# Charlie DuclutSorbonne Université | UPMC · Physico-chimie Curie (PCC) - UMR 168

Charlie Duclut

PhD

## About

37

Publications

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319

Citations

## Publications

Publications (37)

How complex 3D tissue shape emerges during animal development remains an important open question in biology and biophysics. Here, we discover a mechanism for 3D epithelial shape change based on active, in-plane cellular events that is analogous to inanimate “shape programmable” materials, which undergo blueprinted 3D shape transformations from in-p...

The nature of the transition to collective motion in assemblies of aligning self-propelled particles remains a long-standing matter of debate. In this article, we focus on dry active matter and show that weak fluctuations suffice to generically turn second-order mean-field transitions into a ‘discontinuous’ coexistence scenario. Our theory shows ho...

Collective cell dynamics play a crucial role in many developmental and physiological contexts. While two-dimensional (2D) cell migration has been widely studied, how three-dimensional (3D) geometry and topology interplay with collective cell behavior to determine dynamics and functions remains an open question. In this work, we elucidate the biophy...

Odd viscoelastic materials are constrained by fewer symmetries than their even counterparts. The breaking of these symmetries allows these materials to exhibit different features, which have attracted considerable attention in recent years. Immersing a bead in such complex fluids allows for probing their physical properties, highlighting signatures...

We study the impact of nematic alignment on scalar active matter in the disordered phase. We show that nematic torques control the emergent physics of particles interacting via pairwise forces and can either induce or prevent phase separation. The underlying mechanism is a fluctuation-induced renormalization of the mass of the polar field that gene...

How complex 3D tissue shape emerges during animal development remains an important open question in biology and biophysics. Although it is well-established that tissue-scale patterns of in-plane cell behaviors can reshape a tissue in 2D, whether and how such patterns could also deform a tissue in 3D remains unclear. Meanwhile, recent advances in ma...

How morphogenetic movements are robustly coordinated in space and time is a fundamental open question in biology. We study this question using the wing of Drosophila melanogaster, an epithelial tissue that undergoes large-scale tissue flows during pupal stages. Previously, we showed that pupal wing morphogenesis involves both cellular behaviors tha...

We investigate how randomly oriented cell traction forces lead to fluidization in a vertex model of epithelial tissues. We find that the fluidization occurs at a critical value of the traction force magnitude Fc. We show that this transition exhibits critical behavior, similar to the yielding transition of sheared amorphous solids. However, we find...

We introduce a technique relying on the use of auxiliary fields in order to eliminate explicit field-derivatives that plague the high orders renormalization group treatment of shift-symmetric (derivative) theories. This technique simplifies drastically the computation of fluctuations in such theories. This is illustrated by deriving the two-loop re...

When a body moves through a fluid, it can experience a force orthogonal to its movement called lift force. Odd viscous fluids break parity and time-reversal symmetry, suggesting the existence of an odd lift force on tracer particles, even at vanishing Reynolds numbers and for symmetric geometries. It was previously found that an incompressible odd...

We introduce a technique relying on the use of Lagrange multiplier field in order to eliminate explicit field-derivatives that plague the high orders renormalization group treatment of shift-symmetric, derivative, theories. This technique simplifies drastically the computation of fluctuations in such theories. This is illustrated by deriving the tw...

We study the impact of nematic alignment on scalar active matter in the disordered phase. We show that nematic torques control the emergent physics of particles interacting via pairwise forces and can either induce or prevent phase separation. The underlying mechanism is a fluctuation-induced renormalization of the mass of the polar field that gene...

How morphogenetic movements are robustly coordinated in space and time is a fundamental open question in biology. We study this question using the wing of Drosophila melanogaster , an epithelial tissue that undergoes large-scale tissue flows during pupal stages. We showed previously (Etournay et al 2015) that pupal wing morphogenesis involves both...

We investigate how randomly oriented cell traction forces lead to fluidisation in a vertex model of epithelial tissues. We find that the fluidisation occurs at a critical value of the traction force magnitude $F_c$. We show that this transition exhibits critical behaviour, similar to the yielding transition of sheared amorphous solids. However, we...

Collective cell dynamics play a crucial role in many developmental and physiological contexts. While two-dimensional (2D) cell migration has been widely studied, how three-dimensional (3D) geometry and topology interplay with collective cell behavior to determine dynamics and functions remains an open question. In this work, we elucidate the biophy...

Active chiral viscoelastic materials exhibit elastic responses perpendicular to the applied stresses, referred to as odd elasticity. We use a covariant formulation of viscoelasticity combined with an entropy production analysis to show that odd elasticity is not only present in active systems but also in broad classes of passive chiral viscoelastic...

We compute the response matrix for a tracer particle in a compressible fluid with odd viscosity living on a two-dimensional surface. Unlike the incompressible case, we find that an odd compressible fluid can produce an odd lift force on a tracer particle. Using a "shell localization" formalism, we provide analytic expressions for the drag and odd l...

The interplay between cellular growth and cell-cell signaling is essential for the aggregation and proliferation of bacterial colonies, as well as for the self-organization of cell tissues. To investigate this interplay, we focus here on the collective properties of dividing chemotactic cell colonies by studying their long-time and large-scale dyna...

Using concepts from integral geometry, we propose a definition for a local
coarse-grained curvature tensor that is well-defined on polygonal surfaces.
This coarse-grained curvature tensor shows fast convergence to the curvature
tensor of smooth surfaces, capturing with accuracy not only the principal
curvatures but also the principal directions of...

In amorphous solids as in tissues, neighbor exchanges can relax local stresses and allow the material to flow. In this paper, we use an anisotropic vertex model to study T1 rearrangements in polygonal cellular networks. We consider two different physical realizations of the active anisotropic stresses: (i) anisotropic bond tension and (ii) anisotro...

In amorphous solids as in tissues, neighbour exchanges can relax local stresses and allow the material to flow. In this paper, we use an anisotropic vertex model to study T1 rearrangements in polygonal cellular networks. We consider two different physical realization of the active anisotropic stresses: (i) anisotropic bond tension and (ii) anisotro...

The interplay between cellular growth and cell-cell signaling is essential for the aggregation and proliferation of bacterial colonies, as well as for the self-organization of cell tissues. To investigate this interplay, we focus here on the collective properties of dividing chemotactic cell colonies by studying their long-time and large-scale dyna...

Active chiral viscoelastic materials exhibit elastic responses perpendicular to the applied stresses, referred to as odd elasticity. We use a covariant formulation of viscoelasticity combined with an entropy production analysis to show that odd elasticity is not only present in active systems but also in broad classes of passive chiral viscoelastic...

Morphogenesis depends crucially on the complex rheological properties of cell tissues and on their ability to maintain mechanical integrity while rearranging at long times. In this paper, we study the rheology of polygonal cellular networks described by a vertex model in the presence of fluctuations. We use a triangulation method to decompose shear...

Significance
In addition to generating forces and reacting to mechanical cues, tissues are capable of actively pumping fluid and creating electric current. In this work, we examine how a hydraulic or electrical perturbation, imposed, for instance, by a drain of micrometric diameter, can be used to perturb tissue growth. We address this issue in a c...

Using concepts from integral geometry, we propose a definition for a local coarse-grained curvature tensor that is well-defined on polygonal surfaces. This coarse-grained curvature tensor shows fast convergence to the curvature tensor of smooth surfaces, capturing with accuracy not only the principal curvatures but also the principal directions of...

Morphogenesis depends crucially on the complex rheological properties of cell tissues and on their ability to maintain mechanical integrity while rearranging at long times. In this paper, we study the rheology of polygonal cellular networks described by a vertex model in the presence of fluctuations. We use a triangulation method to decompose shear...

A generically observed mechanism that drives the self-organization of living systems is interaction via chemical signals among the individual elements—which may represent cells, bacteria, or even enzymes. Here we propose an unconventional mechanism for such interactions, in the context of chemotaxis, which originates from the polarity of the partic...

We use a theoretical approach to examine the effect of a radial fluid flow or electric current on the growth and homeostasis of a cell spheroid. Such conditions may be generated by a drain of micrometric diameter. To perform this analysis, we describe the tissue as a continuum. We include active mechanical, electric, and hydraulic components in the...

Understanding the hierarchical self-organization of living systems is one of the biggest conceptual challenges of the present century. A generically observed mechanism that drives such organization is interaction among the individual elements---which may represent cells, bacteria, or even enzymes---via chemical signals. We use dynamical renormaliza...

Significance
The presence of fluid-filled cavities is a common feature of multicellular structures. Nucleation and growth of such lumens typically involve the pumping of fluid by cells, which relies on active ion transport. In this paper, we use a continuum description of a spherical cell assembly that takes into account fluid pumping, electric cur...

We discuss the physical mechanisms that promote or suppress the nucleation of a fluid-filled lumen inside a cell assembly or a tissue. We discuss lumen formation in a continuum theory of tissue material properties in which the tissue is described as a two-fluid system to account for its permeation by the interstitial fluid, and we include fluid pum...

This manuscript is focused on the study of critical phenomena taking place out-of-equilibrium. In the description of such phenomena, Langevin equations are ubiquitous and are usually derived in a phenomenological way by adding a noise term to a deterministic mean-field equation. However, I show that for reaction-diffusion processes it is in fact po...

The anisotropic model for landscapes erosion first proposed by Pastor-Satorras and Rothman is believed to capture the physics of erosion at intermediate length scale ($\lesssim3$~km), and to account for the large value of the roughness exponent $\alpha$ observed in real data at this scale. Our study of this model -- conducted using the nonperturbat...

We derive the necessary conditions for implementing a regulator that depends on both momentum and frequency in the nonperturbative renormalization group flow equations of out-of-equilibrium statistical systems. We consider model A as a benchmark and compute its dynamical critical exponent $z$. This allows us to show that frequency regulators compat...

For reaction-diffusion processes with at most bimolecular reactants, we derive well-behaved, numerically-tractable, exact Langevin equations that govern a stochastic variable related to the response field in field theory. Using {\it duality} relations, we show how the particle number and other quantities of interest can be computed. Our work clarif...

The majority of dynamical studies in power systems focus on the high-voltage transmission grids where models consider large generators interacting with crude aggregations of individual small loads. However, new phenomena have been observed indicating that the spatial distribution of collective, nonlinear contribution of these small loads in the low...