Charles Elikwu

Charles Elikwu
Babcock University/ Babcock University Teaching Hospital · Medical Microbiology & Parasitology

MBBS, MSc, FMCPATH
Circulating Genotypes of HBV in Southwest Nigeria; Arboviruses and Non-malaria Febrile illnesses in Southwest Nigeria

About

56
Publications
12,109
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
175
Citations
Additional affiliations
March 2013 - present
Babcock University
Position
  • Faculty Member/Consultant Clinical Microbiologist/Infectious Diseases Physician
Description
  • Virology Group B Streptococci in pregnant women Actively Mentoring young Medical Scientists (Resident doctors, Medical Students): Infection Control, Antibiotics use Reviewer for Journals of Clinical Sciences, Annals of Health Journal
March 2013 - present
Babcock University/Babcock University Teaching Hospital
Position
  • Lecturer/Consultant Clinical Microbiologist/Infectious Diseases Physician
Description
  • 3 years of teaching: Medical Students, Residents: Medical Microbiology Virology Infection Control Laboratory Diagnosis & Management of Patients with Infectious Diseases in ICU, In patients, STI Clinic Radio Talk Show on Viral Infections
June 2012 - March 2013
Bowen University/Bowen University Teaching Hospital
Position
  • Lecturer/Consultant Clinical Microbiologist
Description
  • One years of teaching: Medical Students Medical Microbiology Virology Infection Control Laboratory Diagnosis & Management of Patients with Infectious Diseases in ICU, In patients
Education
October 2006 - May 2012
National Postgraduate Medical College of Nigeria
Field of study
  • Specialist Residency Training in Medical Microbiology & Parasitology/Infectious Diseases
August 2005 - October 2006
University of Lagos
Field of study
  • Master of Science in Medical Microbiology
November 1988 - November 1995
University of Ibadan
Field of study
  • Medicine & Sugery

Publications

Publications (56)
Article
Full-text available
Background: Urinary tract infections (UTI) is commoner in females than males and mainly caused by Gram Negative bacilli. The emergence of Extended-spectrum beta lactamases (ESBL) has made its treatment difficult especially in the community because of limited therapeutic options. This study was undertaken to determine the prevalence of ESBL-producin...
Preprint
Full-text available
Background Salmonellosis causes significant morbidity and mortality in Africa. Despite being endemic in Nigeria, information on circulating lineages of invasive Salmonella is sparse. Methods Sixty-three Salmonella enterica isolated from blood (n=60) and cerebrospinal fluid (CSF, n=3) isolated between 2016 and 2020 from five tertiary hospitals in s...
Article
Full-text available
Background and objectives Commercial Aspergillus IgG antibody assays have become pivotal in the current diagnosis of chronic pulmonary aspergillosis (CPA). However, diagnostic cutoffs have been found to vary from manufactures’ recommendations in different settings. This study aimed to establish the Aspergillus IgG reference range among Nigerians an...
Article
Full-text available
Background: Healthcare workers (HCWs) are at high risk of contracting and spreading the novel Coronavirus Disease 2019 (COVID-19) disease putting themselves, the patients and the community at large at risk. Therefore, there is a need for adequate preparedness in the face of this pandemic. Objectives: To assess the knowledge of HCW (clinical and no...
Conference Paper
Full-text available
Background Trichomoniasis is caused by the adhesion of Trichomonas vaginalis to mucosa of vagina or urethra. Its incidence rate is estimated to be higher than both gonorrhea and chlamydia combined. While largely asymptomatic, it’s associated with preterm delivery, premature rupture of membrane, PID and increased predisposition to HIV infection. Tar...
Article
Full-text available
Coronavirus infection became a global pandemic in March 2020. The number of hospitalized cases in Nigeria and Ogun State has been on a steady increase with a concomitant rise in Mortality. This necessitates a coordinated and a more systemic approach in the management of this deadly disease. As a result of the potential effects of the disease on the...
Article
Full-text available
Coronavirus infection became a global pandemic in March 2020. The number of hospitalized cases in Nigeria and Ogun State has been on a steady increase with a concomitant rise in Mortality. This necessitates a coordinated and a more systemic approach in the management of this deadly disease. As a result of the potential effects of the disease on th...
Article
Background: There are few population-based studies concerning the bowel habits of adult Nigerians. Only one of these was published about a decade ago in the Northcentral region, the others were published over four decades ago. This study was conducted to determine the bowel habits and the frequencies of bowel movement disorders among adults in a So...
Article
Full-text available
Background: Nigeria joined the global community in monitoring antimicrobial prescribing practices since 2015. Results of individual hospital Global Point Prevalence Survey (Global-PPS) have stimulated efforts at instituting hospital-based antimicrobial stewardship (AMS) programmes. We report the trends of antimicrobial prescribing rates and quality...
Article
Full-text available
Background: Antimicrobial resistance (AMR) is a major clinical challenge globally. It is mainly a consequence of inappropriate prescribing and use of antibiotics. Antimicrobial stewardship (AMS) ensures that antibiotics are prescribed and used appropriately. This study assessed AMS practice in selected Nigerian hospitals.Methodology: This was a cro...
Article
Objectives: The Human Immunodeficiency virus causes an infection of public health importance with about 71% of the global burden in Sub-Saharan Africa. In Nigeria, 3.2 million people are living with HIV, and 838,000 - 1.3 million of the cases are found among youths. Although Non- Occupational Human Immunodeficiency Virus (HIV) post-exposure prophyl...
Article
Full-text available
Background: Urinary tract infections (UTIs) is a common medical problem that affects all age groups but with significant morbidity in females because of the nature of their anatomy and physiology. This study was aimed to identify the common causative organisms of UTI and their antimicrobial susceptibility pattern among female students in Babcock Un...
Article
Full-text available
Introduction: Diarrhoea, in general, is well investigated but the epidemiology of Functional Diarrhoea (FDr) as a disease entity has not been adequately evaluated globally, and more especially, in the sub-Saharan African population. Aim: To determine the prevalence and risk factors of FDr, and the associated quality of life in a Nigerian community...
Article
Full-text available
Background: Nasal carriage of methicillin resistant Staphylococcus aureus (MRSA) is a major factor for its transmission especially from the health workers and medical students to their patients. There are a number of published data on the prevalence of MRSA among health workers but data on nasal colonization of medical students by MRSA are sparse i...
Article
Full-text available
Background: An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, China. This new virus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses. That disease, caused by the SARS-CoV-2, has been named c...
Article
Full-text available
Background: Irritable bowel syndrome (IBS) occurs worldwide and portends a huge socioeconomic burden to the individual and society. Though extensively investigated in some other regions, IBS has not been adequately studied in sub-Saharan African. We studied the prevalence of IBS, its risk factors and the health-related quality of life in a Nigerian...
Article
Full-text available
Herpes simplex virus type 2 (HSV-2) is the primary cause of genital herpes worldwide and also has a role in facilitating human immunodeficiency virus (HIV) transmission. The aim of the study was to determine seroprevalence of HSV-2 among the subjects and associated risk factors. In this cross-sectional study, 207 HIV Positive subjects attending a r...
Article
Full-text available
Background: Chlamydia trachomatis is one of the most prevalent bacterial‑causing urogenital infections in men and women worldwide. There have been increasing reports of the prevalence of C. trachomatis in Nigeria. Aims: This study aimed to detect the prevalence of C. trachomatis seromarkers immunoglobulin G (IgG) and immunoglobulin A (IgA) and also...
Article
Full-text available
Genital Chlamydia trachomatis infection causes significant morbidity and mortality in women. A number of epidemiologic studies have suggested that Polymerase Chain Reaction (PCR) is more accurate as a diagnostic tool for Chlamydia trachomatis. However, the use of serological markers may be cost effective and practical in diagnosing and estimating t...
Article
Full-text available
Pre-procedural screening for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are routinely done in several endoscopy centres in Nigeria. These tests constitute an additional layer of financial burden to the patients since most of them settle their medical bills out of pocket. At the same time, the burden of t...
Article
Full-text available
Background Malaria in pregnancy carries a risk of significant adverse maternal and infant outcomes. Intermittent preventive treatment in pregnancy (IPTp) is advocated to reduce its occurrence, but resistance to sulphadoxine-pyrimethamine (SP) is being reported. This study aims to describe the burden of SP resistance and determinants of its occurren...
Article
Full-text available
Toxoplasma gondii is a zoonotic parasite causing high disease burden worldwide. A One Health approach is needed to understand, prevent, and control toxoplasmosis, while knowledge gaps in the One Health aspects have been identified among medical professionals in earlier studies. As a One Health collaboration between veterinary and medical fields, we...
Data
The questionnaire to survey knowledge on toxoplasmosis among medical doctors. (PDF)
Data
People who work in clinical settings have an occupational risk for hepatitis B infection. The data was collected to assess the risk of cleaners in the clinical setting.
Article
Background Hepatitis B infection is a leading pathogenic infection that constitutes occupational hazard to health care workers. The current study examines the knowledge of hepatitis B infection and hepatitis B vaccination and uptake of the vaccine among the cleaners in a tertiary hospital in Nigeria. Materials and methods A cross-sectional hospita...
Article
Introduction Sexually Transmitted Infections are widespread, and have effects on the reproductive and sexual health of the general population particularly youths and adolescents. The study was done to assess the level of knowledge, perception and attitudes towards STI’s by undergraduate students. The objective was to understand and describe the dri...
Article
Background/Objectives Neonatal sepsis is an important cause of morbidity and mortality in the pediatric age group in spite of several attempts at mitigating its effects. This article determines the prevalence of neonatal sepsis and the pathogens responsible for sepsis as well as risk factors and outcome at the Babcock University Teaching Hospital....
Article
Background: Hand hygiene is a vital aspect of infection control and as such requires monitoring. Assessing compliance with hand hygiene and providing healthcare workers with feedback on their performance is important in any hospital hand hygiene improvement program. Aim: to investigate the degree of conformance with hand hygiene by healthcare pers...
Article
Full-text available
Background: Diarrhoea remains the 2nd cause of death among children globally despite the fact that the resources to control and prevent it are inexpensive and widely available. Aim: This study was carried out to evaluate the perception of mothers regarding diarrhoea so as to identify areas in need of further education and enlightenment campaign in...
Article
Full-text available
Introduction: in contrast to industrialized countries, until recently Group B Streptococcus (GBS) was infrequently reported in the developing world. This study was aimed at investigating the prevalence of GBS maternal colonization and to analyze the serotype distribution among the isolates. Methods: vagino-rectal swabs collected from pregnant wome...
Article
BACKGROUND: Urinary tract infections (UTI’s) are among the commonest bacterial infectious disease in clinical practice with a wide range of etiologic agents. It frequently occurs in both the hospital and the community. AIMS/OBJECTIVES:: To determine the etiology of UTI at BUTH and obtain data on their susceptibility and resistance patterns. METHODS...
Article
Full-text available
BACKGROUND: Urinary tract infections (UTI’s) are among the commonest bacterial infectious disease in clinical practice with a wide range of etiologic agents. It frequently occurs in both the hospital and the community. AIMS/OBJECTIVES:: To determine the etiology of UTI at BUTH and obtain data on their susceptibility and resistance patterns. METH...
Article
Full-text available
Background: In spite of advances in antimicrobial therapy over the past few decades’, pneumonia and other respiratory tract infections remain an important cause of morbidity and mortality. Aim: To determine the prevalent pathogens responsible for upper and lower respiratory tract infections in our local institution and the population profiles in wh...
Article
Full-text available
Hepatitis B virus (HBV) has long been recognized as an occupational risk for healthcare workers (HCWs) as a result of regular and routine exposure to blood and other body fluids in the course of their duties. The risk of occupational exposure to such infection has been the concerns of HCWs for years. However, there were scarcities of information on...
Article
Full-text available
Background: Chronic rhinosinusitis (CRS) significantly lowers the quality of life of patients. The common use of broad spectrum antibiotics for its treatment may alter the pathogens that promote the persistence of this condition. However, the data concerning the distribution of bacteria species. in patients with CRS are not consistent. Objective:...
Article
Full-text available
Background: Tuberculosis is the leading cause of death from any single pathogen and it has consistently continued to be a major public health challenge globally. Data show that Nigeria ranks tenth among the 22 high tuberculosis burden countries. Aim: This study intends to describe the profile of tuberculosis infections in Babcock University Teachin...
Article
Full-text available
Introduction: The increasing rates of antimicrobial resistance on the part of pathogens are gradually becoming a pandemic, this has to be curbed to reduce mortality. Background: The vast majority of antimicrobials currently in use are prescribed by Physicians. The Physicians act as a gateway in the control and use of life saving medications such as...
Article
Full-text available
Background: Penicillin is recommended as the first-line agent for intrapartum antibiotic prophylaxis (IAP). Although Group B Streptococcus (GBS) strains are generally susceptible to penicillin with only occasional resistance, they show varying resistance to erythromycin, clindamycin, and tetracycline. Therefore, knowledge of the resistance profile...
Article
Full-text available
Malaria rapid diagnostic test (RDT) is an antigen capture assay that enables rapid diagnosis of malaria without the need for electricity or highly skilled technicians. Though potentially useful, its adoption needs to be guided by local test sensitivity. This study evaluated the diagnostic performance of a commercially available RDT among 200 febril...
Article
Full-text available
Objective: Biosafety is an important element of quality management systems in laboratory practice as it is a measuring tool for compliance with accreditation and certification standards. Our aim was to assess the practices of laboratory personnel towards biosafety measures in their respective laboratories. Methods: The study design was a quantitati...
Article
Full-text available
Prostate biopsy presents a significant percentage of complications. Infection complicates more than 5% of patients subjected to prostate biopsy1 and is the most common reason for hospitalization following prostate biopsy2,3. The factors predicting a higher susceptibility to infection have been largely unknown but some literature have highlighted in...
Article
Full-text available
Introduction: Timely PEP after needle stick exposure to high risk body fluids can reduce the rate of occupational transmission significantly. Ignorance of this may increase the risk of seroconversion to HIV for healthcare workers. This study was conducted with the aim of demonstrating the current level of knowledge and practise of healthcare worke...
Article
Full-text available
Enterobacteriaceae cause a wide range of diseases including urinary tract infections, respiratory tract infections, sepsis, and gastroenteritis. They are the most frequently recovered pathogens from clinical samples and have varying susceptibility patterns. The study set out to determine the susceptibility profile of enterobacteriaceae species at t...
Article
Full-text available
Tuberculosis remains a huge public health challenge particularly in developing nations which typically have weak health systems in place. There is a tendency for HIV and Tuberculosis to co-infect the same patient. The demographic characteristics of patients with tuberculosis and rates of HIV co-infection were determined in this studyA total of 100...
Article
Full-text available
Background: Penicillin is recommended as the first-line agent for intrapartum antibiotic prophylaxis, while ampicillin is considered as an acceptable alternative. Although GBS strains are generally susceptible to penicillin with only occasional resistance, they show varying resistance to erythromycin, clindamycin and tetracycline. Therefore, a know...
Article
Full-text available
Objective: Vertically transmitted cytomegalovirus (CMV) is the most common cause of preventable congenital infection, including deafness and intellectual impairment worldwide. Till date, there is no consensus on routine antenatal screening worldwide. The objective of this study was to determine the prevalence of previous and primary CMV infection a...
Article
Full-text available
Background: Bacterial Vaginosis (BV) is an imbalance of the vaginal normal flora, and it is asymptomatic in most women. Therefore, one of the major ways of diagnosing BV is demonstration of an abnormal flora in the vagina. This can be achieved through various methods including Nugent score. In view of the association of BV with obstetric/gy- naecol...
Article
Full-text available
Background: Bacterial Vaginosis (BV) is an imbalance of the vaginal normal flora, and it is asymptomatic in most women. Therefore, one of the major ways of diagnosing BV is demonstration of an abnormal flora in the vagina. This can be achieved through various methods including Nugent score. In view of the association of BV with obstetric/gy-naecolo...

Network

Cited By

Projects

Projects (6)
Project
The aim is to describe the epidemiology while determinnig the impact of microbiological organisms (especially Chlamydia trachomatis and Mycoplasma genitalium) in gynaecological practice.