Chen Ming

GEOMAR Helmholtz Centre for Ocean Research Kiel · Division of Marine Geodynamics

The poor reversibility of the zinc anode caused by interfacial side reactions and dendritic growth poses significant constraints on the practical application of aqueous zinc‐ion batteries. Herein, a co‐solute, acesulfame potassium, with strongly polar, zincophilic guest anions is introduced into a conventional low‐concentration aqueous electrolyte....

The poor reversibility of the zinc anode caused by interfacial side reactions and dendritic growth poses significant constraints on the practical application of aqueous zinc‐ion batteries. Herein, a co‐solute, acesulfame potassium, with strongly polar, zincophilic guest anions is introduced into a conventional low‐concentration aqueous electrolyte....

Definitive treatment of lung cancer with radiotherapy is challenging, as respiratory motion and anatomical changes can increase the risk of severe off-target effects during radiotherapy. Online adaptive radiotherapy (ART) is an evolving approach that enables timely modification of a treatment plan during the interfraction of radiotherapy, in respon...

Detachment faults at slow‐ and ultraslow‐spreading mid‐ocean ridges are essential for lithosphere‐hydrosphere interactions. However, their coupling with subseafloor hydrothermal circulation is poorly understood. Here, we investigated shallow hydrothermal fluid circulations in the active Dragon Horn detachment fault system of the Southwest Indian Ri...

The importance of uncommon/rare oncogenic drivers in non‐small cell lung cancer (NSCLC) was underscored during the 20th China Lung Cancer Summit. These drivers, while present in a significant proportion of NSCLC patients, remain a challenge for diagnosis and therapeutic targeting. In the never‐smokers/low smokers category with mutations such as EGF...

Oceanic detachment faulting, a major mode of seafloor accretion at slow and ultraslow spreading ridges, is thought to occur during magma‐poor phases and be abandoned when magmatism increases. In this framework, detachment faulting is the result of temporal variations in magma flux, which is inconsistent with recent geophysical observations at the L...

Different from traditional long packet communication, short packet communication, one prominent feature of Internet-of-Things (IoT), suffers from transmission rate degradation, and a significant decoding error probability is inevitably introduced. In this paper, we focus on the resource allocation for uplink multicarrier narrowband communication in...

To propose lung contour deformation feature (LCDF) as a surrogate to estimate the thoracic internal target motion, and to report its performance by correlating with the changing body using a cascade ensemble model (CEM). LCDF, correlated to the respiration driver, is employed without patient-specific motion data sampling and additional training bef...

Exploring multifunctional surface-enhanced Raman scattering (SERS) substrates with high sensitivity, broadband response property and reliable practicability should be required for ultrasensitive molecular detection in complex environments, which is heavily dependent on the photo-induced charge transfer (PICT) efficiency realized on the desirable na...

Purpose: To study the improved rotational robustness by using joint learning of spatially-correlated organ segmentation (SCOS) for thoracic organ delineation. The network structure is not our point. Methods: The SCOS was implemented in a U-net-like model (abbr. SCOS-net) and evaluated on unseen rotated test sets. Two hundred sixty-seven patients...

In this paper, we study joint batching and (task) scheduling to maximise the throughput (i.e., the number of completed tasks) under the practical assumptions of heterogeneous task arrivals and deadlines. The design aims to optimise the number of batches, their starting time instants, and the task-batch association that determines batch sizes. The j...

Adaptive radiotherapy (ART) allows control of dosimetric impact of patient anatomical and functional variations over the treatment course, to minimize normal tissue exposure and maximize dose delivery to tumor. We present the first reported case of fan beam computed tomography (FBCT)-guided online ART for the treatment of small cell lung cancer (SC...

Purpose: This study aimed to illustrate the heterogeneity of immune features in small cell lung cancer (SCLC). Methods: Immunohistochemistry (IHC) staining of CD3, CD4, CD8 and PD-L1 were performed with 55 SCLC FFPE samples from radical resections. Quantitative assessment of CD3+ tumor-infiltrated lymphocytes (TILs) to present the heterogeneity...

Benefiting from the admirable energy density (1086 Wh kg⁻¹), overwhelming security, and low environmental impact, rechargeable zinc–air batteries (ZABs) are deemed to be attractive candidates for lithium‐ion batteries. The exploration of novel oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) bifunctional catalysts is the key to p...

Background: Although preoperative chemotherapy (CT) or chemoradiotherapy (CRT) show survival benefit in patients with locally advanced esophageal squamous cell cancer (ESCC), ESCC still has a dismal prognosis. With the potential benefit of combining immune checkpoint inhibitors (ICIs) neoadjuvantly, we initiated 2 phase II single-armed clinical tri...

Polymetallic sulfides present in mid-ocean ridges (MORs) have become important strategic resources for humans, and a scientific metallogenic model is necessary for the investigation and exploration of these resources. Compared to fast-and slow-spreading MORs, ultraslow-spreading MORs show substantial differences in magma supply, tectonic activity,...

Improving the intrinsic catalytic activity of electrocatalysts is considered to be the “gold standard” to inhibit the shuttle effect in Li–S batteries. The question of how to expose active sites for anchoring and catalytic conversion of the polysulfides represents the direction of this research. The assembly of 0D nanoparticles or 2D nanosheets int...

Wilms' tumor 1-associated protein (WTAP), a component of the m6A methyltransferase complex, recruits the m6A methyltransferases METTL3 and METTL14 to the corresponding mRNA targets to participate in the formation of N6-methyladenosine. However, the molecular mechanism of WTAP in the tumorigenesis and progression of nasopharyngeal carcinoma (NPC) re...

Stage III non‐small cell lung cancer (NSCLC) encompasses a group of diseases with high heterogeneity. Such patients should actively receive comprehensive treatments. It is imperative for all stage III NSCLC patients to receive consultation with a multiple disciplinary team, which allows the development of a proposal for clinical diagnosis and treat...

We experimentally demonstrated a low-complexity probabilistic shaping (PS) 16-ary quadrature amplitude modulation (16QAM) scheme based on intra-symbol bit-weighted distribution matching (Intra-SBWDM) for discrete multi-tone (DMT) symbols with field-programmable gate array implementation in an intensity modulation and direct detection (IM-DD) system...

Background: Zinc finger protein 687 (ZNF687) has previously been discovered as a potential oncogene in individuals with giant cell tumors of the bone, acute myeloid leukemia, and hepatocellular carcinoma. However, its role and mechanism in lung adenocarcinoma (LUAD) remain unclear. Methods: In LUAD cells, tumor, and matched adjacent tissue speci...

Background Radiotherapy (RT) combined with chemotherapy is the standard treatment for T1-2N1M0 nasopharyngeal carcinoma (NPC) based on conventional radiotherapy. However, intensity-modulated radiotherapy (IMRT) has narrowed the treatment gap between RT and chemoradiotherapy. Thus, this retrospective study aimed to compare the efficacy of RT and che...

Background: Patients who previously underwent surgical resection of initial primary lung cancer are at a high risk of developing multiple primary lung cancers (MPLCs). The purpose of this study was to compare the efficacy and safety between stereotactic body radiation therapy (SBRT) and surgery for MPLCs patients after prior radical resection for...

Objectives: To explore the relationship between peripheral blood inflammation parameters and overall survival (OS) and progression-free survival (PFS) of early-stage non-small cell lung cancer patients who underwent stereotactic body radiotherapy (SBRT). Patients and methods: In this study, eligible patients treated with SBRT from 2013 to 2018, and...

Purpose: Radiotherapy continues to play a key role in nearly every cancer, yet little is known about contemporary trials evaluating radiotherapy and its ability to advance cancer care in recent years. The purpose of this study is to describe the evolving landscape of global radiotherapy trials over the past five years. Methods: In this cross-sec...

We experimentally demonstrated a low-complexity probabilistic shaping scheme in a real-time 16QAM-OFDM-based WDM-PON. The PS-OFDM signal with a net rate of 131.88- Gb/s transmission over 25-km SSMF can be achieved with the BER less than 3.8×10 ⁻³ .

Highlights A sensitive and non-virus kit was applied for NA detection post-SC2IV vaccination. Several important factors correlating to NA generation are revealed post-vaccination. Age is the most important index affecting the NA level in SC2IV recipients. Distinct NA-associated factors are identified between male and female recipients. The rat...

Background : Glycolysis affects tumor growth, invasion, treatment resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic signature for lung adenocarcinoma (LUAD) and analyze its relationship with the tumor microenvironment (TME). Methods : We analyzed the data of a training set from The Canc...

Multi-band surface-enhanced Raman spectroscopy (SERS) via multiple excitation wavelengths operated on broadband resonant substrate can empower a high-dimensional comprehensive molecular diagnosis of complex analytes. Herein, we demonstrate an extraordinary multi-resonant SERS active substrate that is composed of three-dimensional (3D) hierarchical...

Oligometastatic non-small-cell lung cancer (NSCLC) is potentially curable. Oligo-recurrence occurs with oligometastatic disease characterized by well-controlled primary lesion. The purpose of the present study was to explore the value of definitive local therapy (DLT) for extracranial single-organ oligorecurrent NSCLC. A total of 81 patients with N...

Background Immunotherapy +/- chemotherapy is currently the standard of care for metastatic NSCLC, but strategies to expand the benefit are still needed. Oligometastatic NSCLC is a state of limited disease in which widespread metastasis has not yet evolved. Locally radiotherapy achieves prolonged progression- free survival and overall survival in a...

Objective To investigate the optimal management of patients with epidermal growth factor receptor gene (EGFR) mutant locally advanced non-small cell lung cancer (LA-NSCLC). Methods Patients with unresectable stage III lung adenocarcinoma (LAC) harboring EGFR mutations from 2012 to 2018 were analyzed retrospectively, and were categorized into three...

In Vehicle-to-Everything (V2X), cellular Device-to-Device (D2D) communication can improve spectrum efficiency, and non-orthogonal multiple access (NOMA) can further strengthen system capacity. However, the execution for NOMA may be affected by the additional interference introduced by cellular links in V2X. In this paper, we study the energy-effici...

Realizing omnidirectional self-powered photodetectors is central to advancing next-generation portable and smart photodetector systems. However, the traditional omnidirectional photodetector is typically achieved by integrating complex hemispherical microlens on multiple photodetectors, which makes the detection system cumbersome and restricts its...

Small cell lung cancer (SCLC) is a highly aggressive tumor type for which limited therapeutic progress has been made. Platinum-based chemotherapy with or without thoracic radiotherapy remains the backbone of treatment, but most patients with SCLC acquire therapeutic resistance. Given the need for more effective therapies, better elucidation of the...

In Vehicle-to-Everything (V2X) communication networks, cellular Device-to-Device (D2D) communication can improve the spectrum efficiency, and non-orthogonal multiple access (NOMA) can further enhance the connection density. However, for the cellular D2D communications, the involved execution condition for NOMA may be affected by the additional inte...

The stress state and rock mechanical properties govern the growth of faults and fractures, which constitute shallow hydrothermal pathways and control the distribution of seafloor massive sulfide (SMS) mounds in the seafloor hydrothermal field. The stress field has an important influence on the formation and persistence of hydrothermal pathways. Bas...

It is challenging to precisely configure the phase shifts of the reflecting elements at the reconfigurable intelligent surface (RIS) due to inherent hardware impairments (HIs). In this paper, the mean square error (MSE) performance is investigated in an RIS-aided single-user multiple-input multipleoutput (MIMO) communication system with transceiver...

Purpose To accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC), a combined predictive model based on pre-treatment CT radiomics features and clinical factors was established. Methods This study retrospectively analyzed the data of 96 patients with early-stage NSCLC...

It is challenging to precisely configure the phase shifts of the reflecting elements at the reconfigurable intelligent surface (RIS) due to inherent hardware impairments (HIs). In this letter, the mean square error (MSE) performance is investigated in an RIS-aided single-user multiple-input multiple-output (MIMO) communication system with transceiv...

The powerful surface-enhanced Raman scattering spectroscopy (SERS) practical technique is not only related to signal enhancement but also heavily dependent on spatial uniformity. Different from the routine hydrophobic substrates, an extraordinary super-hydrophilic SERS sensor is established by loading plasmonic Au nanoparticles (NPs) on two-dimensi...

As for the ultrasensitive diagnosis of biomolecules via surface-enhanced Raman scattering spectroscopy (SERS), the primary requirement is to effectively enhance the activity of nano-substrates. Herein, we report an interesting strategy for further boosting SERS activity by thermal annealing treatment of as-prepared hybrid substrates. Initially, hig...

Although the recent advance of ultra‐thin 2D nanosheets for hydrogen evolution reaction (HER) is remarkable, there are still substantial challenges to reliably control their physioelectric and electrochemical properties to employ as highly‐efficient electrocatalysts. Herein, based on complementary theoretical and experimental studies, the d‐band ce...

Background Prophylactic cranial irradiation (PCI) can reduce the risk of brain metastases (BM) and improve overall survival (OS) in patients with limited-stage small cell lung cancer (LS-SCLC) after partial or complete response to primary therapy. However, some SCLC patients still develop BM after PCI. This study aimed to evaluate the risk factors...

Background Thoracic radiotherapy (TRT) with concurrent chemotherapy is the standard treatment of limited-stage small-cell lung cancer (LS-SCLC). However, there is still a controversy surrounding the treatment strategy especially optimal dosing and fractionation schedule. Current practice patterns among Chinese oncologists are unknown. Materials an...

The increased hydrothermal activity at inside corners is interpreted to be controlled by the high-permeability detachment faults at mid-ocean ridges. Paradoxically, almost none of hydrothermal activity is confirmed to be located at the detachment terminations, where the permeability is theoretically maximal. Here, we use a numerical model to invest...

Abstract Background Anlotinib is a multitarget tyrosine kinase inhibitor for treating patients with advanced non-small cell lung cancer (NSCLC). We aimed to assess the efficacy and safety of anlotinib in elder patients with advanced NSCLC. Methods Elder patients with advanced NSCLC who received anlotinib were enrolled. They were all age ≥ 65 years...

Natural solar-driven synergistic photo-thermal catalytic (PTC) degradation of toxic pollutants provides promising routes for wastewater decontamination. Yet there are no satisfactory nano-catalysts that can simultaneously maximize the utilization of additional significant photo-thermal energy and the contribution of prominent photocatalytic effects...

Ultrasensitive trace-detection of toxic and carcinogenic polycyclic aromatic hydrocarbons (PAHs) can ceaselessly propel the environmental surveillance in aqueous ecosystems. Due to the intrinsic nonadsorptive feature of PAHs, the promising technique of surface-enhanced Raman scattering (SERS) spectroscopy has been restricted to diverse functional l...

Metal Selenides with layer structure has obvious advantages to store guest alkaline metal ions, promote cycling stability and accelerate diffusion kinetics when applied as electrode for batteries. Among them, layer structured Bi2Se3 with large interlayer spacing is expect to have potential applications in rechargeable batteries. In this study, Bi2S...

Tectonic-related hydrothermal fields constitute about half of the hydrothermal activities on slow-ultraslow spreading ridges, and may form sulfides large in size and rich in precious metals. Ore-forming fluids are critical for element migration progressions, thus are key parameter to reveal their genesis and sulfide mineralization processes. Howeve...

Background Previous reports stated that DNA polymerase ζ is highly expressed in lung cancer tissues. The present study aimed to investigate the roles and underlying mechanism of DNA polymerase ζ in lung cancer cell radioresistance. Methods The A549 and HCC827 cells were used to evaluate the effects of different doses of radiation on the mRNA and p...

Background Immune checkpoint inhibitor–related pneumonia (ICIP) is an independent risk factor for immunotherapy-related death. Purpose To evaluate the ICIP, dynamic observation of computed tomography (CT) images of lung cancer patients with ICIP was conducted to study the relationship between the occurrence of ICIP and clinical information. Mater...

TPS373 Background: Esophageal cancer is the eighth most common cancer type and the sixth leading cause of cancer-related death worldwide, and esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer. For patients with locally advanced, unresectable ESCC (AJCC 8th Stage II–IVA), definitive chemoradiotherapy (dCRT) is th...

Non-layered two-dimensional (2D) lead-free all-inorganic perovskites nanoplates have recently attracted considerable attention in photodetectors; however, the in-depth investigation of thickness on photodetection performance is still lacking. In this work, by constructing the famous metal-semiconductor-metal photodetectors, the photodetection behav...

We report an effective strategy to promote the near-infrared surface-enhanced Raman scattering spectroscopy (NIR-SERS) activity by boosting the photon-induced charge transfer (PICT) efficiency at cryogenic temperature. Based on as-prepared Au/Ag nano-urchins (NUs) with abundant surface defects, the extremely low temperature (77 K) can significantly...

Background A substantial proportion of patients with unresectable stage III non-small-cell lung cancer (NSCLC) cannot either tolerate or access concurrent chemoradiotherapy, so sequential chemoradiotherapy is commonly used. We assessed the efficacy and safety of sugemalimab, an anti-PD-L1 antibody, in patients with stage III NSCLC whose disease had...

Immune checkpoint inhibitors (ICIs) have brought new hope for the treatment of patients with small cell lung cancer (SCLC) over the past decades. However, the overall response rate is limited, and is lower than that in non-small cell lung cancer (NSCLC). This is in part because of the lack of pre-existing tumor-infiltrating T lymphocytes (TITLs), e...

The current study aimed to investigate the function of the Hedgehog pathway and its association with epithelial-mesenchymal transition (EMT) in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance in non-small cell lung cancer (NSCLC). Lung tumor tissue specimens from EGFR TKI-resistant patients, including those with b...

Recently, hybrid plasmonic metal/semiconductor-based surface-enhanced Raman scattering (SERS) has attracted ever-increasing attention due to its combined characteristics of electromagnetic (EM) enhancement and chemical (CM) enhancement, holding great potential for trace molecular detection. Herein, we demonstrate an interesting heterostructure by l...

Purpose: Here, we have investigated treatment resistance mechanisms in small cell lung cancer (SCLC) by focusing on comparing the genotype and phenotype in tumor samples of treatment-resistant and treatment-sensitive SCLC. Methods: We conducted whole-exome sequencing on paired tumor samples at diagnosis and relapse from 11 patients with limited-...

Based on plasmonic metallic nanomaterials (NMs) with unique local surface plasmon resonance (LSPR), the photo-excited hot carrier-driven hydrogenation reaction becomes a new family of photocatalytic transformations in recent years. However, the high work function and rapid hot-carrier recombination of plasmonic NMs create huge barriers for widespre...

The flexible and plastic near-infrared surface-enhanced Raman spectroscopy (NIR-SERS) substrate, with efficient tunable surface microstructures for probe molecular detection on irregular targets, has great potential for ultra-sensitive monitoring in real-world scenarios. Herein, we propose an interesting 785 nm laser-excited plastic SERS substrate...