Charles C.N. Wang

Charles C.N. Wang
Asia University · Department of Bioinformatics and Medical Engineering

Ph.D

About

54
Publications
8,107
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348
Citations
Introduction
I am a data scientist with exhaustive experience in Bioinformatics, Semantic Computing, Natural Language Processing and Machine Learning in several domains. I am passionate about learning and always looks forward to solving challenging analytical problems.
Additional affiliations
September 2019 - June 2021
Asia University
Position
  • Professor (Associate)
January 2015 - July 2017
Asia University
Position
  • Researcher
September 2014 - present
Asia University
Position
  • Researcher
Education
September 2010 - July 2014
Asia University
Field of study

Publications

Publications (54)
Article
Full-text available
Background In discussing of quality measurements based on interrupted time series in ischemic stroke, delays are often attributed to weekends effect. This study compared the metrics and outcomes of emergent endovascular thrombectomy (EST) during working hours versus nonworking hours in the emergency department of an Asian medical center. Methods A...
Article
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Background: Cardiovascular management and risk stratification of patients is an important issue in clinics. Patients who have experienced an adverse cardiac event are concerned for their future and want to know the survival probability. Methods: We trained eight state-of-the-art CNN models using polar maps of myocardial perfusion imaging (MPI),...
Article
Full-text available
Background Overcrowding in emergency departments (ED) is a critical problem worldwide, and streaming can alleviate crowding to improve patient flows. Among triage scales, patients labeled as “triage level 3” or “urgent” generally comprise the majority, but there is no uniform criterion for classifying low-severity patients in this diverse populatio...
Article
Full-text available
Improved insight into the molecular mechanisms of triple negative breast cancer (TNBC) is required to predict prognosis and develop a new therapeutic strategy for targeted genes. The aim of this study is to identify key genes which may affect the prognosis of TNBC patients by bioinformatic analysis. In our study, the RNA sequencing (RNA-seq) expres...
Article
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Introduction: Only a proportion of triple-negative breast cancer (TNBC) is immuno-therapy-responsive. We hypothesized that the tumor microenvironment (TME) influences the outcomes of TNBC and investigated the relevant signaling pathways. Materials and Methods: Immune score (IS) and stromal score (SS) were calculated using the ESTIMATE and correlat...
Preprint
Background: Overcrowding in emergency departments (ED) is a critical problem worldwide, and streaming can alleviate crowding to improve patient flows. Among triage scales, patients labeled as “triage level 3” or “urgent” generally comprise the majority, but there is no uniform criterion for classifying low-severity patients in this diverse populati...
Article
Full-text available
The responsiveness of patients with chronic kidney disease (CKD) to nephrologists’ care is unpredictable. We defined the longitudinal stages (LSs) 1–5 of estimated glomerular filtration rate (eGFR) by group-based trajectory modeling for repeated eGFR measurements of 7135 patients with CKD aged 20–90 years from a 13-year pre-end-stage renal disease...
Conference Paper
p>Introduction: Programmed death (PD)-1/PD-ligand 1 immunotherapy increases the pathological complete response rate by 13.6 percentage points when added to neoadjuvant chemotherapy for early triple-negative breast cancer (TNBC) (Schmid et al. 2020). This indicates a proportion of TNBC are immune-responsive while many are not. We hypothesized that t...
Preprint
Background: Only a proportion of triple-negative breast cancer (TNBC) is immunotherapy-responsive. We hypothesized that the tumor microenvironment (TME) might influence the outcomes of TNBC and investigated the relevant signaling pathways. Methods: RNA-seq data of 115 TNBC samples and 112 normal adjacent tissues were retrieved for ESTIMATE, CIBERSO...
Article
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Several natural and human factors are responsible for the defacement of the external walls and tiles of buildings, and the related deterioration can be a public safety hazard. Therefore, active building maintenance and repair processes are essential for ensuring building sustainability. However, conventional inspection methods are time-, cost-, and...
Article
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The aim of this study is to identify potential biomarkers for early diagnosis of gynecologic cancer in order to improve survival. Cervical cancer (CC) and endometrial cancer (EC) are the most common malignant tumors of gynecologic cancer among women in the world. As the underlying molecular mechanisms in both cervical and endometrial cancer remain...
Article
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Background Bacterial cultures allow the identification of infectious disease pathogens. However, obtaining the results of conventional culture methods is time-consuming, taking at least two days. A more efficient alternative is the use of concentrated bacterial samples to accelerate culture growth. Our study focuses on the development of a high-yie...
Article
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Objective Temporary vascular access (TVA) is frequently used during the first dialysis in patients with chronic kidney disease (CKD), and it is associated with an increased risk of infection, central vein stenosis, and mortality. Here, factors associated with TVA in patients with CKD were explored. Methods This study included patients in a single‐...
Article
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Background: Gastrointestinal (GI) cancer including colorectal cancer, gastric cancer, pancreatic cancer, etc., are among the most frequent malignancies diagnosed annually and represent a major public health problem worldwide. Methods: This paper reports an aided curation pipeline to identify potential influential genes for gastrointestinal cance...
Article
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Bladder cancer is a common malignancy with mechanisms of pathogenesis and progression. This study aimed to identify the prognostic hub genes, which are the central modulators to regulate the progression and proliferation in the specific subtype of bladder cancer. The identification of the candidate hub gene was performed by weighted gene co-express...
Article
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Background: Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature can be challenging. In this study, we use text mining to explore UC publications to identify important information that may lead...
Article
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Improved insight into molecular mechanism of head and neck squamous cell carcinoma (HNSCC) is required to predict prognosis and develop a new therapeutic strategy for targeted genes. The aim of this study is to identify significant genes associated with HNSCC and further analyze its prognostic significance. In our study, the cancer genome atlas (TC...
Article
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Multidrug resistance (MDR) is a complicated ever-changing problem in cancer treatment, and P-glycoprotein (P-gp), a drug efflux pump, is regarded as the major cause. In the way of developing P-gp inhibitors, natural products such as phenolic acids have gotten a lot of attention recently. The aim of the present study was to investigate the modulatin...
Article
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Liver X receptor (LXR) is a nuclear receptor that regulates various biological processes, including de novo lipogenesis, cholesterol metabolism, and inflammation. Selective inhibition of LXR may aid the treatment of nonalcoholic fatty liver disease (NAFLD). Sesamin is a naturally occurring lignan in many dietary plants and has a wide range of benef...
Conference Paper
The treadmill exercise test (TET) is a useful and safe initial noninvasive diagnostic stress test for a patient with symptoms of stable angina and intermediate-to-high pre-test probability of coronary artery disease to detect inducible myocardial ischemia. In this study, we present an evaluation and comparison of how machine learning classification...
Conference Paper
Neonatal jaundice is a very common problem in the newborn period, assessment of jaundice in outpatient neonates by visual assessment is inaccurate, problematic; but more exact methodologies are cumbersome and/or expensive. Our goal in this study was to assess the accuracy of a technology based on the analysis of digital images of newborns obtained...
Article
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Strategies targeting endoglin are currently being investigated in clinical trials as an anti-angiogenic therapy. The redundancy between endoglin and vascular endothelial growth factor (VEGF) signaling in angiogenesis was verified. Increased endoglin signaling after an anti-VEGF treatment was observed in patients. Treatment with an endoglin-neutrali...
Article
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Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) cancer. In the present study, a clinically used synthetic steroid hormone, danazol, was investigated for it...
Article
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Breast cancer is one of the most common malignancies. However, the molecular mechanisms underlying its pathogenesis remain to be elucidated. The present study aimed to identify the potential prognostic marker genes associated with the progression of breast cancer. Weighted gene coexpression network analysis was used to construct free-scale gene coe...
Article
Full-text available
P-glycoprotein (P-gp) effluxes lots of chemotherapeutic agents and leads to multidrug resistance (MDR) in cancer treatments. The development of P-gp inhibitors from natural products provide a potential strategy for the beneficial clinical outcomes. This study aimed to evaluate the effects of the natural flavonoid taxifolin, luteolin, (−)-gallocatec...
Conference Paper
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Maize is a well-studied crop. It has been used as a model plant for C4 studies of photosynthesis, as its leaves possess the Kranz Structure (KS). Unfortunately, only few studies addressed the use of computational models to describe dry maize. In particular, the mechanism of KS formation remains unclear during leaf development. This study aims to de...
Article
Nonalcoholic fatty liver disease (NAFLD) is a very common liver disease, and its incidence has significantly increased worldwide. The liver X receptor α (LXRα) is a multifunctional nuclear receptor that controls lipid homeostasis. Inhibition of LXRα transactivation may be beneficial for NAFLD and hyperlipidemia treatment. Ursolic acid (UA) is a pla...
Article
Liver X receptor α (LXRα) controls important biological and pathophysiological processes such as lipid homeostasis. Inhibiting LXRα transactivation may beneficial in the treatment of nonalcoholic fatty liver disease (NAFLD), which is one of the main causes of liver diseases and hyperlipidemia. Oleanolic acid (OA) is a naturally occurring triterpeno...
Article
Full-text available
There have been an enormous number of publications on cancer research. These unstructured cancer-related articles are of great value for cancer diagnostics, treatment, and prevention. The aim of this study is to introduce a recommendation system. It combines text mining (LDA) and semantic computing (GloVe) to understand the meaning of user needs an...
Article
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To characterize the association between epilepsy, use of antiepileptic drugs (AEDs), and the risk of hyperlipidemia, we conducted a nationwide population-based cohort study with data obtained from the National Health Insurance Research Database of Taiwan. The effects of AEDs on lipogenic gene expression were also examined in vitro. We identified 36...
Article
Background: Multidrug resistance (MDR) in cancer is one of the main obstacles in treatment with chemotherapy. Drug efflux through P-glycoprotein is the major mechanism involved in MDR. A potential strategy to provide the best possible clinical outcomes is to develop P-glycoprotein (P-gp) inhibitors from natural products. Purpose: The present stu...
Conference Paper
Full-text available
There have been an enormous number of publications on cancer research. These integrated but unstructured cancer-related articles are of great value for cancer diagnosis, treatment and prevention. In this study, we use the basic concepts underlying text mining and semantic computing to discuss the current state-of-the-art text mining applications in...
Article
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The correlation between hip replacement (Hip-Repl) and chronic osteomyelitis (COM) has not been studied in Asian populations. Thus, we assessed Hip-Repl-related risk of developing COM via a population-based, nationwide, retrospective cohort study. The Hip-Repl cohort was obtained from Taiwan's Longitudinal Health Insurance Database 2000, and includ...
Article
Bioinformatics conceptualizes biological processes in terms of genomics and applies computer science (derived from disciplines such as applied modeling, data mining, machine learning and statistics) to extract knowledge from biological data. This paper introduces the working definitions of bioinformatics and its applications and challenges. We also...
Conference Paper
Full-text available
Cardiovascular disease (CVD) is group of diseases of the heart and blood vessels and a major global cause of death, with more people dying every year from CVDs than from any other cause. Therefore, controlling and preventing CVDs and their complex pathogenesis (i.e., influenced by genetic and lifestyle factors) has gained considerable attention. In...
Conference Paper
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The upstream of genes are expected to contain many still unknown regulatory regions that can increase or decrease the expression of specific genes. The processes of mining distinctive patterns (region) are to extract maximal repeats (patterns) from the upstream DNA sequences of human genes, and then filter out the patterns whose class frequency dis...
Article
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Background This study explored whether antiepileptic drugs (AEDs) use increases the risk of hepatocellular carcinoma (HCC). Methods We conducted a case–control study using data from the National Health Insurance system of Taiwan. The case group comprised 1,454 epilepsy patients with newly diagnosed HCC, and the control group comprised 1,448 epilep...
Article
Restenosis (or neointimal hyperplasia) remains a clinical limitation of percutaneous coronary angioplasty. Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are known to be involved in the development of restenosis. The present study aimed to investigate the ability and molecular mechanisms of methyl protodioscin (1), a s...
Article
Biological and medical intelligence (BMI) has been studied in solos, lacking a systematic methodology. In this paper, we describe how Semantic Computing can enhance biological and medical intelligence. Specifically, we show how Structured Natural Language (SNL) can express many problems in BMI with a finite number of sentence patterns, and show how...
Article
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Several dynamic models of a gene regulatory network of the light-induced floral transition process in Arabidopsis have been developed to capture the behavior of gene transcription and infer predictions based on experimental observations. It has been proven that the models can make accurate and novel predictions, which generate testable hypotheses.T...
Conference Paper
Computer-aided drug design methodologies have proven to be very effective, greatly enhancing the efficiency of drug discovery and development processes. In this paper we describe how to integrate complex drug discovery problems and computational solutions via a semantic interface. In particular we describe a Structured Natural Language approach to...
Article
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Hiding data in the deoxyribose nucleic acid (DNA) can facilitate the authentication and annotation of important plant variety rights. A grant of plant variety rights for a new plant variety gives you the exclusive right to produce for sale and sell propagating material of the variety. Digital watermarking techniques have been proposed for a wide ra...
Conference Paper
Web services have become increasingly important in biomedical research as tools that allow databases and algorithms to be accessed programmatically as computational components in programs. Various biomedical web services differ in their definitions and invocation protocols, as well as their communication and data formats and this presents a barrier...
Conference Paper
Molecular modeling and in silico docking experiments were performed in order to study the mechanism of action of AmpC beta-Lactamase repression via AmpR binding of UDP-MurNAc-L-Ala-D-gamma-Glu-Meso-2,6-Diaminopimelete-D-Ala-D-Ala.
Conference Paper
Full-text available
In this paper, the movement of bacteria, i.e. E. coli, is simulated based on the run and tumble model. The random walk parameters, such as the speed, tumbling frequency, run duration, and the turn angle between two successive runs were taken from experimental measurements, and use them to simulate the bacteria movement in cases of three different u...
Conference Paper
Semantic capability description language (SCDL) plays an important role as a common language and provides a generic format for problem formalization. In this paper we extend SCDL to include dynamic biological systems. A new process description language SPDL (semantic process description language) is presented and several queries as well as their co...

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