: Patients with IPF who underwent serial computed tomography (CT) imaging were retrospectively enrolled. Several structural abnormalities seen o...

Introduction: IMPROVE Bleeding Risk Score (BRS) is known to be validated and widely accepted in medical patients. However, its relevance in surgical patients has so far not been explored. External validation of the IMPROVE BRS on bleeding in surgical patients can hopefully improve clinical practice (for surgical patients). Methods: Data from 698...

IMPORTANCE Cancers are a leading cause of mortality, accounting for nearly 10 million annual deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries' economic growth. However, the global economic cost of cancers and its worldwide distribution have yet to be studied. OBJECTIVE To estimate and project the economic cost of 29 can...

Including the phonon-assisted inelastic process in thermoelectric devices makes it possible to enhance the performance of nonequilibrium work extraction. In this work, we demonstrate that inelastic phonon-thermoelectric devices have a fertile functionality diagram, where particle current and phononic heat currents are coupled and fueled by the chem...

Background Studies on the incidence of venous thromboembolism (VTE) events in patients with interstitial lung disease (ILD) are limited and the results are inconsistent. The aim of this research was to investigate the incidence and risk factors of VTE in ILD during hospitalization. Materials and methods In this retrospective, cross-sectional, obse...

Background Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease in China. It is estimated that there is a large amount of high-risk population who will develop into COPD in the future whereas have not yet been detected. Methods and Design In this context, a nationwide COPD screening program was launched on...

BACKGROUND Although smartphone application (app) for smoking cessation was considered as a promising strategy, the results of studies about apps were inconsistent, and there were few studies on combinations of usual interventions and apps in smoking cessation. OBJECTIVE To evaluate the efficacy of the Cigarette-Burning application combined with me...

Introduction Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality, with no effective treatment at present. Emphysema, a major component of COPD, is a leading cause of human death worldwide. Fibroblast growth factor 2 (FGF2) is implicated in the pathogenesis of pulmonary emphysema and may play an important role in the lung r...

Engineered Extracellular Vesicles In article number 2204910, Jia Yu, Yanlian Yang, Ling Zhu, and co‐workers report an extracellular‐vesicle‐based nanodrug for the targeting delivery of short interfering RNA (siRNA) against N6‐methyladenosine (m6A) reader YTH N6‐methyladenosine RNA binding protein 1 (YTHDF1) for the epigenetic and immune regulation...

[This corrects the article DOI: 10.3389/fphar.2022.848435.].