Charlotte Rebecca Brown

Charlotte Rebecca Brown
Newcastle University | NCL · Faculty of Medical Sciences

Master of Science
Currently doing an Evolutionary Genomics PhD within Dr Sergey Melnikov's lab.

About

3
Publications
304
Reads
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2
Citations
Education
September 2021 - September 2025
Newcastle University
Field of study
  • Evolutionary Genomics
September 2017 - September 2018
Newcastle University
Field of study
  • Computational Systems Biology
September 2013 - June 2017
Sheffield Hallam University
Field of study
  • Human Biology (Hons) (Sandwich)

Publications

Publications (3)
Article
Full-text available
The evolution of microbial parasites involves the counterplay between natural selection forcing parasites to improve and genetic drifts forcing parasites to lose genes and accumulate deleterious mutations. Here, to understand how this counterplay occurs at the scale of individual macromolecules, we describe cryo-EM structure of ribosomes from Encep...
Preprint
Full-text available
Despite the rapidly increasing number of organisms with sequenced genomes, there is no existing resource that simultaneously contains information about genome sequences and the optimal growth conditions for a given species. In the absence of such a resource, we cannot immediately sort genomic sequences by growth conditions, making it difficult to s...
Preprint
Full-text available
The evolution of microbial parasites involves the interplay of two opposing forces. On the one hand, the pressure to survive drives parasites to improve through Darwinian natural selection. On the other, frequent genetic drifts result in genome decay, an evolutionary process in which an ever-increasing burden of deleterious mutations leads to gene...

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