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19
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Introduction
Charles Shang currently works at the Section of General Internal Medicine, Baylor College of Medicine. Charles does research in internal medicine, Developmental Biology, Systems Biology and Physiology.
Additional affiliations
July 2009 - present
Publications
Publications (19)
A model of growth control system suggests that the organizers in embryogenesis continue to exist and partially retain their function after embryogenesis. The organizers are the macroscopic singular points of the morphogen gradient and bioelectric fields. They have higher metabolic rate, higher density of gap junctions and stem cells than the surrou...
The growth control singularity model suggests that acupuncture points (acupoints) originate from organizers in embryogenesis. Organizers are singular points in growth control. Acupuncture can cause perturbation of a system with effects similar to simulated annealing. In clinical trial, the goal of a treatment is to relieve certain disorder which co...
The recent guideline from the European Society of Cardiology and European Society of Anesthesiology recommended the use of B-type natriuretic peptide (BNP) as preoperative testing for high-risk cardiac patients undergoing non-cardiac surgery. In this article, the potential benefits, risks and details for implementing BNP testing in perioperative me...
To the Editor: It is unfortunate that the observational study on β-blocker use and clinical outcomes in stable outpatients did not distinguish different types of β-blockers.¹ In a review of β-blockers for hypertension, three-quarters of participants in randomized controlled trials (RCTs) used atenolol.² Atenolol has been shown repeatedly to be no b...
Background: The gold standard in testing scientific theory requires multiple independent prospective tests. This standard was applied to basic acupuncture research. Objectives: To test whether basic acupuncture research has met the gold standard of science. Data Sources: Literature search and review of publications in MEDLINE and Chinese medical li...
In embryogenesis, every physiological system is developed through a growth control system mediated by organizers and growth control boundaries. The growth control signal transduction is embedded in various physiological functions. Many physiological processes are regulated through growth control mechanisms such as hypertrophy, hyperplasia, atrophy,...
The biological effects of acupuncture include the regulation of a variety of neurohumoral factors and growth control factors. In science, models or hypotheses with confirmed predictions are considered more convincing than models solely based on retrospective explanations. Literature review showed that two biological models of acupuncture have been...
Bioelectric fields have been shown to interact with morphogens and guide growth control. The morphogenetic singularity theory published a decade ago suggests that organizing centers have high density of gap junctions and high electrical conductance. They are the singular points in morphogen gradient and bioelectric field. A growth control system or...
The emerging paradigms in medicine can be seen through mind-body interactions. Observations in many meditative traditions suggest a series of objective indicators of health beyond absence of disease. Several of the physical signs have been confirmed by research or are consistent with modern science. Further correlation with long term health outcome...
Acupuncture points and meridians have been discovered to have high electric conductance which is related to high density of gap junctions. Neurohumoral approach in acupuncture research was instrumental in establishing the scientific validity of acupuncture. Recent advances in the morphogenetic singularity theory suggest that acupuncture points orig...
The early growth response zinc finger transcription factor (EGR-1) and the heterotrimeric guanine nucleotide binding protein encoded by the protooncogene G alpha i-2 each play pivotal roles in signaling pathways that control cell growth and differentiation. The G alpha i-2 gene 5'-flanking region contains a putative binding site (5'-CGCCCCCGC-3') f...
Heterotrimeric G-proteins function as signal transducers for a variety of hormone-coupled enzyme systems in eukaryotic cells. In LLC-PK1 renal cells, vasopressin-stimulated adenylylcyclase activity is regulated in part, by the counterbalancing activity of stimulatory G-proteins (Gs) and inhibitory pertussis toxin-sensitive G-proteins (Gi). Two Gi g...
Several converging points from recent research results on cellular signal transduction, pattern formation, bioelectromagnetism and acupuncture are reviewed. These converging points indicate the general importance of bioelectrochemical oscillations in morphogenesis and physiology: An organism is not only a system of molecules and cells, but also a s...
Previous experiments have suggested that negative charge is an important aspect of the activating region of lambda repressor as it is for at least one class of eukaryotic transcriptional activators. Here we randomize amino acids in the activating region of repressor and assay the function of over 100 variants. We find that acidic residues at the fo...
A hypothesis is proposed on the nature of acupuncture point and organizing center, the role of meridian system in growth regulation, and the mechanism of acupuncture. Both organizing centers and acupuncture points have low electric resistance. The low electric resistance is related to the distribution of gap junction and thus intercellular communic...
Questions
Questions (7)
The postembryonic growth control organizer model (www.sciencedirect.com/science/article/pii/S0079610716300487) suggests that the stem cells likely concentrate at the extreme points of body surface curvature. Is there evidence for or against this prediction?
Thanks
The postembryonic growth control organizer model (www.sciencedirect.com/science/article/pii/S0079610716300487) suggests that the morphogen gradient may partially persist at the extreme points of body surface curvature. Is there evidence for or against this prediction?
Thanks
The effect sizes listed in Cochrane Reviews are often calculated after aggregating several RCTs without explicitly listing the effect sizes of individual RCTs. What is the easiest way to find the effect sizes and other data of individual RCTs included in Cochrane Reviews besides combing through the publications of each individual RCTs? Is there a database which includes the effect sizes of individual RCTs in addition to the full text reviews?
Thanks
A recent review suggested that most models in basic acupuncture research have no prediction or guidance value in clinical research (http://www.hindawi.com/journals/ecam/2011/180805/). The exception may be the following: www.ncbi.nlm.nih.gov/pmc/articles/PMC2644274/
Any other exception?
I am writing an updated review on acupuncture research. Besides the model reviewed in http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644274/ in 2007, has there been any other theory or model on acupuncture which has made predictions and got multiple independent confirmations?
We have used biomagnetometer with 248 axial gradiometers (3600WH, 4D Neuroimaging, San Diego, CA) to measure the pattern of bioelectromagnetic field on human palm but our software is only for MEG. We need a different algorithm for source localization on human palm/hand. Thanks
