Charlie Demené

Charlie Demené
École Supérieure de Physique et de Chimie Industrielles | ESPCI · Physics for Medicine Paris

PhD, Ingénieur ESPCI

About

59
Publications
16,209
Reads
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1,920
Citations
Citations since 2016
49 Research Items
1893 Citations
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20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Additional affiliations
September 2017 - present
École Supérieure de Physique et de Chimie Industrielles
Position
  • Professor (Associate)
January 2017 - August 2017
École Supérieure de Physique et de Chimie Industrielles
Position
  • PostDoc Position
January 2016 - July 2017
Hôpitaux Universitaires de Genève
Position
  • PostDoc Position
Description
  • Working on transcranial and cerebro-vascular applications of Ultrafast Doppler
Education
September 2009 - December 2010
Télécom ParisTech
Field of study
  • Image and Signal processing
September 2006 - September 2010

Publications

Publications (59)
Preprint
Full-text available
Imaging the human brain vasculature with high spatial and temporal resolution remains challenging in the clinic today. Transcranial ultrasound is scarcely used for cerebrovascular imaging, due to low sensitivity and strong phase aberrations induced by the skull bone that only enable major brain vessel imaging, even with ultrasound contrast agent in...
Article
Full-text available
The advent of neuroimaging has increased our understanding of brain function. While most brain-wide functional imaging modalities exploit neurovascular coupling to map brain activity at millimeter resolutions, the recording of functional responses at microscopic scale in mammals remains the privilege of invasive electrophysiological or optical appr...
Article
Objectives The purpose of this study was to demonstrate 3-dimensional (3D) coronary ultrasound localization microscopy (CorULM) of the whole heart beyond the acoustic diffraction limit (<20 μm resolution) at ultrafast frame rate (>1000 images/s). Background Direct assessment of the coronary microcirculation has long been hampered by the limited sp...
Article
Full-text available
How mechanical stress actively impacts the physiology and pathophysiology of cells and tissues is little investigated in vivo. The colon is constantly submitted to multi-frequency spontaneous pulsatile mechanical waves, which highest frequency functions, of 2 s period, remain poorly understood. Here we find in vivo that high frequency pulsatile mec...
Article
Full-text available
Little is known about how neural representations of natural sounds differ across species. For example, speech and music play a unique role in human hearing, yet it is unclear how auditory representations of speech and music differ between humans and other animals. Using functional ultrasound imaging, we measured responses in ferrets to a set of nat...
Article
Ultrasound sensitivity to slow blood flow motion gained two orders of magnitude in the last decade thanks to the advent of ultrafast ultrasound imaging at thousands of frames per second. In neuroscience, this access to small cerebral vessels flow led to the introduction of ultrasound as a new and full-fledged neuroimaging modality. Much as function...
Article
Full-text available
Changes in cerebral blood flow are associated with stroke, aneurysms, vascular cognitive impairment, neurodegenerative diseases and other pathologies. Brain angiograms, typically performed via computed tomography or magnetic resonance imaging, are limited to millimetre-scale resolution and are insensitive to blood-flow dynamics. Here we show that u...
Article
Full-text available
Clinicians have long been interested in functional brain monitoring, as reversible functional losses often precedes observable irreversible structural insults. By characterizing neonatal functional cerebral networks, resting-state functional connectivity is envisioned to provide early markers of cognitive impairments. Here we present a pioneering b...
Article
Full-text available
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20571-9
Article
Full-text available
During locomotion, theta and gamma rhythms are essential to ensure timely communication between brain structures. However, their metabolic cost and contribution to neuroimaging signals remain elusive. To finely characterize neurovascular interactions during locomotion, we simultaneously recorded mesoscale brain hemodynamics using functional ultraso...
Preprint
Full-text available
Little is known about how neural representations of natural sounds differ across species. For example, speech and music play a unique role in human hearing, yet it is unclear how auditory representations of speech and music differ between humans and other animals. Using functional Ultrasound imaging, we measured responses in ferrets to a set of nat...
Article
Full-text available
Functional ultrasound imaging (fUS) is an emerging technique that detects changes of cerebral blood volume triggered by brain activation. Here, we investigate the extent to which fUS faithfully reports local neuronal activation by combining fUS and two-photon microscopy (2PM) in a co-registered single voxel brain volume. Using a machine-learning ap...
Preprint
Full-text available
Brain-machine interfaces (BMI) are powerful devices for restoring function to people living with paralysis. Leveraging significant advances in neurorecording technology, computational power, and understanding of the underlying neural signals, BMI have enabled severely paralyzed patients to control external devices, such as computers and robotic lim...
Article
Full-text available
Brain-machine interfaces (BMI) are powerful devices for restoring function to people living with paralysis. Leveraging significant advances in neurorecording technology, computational power, and understanding of the underlying neural signals, BMI have enabled severely paralyzed patients to control external devices, such as computers and robotic lim...
Chapter
Full-text available
Numerous diseases find their origin and their diagnosis in the physiological behavior of vascular networks [10]. In particular, to understand the architecture and growth of a tumor the study of blood flows is crucial. Recently, Ultrasensitive Doppler has enabled 4D ultrasound imaging of tumor micro-vasculature in mice [5]. In this study, we propose...
Preprint
Full-text available
Theta and gamma rhythms coordinate large cell assemblies during locomotion. Their spread across temporal and spatial scales makes them challenging to observe. Additionally, the metabolic cost of these oscillations and their contribution to neuroimaging signals remains elusive. To finely characterize neurovascular interactions in running rats, we mo...
Preprint
Full-text available
Angiogenesis, the formation of new vessels, is one of the key mechanisms in tumor development and an appealing target for therapy. Non-invasive, high-resolution, high sensitivity, quantitative 3D imaging techniques are required to correctly depict tumor heterogeneous vasculature over time. Ultrafast Doppler was recently introduced and provides an u...
Conference Paper
Full-text available
Numerous diseases find their origin and their diagnosis in the physiological behavior of vascular networks [10]. In particular, to understand the architecture and growth of a tumor the study of blood flows is crucial. Recently, Ultrasensitive Doppler has enabled 4D ultrasound imaging of tumor micro-vasculature in mice [5]. In this study, we propose...
Preprint
Full-text available
Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination of spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep and transcranial monitoring of brain activity and the imaging of dynamics in slow-flowing blood vessels remain challenging. To enhance fUS capabil...
Article
Full-text available
Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination of spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep and transcranial monitoring of brain activity and the imaging of dynamics in slow-flowing blood vessels remain challenging. To enhance fUS capabil...
Article
Angiogenesis, the formation of new vessels, is one of the key mechanisms in tumor development and an appealing target for therapy. Non-invasive, high-resolution, high-sensitivity, quantitative 3-D imaging techniques are required to correctly depict tumor heterogeneous vasculature over time. Ultrafast Doppler was recently introduced and provides an...
Article
Full-text available
Rapid eye movement sleep (REMS) is a peculiar brain state combining the behavioral components of sleep and the electrophysiological profiles of wake. After decades of research our understanding of REMS still is precluded by the difficulty to observe its spontaneous dynamics and the lack of multimodal recording approaches to build comprehensive data...
Article
Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the developing brain. While the oxytocin system was also found to be impaired f...
Article
Full-text available
Patient mortality at one year reaches 90% after out-of-hospital cardiac arrest and resuscitation. Temperature management is one of the main strategies proposed to improve patient outcome after resuscitation and preclinical studies have shown neuroprotective effects when hypothermia is achieved rapidly, although the underlying mechanisms have not ye...
Presentation
Brain-machine interfaces (BMIs) use neurophysiological signals from the brain to control external devices. Ideally, BMIs have high spatiotemporal resolution, are noninvasive, and portable. Most BMIs rely on neuroelectric methods that are either invasive (e.g. microelectrode arrays) or suffer from poor signal fidelity (e.g. EEG). BMIs based on metab...
Poster
High-density neural interfaces require the ability to observe large-scale patterns of neural activity with high spatiotemporal resolution. Ideally, they should be non-invasive (or minimally invasive) to facilitate their applications in research and potential clinical studies. Current methods to monitor neural activity, including electrophysiology,...
Article
The emergence of functional neuroimaging has dramatically accelerated our understanding of the human mind. The advent of functional Magnetic Resonance Imaging paved the way for the next decades’ major discoveries in neuroscience and today remains the “gold standard” for deep brain imaging. Recent improvements in imaging technology have been somewha...
Article
Full-text available
A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve the functional organization of s...
Article
The emergence of functional neuroimaging has dramatically accelerated our understanding of the human mind. The advent of functional Magnetic Resonance Imaging paved the way for the next decades' major discoveries in neuroscience and today remains the "gold standard" for deep brain imaging. Recent improvements in imaging technology have been somewha...
Article
Full-text available
In the last decade, ultrasound imaging has gained new capabilities and produced new insights in the field of neuroscience. The development of new concepts, such as ultrafast ultrasound, has enhanced Doppler sensitivity by orders of magnitude and has paved the way for ultrasonic functional neuroimaging. In this review, we position ultrasound in the...
Article
Full-text available
Singular Value Decomposition (SVD) of Ultrafast imaging ultrasonic datasets has recently been shown to build a vector basis far more adapted to the discrimination of tissue and blood flow than the classical Fourier basis, improving by a large factor clutter filtering and blood flow estimation. However the question of optimally estimating the bounda...
Preprint
Full-text available
A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve the functional organization of s...
Chapter
Full-text available
Ultrasensitive Doppler is a recent medical imaging technique enabling high sensitive acquisition of blood flows which can detect small vascular features without contrast agents. Applied to cerebral tomographic imaging of rodents, this method produces very fine vascular 3D maps of the brain at high spatial resolution of 100 μm. These vascular networ...
Article
Full-text available
Functional neuroimaging modalities are crucial for understanding brain function, but their clinical use is challenging. Recently, the use of ultrasonic plane waves transmitted at ultrafast frame rates was shown to allow for the spatiotemporal identification of brain activation through neurovascular coupling in rodents. Using a customized flexible a...
Article
The stochastic nature of cavitation implies visualization of the cavitation cloud in real-time and in a discriminative manner for the safe use of focused ultrasound therapy. This visualization is sometimes possible with standard echography, but it strongly depends on the quality of the scanner, and is hindered by difficulty in discriminating from h...
Article
Full-text available
Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms linking poor fetal growth and neurocognitive impairment are unclear. Here, we aimed to correlate c...
Conference Paper
Full-text available
Large-scale functional imaging techniques are part of a fast growing field of neuroscience aiming at understanding whole brain activity. The recently introduced Functional Ultrasound Imaging (fUS), based on ultrafast Doppler, is a new very sensitive method monitoring changes in slow blood flow with a high spatial (∼100µm) and temporal (down to the...
Article
Full-text available
The feasibility and reproducibility of liver stiffness measurements using Supersonic Shear-wave Imaging (SSI) in preterm neonate have not been reported. Our aim was to determine if liver stiffness differs between intra-uterine growth restriction (IUGR) and appropriate for gestational age (AGA) preterm infants with/without cholestasis. We measured l...
Article
Ultrafast Doppler imaging was introduced as a technique to quantify blood flow in an entire 2-D field of view, expanding the field of application of ultrasound imaging to the highly sensitive anatomical and functional mapping of blood vessels. We have recently developed 3-D ultrafast ultrasound imaging, a technique that can produce thousands of ult...
Article
Total liquid ventilation provides ultrafast and potently neuro- and cardioprotective cooling after shockable cardiac arrest and myocardial infarction in animals. Our goal was to decipher the effect of hypothermic total liquid ventilation on the systemic and cerebral response to asphyxial cardiac arrest using an original pressure- and volume-control...
Article
Full-text available
Ultrafast ultrasonic imaging is a rapidly developing field based on the unfocused transmission of plane or diverging ultrasound waves. This recent approach to ultrasound imaging leads to a large increase in raw ultrasound data available per acquisition. Bigger synchronous ultrasound imaging datasets can be exploited in order to strongly improve the...
Article
Full-text available
Purpose: Objective Shear wave elastography (SWE) enabled living tissue assessment of stiffness. This is routinely used for breast, thyroid and liver diseases, but there is currently no data for the brain. We aim to characterize elasticity of normal brain parenchyma and brain tumors using SWE. Materials and Methods: Patients with scheduled brain tum...