Cheherazade Trouki- Doctor of Pharmacy
- PhD student - Research Fellow at Italian National Research Council
Cheherazade Trouki
- Doctor of Pharmacy
- PhD student - Research Fellow at Italian National Research Council
PhD student in Science of Drug and Bioactive Sunstances
About
8
Publications
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14
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Introduction
Current institution
Additional affiliations
November 2022 - present
Publications
Publications (8)
We produced a microstructured, electroconductive and nano-functionalized drug eluting cardiac patch (MENDEP) designed to attract endogenous precursor cells, favor their differentiation and counteract adverse ventricular remodeling in situ. MENDEP showed mechanical anisotropy and biaxial strength comparable to porcine myocardium, reduced impedance,...
We investigate the structure and dynamics of a zinc oxide nanocarrier loaded with Carfilzomib, an epoxyketone proteasome inhibitor developed for treating multiple myeloma. We demonstrate that, even though both bare and functionalized zinc oxide supports have been used for drug delivery, their interactions with the reactive functional groups of the...
Herein, we study the assembling of a drug delivery nanocarrier through reactive molecular dynamics simulations based on an appropriately tuned force field. First, we focus on the combination of the various components (all selected in agreement with experiments), namely nanoparticle (ZnO), functional chains (oleic acid), drug (carfilzomib), and solv...
While recent advances in nanotechnology offer significant possibilities for improving the development of targeted drug delivery systems (DDSs), the design of efficient nanocarriers remains challenging due to the complex interactions among nanoparticles, their surfaces, and therapeutic agents in biological environments. To shed light on such difficu...
Beer and its components show potential for reducing hepatic steatosis in rodent models through multiple mechanisms. This study aimed to evaluate beer’s anti-steatotic effects in a high-fat diet (HFD)-induced mouse model of Metabolic dysfunction-Associated Liver Disease (MASLD) and to explore the underlying mechanisms. In the HFD group, steatosis wa...
In this work, we investigated the state of water in the metal–organic framework MIL-101(Cr) by combining 1H magic angle spinning (MAS) NMR, NMR relaxometry, and molecular dynamics (MD) simulations based on a reactive force field. The MD simulations indicated that water molecules are coordinated to the open metal sites and are organized in shells. T...
We have combined reactive molecular dynamics simulations with principal component analysis to provide a clearer view of the interactions and motion of the CO2 molecules inside a metal-organic framework and the movements of the MOF components that regulate storage, adsorption, and diffusion of the guest species. The tens-of-nanometer size of the sim...
