Cheil Moon

Cheil Moon
Daegu Gyeongbuk Institute of Science and Technology | DGIST · Department of Brain & Cognitive Sciences

PhD

About

172
Publications
21,395
Reads
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2,658
Citations
Citations since 2016
97 Research Items
1648 Citations
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Introduction
Skills and Expertise
Additional affiliations
September 2015 - present
Daegu Gyeongbuk Institute of Science and Technology
Position
  • Professor
April 2015 - August 2015
Daegu Gyeongbuk Institute of Science and Technology
Position
  • Professor (Associate)
October 2009 - March 2015
Daegu Gyeongbuk Institute of Science and Technology
Position
  • Professor (Associate)
Education
October 1990 - September 1994
Imperial College London
Field of study
  • Neurobiology
October 1989 - September 1990
Imperial College London
Field of study
  • Biotechnology
March 1984 - February 1989
Yonsei University
Field of study
  • Biochemistry

Publications

Publications (172)
Preprint
Full-text available
Neuritogenesis is critical for the establishment of proper neuronal connections during brain development. Thus, its failure causes neurodevelopmental defects such as intellectual disabilities. Cullin-RING E3 ubiquitin-ligase complexes are involved in neurodevelopmental processes including neurite outgrowth, migration, and differentiation via regula...
Article
Full-text available
The key to current Alzheimer’s disease (AD) therapy is the early diagnosis for prompt intervention, since available treatments only slow the disease progression. Therefore, this lack of promising therapies has called for diagnostic screening tests to identify those likely to develop full-blown AD. Recent AD diagnosis guidelines incorporated core bi...
Article
Full-text available
Parkinson's disease is a neurodegenerative disease characterized by progressive dopaminergic neuronal loss. Motor deficits experienced by patients with Parkinson's disease are well documented, but non-motor symptoms, including mood disorders associated with circadian disturbances, are also frequent features. One common phenomenon is "sundowning syn...
Article
Animals detect and discriminate countless environmental chemicals for their well-being and survival. Although a single chemical can trigger opposing behavioral responses depending on its concentration, the mechanisms underlying such a concentration-dependent switching remain poorly understood. Here, we show that C. elegans exhibits either attractio...
Article
Full-text available
Erythropoietin (EPO) is a well-known erythropoietic cytokine having a tissue-protective effect in various tissues against hypoxic stress, including the brain. Thus, its recombinants may function as neuroprotective compounds. However, despite considerable neuroprotective effects, the EPO-based therapeutic approach has side effects, including hyper-e...
Article
Full-text available
Alzheimer's disease (AD) is the most prevalent form of dementia. Key AD symptoms include memory and cognitive decline; however, comorbid symptoms such as depression and sensory-perceptual dysfunction are often reported. Among these, a deterioration of olfactory sensation is observed in approximately 90% of AD patients. However, the precise pathophy...
Article
Full-text available
Detecting Alzheimer's disease (AD) is an important step in preventing pathological brain damage. Working memory (WM)-related network modulation can be a pathological feature of AD, but is usually modulated by untargeted cognitive processes and individual variance, resulting in the concealment of this key information. Therefore, in this study, we co...
Article
Full-text available
The brain’s mechanisms for categorizing different odors have long been a research focus. Previous studies suggest that odor categorization may involve multiple neurological processes within the brain with temporal and spatial neuronal activation. However, there is limited evidence regarding temporally mediated mechanisms in humans, especially milli...
Preprint
Full-text available
Background: Parkinson’s disease is a neurodegenerative disease characterized by progressive dopaminergic (DAergic) neuronal loss. Motor deficits experienced by patients with Parkinson’s disease are well documented, but non-motor symptoms, including mood disorders associated with circadian disturbances, are also frequent features. One common phenome...
Article
Full-text available
Guanine nucleotide binding protein (G protein) gamma 8 (Gng8) is a subunit of G proteins and expressed in the medial habenula (MHb) and interpeduncular nucleus (IPN). Recent studies have demonstrated that Gng8 is involved in brain development; however, the roles of Gng8 on cognitive function have not yet been addressed. In the present study, we inv...
Article
Full-text available
As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propos...
Article
Full-text available
Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and...
Article
Full-text available
As a surrogate for human tactile cognition, an artificial tactile perception and cognition system are proposed to produce smooth/soft and rough tactile sensations by its user's tactile feeling; and named this system as “tactile avatar”. A piezoelectric tactile sensor is developed to record dynamically various physical information such as pressure,...
Article
Full-text available
In article number 2002362, Ji‐Woong Choi, Jae Eun Jang, and co‐workers suggest a tactile avatar system as a surrogate for human tactile cognition producing smooth/soft and rough tactile sensation. Because the tactile responses vary among humans, the deep learning network is designed considering the cognitive processing of independent tactile featur...
Preprint
Full-text available
As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propos...
Article
Full-text available
Background Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which is one of the toxic factors upregulated early in AD, has been identified in many studies, even in the peripheral areas of the olfactory system, the pathology involving olfactory sensory neurons (...
Article
Full-text available
During mid-life, women experienced not only physical but also neurological transition. Because of this, many women suffer from physiological and/or psychological menopausal symptoms. Although hormone therapy (HT) was broadly used to alleviate menopausal symptoms, HT showed inconsistent effects in case of psychological symptoms. Moreover, mid-life w...
Article
Full-text available
Odor habituation is a phenomenon that after repeated exposure to an odor, is characterized by decreased responses to it. The central nervous system is involved in odor habituation. To study odor habituation in humans, measurement of event-related potentials (ERPs) has been widely used in the olfactory system and other sensory systems, because of th...
Preprint
Full-text available
Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although the causes of damage have been proposed in every olfactory system including olfactory epithelium, olfactory bulb and olfactory cortex, the main causes of AD- related hyposmia are largely unknown. Methods: We here foc...
Preprint
Full-text available
Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which is one of the toxic factors upregulated early in AD, has been identified in many studies, even in the peripheral areas. The pathology involving olfactory sensory neurons (OSNs) remains poorly un...
Preprint
Full-text available
Background: Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which is one of the toxic factors upregulated early in AD, has been identified in many studies, even in the peripheral areas. The pathology involving olfactory sensory neurons (OSNs) remains poorly un...
Article
Full-text available
Total tau (t-tau) and phosphorylated tau (p-tau) protein elevations in cerebrospinal fluid (CFS) are well-established hallmarks of Alzheimer’s disease (AD), while the associations of serum t-tau and p-tau levels with AD have been inconsistent across studies. To identify more accessible non-invasive AD biomarkers, we measured serum tau proteins and...
Article
Full-text available
Despite clinical evidence indicating a close relationship between olfactory dysfunction and Alzheimer’s disease (AD), further investigations are warranted to determine the diagnostic potential of nasal surrogate biomarkers for AD. In this study, we first identified soluble amyloid-β (Aβ), the key biomarker of AD, in patient nasal discharge using pr...
Article
Plasmonic sensors have received much attention in recent years since they are highly sensitive to the refractive index changes of surrounding dielectric and can be applied to spectrometer-free biosensing. In particular, the sensing based on the color factors and the imaging is considered as a powerful method due to its simplified sensing process as...
Article
Full-text available
More than one-half of the interneurons in a mouse olfactory bulb (OB) develop during the first week after birth and predominantly connect to excitatory tufted cells near the superficial granule cell layer (sGCL), unlike late-born interneurons. However, the molecular mechanisms underlying the temporal specification are yet to be identified. In this...
Article
Full-text available
Characterizing an odor quality is difficult for humans. Ever-increasing physiological and behavioral studies have characterized odor quality and demonstrated high performance of human odor categorization. However, there are no precise methods for measuring the multidimensional axis of an odor quality. Furthermore, it can be altered by individual ex...
Article
Full-text available
Hypothalamic glial cells named tanycytes, which line the 3rd ventricle (3V), are components of the hypothalamic network that regulates a diverse array of metabolic functions for energy homeostasis. Herein, we report that TSPO (translocator protein), an outer mitochondrial protein, is highly enriched in tanycytes and regulates homeostatic responses...
Article
An artificial tactile system has attracted tremendous interest and intensive study, since it can be applied as a new functional interface between humans and electronic devices. Unfortunately, most previous works focused on improving the sensitivity of sensors. However, humans also respond to psychological feelings for sensations such as pain, softn...
Article
Full-text available
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Article
Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer ce...
Article
Full-text available
Among the genetic variations in the monoamine oxidase A (MAOA) gene, upstream variable number tandem repeats (uVNTRs) of the promoter have been associated with individual differences in human physiology and aggressive behaviour. However, the evidence for a molecular or neural link between MAOA uVNTRs and aggression remains ambiguous. Additionally,...
Article
Full-text available
Regulated cell death (RCD) plays a fundamental role in human health and disease. Apoptosis is the best-studied mode of RCD, but the importance of other modes has recently been gaining attention. We have previously demonstrated that adult rat hippocampal neural stem (HCN) cells undergo autophagy-dependent cell death (ADCD) following insulin withdraw...
Article
Aggression is a complex, ubiquitous phenomenon that impacts behavioral traits and psychological health. Assessing aggression is challenging because aggression constitutes multiple subtraits, such as anger, reactive aggression, and overt aggression. Conventional methods of assessing aggression are susceptible to bias because they mainly rely upon se...
Article
A color-sensitive and spectrometer-free sensing method using plasmonic nanohole arrays and the color components, L* a* and b* of the CIELAB defined by the international commission on illumination (CIE) is introduced for the analysis of optically transparent materials in the visible range. Spectral analysis based on plasmonic nanoparticles or nanost...
Article
Full-text available
The olfactory system can detect many odorants with high sensitivity and selectivity based on the expression of nearly a thousand types of olfactory receptors (ORs) in olfactory receptor neurons (ORNs). These ORs have a dynamic odorant detection range and contribute to signal encoding processes in the olfactory bulb (OB). To harness the capabilities...
Data
Classification of waforms measured in the MEA. (a) Representative waveforms measured near supporting cells, (b) representative waveforms measured near somatic area of ORNs, and (c) representative waveforms measured near dendritic area of ORNs.
Data
Waveform of measured field potential. (A) Waveforms of field potential upon IBMP(1 µM, 10 µM, 100 µM) stimulation in the first session. (B) Waveforms of field potential upon IBMP(1 µM, 10 µM, 100 µM) stimulation in the second session.
Data
Waveform of measured field potential. (A) Waveforms of field potential upon three times of 100µM IVA stimulation. (B) Waveforms of field potential upon three times of 100µM citralva stimulation. (C) Waveforms of field potential upon three times of 100µM IBMP stimulation.
Article
Full-text available
Olfactory receptors (ORs) are G protein-coupled receptors that perform important physiological functions beyond their role as odorant detectors in the olfactory sensory neurons. In the present study, we describe a novel role for one of these ORs, mouse olfactory receptor 23 (MOR23), as a regulator of adipogenesis and thermogenesis in 3T3-L1 cells....
Article
A capsule‐type microrobot exhibits “Pick‐and‐Drop” (P&D) motion for possible drug and cell transport via a corkscrew motion. Drugs or cells can be encapsulated in the microrobot's container by the P&D motion or attached to the surface of the cap, which can be used as a cell supporting structure. This work is discussed in article number 1700985 by H...
Article
A capsule-type microrobot exhibits "pick-and-drop" (P&D) motion to hold a particle within a confined volume and transports it via a corkscrewing motion. The P&D motion is possible because the capsule-type microrobot has two parts: a plunger and a cap. The fabricated microrobots are wirelessly controlled by a magnetic manipulator. Drugs or cells can...
Chapter
The sense of smell, mediated by specialized sensory neurons in the nasal cavity, plays a variety of critical roles in fundamental life events. Mammals have two distinct olfactory systems—the main, and the accessory olfactory system, the latter of which is used mainly to detect pheromones. Similar to the sense of taste, the sense of smell is a form...